2xes - Revision history

OCA at 08:04, 23 October 2024

2024-10-23T08:04:27Z

← Older revision		Revision as of 08:04, 23 October 2024
Line 3:		Line 3:
	<StructureSection load='2xes' size='340' side='right'caption='[[2xes]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2xes' size='340' side='right'caption='[[2xes]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xes]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XES OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XES FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xes]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XES OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XES FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=K:POTASSIUM+ION'>K</scene>~~, ~~<scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~MSE~~:~~SELENOMETHIONINE~~'>~~MSE~~</scene><~~/td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td><~~td class~~=~~"sblockDat"><div style~~=~~'overflow~~: ~~auto; max-height: 3em;~~'>~~[[2xeq\|2xeq]], [[2xer\|2xer]]~~</~~div~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xes OCA], [https://pdbe.org/2xes PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xes RCSB], [https://www.ebi.ac.uk/pdbsum/2xes PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xes ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xes OCA], [https://pdbe.org/2xes PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xes RCSB], [https://www.ebi.ac.uk/pdbsum/2xes PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xes ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/PATL1_HUMAN PATL1_HUMAN]] RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus (HCV).<ref>PMID:17936923</ref> <ref>PMID:19628699</ref> <ref>PMID:20584987</ref> <ref>PMID:20852261</ref> <ref>PMID:20543818</ref>		[https://www.uniprot.org/uniprot/PATL1_HUMAN PATL1_HUMAN] RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus (HCV).<ref>PMID:17936923</ref> <ref>PMID:19628699</ref> <ref>PMID:20584987</ref> <ref>PMID:20852261</ref> <ref>PMID:20543818</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 16:		Line 15:
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xe/2xes_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xe/2xes_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
Line 34:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Tritschler, F]]		[[Category: Tritschler F]]
	[[Category: Weichenrieder, O]]		[[Category: Weichenrieder O]]
	~~[[Category: Mrna decapping]]~~
	~~[[Category: P-body]]~~
	~~[[Category: Rna binding protein~~]]

OCA at 10:51, 13 April 2022

2022-04-13T10:51:33Z

← Older revision		Revision as of 10:51, 13 April 2022
Line 3:		Line 3:
	<StructureSection load='2xes' size='340' side='right'caption='[[2xes]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2xes' size='340' side='right'caption='[[2xes]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xes]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XES OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2XES FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xes]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XES OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XES FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xeq\|2xeq]], [[2xer\|2xer]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xeq\|2xeq]], [[2xer\|2xer]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2xes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xes OCA], [~~http~~://pdbe.org/2xes PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xes RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xes PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xes ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xes OCA], [https://pdbe.org/2xes PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xes RCSB], [https://www.ebi.ac.uk/pdbsum/2xes PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xes ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/PATL1_HUMAN PATL1_HUMAN]] RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus (HCV).<ref>PMID:17936923</ref> <ref>PMID:19628699</ref> <ref>PMID:20584987</ref> <ref>PMID:20852261</ref> <ref>PMID:20543818</ref>		[[https://www.uniprot.org/uniprot/PATL1_HUMAN PATL1_HUMAN]] RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus (HCV).<ref>PMID:17936923</ref> <ref>PMID:19628699</ref> <ref>PMID:20584987</ref> <ref>PMID:20852261</ref> <ref>PMID:20543818</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 15:12, 8 July 2020

2020-07-08T15:12:48Z

← Older revision		Revision as of 15:12, 8 July 2020
Line 1:		Line 1:

	==Human PatL1 C-terminal domain (loop variant)==		==Human PatL1 C-terminal domain (loop variant)==
	<StructureSection load='2xes' size='340' side='right' caption='[[2xes]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2xes' size='340' side='right'caption='[[2xes]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xes]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XES OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XES FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xes]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XES OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XES FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xeq\|2xeq]], [[2xer\|2xer]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xeq\|2xeq]], [[2xer\|2xer]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xes OCA], [http://pdbe.org/2xes PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xes RCSB], [http://www.ebi.ac.uk/pdbsum/2xes PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xes ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xes OCA], [http://pdbe.org/2xes PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xes RCSB], [http://www.ebi.ac.uk/pdbsum/2xes PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xes ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Tritschler, F]]		[[Category: Tritschler, F]]
	[[Category: Weichenrieder, O]]		[[Category: Weichenrieder, O]]

OCA at 09:35, 3 October 2018

2018-10-03T09:35:47Z

← Older revision		Revision as of 09:35, 3 October 2018
Line 1:		Line 1:

	==~~HUMAN PATL1~~ C-~~TERMINAL DOMAIN~~ (~~LOOP VARIANT~~)==		==Human PatL1 C-terminal domain (loop variant)==
	<StructureSection load='2xes' size='340' side='right' caption='[[2xes]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2xes' size='340' side='right' caption='[[2xes]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xe/2xes_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xe/2xes_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 06:02, 5 August 2016

2016-08-05T06:02:01Z

← Older revision		Revision as of 06:02, 5 August 2016
Line 1:		Line 1:

	==HUMAN PATL1 C-TERMINAL DOMAIN (LOOP VARIANT)==		==HUMAN PATL1 C-TERMINAL DOMAIN (LOOP VARIANT)==
	<StructureSection load='2xes' size='340' side='right' caption='[[2xes]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2xes' size='340' side='right' caption='[[2xes]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xes]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XES OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XES FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xes]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XES OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XES FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xeq\|2xeq]], [[2xer\|2xer]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xeq\|2xeq]], [[2xer\|2xer]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xes OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xes RCSB], [http://www.ebi.ac.uk/pdbsum/2xes PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xes OCA], [http://pdbe.org/2xes PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xes RCSB], [http://www.ebi.ac.uk/pdbsum/2xes PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xes ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xes ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2xes" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Tritschler, F]]		[[Category: Tritschler, F]]
	[[Category: Weichenrieder, O]]		[[Category: Weichenrieder, O]]

OCA at 16:21, 25 December 2014

2014-12-25T16:21:35Z

← Older revision		Revision as of 16:21, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xes OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xes RCSB], [http://www.ebi.ac.uk/pdbsum/2xes PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xes OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xes RCSB], [http://www.ebi.ac.uk/pdbsum/2xes PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/PATL1_HUMAN PATL1_HUMAN]] RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus (HCV).<ref>PMID:17936923</ref> <ref>PMID:19628699</ref> <ref>PMID:20584987</ref> <ref>PMID:20852261</ref> <ref>PMID:20543818</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 12:25, 18 December 2014

2014-12-18T12:25:35Z

← Older revision		Revision as of 12:25, 18 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_2xes\| PDB=2xes \| SCENE= }}~~		==HUMAN PATL1 C-TERMINAL DOMAIN (LOOP VARIANT)==
	===HUMAN PATL1 C-TERMINAL DOMAIN (LOOP VARIANT)===		<StructureSection load='2xes' size='340' side='right' caption='[[2xes]], [[Resolution\|resolution]] 2.10Å' scene=''>
	~~{{ABSTRACT_PUBMED_20543818}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2xes]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XES OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XES FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
			<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xeq\|2xeq]], [[2xer\|2xer]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xes OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xes RCSB], [http://www.ebi.ac.uk/pdbsum/2xes PDBsum]</span></td></tr>
			</table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xe/2xes_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Pat proteins regulate the transition of mRNAs from a state that is translationally active to one that is repressed, committing targeted mRNAs to degradation. Pat proteins contain a conserved N-terminal sequence, a proline-rich region, a Mid domain and a C-terminal domain (Pat-C). We show that Pat-C is essential for the interaction with mRNA decapping factors (i.e. DCP2, EDC4 and LSm1-7), whereas the P-rich region and Mid domain have distinct functions in modulating these interactions. DCP2 and EDC4 binding is enhanced by the P-rich region and does not require LSm1-7. LSm1-7 binding is assisted by the Mid domain and is reduced by the P-rich region. Structural analysis revealed that Pat-C folds into an alpha-alpha superhelix, exposing conserved and basic residues on one side of the domain. This conserved and basic surface is required for RNA, DCP2, EDC4 and LSm1-7 binding. The multiplicity of interactions mediated by Pat-C suggests that certain of these interactions are mutually exclusive and, therefore, that Pat proteins switch decapping partners allowing transitions between sequential steps in the mRNA decapping pathway.

	~~==Function==~~		The C-terminal alpha-alpha superhelix of Pat is required for mRNA decapping in metazoa.,Braun JE, Tritschler F, Haas G, Igreja C, Truffault V, Weichenrieder O, Izaurralde E EMBO J. 2010 Jul 21;29(14):2368-80. Epub 2010 Jun 11. PMID:20543818<ref>PMID:20543818</ref>
	~~[[http://www.uniprot.org/uniprot/PATL1_HUMAN PATL1_HUMAN]] RNA~~-~~binding protein involved in deadenylation~~-~~dependent decapping~~ of ~~mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required~~ for ~~cytoplasmic~~ mRNA ~~processing body (P-body) assembly~~. ~~In case of infection~~, ~~required for translation and replication of hepatitis~~ C ~~virus~~ (~~HCV~~).~~<ref>PMID:17936923</ref><ref>PMID:19628699</ref><ref>PMID:20584987</ref><ref>~~PMID:~~20852261</ref>~~<ref>PMID:20543818</ref>

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[2xes]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2XES OCA].~~		</div>
			== References ==
	==~~Reference~~==		<references/>
	~~<ref group="xtra">PMID:020543818</ref>~~<references ~~group="xtra"~~/><~~references~~/>		__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Tritschler, F.]]		[[Category: Tritschler, F]]
	[[Category: Weichenrieder, O.]]		[[Category: Weichenrieder, O]]
	[[Category: Mrna decapping]]		[[Category: Mrna decapping]]
	[[Category: P-body]]		[[Category: P-body]]
	[[Category: Rna binding protein]]		[[Category: Rna binding protein]]

OCA at 09:18, 27 March 2013

2013-03-27T09:18:33Z

← Older revision		Revision as of 09:18, 27 March 2013
Line 1:		Line 1:
	~~[[Image:2xes.png\|left\|200px]]~~

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2xes", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2xes\| PDB=2xes \| SCENE= }}		{{STRUCTURE_2xes\| PDB=2xes \| SCENE= }}

	===HUMAN PATL1 C-TERMINAL DOMAIN (LOOP VARIANT)===		===HUMAN PATL1 C-TERMINAL DOMAIN (LOOP VARIANT)===
			{{ABSTRACT_PUBMED_20543818}}

			==Function==
	~~<!--~~		[[http://www.uniprot.org/uniprot/PATL1_HUMAN PATL1_HUMAN]] RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus (HCV).<ref>PMID:17936923</ref><ref>PMID:19628699</ref><ref>PMID:20584987</ref><ref>PMID:20852261</ref><ref>PMID:20543818</ref>
	~~The line below this paragraph, {{ABSTRACT_PUBMED_20543818}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov)~~, ~~where 20543818 is~~ the ~~PubMed ID number~~.
	-->
	~~{{ABSTRACT_PUBMED_20543818}}~~

	==About this Structure==		==About this Structure==
Line 22:		Line 10:

	==Reference==		==Reference==
	<ref group="xtra">PMID:020543818</ref><references group="xtra"/>		<ref group="xtra">PMID:020543818</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Tritschler, F.]]		[[Category: Tritschler, F.]]
	[[Category: Weichenrieder, O.]]		[[Category: Weichenrieder, O.]]
			[[Category: Mrna decapping]]
			[[Category: P-body]]
			[[Category: Rna binding protein]]

OCA: Protected "2xes" [edit=sysop:move=sysop]

2011-05-18T06:00:06Z

Protected "2xes" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:00, 18 May 2011
(No difference)

OCA at 06:00, 18 May 2011

2011-05-18T06:00:03Z

← Older revision		Revision as of 06:00, 18 May 2011
Line 1:		Line 1:
	~~{{Seed}}~~
	[[Image:2xes.png\|left\|200px]]		[[Image:2xes.png\|left\|200px]]

Line 20:		Line 19:

	==About this Structure==		==About this Structure==
	~~2XES~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XES OCA].		[[2xes]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XES OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~20543818~~</ref><references group="xtra"/>		<ref group="xtra">PMID:020543818</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Tritschler, F.]]		[[Category: Tritschler, F.]]
	[[Category: Weichenrieder, O.]]		[[Category: Weichenrieder, O.]]
	~~[[Category: Mrna decapping]]~~
	~~[[Category: P-body]]~~
	~~[[Category: Rna binding protein]]~~

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 23 08:39:24 2010''~~