2xml - Revision history

OCA at 10:34, 20 December 2023

2023-12-20T10:34:34Z

← Older revision		Revision as of 10:34, 20 December 2023
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	<StructureSection load='2xml' size='340' side='right'caption='[[2xml]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='2xml' size='340' side='right'caption='[[2xml]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xml]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XML OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2XML FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xml]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XML FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=OGA:N-OXALYLGLYCINE'>OGA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.55Å</td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xdp\|2xdp]]~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=OGA:N-OXALYLGLYCINE'>OGA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2xml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xml OCA], [~~http~~://pdbe.org/2xml PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xml RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xml PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xml ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xml OCA], [https://pdbe.org/2xml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xml RCSB], [https://www.ebi.ac.uk/pdbsum/2xml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xml ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/KDM4C_HUMAN KDM4C_HUMAN]] Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.<ref>PMID:16603238</ref>		[https://www.uniprot.org/uniprot/KDM4C_HUMAN KDM4C_HUMAN] Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.<ref>PMID:16603238</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Arrowsmith, C]]		[[Category: Arrowsmith C]]
	[[Category: Bountra, C]]		[[Category: Bountra C]]
	[[Category: Carpenter, L]]		[[Category: Carpenter L]]
	~~[[Category: Delft, F von~~]]		[[Category: Edwards A]]
	[[Category: Edwards, A]]		[[Category: Gileadi C]]
	[[Category: Gileadi, C]]		[[Category: Krojer T]]
	[[Category: Krojer, T]]		[[Category: Ng S]]
	[[Category: Ng, S]]		[[Category: Oppermann U]]
	[[Category: Oppermann, U]]		[[Category: Pike ACW]]
	[[Category: Pike~~, A C.W~~]]		[[Category: Weigelt J]]
	[[Category: Weigelt, J]]		[[Category: Yue WW]]
	[[Category: Yue~~, W W~~]]		[[Category: Von Delft F]]
	[[Category: ~~Metal binding]]~~
	~~[[Category: Oxidoreductase]]~~
	~~[[Category: Transcription regulation~~]]

OCA at 10:45, 16 September 2020

2020-09-16T10:45:51Z

← Older revision		Revision as of 10:45, 16 September 2020
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	==Crystal structure of human JMJD2C catalytic domain==		==Crystal structure of human JMJD2C catalytic domain==
	<StructureSection load='2xml' size='340' side='right' caption='[[2xml]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='2xml' size='340' side='right'caption='[[2xml]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xml]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XML OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XML FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xml]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XML OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XML FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=OGA:N-OXALYLGLYCINE'>OGA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=OGA:N-OXALYLGLYCINE'>OGA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xdp\|2xdp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xdp\|2xdp]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xml OCA], [http://pdbe.org/2xml PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xml RCSB], [http://www.ebi.ac.uk/pdbsum/2xml PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xml ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xml OCA], [http://pdbe.org/2xml PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xml RCSB], [http://www.ebi.ac.uk/pdbsum/2xml PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xml ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 31:		Line 31:

	==See Also==		==See Also==
	*[[Jumonji domain-containing protein\|Jumonji domain-containing protein]]		*[[Jumonji domain-containing protein 3D structures\|Jumonji domain-containing protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Arrowsmith, C]]		[[Category: Arrowsmith, C]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]

OCA at 08:20, 12 December 2018

2018-12-12T08:20:25Z

← Older revision		Revision as of 08:20, 12 December 2018
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xm/2xml_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xm/2xml_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 17:34, 9 March 2017

2017-03-09T17:34:17Z

← Older revision		Revision as of 17:34, 9 March 2017
Line 1:		Line 1:

	==Crystal structure of human JMJD2C catalytic domain==		==Crystal structure of human JMJD2C catalytic domain==
	<StructureSection load='2xml' size='340' side='right' caption='[[2xml]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='2xml' size='340' side='right' caption='[[2xml]], [[Resolution\|resolution]] 2.55Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=OGA:N-OXALYLGLYCINE'>OGA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=OGA:N-OXALYLGLYCINE'>OGA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xdp\|2xdp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xdp\|2xdp]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xml OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xml RCSB], [http://www.ebi.ac.uk/pdbsum/2xml PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xml OCA], [http://pdbe.org/2xml PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xml RCSB], [http://www.ebi.ac.uk/pdbsum/2xml PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xml ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xml ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2xml" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[~~Lysine~~-~~specific histone demethylase~~\|~~Lysine~~-~~specific histone demethylase~~]]		*[[Jumonji domain-containing protein\|Jumonji domain-containing protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:24, 13 May 2015

2015-05-13T06:24:12Z

← Older revision		Revision as of 06:24, 13 May 2015
Line 2:		Line 2:
	<StructureSection load='2xml' size='340' side='right' caption='[[2xml]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='2xml' size='340' side='right' caption='[[2xml]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xml]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XML OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XML FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xml]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XML OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XML FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=OGA:N-OXALYLGLYCINE'>OGA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=OGA:N-OXALYLGLYCINE'>OGA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xdp\|2xdp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xdp\|2xdp]]</td></tr>
Line 19:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			N(epsilon)-Methylations of histone lysine residues play critical roles in cell biology by "marking" chromatin for transcriptional activation or repression. Lysine demethylases reverse N(epsilon)-methylation in a sequence- and methylation-selective manner. The determinants of sequence selectivity for histone demethylases have been unclear. The human JMJD2 (KDM4) H3K9 and H3K36 demethylases can be divided into members that act on both H3K9 and H3K36 and H3K9 alone. Kinetic, crystallographic, and mutagenetic studies in vitro and in cells on KDM4A-E reveal that selectivity is determined by multiple interactions within the catalytic domain but outside the active site. Structurally informed phylogenetic analyses reveal that KDM4A-C orthologues exist in all genome-sequenced vertebrates with earlier animals containing only a single KDM4 enzyme. KDM4D orthologues only exist in eutherians (placental mammals) where they are conserved, including proposed substrate sequence-determining residues. The results will be useful for the identification of inhibitors for specific histone demethylases.

			Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family.,Hillringhaus L, Yue WW, Rose NR, Ng SS, Gileadi C, Loenarz C, Bello SH, Bray JE, Schofield CJ, Oppermann U J Biol Chem. 2011 Dec 2;286(48):41616-25. Epub 2011 Sep 13. PMID:21914792<ref>PMID:21914792</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

			==See Also==
			*[[Lysine-specific histone demethylase\|Lysine-specific histone demethylase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Arrowsmith, C]]		[[Category: Arrowsmith, C]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]
	[[Category: Carpenter, L]]		[[Category: Carpenter, L]]
	[[Category: Delft, F ~~Von~~]]		[[Category: Delft, F von]]
	[[Category: Edwards, A]]		[[Category: Edwards, A]]
	[[Category: Gileadi, C]]		[[Category: Gileadi, C]]

OCA at 16:29, 25 December 2014

2014-12-25T16:29:24Z

← Older revision		Revision as of 16:29, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xml OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xml RCSB], [http://www.ebi.ac.uk/pdbsum/2xml PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xml OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xml RCSB], [http://www.ebi.ac.uk/pdbsum/2xml PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/KDM4C_HUMAN KDM4C_HUMAN]] Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.<ref>PMID:16603238</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 17:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C.]]		[[Category: Arrowsmith, C]]
	[[Category: Bountra, C.]]		[[Category: Bountra, C]]
	[[Category: Carpenter, L.]]		[[Category: Carpenter, L]]
	[[Category: Delft, F Von.]]		[[Category: Delft, F Von]]
	[[Category: Edwards, A.]]		[[Category: Edwards, A]]
	[[Category: Gileadi, C.]]		[[Category: Gileadi, C]]
	[[Category: Krojer, T.]]		[[Category: Krojer, T]]
	[[Category: Ng, S.]]		[[Category: Ng, S]]
	[[Category: Oppermann, U.]]		[[Category: Oppermann, U]]
	[[Category: Pike, A C.W.]]		[[Category: Pike, A C.W]]
	[[Category: Weigelt, J.]]		[[Category: Weigelt, J]]
	[[Category: Yue, W W.]]		[[Category: Yue, W W]]
	[[Category: Metal binding]]		[[Category: Metal binding]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]

OCA at 13:20, 22 October 2014

2014-10-22T13:20:49Z

← Older revision		Revision as of 13:20, 22 October 2014
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	~~[[Image:2xml.png\|left\|200px]]~~		==Crystal structure of human JMJD2C catalytic domain==
			<StructureSection load='2xml' size='340' side='right' caption='[[2xml]], [[Resolution\|resolution]] 2.55Å' scene=''>
	~~{{STRUCTURE_2xml\| PDB=2xml \| SCENE= }}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2xml]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XML OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XML FirstGlance]. <br>
	===Crystal structure of human JMJD2C catalytic domain===		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=OGA:N-OXALYLGLYCINE'>OGA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xdp\|2xdp]]</td></tr>
	~~{{ABSTRACT_PUBMED_021914792}}~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xml OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xml RCSB], [http://www.ebi.ac.uk/pdbsum/2xml PDBsum]</span></td></tr>
			</table>
	==~~About this Structure~~==		== Evolutionary Conservation ==
	[[2xml]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XML OCA].		[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xm/2xml_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C.]]		[[Category: Arrowsmith, C.]]

OCA: Protected "2xml" [edit=sysop:move=sysop]

2012-12-05T09:54:15Z

Protected "2xml" [edit=sysop:move=sysop]

← Older revision	Revision as of 09:54, 5 December 2012
(No difference)

OCA at 09:54, 5 December 2012

2012-12-05T09:54:13Z

← Older revision		Revision as of 09:54, 5 December 2012
Line 1:		Line 1:
	~~{{Seed}}~~		[[Image:2xml.png\|left\|200px]]
	[[Image:2xml.~~jpg~~\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2xml", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2xml\| PDB=2xml \| SCENE= }}		{{STRUCTURE_2xml\| PDB=2xml \| SCENE= }}

	===~~CRYSTAL STRUCTURE OF HUMAN~~ JMJD2C ~~CATALYTIC DOMAIN~~===		===Crystal structure of human JMJD2C catalytic domain===

			{{ABSTRACT_PUBMED_021914792}}

	==About this Structure==		==About this Structure==
	~~2XML~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XML OCA].		[[2xml]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XML OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C.]]		[[Category: Arrowsmith, C.]]
	[[Category: Bountra, C.]]		[[Category: Bountra, C.]]
	[[Category: Carpenter, L.]]		[[Category: Carpenter, L.]]
			[[Category: Delft, F Von.]]
	[[Category: Edwards, A.]]		[[Category: Edwards, A.]]
	[[Category: Gileadi, C.]]		[[Category: Gileadi, C.]]
Line 25:		Line 20:
	[[Category: Oppermann, U.]]		[[Category: Oppermann, U.]]
	[[Category: Pike, A C.W.]]		[[Category: Pike, A C.W.]]
	~~[[Category: Vondelft, F.]]~~
	[[Category: Weigelt, J.]]		[[Category: Weigelt, J.]]
	[[Category: Yue, W W.]]		[[Category: Yue, W W.]]
Line 31:		Line 25:
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 29 08:10:58 2010''~~

OCA at 05:01, 29 September 2010

2010-09-29T05:01:44Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{Seed}}
-The entry 2xml is ON HOLD
+<!--
-Authors: Yue, W.W., Gileadi, C., Krojer, T., Pike, A.C.W., vonDelft, F., Ng, S., Carpenter, L., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
+===CRYSTAL STRUCTURE OF HUMAN JMJD2C CATALYTIC DOMAIN===
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug  4 08:41:22 2010''
+==About this Structure==