2xtd - Revision history

OCA at 10:38, 20 December 2023

2023-12-20T10:38:56Z

← Older revision		Revision as of 10:38, 20 December 2023
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	<StructureSection load='2xtd' size='340' side='right'caption='[[2xtd]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='2xtd' size='340' side='right'caption='[[2xtd]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xtd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XTD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XTD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xtd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XTD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XTD FirstGlance]. <br>
	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[2xtc\|2xtc]]~~, [[~~2xte~~\|~~2xte~~]]~~</div>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.2Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xtd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xtd OCA], [https://pdbe.org/2xtd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xtd RCSB], [https://www.ebi.ac.uk/pdbsum/2xtd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xtd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xtd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xtd OCA], [https://pdbe.org/2xtd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xtd RCSB], [https://www.ebi.ac.uk/pdbsum/2xtd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xtd ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/TBL1X_HUMAN TBL1X_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Fairall, L]]		[[Category: Fairall L]]
	[[Category: Greenwood~~, J A~~]]		[[Category: Greenwood JA]]
	[[Category: Oberoi, J]]		[[Category: Oberoi J]]
	[[Category: Schwabe~~, J W.R~~]]		[[Category: Schwabe JWR]]
	[[Category: Watson~~, P J]]~~		[[Category: Watson PJ]]
	~~[[Category: N-cor repressor complex]]~~
	~~[[Category: Proteasome]]~~
	~~[[Category: Transcription~~]]

OCA at 12:17, 27 April 2022

2022-04-27T12:17:03Z

← Older revision		Revision as of 12:17, 27 April 2022
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	<StructureSection load='2xtd' size='340' side='right'caption='[[2xtd]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='2xtd' size='340' side='right'caption='[[2xtd]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xtd]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XTD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2XTD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xtd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XTD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XTD FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xtc\|2xtc]], [[2xte\|2xte]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xtc\|2xtc]], [[2xte\|2xte]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2xtd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xtd OCA], [~~http~~://pdbe.org/2xtd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xtd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xtd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xtd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xtd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xtd OCA], [https://pdbe.org/2xtd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xtd RCSB], [https://www.ebi.ac.uk/pdbsum/2xtd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xtd ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 12:20, 22 July 2020

2020-07-22T12:20:27Z

← Older revision		Revision as of 12:20, 22 July 2020
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	==Structure of the TBL1 tetramerisation domain==		==Structure of the TBL1 tetramerisation domain==
	<StructureSection load='2xtd' size='340' side='right' caption='[[2xtd]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='2xtd' size='340' side='right'caption='[[2xtd]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xtd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XTD OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XTD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xtd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XTD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XTD FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xtc\|2xtc]], [[2xte\|2xte]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xtc\|2xtc]], [[2xte\|2xte]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xtd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xtd OCA], [http://pdbe.org/2xtd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xtd RCSB], [http://www.ebi.ac.uk/pdbsum/2xtd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xtd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xtd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xtd OCA], [http://pdbe.org/2xtd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xtd RCSB], [http://www.ebi.ac.uk/pdbsum/2xtd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xtd ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Fairall, L]]		[[Category: Fairall, L]]
	[[Category: Greenwood, J A]]		[[Category: Greenwood, J A]]

OCA at 09:02, 10 October 2018

2018-10-10T09:02:17Z

← Older revision		Revision as of 09:02, 10 October 2018
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	==~~STRUCTURE OF THE~~ TBL1 ~~TETRAMERISATION DOMAIN~~==		==Structure of the TBL1 tetramerisation domain==
	<StructureSection load='2xtd' size='340' side='right' caption='[[2xtd]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='2xtd' size='340' side='right' caption='[[2xtd]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 06:57, 5 August 2016

2016-08-05T06:57:16Z

← Older revision		Revision as of 06:57, 5 August 2016
Line 1:		Line 1:

	==STRUCTURE OF THE TBL1 TETRAMERISATION DOMAIN==		==STRUCTURE OF THE TBL1 TETRAMERISATION DOMAIN==
	<StructureSection load='2xtd' size='340' side='right' caption='[[2xtd]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='2xtd' size='340' side='right' caption='[[2xtd]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xtd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XTD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XTD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xtd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XTD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XTD FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xtc\|2xtc]], [[2xte\|2xte]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xtc\|2xtc]], [[2xte\|2xte]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xtd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xtd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xtd RCSB], [http://www.ebi.ac.uk/pdbsum/2xtd PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xtd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xtd OCA], [http://pdbe.org/2xtd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xtd RCSB], [http://www.ebi.ac.uk/pdbsum/2xtd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xtd ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2xtd" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Fairall, L]]		[[Category: Fairall, L]]
	[[Category: Greenwood, J A]]		[[Category: Greenwood, J A]]

OCA at 00:02, 25 December 2014

2014-12-25T00:02:19Z

← Older revision		Revision as of 00:02, 25 December 2014
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	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Fairall, L.]]		[[Category: Fairall, L]]
	[[Category: Greenwood, J A.]]		[[Category: Greenwood, J A]]
	[[Category: Oberoi, J.]]		[[Category: Oberoi, J]]
	[[Category: Schwabe, J W.R.]]		[[Category: Schwabe, J W.R]]
	[[Category: Watson, P J.]]		[[Category: Watson, P J]]
	[[Category: N-cor repressor complex]]		[[Category: N-cor repressor complex]]
	[[Category: Proteasome]]		[[Category: Proteasome]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 13:10, 22 October 2014

2014-10-22T13:10:47Z

← Older revision		Revision as of 13:10, 22 October 2014
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	[[~~Image~~:~~2xtd~~.~~png~~\|~~left~~\|~~200px~~]]		==STRUCTURE OF THE TBL1 TETRAMERISATION DOMAIN==
			<StructureSection load='2xtd' size='340' side='right' caption='[[2xtd]], [[Resolution\|resolution]] 3.20Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2xtd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XTD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XTD FirstGlance]. <br>
			</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xtc\|2xtc]], [[2xte\|2xte]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xtd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xtd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xtd RCSB], [http://www.ebi.ac.uk/pdbsum/2xtd PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Eukaryotic transcriptional repressors function by recruiting large coregulatory complexes that target histone deacetylase enzymes to gene promoters and enhancers. Transcriptional repression complexes, assembled by the corepressor NCoR and its homolog SMRT, are crucial in many processes, including development and metabolic physiology. The core repression complex involves the recruitment of three proteins, HDAC3, GPS2 and TBL1, to a highly conserved repression domain within SMRT and NCoR. We have used structural and functional approaches to gain insight into the architecture and biological role of this complex. We report the crystal structure of the tetrameric oligomerization domain of TBL1, which interacts with both SMRT and GPS2, and the NMR structure of the interface complex between GPS2 and SMRT. These structures, together with computational docking, mutagenesis and functional assays, reveal the assembly mechanism and stoichiometry of the corepressor complex.

	~~{{STRUCTURE_2xtd\| PDB=2xtd \| SCENE= }}~~		Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery.,Oberoi J, Fairall L, Watson PJ, Yang JC, Czimmerer Z, Kampmann T, Goult BT, Greenwood JA, Gooch JT, Kallenberger BC, Nagy L, Neuhaus D, Schwabe JW Nat Struct Mol Biol. 2011 Jan 16. PMID:21240272<ref>PMID:21240272</ref>

	~~===STRUCTURE OF THE TBL1 TETRAMERISATION DOMAIN===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_21240272}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2xtd]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2XTD OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:021240272<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Fairall, L.]]		[[Category: Fairall, L.]]

OCA at 20:02, 7 January 2013

2013-01-07T20:02:33Z

← Older revision		Revision as of 20:02, 7 January 2013
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	[[Image:2xtd.png\|left\|200px]]		[[Image:2xtd.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2xtd", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2xtd\| PDB=2xtd \| SCENE= }}		{{STRUCTURE_2xtd\| PDB=2xtd \| SCENE= }}

	===STRUCTURE OF THE TBL1 TETRAMERISATION DOMAIN===		===STRUCTURE OF THE TBL1 TETRAMERISATION DOMAIN===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_21240272}}, adds the Publication Abstract to the page~~
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	{{ABSTRACT_PUBMED_21240272}}		{{ABSTRACT_PUBMED_21240272}}

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	==Reference==		==Reference==
	<ref group="xtra">PMID:~~21240272~~</ref><references group="xtra"/>		<ref group="xtra">PMID:021240272</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Fairall, L.]]		[[Category: Fairall, L.]]
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	[[Category: Schwabe, J W.R.]]		[[Category: Schwabe, J W.R.]]
	[[Category: Watson, P J.]]		[[Category: Watson, P J.]]
			[[Category: N-cor repressor complex]]
			[[Category: Proteasome]]
			[[Category: Transcription]]

OCA at 04:45, 16 February 2011

2011-02-16T04:45:33Z

← Older revision		Revision as of 04:45, 16 February 2011
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	[[Image:2xtd.~~jpg~~\|left\|200px]]		[[Image:2xtd.png\|left\|200px]]

	<!--		<!--
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	===STRUCTURE OF THE TBL1 TETRAMERISATION DOMAIN===		===STRUCTURE OF THE TBL1 TETRAMERISATION DOMAIN===


			<!--
			The line below this paragraph, {{ABSTRACT_PUBMED_21240272}}, adds the Publication Abstract to the page
			(as it appears on PubMed at http://www.pubmed.gov), where 21240272 is the PubMed ID number.
			-->
			{{ABSTRACT_PUBMED_21240272}}

	==About this Structure==		==About this Structure==
	[[2xtd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XTD OCA].		[[2xtd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XTD OCA].

			==Reference==
			<ref group="xtra">PMID:21240272</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Fairall, L.]]		[[Category: Fairall, L.]]
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	[[Category: Oberoi, J.]]		[[Category: Oberoi, J.]]
	[[Category: Schwabe, J W.R.]]		[[Category: Schwabe, J W.R.]]
	[[Category: Watson, P.]]		[[Category: Watson, P J.]]

OCA: Protected "2xtd" [edit=sysop:move=sysop]

2011-01-19T06:12:53Z

Protected "2xtd" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:12, 19 January 2011
(No difference)