2xus - Revision history

OCA at 10:39, 20 December 2023

2023-12-20T10:39:32Z

← Older revision		Revision as of 10:39, 20 December 2023
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	<StructureSection load='2xus' size='340' side='right'caption='[[2xus]], [[Resolution\|resolution]] 1.91Å' scene=''>		<StructureSection load='2xus' size='340' side='right'caption='[[2xus]], [[Resolution\|resolution]] 1.91Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xus]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XUS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xus]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XUS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.912Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xus OCA], [https://pdbe.org/2xus PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xus RCSB], [https://www.ebi.ac.uk/pdbsum/2xus PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xus ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xus OCA], [https://pdbe.org/2xus PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xus RCSB], [https://www.ebi.ac.uk/pdbsum/2xus PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xus ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/BRMS1_HUMAN BRMS1_HUMAN]] Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.<ref>PMID:14581478</ref> <ref>PMID:17000776</ref> <ref>PMID:20830743</ref>		[https://www.uniprot.org/uniprot/BRMS1_HUMAN BRMS1_HUMAN] Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.<ref>PMID:14581478</ref> <ref>PMID:17000776</ref> <ref>PMID:20830743</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Bravo, J]]		[[Category: Bravo J]]
	[[Category: Neira~~, J L~~]]		[[Category: Neira JL]]
	[[Category: Ortiz-Lombardia, M]]		[[Category: Ortiz-Lombardia M]]
	[[Category: Rivera, J]]		[[Category: Rivera J]]
	[[Category: Romero, A]]		[[Category: Romero A]]
	[[Category: Spinola-Amilibia, M]]		[[Category: Spinola-Amilibia M]]
	~~[[Category: Breast cancer metastasis]]~~
	~~[[Category: Protein binding~~]]

OCA at 12:17, 27 April 2022

2022-04-27T12:17:34Z

← Older revision		Revision as of 12:17, 27 April 2022
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	<StructureSection load='2xus' size='340' side='right'caption='[[2xus]], [[Resolution\|resolution]] 1.91Å' scene=''>		<StructureSection load='2xus' size='340' side='right'caption='[[2xus]], [[Resolution\|resolution]] 1.91Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xus]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2XUS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xus]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XUS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2xus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xus OCA], [~~http~~://pdbe.org/2xus PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xus RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xus PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xus ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xus OCA], [https://pdbe.org/2xus PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xus RCSB], [https://www.ebi.ac.uk/pdbsum/2xus PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xus ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/BRMS1_HUMAN BRMS1_HUMAN]] Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.<ref>PMID:14581478</ref> <ref>PMID:17000776</ref> <ref>PMID:20830743</ref>		[[https://www.uniprot.org/uniprot/BRMS1_HUMAN BRMS1_HUMAN]] Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.<ref>PMID:14581478</ref> <ref>PMID:17000776</ref> <ref>PMID:20830743</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:21, 22 July 2020

2020-07-22T12:21:39Z

← Older revision		Revision as of 12:21, 22 July 2020
Line 1:		Line 1:

	==Crystal Structure of the BRMS1 N-terminal region==		==Crystal Structure of the BRMS1 N-terminal region==
	<StructureSection load='2xus' size='340' side='right' caption='[[2xus]], [[Resolution\|resolution]] 1.91Å' scene=''>		<StructureSection load='2xus' size='340' side='right'caption='[[2xus]], [[Resolution\|resolution]] 1.91Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xus]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUS OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XUS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xus]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XUS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xus OCA], [http://pdbe.org/2xus PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xus RCSB], [http://www.ebi.ac.uk/pdbsum/2xus PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xus ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xus OCA], [http://pdbe.org/2xus PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xus RCSB], [http://www.ebi.ac.uk/pdbsum/2xus PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xus ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Bravo, J]]		[[Category: Bravo, J]]
	[[Category: Neira, J L]]		[[Category: Neira, J L]]

OCA at 09:21, 10 October 2018

2018-10-10T09:21:07Z

← Older revision		Revision as of 09:21, 10 October 2018
Line 1:		Line 1:

	==~~CRYSTAL STRUCTURE OF THE~~ BRMS1 N-~~TERMINAL REGION~~==		==Crystal Structure of the BRMS1 N-terminal region==
	<StructureSection load='2xus' size='340' side='right' caption='[[2xus]], [[Resolution\|resolution]] 1.91Å' scene=''>		<StructureSection load='2xus' size='340' side='right' caption='[[2xus]], [[Resolution\|resolution]] 1.91Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 12:26, 5 August 2016

2016-08-05T12:26:56Z

← Older revision		Revision as of 12:26, 5 August 2016
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF THE BRMS1 N-TERMINAL REGION==		==CRYSTAL STRUCTURE OF THE BRMS1 N-TERMINAL REGION==
	<StructureSection load='2xus' size='340' side='right' caption='[[2xus]], [[Resolution\|resolution]] 1.91Å' scene=''>		<StructureSection load='2xus' size='340' side='right' caption='[[2xus]], [[Resolution\|resolution]] 1.91Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xus]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XUS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xus]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XUS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xus OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xus RCSB], [http://www.ebi.ac.uk/pdbsum/2xus PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xus OCA], [http://pdbe.org/2xus PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xus RCSB], [http://www.ebi.ac.uk/pdbsum/2xus PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xus ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/BRMS1_HUMAN BRMS1_HUMAN]] Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.<ref>PMID:14581478</ref> <ref>PMID:17000776</ref> <ref>PMID:20830743</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2xus" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Bravo, J]]		[[Category: Bravo, J]]
	[[Category: Neira, J L]]		[[Category: Neira, J L]]

OCA at 23:07, 3 January 2015

2015-01-03T23:07:01Z

← Older revision		Revision as of 23:07, 3 January 2015
Line 2:		Line 2:
	<StructureSection load='2xus' size='340' side='right' caption='[[2xus]], [[Resolution\|resolution]] 1.91Å' scene=''>		<StructureSection load='2xus' size='340' side='right' caption='[[2xus]], [[Resolution\|resolution]] 1.91Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xus]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUS OCA]. <br>		<table><tr><td colspan='2'>[[2xus]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XUS FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~><br>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xus OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xus RCSB], [http://www.ebi.ac.uk/pdbsum/2xus PDBsum]</span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xus OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xus RCSB], [http://www.ebi.ac.uk/pdbsum/2xus PDBsum]</span></td></tr>		</table>
	<table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 13:		Line 12:
	The Structure of BRMS1 Nuclear Export Signal and SNX6 Interacting Region Reveals a Hexamer Formed by Antiparallel Coiled Coils.,Spinola-Amilibia M, Rivera J, Ortiz-Lombardia M, Romero A, Neira JL, Bravo J J Mol Biol. 2011 Sep 2;411(5):1114-27. Epub 2011 Jul 18. PMID:21777593<ref>PMID:21777593</ref>		The Structure of BRMS1 Nuclear Export Signal and SNX6 Interacting Region Reveals a Hexamer Formed by Antiparallel Coiled Coils.,Spinola-Amilibia M, Rivera J, Ortiz-Lombardia M, Romero A, Neira JL, Bravo J J Mol Biol. 2011 Sep 2;411(5):1114-27. Epub 2011 Jul 18. PMID:21777593<ref>PMID:21777593</ref>

	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 20:		Line 19:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bravo, J.]]		[[Category: Bravo, J]]
	[[Category: Neira, J L.]]		[[Category: Neira, J L]]
	[[Category: Ortiz-Lombardia, M.]]		[[Category: Ortiz-Lombardia, M]]
	[[Category: Rivera, J.]]		[[Category: Rivera, J]]
	[[Category: Romero, A.]]		[[Category: Romero, A]]
	[[Category: Spinola-Amilibia, M.]]		[[Category: Spinola-Amilibia, M]]
	[[Category: Breast cancer metastasis]]		[[Category: Breast cancer metastasis]]
	[[Category: Protein binding]]		[[Category: Protein binding]]

OCA at 07:42, 14 May 2014

2014-05-14T07:42:14Z

← Older revision		Revision as of 07:42, 14 May 2014
Line 1:		Line 1:
	[[~~Image~~:2xus.~~png\|left\|200px~~]]		==CRYSTAL STRUCTURE OF THE BRMS1 N-TERMINAL REGION==
			<StructureSection load='2xus' size='340' side='right' caption='[[2xus]], [[Resolution\|resolution]] 1.91Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2xus]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUS OCA]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xus OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xus RCSB], [http://www.ebi.ac.uk/pdbsum/2xus PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			We present here the first structural report derived from breast cancer metastasis suppressor 1 (BRMS1), a member of the metastasis suppressor protein group, which, during recent years, have drawn much attention since they suppress metastasis without affecting the growth of the primary tumor. The relevance of the predicted N-terminal coiled coil on the molecular recognition of some of the BRMS1 partners, on its cellular localization and on the role of BRMS1 biological functions such as transcriptional repression prompted us to characterize its three-dimensional structure by X-ray crystallography. The structure of BRMS1 N-terminal region reveals that residues 51-98 form an antiparallel coiled-coil motif and, also, that it has the capability of homo-oligomerizing in a hexameric conformation by forming a trimer of coiled-coil dimers. We have also performed hydrodynamic experiments that strongly supported the prevalence in solution of this quaternary structure for BRMS1(51-98). This work explores the structural features of BRMS1 N-terminal region to help clarify the role of this area in the context of the full-length protein. Our crystallographic and biophysical results suggest that the biological function of BRMS1 may be affected by its ability to promote molecular clustering through its N-terminal coiled-coil region.

	<!--		The Structure of BRMS1 Nuclear Export Signal and SNX6 Interacting Region Reveals a Hexamer Formed by Antiparallel Coiled Coils.,Spinola-Amilibia M, Rivera J, Ortiz-Lombardia M, Romero A, Neira JL, Bravo J J Mol Biol. 2011 Sep 2;411(5):1114-27. Epub 2011 Jul 18. PMID:21777593<ref>PMID:21777593</ref>
	~~The line below this paragraph~~, ~~containing "STRUCTURE_2xus"~~, ~~creates the "Structure Box" on the page~~.
	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display~~.
	-->
	~~{{STRUCTURE_2xus\| PDB=2xus \| SCENE= }}~~

	~~===CRYSTAL STRUCTURE OF THE BRMS1 N-TERMINAL REGION===~~		From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
			</div>
			== References ==
	~~<!--~~		<references/>
	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_21777593}}, adds the Publication Abstract to~~ the ~~page~~		__TOC__
	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21777593 is the PubMed ID number~~.		</StructureSection>
	-->
	~~{{ABSTRACT_PUBMED_21777593}}~~

	~~==About this Structure==~~
	~~[[2xus]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUS OCA].~~

	==~~Reference~~==
	<~~ref group="xtra">PMID:021777593<~~/~~ref~~><~~ref group="xtra">PMID:019052374</ref><references group="xtra"~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bravo, J.]]		[[Category: Bravo, J.]]

OCA at 06:07, 24 August 2011

2011-08-24T06:07:39Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:2xus.png|left|200px]]
-The entry 2xus is ON HOLD  until Paper Publication
+<!--
-Authors: Spinola-Amilibia, M., Rivera, J., Ortiz-Lombardia, M., Romero, A., Neira, J.L., Bravo, J.
+===CRYSTAL STRUCTURE OF THE BRMS1 N-TERMINAL REGION===
-Description: Crystal Structure of the BRMS1 N-terminal region

OCA: Protected "2xus" [edit=sysop:move=sysop]

2011-06-29T05:29:04Z

Protected "2xus" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:29, 29 June 2011
(No difference)

OCA at 05:29, 29 June 2011

2011-06-29T05:29:03Z

← Older revision		Revision as of 05:29, 29 June 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 2xus is ON HOLD		The entry 2xus is ON HOLD until Paper Publication

	Authors: Spinola-Amilibia, M., Rivera, J., Ortiz-Lombardia, M., Romero, A., Neira, J.L., Bravo, J.		Authors: Spinola-Amilibia, M., Rivera, J., Ortiz-Lombardia, M., Romero, A., Neira, J.L., Bravo, J.

	Description: Crystal Structure of the BRMS1 N-terminal region		Description: Crystal Structure of the BRMS1 N-terminal region

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 3 09:56:50 2010''~~