2yip - Revision history

OCA at 08:14, 23 August 2023

2023-08-23T08:14:25Z

← Older revision		Revision as of 08:14, 23 August 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2yip]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Sarcocystis_muris Sarcocystis muris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YIP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YIP FirstGlance]. <br>		<table><tr><td colspan='2'>[[2yip]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Sarcocystis_muris Sarcocystis muris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YIP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YIP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=YIO:(2R,3R,4S,5R,6S)-2-(HYDROXYMETHYL)-6-SULFANYL-OXANE-3,4,5-TRIOL'>YIO</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.14Å</td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2yil\|2yil]], [[2yio\|2yio]]</div~~></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=YIO:(2R,3R,4S,5R,6S)-2-(HYDROXYMETHYL)-6-SULFANYL-OXANE-3,4,5-TRIOL'>YIO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yip OCA], [https://pdbe.org/2yip PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yip RCSB], [https://www.ebi.ac.uk/pdbsum/2yip PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yip ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yip OCA], [https://pdbe.org/2yip PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yip RCSB], [https://www.ebi.ac.uk/pdbsum/2yip PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yip ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/MIA2_SARMU MIA2_SARMU]] Galactose-binding lectin. Plays a role in adhesion to the host cell. Has a potential role in invasion of host cells.<ref>PMID:12743810</ref> <ref>PMID:22101820</ref>		[https://www.uniprot.org/uniprot/MIA2_SARMU MIA2_SARMU] Galactose-binding lectin. Plays a role in adhesion to the host cell. Has a potential role in invasion of host cells.<ref>PMID:12743810</ref> <ref>PMID:22101820</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Sarcocystis muris]]		[[Category: Sarcocystis muris]]
	[[Category: Heinemann, U]]		[[Category: Heinemann U]]
	[[Category: Mueller~~, J J]]~~		[[Category: Mueller JJ]]
	~~[[Category: Apple-domain tandem repeat]]~~
	~~[[Category: Cellular adhesion]]~~
	~~[[Category: Galactose-binding lectin]]~~
	~~[[Category: Micronemal protein]]~~
	~~[[Category: Pan_1]]~~
	~~[[Category: Pan_ap]]~~
	~~[[Category: Sugar binding protein~~]]

OCA at 15:05, 17 November 2021

2021-11-17T15:05:57Z

← Older revision		Revision as of 15:05, 17 November 2021
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	<StructureSection load='2yip' size='340' side='right'caption='[[2yip]], [[Resolution\|resolution]] 2.14Å' scene=''>		<StructureSection load='2yip' size='340' side='right'caption='[[2yip]], [[Resolution\|resolution]] 2.14Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2yip]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Sarcocystis_muris Sarcocystis muris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YIP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2YIP FirstGlance]. <br>		<table><tr><td colspan='2'>[[2yip]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Sarcocystis_muris Sarcocystis muris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YIP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YIP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=YIO:(2R,3R,4S,5R,6S)-2-(HYDROXYMETHYL)-6-SULFANYL-OXANE-3,4,5-TRIOL'>YIO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=YIO:(2R,3R,4S,5R,6S)-2-(HYDROXYMETHYL)-6-SULFANYL-OXANE-3,4,5-TRIOL'>YIO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yil\|2yil]], [[2yio\|2yio]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2yil\|2yil]], [[2yio\|2yio]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2yip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yip OCA], [~~http~~://pdbe.org/2yip PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2yip RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2yip PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2yip ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yip OCA], [https://pdbe.org/2yip PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yip RCSB], [https://www.ebi.ac.uk/pdbsum/2yip PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yip ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/MIA2_SARMU MIA2_SARMU]] Galactose-binding lectin. Plays a role in adhesion to the host cell. Has a potential role in invasion of host cells.<ref>PMID:12743810</ref> <ref>PMID:22101820</ref>		[[https://www.uniprot.org/uniprot/MIA2_SARMU MIA2_SARMU]] Galactose-binding lectin. Plays a role in adhesion to the host cell. Has a potential role in invasion of host cells.<ref>PMID:12743810</ref> <ref>PMID:22101820</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 06:05, 10 July 2019

2019-07-10T06:05:31Z

← Older revision		Revision as of 06:05, 10 July 2019
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	==Crystal Structure of Parasite Sarcocystis muris Microneme Protein SML- 2 in complex with 1-Thio-beta-D-Galactose (SPACEGROUP P212121)==		==Crystal Structure of Parasite Sarcocystis muris Microneme Protein SML- 2 in complex with 1-Thio-beta-D-Galactose (SPACEGROUP P212121)==
	<StructureSection load='2yip' size='340' side='right' caption='[[2yip]], [[Resolution\|resolution]] 2.14Å' scene=''>		<StructureSection load='2yip' size='340' side='right'caption='[[2yip]], [[Resolution\|resolution]] 2.14Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2yip]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Sarcocystis_muris Sarcocystis muris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YIP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YIP FirstGlance]. <br>		<table><tr><td colspan='2'>[[2yip]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Sarcocystis_muris Sarcocystis muris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YIP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YIP FirstGlance]. <br>
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Sarcocystis muris]]		[[Category: Sarcocystis muris]]
	[[Category: Heinemann, U]]		[[Category: Heinemann, U]]

OCA at 08:49, 17 October 2018

2018-10-17T08:49:52Z

← Older revision		Revision as of 08:49, 17 October 2018
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	==~~CRYSTAL STRUCTURE OF PARASITE SARCOCYSTIS MURIS MICRONEME PROTEIN~~ SML-2 ~~IN COMPLEX WITH~~ 1-~~THIO~~-~~BETA~~-D-~~GALACTOSE~~ (SPACEGROUP P212121)==		==Crystal Structure of Parasite Sarcocystis muris Microneme Protein SML- 2 in complex with 1-Thio-beta-D-Galactose (SPACEGROUP P212121)==
	<StructureSection load='2yip' size='340' side='right' caption='[[2yip]], [[Resolution\|resolution]] 2.14Å' scene=''>		<StructureSection load='2yip' size='340' side='right' caption='[[2yip]], [[Resolution\|resolution]] 2.14Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 07:18, 4 August 2016

2016-08-04T07:18:56Z

← Older revision		Revision as of 07:18, 4 August 2016
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF PARASITE SARCOCYSTIS MURIS MICRONEME PROTEIN SML-2 IN COMPLEX WITH 1-THIO-BETA-D-GALACTOSE (SPACEGROUP P212121)==		==CRYSTAL STRUCTURE OF PARASITE SARCOCYSTIS MURIS MICRONEME PROTEIN SML-2 IN COMPLEX WITH 1-THIO-BETA-D-GALACTOSE (SPACEGROUP P212121)==
	<StructureSection load='2yip' size='340' side='right' caption='[[2yip]], [[Resolution\|resolution]] 2.14Å' scene=''>		<StructureSection load='2yip' size='340' side='right' caption='[[2yip]], [[Resolution\|resolution]] 2.14Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=YIO:(2R,3R,4S,5R,6S)-2-(HYDROXYMETHYL)-6-SULFANYL-OXANE-3,4,5-TRIOL'>YIO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=YIO:(2R,3R,4S,5R,6S)-2-(HYDROXYMETHYL)-6-SULFANYL-OXANE-3,4,5-TRIOL'>YIO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yil\|2yil]], [[2yio\|2yio]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yil\|2yil]], [[2yio\|2yio]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yip OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yip RCSB], [http://www.ebi.ac.uk/pdbsum/2yip PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yip OCA], [http://pdbe.org/2yip PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yip RCSB], [http://www.ebi.ac.uk/pdbsum/2yip PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yip ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/MIA2_SARMU MIA2_SARMU]] Galactose-binding lectin. Plays a role in adhesion to the host cell. Has a potential role in invasion of host cells.<ref>PMID:12743810</ref> <ref>PMID:22101820</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2yip" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 21:10, 3 January 2015

2015-01-03T21:10:54Z

← Older revision		Revision as of 21:10, 3 January 2015
Line 2:		Line 2:
	<StructureSection load='2yip' size='340' side='right' caption='[[2yip]], [[Resolution\|resolution]] 2.14Å' scene=''>		<StructureSection load='2yip' size='340' side='right' caption='[[2yip]], [[Resolution\|resolution]] 2.14Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2yip]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Sarcocystis_muris Sarcocystis muris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YIP OCA]. <br>		<table><tr><td colspan='2'>[[2yip]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Sarcocystis_muris Sarcocystis muris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YIP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YIP FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=YIO:(2R,3R,4S,5R,6S)-2-(HYDROXYMETHYL)-6-SULFANYL-OXANE-3,4,5-TRIOL'>YIO</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=YIO:(2R,3R,4S,5R,6S)-2-(HYDROXYMETHYL)-6-SULFANYL-OXANE-3,4,5-TRIOL'>YIO</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yil\|2yil]], [[2yio\|2yio]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yil\|2yil]], [[2yio\|2yio]]</td></tr>
	<tr~~><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class~~='~~plainlinks~~'~~>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yip OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yip RCSB], [http://www.ebi.ac.uk/pdbsum/2yip PDBsum]</span></td></tr>
	~~<tr~~><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yip OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yip RCSB], [http://www.ebi.ac.uk/pdbsum/2yip PDBsum]</span></td></tr>		</table>
	<table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	PAN-modular structure of microneme protein SML-2 from the parasite Sarcocystis muris at 1.95 A resolution and its complex with 1-thio-beta-D-galactose.,Muller JJ, Weiss MS, Heinemann U Acta Crystallogr D Biol Crystallogr. 2011 Nov;67(Pt 11):936-44. Epub 2011, Oct 19. PMID:22101820<ref>PMID:22101820</ref>		PAN-modular structure of microneme protein SML-2 from the parasite Sarcocystis muris at 1.95 A resolution and its complex with 1-thio-beta-D-galactose.,Muller JJ, Weiss MS, Heinemann U Acta Crystallogr D Biol Crystallogr. 2011 Nov;67(Pt 11):936-44. Epub 2011, Oct 19. PMID:22101820<ref>PMID:22101820</ref>

	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 21:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Sarcocystis muris]]		[[Category: Sarcocystis muris]]
	[[Category: Heinemann, U.]]		[[Category: Heinemann, U]]
	[[Category: Mueller, J J.]]		[[Category: Mueller, J J]]
	[[Category: Apple-domain tandem repeat]]		[[Category: Apple-domain tandem repeat]]
	[[Category: Cellular adhesion]]		[[Category: Cellular adhesion]]

OCA at 07:40, 14 May 2014

2014-05-14T07:40:55Z

← Older revision		Revision as of 07:40, 14 May 2014
Line 1:		Line 1:
	[[~~Image~~:~~2yip~~.~~png~~\|~~left~~\|~~200px~~]]		==CRYSTAL STRUCTURE OF PARASITE SARCOCYSTIS MURIS MICRONEME PROTEIN SML-2 IN COMPLEX WITH 1-THIO-BETA-D-GALACTOSE (SPACEGROUP P212121)==
			<StructureSection load='2yip' size='340' side='right' caption='[[2yip]], [[Resolution\|resolution]] 2.14Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2yip]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Sarcocystis_muris Sarcocystis muris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YIP OCA]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=YIO:(2R,3R,4S,5R,6S)-2-(HYDROXYMETHYL)-6-SULFANYL-OXANE-3,4,5-TRIOL'>YIO</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yil\|2yil]], [[2yio\|2yio]]</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yip OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yip RCSB], [http://www.ebi.ac.uk/pdbsum/2yip PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The microneme protein SML-2 is a member of a small family of galactose-specific lectins that play a role during host-cell invasion by the apicomplexan parasite Sarcocystis muris. The structures of apo SML-2 and the 1-thio-beta-D-galactose-SML-2 complex were determined at 1.95 and 2.1 A resolution, respectively, by sulfur-SAD phasing. Highly elongated dimers are formed by PAN-domain tandems in the protomer, bearing the galactose-binding cavities at the distal apple-like domains. The detailed structure of the binding site in SML-2 explains the high specificity of galactose-endgroup binding and the broader specificity of the related Toxoplasma gondii protein TgMIC4 towards galactose and glucose. A large buried surface of highly hydrophobic character and 24 intersubunit hydrogen bonds stabilize the dimers and half of the 12 disulfides per dimer are shielded from the solvent by the polypeptide chain, thereby enhancing the resistance of the parasite protein towards unfolding and proteolysis that allows it to survive within the intestinal tracts of the intermediate and final hosts.

	<!--		PAN-modular structure of microneme protein SML-2 from the parasite Sarcocystis muris at 1.95 A resolution and its complex with 1-thio-beta-D-galactose.,Muller JJ, Weiss MS, Heinemann U Acta Crystallogr D Biol Crystallogr. 2011 Nov;67(Pt 11):936-44. Epub 2011, Oct 19. PMID:22101820<ref>PMID:22101820</ref>
	~~The line below this paragraph~~, ~~containing "STRUCTURE_2yip"~~, ~~creates the "Structure Box" on the page~~.
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter~~ (~~which sets the initial scene displayed when the page is loaded~~),
	~~or leave the SCENE parameter empty for the default display~~.
	-->
	~~{{STRUCTURE_2yip\| PDB=2yip \| SCENE= }}~~

	~~===CRYSTAL STRUCTURE OF PARASITE SARCOCYSTIS MURIS MICRONEME PROTEIN SML-2 IN COMPLEX WITH 1-THIO-BETA-D-GALACTOSE (SPACEGROUP P212121)===~~		From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
			</div>
			== References ==
	~~<!--~~		<references/>
	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_22101820}}, adds the Publication Abstract to~~ the ~~page~~		__TOC__
	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22101820 is the PubMed ID number~~.		</StructureSection>
	-->
	~~{{ABSTRACT_PUBMED_22101820}}~~

	~~==About this Structure==~~
	~~[[2yip]] is a 6 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Sarcocystis_muris Sarcocystis muris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YIP OCA].~~

	==~~Reference~~==
	<~~ref group="xtra">PMID:022101820<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Sarcocystis muris]]		[[Category: Sarcocystis muris]]
	[[Category: Heinemann, U.]]		[[Category: Heinemann, U.]]

OCA at 05:26, 30 November 2011

2011-11-30T05:26:49Z

← Older revision		Revision as of 05:26, 30 November 2011
Line 1:		Line 1:
	[[Image:2yip.~~jpg~~\|left\|200px]]		[[Image:2yip.png\|left\|200px]]

	<!--		<!--
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	===CRYSTAL STRUCTURE OF PARASITE SARCOCYSTIS MURIS MICRONEME PROTEIN SML-2 IN COMPLEX WITH 1-THIO-BETA-D-GALACTOSE (SPACEGROUP P212121)===		===CRYSTAL STRUCTURE OF PARASITE SARCOCYSTIS MURIS MICRONEME PROTEIN SML-2 IN COMPLEX WITH 1-THIO-BETA-D-GALACTOSE (SPACEGROUP P212121)===


			<!--
			The line below this paragraph, {{ABSTRACT_PUBMED_22101820}}, adds the Publication Abstract to the page
			(as it appears on PubMed at http://www.pubmed.gov), where 22101820 is the PubMed ID number.
			-->
			{{ABSTRACT_PUBMED_22101820}}

	==About this Structure==		==About this Structure==
	[[2yip]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Sarcocystis_muris Sarcocystis muris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YIP OCA].		[[2yip]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Sarcocystis_muris Sarcocystis muris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YIP OCA].

			==Reference==
			<ref group="xtra">PMID:022101820</ref><references group="xtra"/>
	[[Category: Sarcocystis muris]]		[[Category: Sarcocystis muris]]
	[[Category: Heinemann, U.]]		[[Category: Heinemann, U.]]

OCA at 08:28, 2 November 2011

2011-11-02T08:28:37Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:2yip.jpg|left|200px]]
-The entry 2yip is ON HOLD  until Paper Publication
+<!--
-Authors: Mueller, J.J., Heinemann, U.
+===CRYSTAL STRUCTURE OF PARASITE SARCOCYSTIS MURIS MICRONEME PROTEIN SML-2 IN COMPLEX WITH 1-THIO-BETA-D-GALACTOSE (SPACEGROUP P212121)===
-Description: Crystal Structure of Parasite Sarcocystis muris Microneme Protein SML-2 in complex with 1-Thio-beta-D-Galactose (SPACEGROUP P212121)

OCA: Protected "2yip" [edit=sysop:move=sysop]

2011-05-25T04:55:28Z

Protected "2yip" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:55, 25 May 2011
(No difference)