2ync - Revision history

OCA at 14:06, 1 February 2024

2024-02-01T14:06:18Z

← Older revision		Revision as of 14:06, 1 February 2024
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	<StructureSection load='2ync' size='340' side='right'caption='[[2ync]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='2ync' size='340' side='right'caption='[[2ync]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ync]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Haemamoeba_vivax Haemamoeba~~ vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YNC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YNC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ync]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YNC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YNC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=YNC:TETRADEC-13-YNOIC+ACID+-+COA+THIOESTER'>YNC</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.75Å</td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4a95\|4a95]], [[4b10\|4b10]], [[4b11\|4b11]], [[4b12\|4b12]], [[4b13\|4b13]], [[4b14\|4b14]], [[4bbh\|4bbh]], [[2ynd\|2ynd]], [[2yne\|2yne]]</div></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=YNC:TETRADEC-13-YNOIC+ACID+-+COA+THIOESTER'>YNC</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ync FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ync OCA], [https://pdbe.org/2ync PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ync RCSB], [https://www.ebi.ac.uk/pdbsum/2ync PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ync ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ync FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ync OCA], [https://pdbe.org/2ync PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ync RCSB], [https://www.ebi.ac.uk/pdbsum/2ync PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ync ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/A5K1A2_PLAVS A5K1A2_PLAVS]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).[RuleBase:RU000586]		[https://www.uniprot.org/uniprot/A5K1A2_PLAVS A5K1A2_PLAVS] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).[RuleBase:RU000586]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Glycylpeptide N-tetradecanoyltransferase]]~~
	~~[[Category: Haemamoeba vivax]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Bottrill~~, A R~~]]		[[Category: Plasmodium vivax]]
	[[Category: Brannigan~~, J A~~]]		[[Category: Bottrill AR]]
	[[Category: Broncel, M]]		[[Category: Brannigan JA]]
	[[Category: Clough, B]]		[[Category: Broncel M]]
	[[Category: Grainger, M]]		[[Category: Clough B]]
	[[Category: Heal~~, W P~~]]		[[Category: Grainger M]]
	[[Category: Holder~~, A A~~]]		[[Category: Heal WP]]
	[[Category: Leatherbarrow~~, R J~~]]		[[Category: Holder AA]]
	[[Category: Mann, D]]		[[Category: Leatherbarrow RJ]]
	[[Category: Rackham~~, M D~~]]		[[Category: Mann D]]
	[[Category: Serwa~~, R A~~]]		[[Category: Rackham MD]]
	[[Category: Tate~~, E W~~]]		[[Category: Serwa RA]]
	[[Category: Wilkinson~~, A J~~]]		[[Category: Tate EW]]
	[[Category: Wright~~, M H]]~~		[[Category: Wilkinson AJ]]
	~~[[Category: Malaria]]~~		[[Category: Wright MH]]
	~~[[Category: Myristoylation]]~~
	~~[[Category: Transferase~~]]

OCA at 12:33, 27 April 2022

2022-04-27T12:33:25Z

← Older revision		Revision as of 12:33, 27 April 2022
Line 3:		Line 3:
	<StructureSection load='2ync' size='340' side='right'caption='[[2ync]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='2ync' size='340' side='right'caption='[[2ync]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ync]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Haemamoeba_vivax Haemamoeba vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YNC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2YNC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ync]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemamoeba_vivax Haemamoeba vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YNC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YNC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=YNC:TETRADEC-13-YNOIC+ACID+-+COA+THIOESTER'>YNC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=YNC:TETRADEC-13-YNOIC+ACID+-+COA+THIOESTER'>YNC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a95\|4a95]], [[4b10\|4b10]], [[4b11\|4b11]], [[4b12\|4b12]], [[4b13\|4b13]], [[4b14\|4b14]], [[4bbh\|4bbh]], [[2ynd\|2ynd]], [[2yne\|2yne]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4a95\|4a95]], [[4b10\|4b10]], [[4b11\|4b11]], [[4b12\|4b12]], [[4b13\|4b13]], [[4b14\|4b14]], [[4bbh\|4bbh]], [[2ynd\|2ynd]], [[2yne\|2yne]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2ync FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ync OCA], [~~http~~://pdbe.org/2ync PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ync RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ync PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ync ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ync FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ync OCA], [https://pdbe.org/2ync PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ync RCSB], [https://www.ebi.ac.uk/pdbsum/2ync PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ync ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/A5K1A2_PLAVS A5K1A2_PLAVS]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).[RuleBase:RU000586]		[[https://www.uniprot.org/uniprot/A5K1A2_PLAVS A5K1A2_PLAVS]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).[RuleBase:RU000586]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:58, 22 July 2020

2020-07-22T12:58:43Z

← Older revision		Revision as of 12:58, 22 July 2020
Line 1:		Line 1:

	==Plasmodium vivax N-myristoyltransferase in complex with YnC12-CoA thioester.==		==Plasmodium vivax N-myristoyltransferase in complex with YnC12-CoA thioester.==
	<StructureSection load='2ync' size='340' side='right' caption='[[2ync]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='2ync' size='340' side='right'caption='[[2ync]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ync]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemamoeba_vivax Haemamoeba vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YNC OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2YNC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ync]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemamoeba_vivax Haemamoeba vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YNC OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2YNC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=YNC:TETRADEC-13-YNOIC+ACID+-+COA+THIOESTER'>YNC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=YNC:TETRADEC-13-YNOIC+ACID+-+COA+THIOESTER'>YNC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a95\|4a95]], [[4b10\|4b10]], [[4b11\|4b11]], [[4b12\|4b12]], [[4b13\|4b13]], [[4b14\|4b14]], [[4bbh\|4bbh]], [[2ynd\|2ynd]], [[2yne\|2yne]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a95\|4a95]], [[4b10\|4b10]], [[4b11\|4b11]], [[4b12\|4b12]], [[4b13\|4b13]], [[4b14\|4b14]], [[4bbh\|4bbh]], [[2ynd\|2ynd]], [[2yne\|2yne]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ync FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ync OCA], [http://pdbe.org/2ync PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ync RCSB], [http://www.ebi.ac.uk/pdbsum/2ync PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ync ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2ync FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ync OCA], [http://pdbe.org/2ync PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ync RCSB], [http://www.ebi.ac.uk/pdbsum/2ync PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ync ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	[[Category: Glycylpeptide N-tetradecanoyltransferase]]		[[Category: Glycylpeptide N-tetradecanoyltransferase]]
	[[Category: Haemamoeba vivax]]		[[Category: Haemamoeba vivax]]
			[[Category: Large Structures]]
	[[Category: Bottrill, A R]]		[[Category: Bottrill, A R]]
	[[Category: Brannigan, J A]]		[[Category: Brannigan, J A]]

OCA at 09:25, 17 October 2018

2018-10-17T09:25:53Z

← Older revision		Revision as of 09:25, 17 October 2018
Line 3:		Line 3:
	<StructureSection load='2ync' size='340' side='right' caption='[[2ync]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='2ync' size='340' side='right' caption='[[2ync]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ync]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Plavi Plavi~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YNC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YNC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ync]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemamoeba_vivax Haemamoeba vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YNC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YNC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=YNC:TETRADEC-13-YNOIC+ACID+-+COA+THIOESTER'>YNC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=YNC:TETRADEC-13-YNOIC+ACID+-+COA+THIOESTER'>YNC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a95\|4a95]], [[4b10\|4b10]], [[4b11\|4b11]], [[4b12\|4b12]], [[4b13\|4b13]], [[4b14\|4b14]], [[4bbh\|4bbh]], [[2ynd\|2ynd]], [[2yne\|2yne]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a95\|4a95]], [[4b10\|4b10]], [[4b11\|4b11]], [[4b12\|4b12]], [[4b13\|4b13]], [[4b14\|4b14]], [[4bbh\|4bbh]], [[2ynd\|2ynd]], [[2yne\|2yne]]</td></tr>
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Glycylpeptide N-tetradecanoyltransferase]]		[[Category: Glycylpeptide N-tetradecanoyltransferase]]
	[[Category: ~~Plavi~~]]		[[Category: Haemamoeba vivax]]
	[[Category: Bottrill, A R]]		[[Category: Bottrill, A R]]
	[[Category: Brannigan, J A]]		[[Category: Brannigan, J A]]

OCA at 23:10, 5 August 2016

2016-08-05T23:10:41Z

← Older revision		Revision as of 23:10, 5 August 2016
Line 1:		Line 1:

	==Plasmodium vivax N-myristoyltransferase in complex with YnC12-CoA thioester.==		==Plasmodium vivax N-myristoyltransferase in complex with YnC12-CoA thioester.==
	<StructureSection load='2ync' size='340' side='right' caption='[[2ync]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='2ync' size='340' side='right' caption='[[2ync]], [[Resolution\|resolution]] 1.75Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a95\|4a95]], [[4b10\|4b10]], [[4b11\|4b11]], [[4b12\|4b12]], [[4b13\|4b13]], [[4b14\|4b14]], [[4bbh\|4bbh]], [[2ynd\|2ynd]], [[2yne\|2yne]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a95\|4a95]], [[4b10\|4b10]], [[4b11\|4b11]], [[4b12\|4b12]], [[4b13\|4b13]], [[4b14\|4b14]], [[4bbh\|4bbh]], [[2ynd\|2ynd]], [[2yne\|2yne]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ync FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ync OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ync RCSB], [http://www.ebi.ac.uk/pdbsum/2ync PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ync FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ync OCA], [http://pdbe.org/2ync PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ync RCSB], [http://www.ebi.ac.uk/pdbsum/2ync PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ync ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2ync" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:41, 25 December 2014

2014-12-25T06:41:33Z

← Older revision		Revision as of 06:41, 25 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_2ync\| PDB=2ync \| SCENE= }}~~		==Plasmodium vivax N-myristoyltransferase in complex with YnC12-CoA thioester.==
	===Plasmodium vivax N-myristoyltransferase in complex with YnC12-CoA thioester.===		<StructureSection load='2ync' size='340' side='right' caption='[[2ync]], [[Resolution\|resolution]] 1.75Å' scene=''>
	~~{{ABSTRACT_PUBMED_24451586}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2ync]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Plavi Plavi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YNC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YNC FirstGlance]. <br>
	==Function==		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=YNC:TETRADEC-13-YNOIC+ACID+-+COA+THIOESTER'>YNC</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a95\|4a95]], [[4b10\|4b10]], [[4b11\|4b11]], [[4b12\|4b12]], [[4b13\|4b13]], [[4b14\|4b14]], [[4bbh\|4bbh]], [[2ynd\|2ynd]], [[2yne\|2yne]]</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ync FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ync OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ync RCSB], [http://www.ebi.ac.uk/pdbsum/2ync PDBsum]</span></td></tr>
			</table>
			== Function ==
	[[http://www.uniprot.org/uniprot/A5K1A2_PLAVS A5K1A2_PLAVS]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).[RuleBase:RU000586]		[[http://www.uniprot.org/uniprot/A5K1A2_PLAVS A5K1A2_PLAVS]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).[RuleBase:RU000586]
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Malaria is an infectious disease caused by parasites of the genus Plasmodium, which leads to approximately one million deaths per annum worldwide. Chemical validation of new antimalarial targets is urgently required in view of rising resistance to current drugs. One such putative target is the enzyme N-myristoyltransferase, which catalyses the attachment of the fatty acid myristate to protein substrates (N-myristoylation). Here, we report an integrated chemical biology approach to explore protein myristoylation in the major human parasite P. falciparum, combining chemical proteomic tools for identification of the myristoylated and glycosylphosphatidylinositol-anchored proteome with selective small-molecule N-myristoyltransferase inhibitors. We demonstrate that N-myristoyltransferase is an essential and chemically tractable target in malaria parasites both in vitro and in vivo, and show that selective inhibition of N-myristoylation leads to catastrophic and irreversible failure to assemble the inner membrane complex, a critical subcellular organelle in the parasite life cycle. Our studies provide the basis for the development of new antimalarials targeting N-myristoyltransferase.

	~~==About this Structure==~~		Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach.,Wright MH, Clough B, Rackham MD, Rangachari K, Brannigan JA, Grainger M, Moss DK, Bottrill AR, Heal WP, Broncel M, Serwa RA, Brady D, Mann DJ, Leatherbarrow RJ, Tewari R, Wilkinson AJ, Holder AA, Tate EW Nat Chem. 2014 Feb;6(2):112-21. doi: 10.1038/nchem.1830. Epub 2013 Dec 22. PMID:24451586<ref>PMID:24451586</ref>
	~~[[2ync]] is a 3 chain structure~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.~~il/oca-bin~~/~~ocashort?id=2YNC OCA].~~

	==~~Reference~~==		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~<ref group="xtra">PMID:024451586</ref>~~<references ~~group="xtra"~~/><~~references~~/>		</div>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Glycylpeptide N-tetradecanoyltransferase]]		[[Category: Glycylpeptide N-tetradecanoyltransferase]]
	[[Category: Bottrill, A R.]]		[[Category: Plavi]]
	[[Category: Brannigan, J A.]]		[[Category: Bottrill, A R]]
	[[Category: Broncel, M.]]		[[Category: Brannigan, J A]]
	[[Category: Clough, B.]]		[[Category: Broncel, M]]
	[[Category: Grainger, M.]]		[[Category: Clough, B]]
	[[Category: Heal, W P.]]		[[Category: Grainger, M]]
	[[Category: Holder, A A.]]		[[Category: Heal, W P]]
	[[Category: Leatherbarrow, R J.]]		[[Category: Holder, A A]]
	[[Category: Mann, D.]]		[[Category: Leatherbarrow, R J]]
	[[Category: Rackham, M D.]]		[[Category: Mann, D]]
	[[Category: Serwa, R A.]]		[[Category: Rackham, M D]]
	[[Category: Tate, E W.]]		[[Category: Serwa, R A]]
	[[Category: Wilkinson, A J.]]		[[Category: Tate, E W]]
	[[Category: Wright, M H.]]		[[Category: Wilkinson, A J]]
			[[Category: Wright, M H]]
	[[Category: Malaria]]		[[Category: Malaria]]
	[[Category: Myristoylation]]		[[Category: Myristoylation]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 08:36, 5 February 2014

2014-02-05T08:36:30Z

← Older revision		Revision as of 08:36, 5 February 2014
Line 1:		Line 1:
	{{STRUCTURE_2ync\| PDB=2ync \| SCENE= }}		{{STRUCTURE_2ync\| PDB=2ync \| SCENE= }}
	===Plasmodium vivax N-myristoyltransferase in complex with YnC12-CoA thioester.===		===Plasmodium vivax N-myristoyltransferase in complex with YnC12-CoA thioester.===
			{{ABSTRACT_PUBMED_24451586}}

	==Function==		==Function==
Line 7:		Line 8:
	==About this Structure==		==About this Structure==
	[[2ync]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YNC OCA].		[[2ync]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YNC OCA].

			==Reference==
			<ref group="xtra">PMID:024451586</ref><references group="xtra"/><references/>
	[[Category: Glycylpeptide N-tetradecanoyltransferase]]		[[Category: Glycylpeptide N-tetradecanoyltransferase]]
	[[Category: Bottrill, A R.]]		[[Category: Bottrill, A R.]]

OCA at 08:19, 15 January 2014

2014-01-15T08:19:02Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_2ync|  PDB=2ync  |  SCENE=  }}
-The entry 2ync is ON HOLD  until Paper Publication
+==Function==
-Authors: Wright, M.H., Clough, B., Rackham, M.D., Brannigan, J.A., Grainger, M., Bottrill, A.R., Heal, W.P., Broncel, M., Serwa, R.A., Mann, D., Leatherbarrow, R.J., Wilkinson, A.J., Holder, A.A., Tate, E.W.
+==About this Structure==
+[[2ync]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YNC OCA].
-Description: Plasmodium vivax N-myristoyltransferase in complex with YnC12-CoA thioester.
+[[Category: Glycylpeptide N-tetradecanoyltransferase]]

OCA at 06:12, 28 August 2013

2013-08-28T06:12:58Z

← Older revision		Revision as of 06:12, 28 August 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 2ync is ON HOLD		The entry 2ync is ON HOLD until Paper Publication

	Authors: Wright, M.H., Clough, B., Rackham, M.D., Brannigan, J.A., Grainger, M., Bottrill, A.R., Heal, W.P., Broncel, M., Serwa, R.A., Mann, D., Leatherbarrow, R.J., Wilkinson, A.J., Holder, A.A., Tate, E.W.		Authors: Wright, M.H., Clough, B., Rackham, M.D., Brannigan, J.A., Grainger, M., Bottrill, A.R., Heal, W.P., Broncel, M., Serwa, R.A., Mann, D., Leatherbarrow, R.J., Wilkinson, A.J., Holder, A.A., Tate, E.W.

	Description: Plasmodium vivax N-myristoyltransferase in complex with YnC12-CoA thioester.		Description: Plasmodium vivax N-myristoyltransferase in complex with YnC12-CoA thioester.

OCA: Protected "2ync" [edit=sysop:move=sysop]

2012-10-24T06:51:43Z

Protected "2ync" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:51, 24 October 2012
(No difference)