2zos - Revision history

OCA at 05:39, 17 October 2024

2024-10-17T05:39:12Z

← Older revision		Revision as of 05:39, 17 October 2024
Line 3:		Line 3:
	<StructureSection load='2zos' size='340' side='right'caption='[[2zos]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2zos' size='340' side='right'caption='[[2zos]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2zos]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~'pyrococcus_shinkaii' 'pyrococcus shinkaii'~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZOS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2zos]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZOS FirstGlance]. <br>
	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[1wzc\|1wzc]]</div>~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>mngB, PH0926 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~53953 'Pyrococcus shinkaii'])</td~~><~~/tr>~~
	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>[https://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_phosphatase Mannosyl-3-phosphoglycerate phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.70 3.1.3.70] </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zos OCA], [https://pdbe.org/2zos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zos RCSB], [https://www.ebi.ac.uk/pdbsum/2zos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zos ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zos OCA], [https://pdbe.org/2zos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zos RCSB], [https://www.ebi.ac.uk/pdbsum/2zos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zos ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/MPGP_PYRHO MPGP_PYRHO]] Hydrolyzes mannosyl-3-phosphoglycerate (MPG) to form the osmolyte mannosylglycerate (MG). The enzyme is absolutely specific for MPG.		[https://www.uniprot.org/uniprot/MPGP_PYRHO MPGP_PYRHO] Hydrolyzes mannosyl-3-phosphoglycerate (MPG) to form the osmolyte mannosylglycerate (MG). The enzyme is absolutely specific for MPG.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 17:		Line 15:
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zo/2zos_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zo/2zos_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
Line 35:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Pyrococcus shinkaii]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Mannosyl-3-phosphoglycerate phosphatase~~]]		[[Category: Pyrococcus horikoshii]]
	[[Category: Kawamura, T]]		[[Category: Kawamura T]]
	[[Category: Tanaka, I]]		[[Category: Tanaka I]]
	[[Category: Watanabe, N]]		[[Category: Watanabe N]]
	~~[[Category: Cytoplasm]]~~
	~~[[Category: Haloacid dehalogenase like hydrolase]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: Magnesium]]~~
	~~[[Category: Mannosylglycerate]]~~
	~~[[Category: Phosphatase~~]]

OCA at 07:18, 10 November 2021

2021-11-10T07:18:09Z

← Older revision		Revision as of 07:18, 10 November 2021
Line 1:		Line 1:

	==Crystal structure of mannosyl-3-phosphoglycerate phosphatase from Pyrococcus horikoshii==		==Crystal structure of mannosyl-3-phosphoglycerate phosphatase from Pyrococcus horikoshii==
	<StructureSection load='2zos' size='340' side='right' caption='[[2zos]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2zos' size='340' side='right'caption='[[2zos]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2zos]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/'pyrococcus_shinkaii' 'pyrococcus shinkaii']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZOS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ZOS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2zos]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/'pyrococcus_shinkaii' 'pyrococcus shinkaii']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZOS FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wzc\|1wzc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1wzc\|1wzc]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mngB, PH0926 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53953 'Pyrococcus shinkaii'])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mngB, PH0926 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53953 'Pyrococcus shinkaii'])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_phosphatase Mannosyl-3-phosphoglycerate phosphatase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.70 3.1.3.70] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_phosphatase Mannosyl-3-phosphoglycerate phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.70 3.1.3.70] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2zos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zos OCA], [~~http~~://pdbe.org/2zos PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2zos RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2zos PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2zos ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zos OCA], [https://pdbe.org/2zos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zos RCSB], [https://www.ebi.ac.uk/pdbsum/2zos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zos ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/MPGP_PYRHO MPGP_PYRHO]] Hydrolyzes mannosyl-3-phosphoglycerate (MPG) to form the osmolyte mannosylglycerate (MG). The enzyme is absolutely specific for MPG.		[[https://www.uniprot.org/uniprot/MPGP_PYRHO MPGP_PYRHO]] Hydrolyzes mannosyl-3-phosphoglycerate (MPG) to form the osmolyte mannosylglycerate (MG). The enzyme is absolutely specific for MPG.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Pyrococcus shinkaii]]		[[Category: Pyrococcus shinkaii]]
			[[Category: Large Structures]]
	[[Category: Mannosyl-3-phosphoglycerate phosphatase]]		[[Category: Mannosyl-3-phosphoglycerate phosphatase]]
	[[Category: Kawamura, T]]		[[Category: Kawamura, T]]

OCA at 06:54, 18 October 2018

2018-10-18T06:54:57Z

← Older revision		Revision as of 06:54, 18 October 2018
Line 16:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zo/2zos_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zo/2zos_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 40:		Line 40:
	[[Category: Tanaka, I]]		[[Category: Tanaka, I]]
	[[Category: Watanabe, N]]		[[Category: Watanabe, N]]
			[[Category: Cytoplasm]]
	[[Category: Haloacid dehalogenase like hydrolase]]		[[Category: Haloacid dehalogenase like hydrolase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 02:44, 5 August 2016

2016-08-05T02:44:21Z

← Older revision		Revision as of 02:44, 5 August 2016
Line 1:		Line 1:

	==Crystal structure of mannosyl-3-phosphoglycerate phosphatase from Pyrococcus horikoshii==		==Crystal structure of mannosyl-3-phosphoglycerate phosphatase from Pyrococcus horikoshii==
	<StructureSection load='2zos' size='340' side='right' caption='[[2zos]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2zos' size='340' side='right' caption='[[2zos]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2zos]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pyrococcus_horikoshii Pyrococcus horikoshii~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZOS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2zos]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/'pyrococcus_shinkaii' 'pyrococcus shinkaii']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZOS FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wzc\|1wzc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wzc\|1wzc]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mngB, PH0926 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53953 Pyrococcus ~~horikoshii~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mngB, PH0926 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53953 'Pyrococcus shinkaii'])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_phosphatase Mannosyl-3-phosphoglycerate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.70 3.1.3.70] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_phosphatase Mannosyl-3-phosphoglycerate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.70 3.1.3.70] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zos RCSB], [http://www.ebi.ac.uk/pdbsum/2zos PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zos OCA], [http://pdbe.org/2zos PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zos RCSB], [http://www.ebi.ac.uk/pdbsum/2zos PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zos ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zos ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 30:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2zos" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Pyrococcus shinkaii]]
	[[Category: Mannosyl-3-phosphoglycerate phosphatase]]		[[Category: Mannosyl-3-phosphoglycerate phosphatase]]
	~~[[Category: Pyrococcus horikoshii]]~~
	[[Category: Kawamura, T]]		[[Category: Kawamura, T]]
	[[Category: Tanaka, I]]		[[Category: Tanaka, I]]

OCA at 15:12, 25 December 2014

2014-12-25T15:12:53Z

← Older revision		Revision as of 15:12, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2zos]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZOS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2zos]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZOS FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wzc\|1wzc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wzc\|1wzc]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mngB, PH0926 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53953 Pyrococcus horikoshii])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mngB, PH0926 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53953 Pyrococcus horikoshii])</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_phosphatase Mannosyl-3-phosphoglycerate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.70 3.1.3.70] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_phosphatase Mannosyl-3-phosphoglycerate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.70 3.1.3.70] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zos RCSB], [http://www.ebi.ac.uk/pdbsum/2zos PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zos RCSB], [http://www.ebi.ac.uk/pdbsum/2zos PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/MPGP_PYRHO MPGP_PYRHO]] Hydrolyzes mannosyl-3-phosphoglycerate (MPG) to form the osmolyte mannosylglycerate (MG). The enzyme is absolutely specific for MPG.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	[[Category: Mannosyl-3-phosphoglycerate phosphatase]]		[[Category: Mannosyl-3-phosphoglycerate phosphatase]]
	[[Category: Pyrococcus horikoshii]]		[[Category: Pyrococcus horikoshii]]
	[[Category: Kawamura, T.]]		[[Category: Kawamura, T]]
	[[Category: Tanaka, I.]]		[[Category: Tanaka, I]]
	[[Category: Watanabe, N.]]		[[Category: Watanabe, N]]
	[[Category: Haloacid dehalogenase like hydrolase]]		[[Category: Haloacid dehalogenase like hydrolase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 04:49, 2 October 2014

2014-10-02T04:49:21Z

← Older revision		Revision as of 04:49, 2 October 2014
Line 1:		Line 1:
	[[Image:~~2zos~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of mannosyl-3-phosphoglycerate phosphatase from Pyrococcus horikoshii==
			<StructureSection load='2zos' size='340' side='right' caption='[[2zos]], [[Resolution\|resolution]] 1.70Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2zos]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZOS FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wzc\|1wzc]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mngB, PH0926 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53953 Pyrococcus horikoshii])</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_phosphatase Mannosyl-3-phosphoglycerate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.70 3.1.3.70] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zos RCSB], [http://www.ebi.ac.uk/pdbsum/2zos PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zo/2zos_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Mannosyl-3-phosphoglycerate phosphatase (MPGP) catalyzes the dephosphorylation of alpha-mannosyl-3-phosphoglycerate (MPG) to produce alpha-mannosylglycerate (MG). In the hyperthermophile Pyrococcus horikoshii, MPGP plays a role in a series of enzyme reactions that are involved in the MG-biosynthesis pathway, which is important for maintaining life under conditions of high salt concentration. Crystal structures of P. horikoshii MPGP (PhoMPGP) in the holo form and in the apo form lacking the magnesium ion were determined by the multiple-wavelength anomalous diffraction method using SeMet-substituted PhoMPGP. PhoMPGP consists of two domains: a core domain that is conserved in the haloacid dehalogenase superfamily and a cap domain that is specific to the C2B cap subclass of the superfamily. Apo-form crystals contain two PhoMPGP molecules: one in the open conformation and the other in the closed conformation. In holo-form crystals both of the two molecules are in the closed conformation with phosphate and magnesium ions. PhoMPGP has a specific hairpin loop that is bent towards the active site in the closed conformation of both the apo and holo forms. PhoMPGP has a cavity between the two domains which is considered to be the substrate-binding site as a phosphate ion is located in the cavity, mimicking the binding manner of the phosphate group of MPG. The cavity is sequestered in the closed conformation such that a conformational change is indispensable for the release of products. A salt bridge from the general acid/base Asp10 to Arg170 is observed in the holo-form PhoMPGP which is not present in the open form. The importance of the conformational change in the activity of PhoMPGP is discussed.

	~~{{STRUCTURE_2zos\| PDB=2zos \| SCENE= }}~~		Structure of mannosyl-3-phosphoglycerate phosphatase from Pyrococcus horikoshii.,Kawamura T, Watanabe N, Tanaka I Acta Crystallogr D Biol Crystallogr. 2008 Dec;64(Pt 12):1267-76. Epub 2008, Nov 18. PMID:19018103<ref>PMID:19018103</ref>

	~~===Crystal structure~~ of ~~mannosyl-3-phosphoglycerate phosphatase from Pyrococcus horikoshii===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_19018103}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2zos]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2ZOS OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:019018103<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Mannosyl-3-phosphoglycerate phosphatase]]		[[Category: Mannosyl-3-phosphoglycerate phosphatase]]
	[[Category: Pyrococcus horikoshii]]		[[Category: Pyrococcus horikoshii]]

OCA: Protected "2zos" [edit=sysop:move=sysop]

2013-01-07T17:49:45Z

Protected "2zos" [edit=sysop:move=sysop]

← Older revision	Revision as of 17:49, 7 January 2013
(No difference)

OCA at 17:49, 7 January 2013

2013-01-07T17:49:40Z

← Older revision		Revision as of 17:49, 7 January 2013
Line 1:		Line 1:
	~~{{Seed}}~~		[[Image:2zos.png\|left\|200px]]
	[[Image:2zos.~~jpg~~\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2zos", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2zos\| PDB=2zos \| SCENE= }}		{{STRUCTURE_2zos\| PDB=2zos \| SCENE= }}

	===Crystal structure of mannosyl-3-phosphoglycerate phosphatase from Pyrococcus horikoshii===		===Crystal structure of mannosyl-3-phosphoglycerate phosphatase from Pyrococcus horikoshii===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_19018103}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 19018103 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_19018103}}		{{ABSTRACT_PUBMED_19018103}}

	==About this Structure==		==About this Structure==
	~~2ZOS~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZOS OCA].		[[2zos]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZOS OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~19018103~~</ref><references group="xtra"/>		<ref group="xtra">PMID:019018103</ref><references group="xtra"/>
	[[Category: Mannosyl-3-phosphoglycerate phosphatase]]		[[Category: Mannosyl-3-phosphoglycerate phosphatase]]
	[[Category: Pyrococcus horikoshii]]		[[Category: Pyrococcus horikoshii]]
Line 29:		Line 17:
	[[Category: Tanaka, I.]]		[[Category: Tanaka, I.]]
	[[Category: Watanabe, N.]]		[[Category: Watanabe, N.]]
	~~[[Category: Cytoplasm]]~~
	[[Category: Haloacid dehalogenase like hydrolase]]		[[Category: Haloacid dehalogenase like hydrolase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
Line 35:		Line 22:
	[[Category: Mannosylglycerate]]		[[Category: Mannosylglycerate]]
	[[Category: Phosphatase]]		[[Category: Phosphatase]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 28 09:45:03 2009''~~

OCA at 07:45, 28 January 2009

2009-01-28T07:45:10Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{Seed}}
-The entry 2zos is ON HOLD  until Paper Publication
+<!--
-Authors: Kawamura, T., Watanabe, N., Tanaka, I.
+===Crystal structure of mannosyl-3-phosphoglycerate phosphatase from Pyrococcus horikoshii===
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Jul 11 13:02:31 2008''
+<!--

OCA: New page: '''Unreleased structure''' The entry 2zos is ON HOLD until Paper Publication Authors: Kawamura, T., Watanabe, N., Tanaka, I. Description: Crystal structure of mannosyl-3-phosphoglycera...

2008-07-11T10:02:32Z

New page: '''Unreleased structure''' The entry 2zos is ON HOLD until Paper Publication Authors: Kawamura, T., Watanabe, N., Tanaka, I. Description: Crystal structure of mannosyl-3-phosphoglycera...

New page

'''Unreleased structure'''

The entry 2zos is ON HOLD until Paper Publication

Authors: Kawamura, T., Watanabe, N., Tanaka, I.

Description: Crystal structure of mannosyl-3-phosphoglycerate phosphatase from Pyrococcus horikoshii

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Jul 11 13:02:31 2008''