2zza - Revision history

OCA at 14:03, 1 November 2023

2023-11-01T14:03:53Z

← Older revision		Revision as of 14:03, 1 November 2023
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	<StructureSection load='2zza' size='340' side='right'caption='[[2zza]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2zza' size='340' side='right'caption='[[2zza]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2zza]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Jcm_11435 Jcm 11435~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZZA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZZA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2zza]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Moritella_profunda Moritella profunda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZZA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZZA FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>~~, ~~<scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~dyrA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=111291 JCM 11435])</td~~></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
	<~~tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3]~~ </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zza OCA], [https://pdbe.org/2zza PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zza RCSB], [https://www.ebi.ac.uk/pdbsum/2zza PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zza ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zza OCA], [https://pdbe.org/2zza PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zza RCSB], [https://www.ebi.ac.uk/pdbsum/2zza PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zza ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/Q70YQ6_MORPR Q70YQ6_MORPR]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194]		[https://www.uniprot.org/uniprot/Q70YQ6_MORPR Q70YQ6_MORPR] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Dihydrofolate reductase]]~~
	~~[[Category: Jcm 11435]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Akasaka, K]]~~
	~~[[Category: Gekko, K]]~~
	~~[[Category: Hata, K]]~~
	~~[[Category: Murakami, C]]~~
	~~[[Category: Ohmae, E]]~~
	~~[[Category: Shiro, Y]]~~
	~~[[Category: Tanaka, T]]~~
	~~[[Category: Deep-sea]]~~
	~~[[Category: Folic acid]]~~
	~~[[Category: High pressure]]~~
	~~[[Category: Low temperature]]~~
	[[Category: Moritella profunda]]		[[Category: Moritella profunda]]
	[[Category: ~~Nadp~~]]		[[Category: Akasaka K]]
	[[Category: ~~Oxidoreductase~~]]		[[Category: Gekko K]]
	[[Category: ~~Piezophilic~~]]		[[Category: Hata K]]
	[[Category: ~~Psychrophilic~~]]		[[Category: Murakami C]]
	[[Category: ~~Psychropiezophilic~~]]		[[Category: Ohmae E]]
			[[Category: Shiro Y]]
			[[Category: Tanaka T]]

OCA at 16:11, 22 December 2021

2021-12-22T16:11:34Z

← Older revision		Revision as of 16:11, 22 December 2021
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	==Moritella profunda Dihydrofolate reductase complex with NADP+ and Folate==		==Moritella profunda Dihydrofolate reductase complex with NADP+ and Folate==
	<StructureSection load='2zza' size='340' side='right' caption='[[2zza]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2zza' size='340' side='right'caption='[[2zza]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2zza]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Jcm_11435 Jcm 11435]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZZA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ZZA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2zza]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Jcm_11435 Jcm 11435]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZZA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZZA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dyrA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=111291 JCM 11435])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dyrA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=111291 JCM 11435])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2zza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zza OCA], [~~http~~://pdbe.org/2zza PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2zza RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2zza PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2zza ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zza OCA], [https://pdbe.org/2zza PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zza RCSB], [https://www.ebi.ac.uk/pdbsum/2zza PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zza ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/Q70YQ6_MORPR Q70YQ6_MORPR]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194]		[[https://www.uniprot.org/uniprot/Q70YQ6_MORPR Q70YQ6_MORPR]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]		*[[Dihydrofolate reductase 3D structures\|Dihydrofolate reductase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Dihydrofolate reductase]]		[[Category: Dihydrofolate reductase]]
	[[Category: Jcm 11435]]		[[Category: Jcm 11435]]
			[[Category: Large Structures]]
	[[Category: Akasaka, K]]		[[Category: Akasaka, K]]
	[[Category: Gekko, K]]		[[Category: Gekko, K]]

OCA at 06:55, 18 October 2018

2018-10-18T06:55:29Z

← Older revision		Revision as of 06:55, 18 October 2018
Line 1:		Line 1:

	==Moritella profunda Dihydrofolate reductase complex with NADP+ and Folate==		==Moritella profunda Dihydrofolate reductase complex with NADP+ and Folate==
	<StructureSection load='2zza' size='340' side='right' caption='[[2zza]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2zza' size='340' side='right' caption='[[2zza]], [[Resolution\|resolution]] 2.00Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dyrA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=111291 JCM 11435])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dyrA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=111291 JCM 11435])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zza OCA], [http://pdbe.org/2zza PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zza RCSB], [http://www.ebi.ac.uk/pdbsum/2zza PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zza OCA], [http://pdbe.org/2zza PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zza RCSB], [http://www.ebi.ac.uk/pdbsum/2zza PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zza ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zz/2zza_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zz/2zza_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 02:39, 10 February 2016

2016-02-10T02:39:04Z

← Older revision		Revision as of 02:39, 10 February 2016
Line 2:		Line 2:
	<StructureSection load='2zza' size='340' side='right' caption='[[2zza]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2zza' size='340' side='right' caption='[[2zza]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2zza]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Moritella_profunda Moritella profunda~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZZA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2zza]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Jcm_11435 Jcm 11435]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZZA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dyrA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=111291 ~~Moritella profunda~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dyrA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=111291 JCM 11435])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zza OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zza RCSB], [http://www.ebi.ac.uk/pdbsum/2zza PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zza OCA], [http://pdbe.org/2zza PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zza RCSB], [http://www.ebi.ac.uk/pdbsum/2zza PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zza ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Dihydrofolate reductase]]		[[Category: Dihydrofolate reductase]]
	[[Category: ~~Moritella profunda~~]]		[[Category: Jcm 11435]]
	[[Category: Akasaka, K]]		[[Category: Akasaka, K]]
	[[Category: Gekko, K]]		[[Category: Gekko, K]]
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	[[Category: High pressure]]		[[Category: High pressure]]
	[[Category: Low temperature]]		[[Category: Low temperature]]
			[[Category: Moritella profunda]]
	[[Category: Nadp]]		[[Category: Nadp]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 11:12, 25 December 2014

2014-12-25T11:12:54Z

← Older revision		Revision as of 11:12, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2zza]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Moritella_profunda Moritella profunda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZZA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2zza]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Moritella_profunda Moritella profunda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZZA FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dyrA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=111291 Moritella profunda])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dyrA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=111291 Moritella profunda])</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zza OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zza RCSB], [http://www.ebi.ac.uk/pdbsum/2zza PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zza OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zza RCSB], [http://www.ebi.ac.uk/pdbsum/2zza PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/Q70YQ6_MORPR Q70YQ6_MORPR]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 27:
	[[Category: Dihydrofolate reductase]]		[[Category: Dihydrofolate reductase]]
	[[Category: Moritella profunda]]		[[Category: Moritella profunda]]
	[[Category: Akasaka, K.]]		[[Category: Akasaka, K]]
	[[Category: Gekko, K.]]		[[Category: Gekko, K]]
	[[Category: Hata, K.]]		[[Category: Hata, K]]
	[[Category: Murakami, C.]]		[[Category: Murakami, C]]
	[[Category: Ohmae, E.]]		[[Category: Ohmae, E]]
	[[Category: Shiro, Y.]]		[[Category: Shiro, Y]]
	[[Category: Tanaka, T.]]		[[Category: Tanaka, T]]
	[[Category: Deep-sea]]		[[Category: Deep-sea]]
	~~[[Category: Dihydrofolate reductase]]~~
	[[Category: Folic acid]]		[[Category: Folic acid]]
	[[Category: High pressure]]		[[Category: High pressure]]
	[[Category: Low temperature]]		[[Category: Low temperature]]
	~~[[Category: Moritella profunda]]~~
	[[Category: Nadp]]		[[Category: Nadp]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 06:23, 29 September 2014

2014-09-29T06:23:45Z

← Older revision		Revision as of 06:23, 29 September 2014
Line 1:		Line 1:
	~~[[Image:2zza.png\|left\|200px]]~~		==Moritella profunda Dihydrofolate reductase complex with NADP+ and Folate==
			<StructureSection load='2zza' size='340' side='right' caption='[[2zza]], [[Resolution\|resolution]] 2.00Å' scene=''>
	~~{{STRUCTURE_2zza\| PDB=2zza \| SCENE= }}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2zza]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Moritella_profunda Moritella profunda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZZA FirstGlance]. <br>
	===Moritella profunda Dihydrofolate reductase complex with NADP+ and Folate===		</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene><br>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dyrA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=111291 Moritella profunda])</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
	==~~About this Structure~~==		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zza OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zza RCSB], [http://www.ebi.ac.uk/pdbsum/2zza PDBsum]</span></td></tr>
	[[2zza]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Moritella_profunda Moritella profunda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZZA OCA].		<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zz/2zza_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>

	==See Also==		==See Also==
	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]		*[[Dihydrofolate reductase\|Dihydrofolate reductase]]
			__TOC__
			</StructureSection>
	[[Category: Dihydrofolate reductase]]		[[Category: Dihydrofolate reductase]]
	[[Category: Moritella profunda]]		[[Category: Moritella profunda]]

OCA at 16:02, 20 October 2012

2012-10-20T16:02:23Z

← Older revision		Revision as of 16:02, 20 October 2012
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
	[[2zza]] is a 2 chain structure ~~of [[Dihydrofolate reductase]]~~ with sequence from [http://en.wikipedia.org/wiki/Moritella_profunda Moritella profunda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZZA OCA].		[[2zza]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Moritella_profunda Moritella profunda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZZA OCA].

	==See Also==		==See Also==

OCA at 20:23, 26 July 2012

2012-07-26T20:23:02Z

← Older revision		Revision as of 20:23, 26 July 2012
Line 1:		Line 1:
	[[Image:2zza.png\|left\|200px]]		[[Image:2zza.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2zza", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2zza\| PDB=2zza \| SCENE= }}		{{STRUCTURE_2zza\| PDB=2zza \| SCENE= }}

Line 16:		Line 10:

	==See Also==		==See Also==
	*[[Dihydrofolate reductase]]		*[[Dihydrofolate reductase\|Dihydrofolate reductase]]
	[[Category: Dihydrofolate reductase]]		[[Category: Dihydrofolate reductase]]
	[[Category: Moritella profunda]]		[[Category: Moritella profunda]]

OCA: Protected "2zza" [edit=sysop:move=sysop]

2010-12-26T08:21:13Z

Protected "2zza" [edit=sysop:move=sysop]

← Older revision	Revision as of 08:21, 26 December 2010
(No difference)

OCA at 08:21, 26 December 2010

2010-12-26T08:21:11Z

← Older revision		Revision as of 08:21, 26 December 2010
Line 1:		Line 1:
	~~{{Seed}}~~		[[Image:2zza.png\|left\|200px]]
	[[Image:2zza.~~jpg~~\|left\|200px]]

	<!--		<!--
Line 14:		Line 13:

	==About this Structure==		==About this Structure==
	~~2ZZA~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Moritella_profunda Moritella profunda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZZA OCA].		[[2zza]] is a 2 chain structure of [[Dihydrofolate reductase]] with sequence from [http://en.wikipedia.org/wiki/Moritella_profunda Moritella profunda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZZA OCA].

			==See Also==
			*[[Dihydrofolate reductase]]
	[[Category: Dihydrofolate reductase]]		[[Category: Dihydrofolate reductase]]
	[[Category: Moritella profunda]]		[[Category: Moritella profunda]]
Line 35:		Line 37:
	[[Category: Psychrophilic]]		[[Category: Psychrophilic]]
	[[Category: Psychropiezophilic]]		[[Category: Psychropiezophilic]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 25 13:55:31 2010''~~