331d - Revision history

OCA at 08:45, 13 August 2026

2026-08-13T08:45:28Z

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 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=331d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=331d OCA], [https://pdbe.org/331d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=331d RCSB], [https://www.ebi.ac.uk/pdbsum/331d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=331d ProSAT]</span></td></tr>
 </table>
 __TOC__
 </StructureSection>

OCA at 08:39, 7 February 2024

2024-02-07T08:39:11Z

← Older revision		Revision as of 08:39, 7 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[331d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=331D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=331D FirstGlance]. <br>		<table><tr><td colspan='2'>[[331d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=331D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=331D FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.65Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=331d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=331d OCA], [https://pdbe.org/331d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=331d RCSB], [https://www.ebi.ac.uk/pdbsum/331d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=331d ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=331d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=331d OCA], [https://pdbe.org/331d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=331d RCSB], [https://www.ebi.ac.uk/pdbsum/331d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=331d ProSAT]</span></td></tr>
	</table>		</table>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	The crystal structure of the DNA heptamer d(GCGCGCG) has been solved at 1.65 A resolution by the molecular replacement method and refined to an R-value of 0.184 for 3598 reflections. The heptamer forms a Z-DNA d(CGCGCG)2 with 5'-overhang G residues instead of an A-DNA d(GCGCGC)2 with 3'-overhang G residues. The overhang G residues from parallel strands of two adjacent duplexes form a trans reverse Hoogsteen G x G basepair that stacks on the six Z-DNA basepairs to produce a pseudocontinuous helix. The reverse Hoogsteen G x G basepair is unusual in that the displacement of one G base relative to the other allows them to participate in a bifurcated (G1)N2 . . . N7(G8) and an enhanced (G8)C8-H . . . O6(G1) hydrogen bond, in addition to the two usual hydrogen bonds. The 5'-overhang G residues are anti and C2'-endo while the 3'-terminal G residues are syn and C2'-endo. The conformations of both G residues are different from the syn/C3'-endo for the guanosine in a standard Z-DNA. The two cobalt hexammine ions bind to the phosphate groups in both GpC and CpG steps in Z(I) and Z(II) conformations. The water structure motif is similar to the other Z-DNA structures.

	~~Crystal structure of d(GCGCGCG) with 5'-overhang G residues.,Pan B, Ban C, Wahl MC, Sundaralingam M Biophys J. 1997 Sep;73(3):1553-61. PMID:9284322<ref>PMID:9284322</ref>~~

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 331d" style="background-color:#fffaf0;"></div>~~
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Ban, C]]		[[Category: Ban C]]
	[[Category: Pan, B]]		[[Category: Pan B]]
	[[Category: Sundaralingam, M]]		[[Category: Sundaralingam M]]
	[[Category: Wahl, M]]		[[Category: Wahl M]]
	~~[[Category: Dna]]~~
	~~[[Category: Double helix]]~~
	~~[[Category: Flipped-out base]]~~
	~~[[Category: Overhanging base]]~~
	~~[[Category: Z-dna~~]]

OCA at 13:23, 4 May 2022

2022-05-04T13:23:50Z

← Older revision		Revision as of 13:23, 4 May 2022
Line 3:		Line 3:
	<StructureSection load='331d' size='340' side='right'caption='[[331d]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='331d' size='340' side='right'caption='[[331d]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[331d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=331D OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=331D FirstGlance]. <br>		<table><tr><td colspan='2'>[[331d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=331D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=331D FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=331d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=331d OCA], [~~http~~://pdbe.org/331d PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=331d RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/331d PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=331d ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=331d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=331d OCA], [https://pdbe.org/331d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=331d RCSB], [https://www.ebi.ac.uk/pdbsum/331d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=331d ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 12:13, 29 July 2020

2020-07-29T12:13:32Z

← Older revision		Revision as of 12:13, 29 July 2020
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF D(GCGCGCG) WITH 5'-OVERHANG G'S==		==CRYSTAL STRUCTURE OF D(GCGCGCG) WITH 5'-OVERHANG G'S==
	<StructureSection load='331d' size='340' side='right' caption='[[331d]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='331d' size='340' side='right'caption='[[331d]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[331d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=331D OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=331D FirstGlance]. <br>		<table><tr><td colspan='2'>[[331d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=331D OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=331D FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=331d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=331d OCA], [http://pdbe.org/331d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=331d RCSB], [http://www.ebi.ac.uk/pdbsum/331d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=331d ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=331d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=331d OCA], [http://pdbe.org/331d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=331d RCSB], [http://www.ebi.ac.uk/pdbsum/331d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=331d ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Ban, C]]		[[Category: Ban, C]]
	[[Category: Pan, B]]		[[Category: Pan, B]]

OCA at 04:33, 5 August 2016

2016-08-05T04:33:27Z

← Older revision		Revision as of 04:33, 5 August 2016
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF D(GCGCGCG) WITH 5'-OVERHANG G'S==		==CRYSTAL STRUCTURE OF D(GCGCGCG) WITH 5'-OVERHANG G'S==
	<StructureSection load='331d' size='340' side='right' caption='[[331d]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='331d' size='340' side='right' caption='[[331d]], [[Resolution\|resolution]] 1.65Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[331d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=331D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=331D FirstGlance]. <br>		<table><tr><td colspan='2'>[[331d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=331D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=331D FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=331d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=331d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=331d RCSB], [http://www.ebi.ac.uk/pdbsum/331d PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=331d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=331d OCA], [http://pdbe.org/331d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=331d RCSB], [http://www.ebi.ac.uk/pdbsum/331d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=331d ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 331d" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 23:00, 3 January 2015

2015-01-03T23:00:50Z

← Older revision		Revision as of 23:00, 3 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[331d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=331D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=331D FirstGlance]. <br>		<table><tr><td colspan='2'>[[331d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=331D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=331D FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=331d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=331d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=331d RCSB], [http://www.ebi.ac.uk/pdbsum/331d PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=331d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=331d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=331d RCSB], [http://www.ebi.ac.uk/pdbsum/331d PDBsum]</span></td></tr>
	<table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Ban, C.]]		[[Category: Ban, C]]
	[[Category: Pan, B.]]		[[Category: Pan, B]]
	[[Category: Sundaralingam, M.]]		[[Category: Sundaralingam, M]]
	[[Category: Wahl, M.]]		[[Category: Wahl, M]]
	[[Category: Dna]]		[[Category: Dna]]
	[[Category: Double helix]]		[[Category: Double helix]]

OCA at 07:00, 9 June 2014

2014-06-09T07:00:20Z

← Older revision		Revision as of 07:00, 9 June 2014
Line 1:		Line 1:
	[[~~Image~~:331d.~~png\|left\|200px~~]]		==CRYSTAL STRUCTURE OF D(GCGCGCG) WITH 5'-OVERHANG G'S==
			<StructureSection load='331d' size='340' side='right' caption='[[331d]], [[Resolution\|resolution]] 1.65Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[331d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=331D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=331D FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene><br>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=331d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=331d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=331d RCSB], [http://www.ebi.ac.uk/pdbsum/331d PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The crystal structure of the DNA heptamer d(GCGCGCG) has been solved at 1.65 A resolution by the molecular replacement method and refined to an R-value of 0.184 for 3598 reflections. The heptamer forms a Z-DNA d(CGCGCG)2 with 5'-overhang G residues instead of an A-DNA d(GCGCGC)2 with 3'-overhang G residues. The overhang G residues from parallel strands of two adjacent duplexes form a trans reverse Hoogsteen G x G basepair that stacks on the six Z-DNA basepairs to produce a pseudocontinuous helix. The reverse Hoogsteen G x G basepair is unusual in that the displacement of one G base relative to the other allows them to participate in a bifurcated (G1)N2 . . . N7(G8) and an enhanced (G8)C8-H . . . O6(G1) hydrogen bond, in addition to the two usual hydrogen bonds. The 5'-overhang G residues are anti and C2'-endo while the 3'-terminal G residues are syn and C2'-endo. The conformations of both G residues are different from the syn/C3'-endo for the guanosine in a standard Z-DNA. The two cobalt hexammine ions bind to the phosphate groups in both GpC and CpG steps in Z(I) and Z(II) conformations. The water structure motif is similar to the other Z-DNA structures.

	~~{{STRUCTURE_331d\| PDB=331d \| SCENE= }}~~		Crystal structure of d(GCGCGCG) with 5'-overhang G residues.,Pan B, Ban C, Wahl MC, Sundaralingam M Biophys J. 1997 Sep;73(3):1553-61. PMID:9284322<ref>PMID:9284322</ref>

	~~===CRYSTAL STRUCTURE OF D(GCGCGCG) WITH 5'-OVERHANG G'S===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_9284322}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[331d]] is~~ a ~~2 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=331D OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:009284322<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Ban, C.]]		[[Category: Ban, C.]]
	[[Category: Pan, B.]]		[[Category: Pan, B.]]

OCA: Protected "331d" [edit=sysop:move=sysop]

2012-08-14T18:24:24Z

Protected "331d" [edit=sysop:move=sysop]

← Older revision	Revision as of 18:24, 14 August 2012
(No difference)

OCA at 18:24, 14 August 2012

2012-08-14T18:24:22Z

← Older revision		Revision as of 18:24, 14 August 2012
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	~~{{Seed}}~~
	[[Image:331d.png\|left\|200px]]		[[Image:331d.png\|left\|200px]]

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	~~The line below this paragraph, containing "STRUCTURE_331d", creates the "Structure Box" on the page.~~
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	~~or leave the SCENE parameter empty for the default display.~~
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	{{STRUCTURE_331d\| PDB=331d \| SCENE= }}		{{STRUCTURE_331d\| PDB=331d \| SCENE= }}

	===CRYSTAL STRUCTURE OF D(GCGCGCG) WITH 5'-OVERHANG G'S===		===CRYSTAL STRUCTURE OF D(GCGCGCG) WITH 5'-OVERHANG G'S===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_9284322}}, adds the Publication Abstract to the page~~
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	{{ABSTRACT_PUBMED_9284322}}		{{ABSTRACT_PUBMED_9284322}}

	==About this Structure==		==About this Structure==
	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=331D OCA].		[[331d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=331D OCA].

	==Reference==		==Reference==
	~~Crystal structure of d(GCGCGCG) with 5'-overhang G residues., Pan B, Ban C, Wahl MC, Sundaralingam M, Biophys J. 1997 Sep;73(3):1553-61.~~ PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~9284322 9284322]~~		<ref group="xtra">PMID:009284322</ref><references group="xtra"/>
	[[Category: Ban, C.]]		[[Category: Ban, C.]]
	[[Category: Pan, B.]]		[[Category: Pan, B.]]
	[[Category: Sundaralingam, M.]]		[[Category: Sundaralingam, M.]]
	[[Category: Wahl, M.]]		[[Category: Wahl, M.]]
			[[Category: Dna]]
	[[Category: Double helix]]		[[Category: Double helix]]
	[[Category: Flipped-out base]]		[[Category: Flipped-out base]]
	[[Category: Overhanging base]]		[[Category: Overhanging base]]
	[[Category: Z-dna]]		[[Category: Z-dna]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:55:31 2008''~~

OCA at 01:55, 29 July 2008

2008-07-29T01:55:40Z

← Older revision		Revision as of 01:55, 29 July 2008
Line 1:		Line 1:
	[[Image:331d.~~gif~~\|left\|200px]]		{{Seed}}
			[[Image:331d.png\|left\|200px]]

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	{{STRUCTURE_331d\| PDB=331d \| SCENE= }}		{{STRUCTURE_331d\| PDB=331d \| SCENE= }}

	~~'''~~CRYSTAL STRUCTURE OF D(GCGCGCG) WITH 5'-OVERHANG G'S~~'''~~		===CRYSTAL STRUCTURE OF D(GCGCGCG) WITH 5'-OVERHANG G'S===


	~~==Overview==~~		<!--
	The crystal structure of the DNA heptamer d(GCGCGCG) has been solved at 1.65 A resolution by the molecular replacement method and refined to an R-value of 0.184 for 3598 reflections. The heptamer forms a Z-DNA d(CGCGCG)2 with 5'-~~overhang G residues instead of an A~~-~~DNA d(GCGCGC)2 with 3'-overhang G residues.~~ The ~~overhang G residues from parallel strands of two adjacent duplexes form a trans reverse Hoogsteen G x G basepair that stacks on~~ the ~~six Z-DNA basepairs~~ to ~~produce a pseudocontinuous helix. The reverse Hoogsteen G x G basepair is unusual in that~~ the ~~displacement of one G base relative to the other allows them to participate in a bifurcated~~ (~~G1)N2 .~~ . . ~~N7(G8~~) ~~and an enhanced (G8)C8-H . . . O6(G1) hydrogen bond~~, ~~in addition to~~ the ~~two usual hydrogen bonds~~. ~~The 5'~~-~~overhang G residues are anti and C2'~~-endo while the 3'-terminal G residues are syn and C2'-endo. The conformations of both G residues are different from the syn/C3'-endo for the guanosine in a standard Z-DNA. The two cobalt hexammine ions bind to the phosphate groups in both GpC and CpG steps in Z(I) and Z(II) conformations. The water structure motif is similar to the other Z-DNA structures.		The line below this paragraph, {{ABSTRACT_PUBMED_9284322}}, adds the Publication Abstract to the page
			(as it appears on PubMed at http://www.pubmed.gov), where 9284322 is the PubMed ID number.
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			{{ABSTRACT_PUBMED_9284322}}

	==About this Structure==		==About this Structure==
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	[[Category: Overhanging base]]		[[Category: Overhanging base]]
	[[Category: Z-dna]]		[[Category: Z-dna]]
	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 20~~:16:05 2008''
			''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:55:31 2008''