3a67 - Revision history

OCA at 01:35, 21 November 2024

2024-11-21T01:35:14Z

← Older revision		Revision as of 01:35, 21 November 2024
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a6/3a67_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a6/3a67_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 14:13, 1 November 2023

2023-11-01T14:13:31Z

← Older revision		Revision as of 14:13, 1 November 2023
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	<StructureSection load='3a67' size='340' side='right'caption='[[3a67]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3a67' size='340' side='right'caption='[[3a67]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3a67]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A67 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3A67 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3a67]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A67 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A67 FirstGlance]. <br>
	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[1c08\|1c08]]~~, [[~~1j1o~~\|~~1j1o~~]]~~, [[1j1p\|1j1p]], [[1j1x\|1j1x]], [[2dqi\|2dqi]], [[2dqj\|2dqj]], [[3a6b\|3a6b]], [[3a6c\|3a6c]]</td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.~~17 3.2.1.17] </span>~~</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a67 OCA], [https://pdbe.org/3a67 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a67 RCSB], [https://www.ebi.ac.uk/pdbsum/3a67 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a67 ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3a67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a67 OCA], [~~http~~://pdbe.org/3a67 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3a67 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3a67 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3a67 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>		[https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 39:		Line 38:
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Lk3 transgenic mice]]~~		[[Category: Mus musculus]]
	~~[[Category: Lysozyme~~]]		[[Category: Kondo H]]
	[[Category: Kondo, H]]		[[Category: Kumagai I]]
	[[Category: Kumagai, I]]		[[Category: Nakanishi T]]
	[[Category: Nakanishi, T]]		[[Category: Shiroishi M]]
	[[Category: Shiroishi, M]]		[[Category: Tsumoto K]]
	[[Category: Tsumoto, K]]		[[Category: Yokota A]]
	[[Category: Yokota, A]]
	~~[[Category: Allergen]]~~
	~~[[Category: Antigen-antibody complex]]~~
	~~[[Category: Antimicrobial]]~~
	~~[[Category: Bacteriolytic enzyme]]~~
	~~[[Category: Disulfide bond]]~~
	~~[[Category: Glycosidase]]~~
	~~[[Category: Immune system-hydrolase complex]]~~
	~~[[Category: Mutant~~]]

OCA at 12:17, 29 July 2020

2020-07-29T12:17:25Z

← Older revision		Revision as of 12:17, 29 July 2020
Line 1:		Line 1:

	==Crystal Structure of HyHEL-10 Fv mutant LN31D complexed with hen egg white lysozyme==		==Crystal Structure of HyHEL-10 Fv mutant LN31D complexed with hen egg white lysozyme==
	<StructureSection load='3a67' size='340' side='right' caption='[[3a67]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3a67' size='340' side='right'caption='[[3a67]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3a67]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A67 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3A67 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3a67]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A67 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3A67 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c08\|1c08]], [[1j1o\|1j1o]], [[1j1p\|1j1p]], [[1j1x\|1j1x]], [[2dqi\|2dqi]], [[2dqj\|2dqj]], [[3a6b\|3a6b]], [[3a6c\|3a6c]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c08\|1c08]], [[1j1o\|1j1o]], [[1j1p\|1j1p]], [[1j1x\|1j1x]], [[2dqi\|2dqi]], [[2dqj\|2dqj]], [[3a6b\|3a6b]], [[3a6c\|3a6c]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3a67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a67 OCA], [http://pdbe.org/3a67 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3a67 RCSB], [http://www.ebi.ac.uk/pdbsum/3a67 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3a67 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3a67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a67 OCA], [http://pdbe.org/3a67 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3a67 RCSB], [http://www.ebi.ac.uk/pdbsum/3a67 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3a67 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</StructureSection>		</StructureSection>
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
			[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]

OCA at 07:41, 24 October 2018

2018-10-24T07:41:20Z

← Older revision		Revision as of 07:41, 24 October 2018
Line 1:		Line 1:

	==Crystal Structure of HyHEL-10 Fv mutant LN31D complexed with hen egg white lysozyme==		==Crystal Structure of HyHEL-10 Fv mutant LN31D complexed with hen egg white lysozyme==
	<StructureSection load='3a67' size='340' side='right' caption='[[3a67]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3a67' size='340' side='right' caption='[[3a67]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3a67]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Chick Chick~~] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A67 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3A67 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3a67]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A67 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3A67 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c08\|1c08]], [[1j1o\|1j1o]], [[1j1p\|1j1p]], [[1j1x\|1j1x]], [[2dqi\|2dqi]], [[2dqj\|2dqj]], [[3a6b\|3a6b]], [[3a6c\|3a6c]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c08\|1c08]], [[1j1o\|1j1o]], [[1j1p\|1j1p]], [[1j1x\|1j1x]], [[2dqi\|2dqi]], [[2dqj\|2dqj]], [[3a6b\|3a6b]], [[3a6c\|3a6c]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3a67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a67 OCA], [http://pdbe.org/3a67 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3a67 RCSB], [http://www.ebi.ac.uk/pdbsum/3a67 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3a67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a67 OCA], [http://pdbe.org/3a67 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3a67 RCSB], [http://www.ebi.ac.uk/pdbsum/3a67 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3a67 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a6/3a67_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a6/3a67_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	==See Also==		==See Also==
	*[[Lysozyme 3D structures\|Lysozyme 3D structures]]		*[[Lysozyme 3D structures\|Lysozyme 3D structures]]
	*[[Monoclonal ~~Antibody~~\|Monoclonal ~~Antibody~~]]		*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Chick~~]]		[[Category: Gallus gallus]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]

OCA at 13:00, 8 February 2016

2016-02-08T13:00:11Z

← Older revision		Revision as of 13:00, 8 February 2016
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	<StructureSection load='3a67' size='340' side='right' caption='[[3a67]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3a67' size='340' side='right' caption='[[3a67]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3a67]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Gallus_gallus Gallus gallus~~] and [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A67 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3A67 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3a67]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A67 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3A67 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c08\|1c08]], [[1j1o\|1j1o]], [[1j1p\|1j1p]], [[1j1x\|1j1x]], [[2dqi\|2dqi]], [[2dqj\|2dqj]], [[3a6b\|3a6b]], [[3a6c\|3a6c]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c08\|1c08]], [[1j1o\|1j1o]], [[1j1p\|1j1p]], [[1j1x\|1j1x]], [[2dqi\|2dqi]], [[2dqj\|2dqj]], [[3a6b\|3a6b]], [[3a6c\|3a6c]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3a67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a67 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3a67 RCSB], [http://www.ebi.ac.uk/pdbsum/3a67 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3a67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a67 OCA], [http://pdbe.org/3a67 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3a67 RCSB], [http://www.ebi.ac.uk/pdbsum/3a67 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3a67 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3a67" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Gallus gallus~~]]		[[Category: Chick]]
			[[Category: Lk3 transgenic mice]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]
	~~[[Category: Mus musculus]]~~
	[[Category: Kondo, H]]		[[Category: Kondo, H]]
	[[Category: Kumagai, I]]		[[Category: Kumagai, I]]

OCA at 23:29, 24 December 2014

2014-12-24T23:29:41Z

← Older revision		Revision as of 23:29, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3a67]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A67 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3A67 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3a67]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A67 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3A67 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c08\|1c08]], [[1j1o\|1j1o]], [[1j1p\|1j1p]], [[1j1x\|1j1x]], [[2dqi\|2dqi]], [[2dqj\|2dqj]], [[3a6b\|3a6b]], [[3a6c\|3a6c]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c08\|1c08]], [[1j1o\|1j1o]], [[1j1p\|1j1p]], [[1j1x\|1j1x]], [[2dqi\|2dqi]], [[2dqj\|2dqj]], [[3a6b\|3a6b]], [[3a6c\|3a6c]]</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3a67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a67 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3a67 RCSB], [http://www.ebi.ac.uk/pdbsum/3a67 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3a67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a67 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3a67 RCSB], [http://www.ebi.ac.uk/pdbsum/3a67 PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	[[Category: Lysozyme]]		[[Category: Lysozyme]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Kondo, H.]]		[[Category: Kondo, H]]
	[[Category: Kumagai, I.]]		[[Category: Kumagai, I]]
	[[Category: Nakanishi, T.]]		[[Category: Nakanishi, T]]
	[[Category: Shiroishi, M.]]		[[Category: Shiroishi, M]]
	[[Category: Tsumoto, K.]]		[[Category: Tsumoto, K]]
	[[Category: Yokota, A.]]		[[Category: Yokota, A]]
	[[Category: Allergen]]		[[Category: Allergen]]
	[[Category: Antigen-antibody complex]]		[[Category: Antigen-antibody complex]]

OCA at 08:38, 29 September 2014

2014-09-29T08:38:02Z

← Older revision		Revision as of 08:38, 29 September 2014
Line 1:		Line 1:
	[[Image:~~3a67~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal Structure of HyHEL-10 Fv mutant LN31D complexed with hen egg white lysozyme==
			<StructureSection load='3a67' size='340' side='right' caption='[[3a67]], [[Resolution\|resolution]] 1.80Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3a67]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A67 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3A67 FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c08\|1c08]], [[1j1o\|1j1o]], [[1j1p\|1j1p]], [[1j1x\|1j1x]], [[2dqi\|2dqi]], [[2dqj\|2dqj]], [[3a6b\|3a6b]], [[3a6c\|3a6c]]</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3a67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a67 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3a67 RCSB], [http://www.ebi.ac.uk/pdbsum/3a67 PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a6/3a67_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Many germ line antibodies have asparagine residues at specific sites to achieve specific antigen recognition. To study the role of asparagine residues in the stabilization of antigen-antibody complexes, we examined the interaction between hen egg white lysozyme (HEL) and the corresponding HyHEL-10 variable domain fragment (Fv). We introduced Ala and Asp substitutions into the Fv side chains of L-Asn-31, L-Asn-32, and L-Asn-92, which interact directly with residues in HEL via hydrogen bonding in the wild-type Fv-HEL complex, and we investigated the interactions between these mutant antibodies and HEL. Isothermal titration calorimetric analysis showed that all the mutations decreased the negative enthalpy change and decreased the association constants of the interaction. Structural analyses showed that the effects of the mutations on the structure of the complex could be compensated for by conformational changes and/or by gains in other interactions. Consequently, the contribution of two hydrogen bonds was minor, and their abolition by mutation resulted in only a slight decrease in the affinity of the antibody for its antigen. By comparison, the other two hydrogen bonds buried at the interfacial area had large enthalpic advantage, despite entropic loss that was perhaps due to stiffening of the interface by the bonds, and were crucial to the strength of the interaction. Deletion of these strong hydrogen bonds could not be compensated for by other structural changes. Our results suggest that asparagine can provide the two functional groups for strong hydrogen bond formation, and their contribution to the antigen-antibody interaction can be attributed to their limited flexibility and accessibility at the complex interface.

	~~{{STRUCTURE_3a67\| PDB=3a67 \| SCENE= }}~~		Contribution of asparagine residues to the stabilization of a proteinaceous antigen-antibody complex, HyHEL-10-hen egg white lysozyme.,Yokota A, Tsumoto K, Shiroishi M, Nakanishi T, Kondo H, Kumagai I J Biol Chem. 2010 Mar 5;285(10):7686-96. Epub 2009 Dec 28. PMID:20038580<ref>PMID:20038580</ref>

	~~===Crystal Structure~~ of ~~HyHEL-10 Fv mutant LN31D complexed with hen egg white lysozyme===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_20038580}}~~

	~~==About this Structure==~~
	~~[[3a67]] is a 3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Gallus_gallus Gallus gallus] and [http://en~~.~~wikipedia.org~~/~~wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A67 OCA].~~

	==See Also==		==See Also==
	*[[~~Hen Egg-White (HEW)~~ Lysozyme\|~~Hen Egg-White (HEW)~~ Lysozyme]]		*[[Lysozyme 3D structures\|Lysozyme 3D structures]]
			*[[Monoclonal Antibody\|Monoclonal Antibody]]
	==~~Reference~~==		== References ==
	<~~ref group="xtra">PMID:020038580<~~/~~ref~~><~~references group="xtra"~~/>		<references/>
			__TOC__
			</StructureSection>
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]

OCA at 10:13, 20 October 2012

2012-10-20T10:13:21Z

← Older revision		Revision as of 10:13, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[3a67]] is a 3 chain structure ~~of [[Hen Egg-White (HEW) Lysozyme]]~~ with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A67 OCA].		[[3a67]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A67 OCA].

	==See Also==		==See Also==

OCA: Protected "3a67" [edit=sysop:move=sysop]

2012-07-26T01:23:24Z

Protected "3a67" [edit=sysop:move=sysop]

← Older revision	Revision as of 01:23, 26 July 2012
(No difference)

OCA at 01:23, 26 July 2012

2012-07-26T01:23:23Z

← Older revision		Revision as of 01:23, 26 July 2012
Line 1:		Line 1:
	~~{{Seed}}~~
	[[Image:3a67.png\|left\|200px]]		[[Image:3a67.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3a67", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3a67\| PDB=3a67 \| SCENE= }}		{{STRUCTURE_3a67\| PDB=3a67 \| SCENE= }}

	===Crystal Structure of HyHEL-10 Fv mutant LN31D complexed with hen egg white lysozyme===		===Crystal Structure of HyHEL-10 Fv mutant LN31D complexed with hen egg white lysozyme===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_20038580}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 20038580 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_20038580}}		{{ABSTRACT_PUBMED_20038580}}

	==About this Structure==		==About this Structure==
	~~3A67~~ is a 3 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A67 OCA].		[[3a67]] is a 3 chain structure of [[Hen Egg-White (HEW) Lysozyme]] with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A67 OCA].

			==See Also==
			*[[Hen Egg-White (HEW) Lysozyme\|Hen Egg-White (HEW) Lysozyme]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~20038580~~</ref><references group="xtra"/>		<ref group="xtra">PMID:020038580</ref><references group="xtra"/>
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]
Line 41:		Line 32:
	[[Category: Immune system-hydrolase complex]]		[[Category: Immune system-hydrolase complex]]
	[[Category: Mutant]]		[[Category: Mutant]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 17 09:51:22 2010''~~