3ap1 - Revision history

OCA at 15:50, 4 October 2023

2023-10-04T15:50:47Z

← Older revision		Revision as of 15:50, 4 October 2023
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	<StructureSection load='3ap1' size='340' side='right'caption='[[3ap1]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3ap1' size='340' side='right'caption='[[3ap1]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ap1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AP1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AP1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ap1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AP1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AP1 FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=A3P:ADENOSINE~~-~~3-5-DIPHOSPHATE'>A3P</scene>~~, ~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[3ap2\|3ap2]], [[3ap3\|3ap3]]</div>~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>TPST2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])</td~~><~~/tr>~~
	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Protein-tyrosine_sulfotransferase Protein-tyrosine sulfotransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.2.20 2.8.2.20]~~ </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ap1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ap1 OCA], [https://pdbe.org/3ap1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ap1 RCSB], [https://www.ebi.ac.uk/pdbsum/3ap1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ap1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ap1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ap1 OCA], [https://pdbe.org/3ap1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ap1 RCSB], [https://www.ebi.ac.uk/pdbsum/3ap1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ap1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/TPST2_HUMAN TPST2_HUMAN]] Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides.		[https://www.uniprot.org/uniprot/TPST2_HUMAN TPST2_HUMAN] Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
	*[[Sulfotransferase\|Sulfotransferase]]		*[[Sulfotransferase 3D structures\|Sulfotransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Protein-tyrosine sulfotransferase]]~~		[[Category: Adachi R]]
	[[Category: Adachi, R]]		[[Category: Fujikawa Y]]
	[[Category: Fujikawa, Y]]		[[Category: Kakuta Y]]
	[[Category: Kakuta, Y]]		[[Category: Kawaguchi Y]]
	[[Category: Kawaguchi, Y]]		[[Category: Kimura M]]
	[[Category: Kimura, M]]		[[Category: Kurogi K]]
	[[Category: Kurogi, K]]		[[Category: Liu M-C]]
	[[Category: Liu, M C]]		[[Category: Mishiro-Sato E]]
	[[Category: Mishiro-Sato, E]]		[[Category: Nakanishi Y]]
	[[Category: Nakanishi, Y]]		[[Category: Sakakibara Y]]
	[[Category: Sakakibara, Y]]		[[Category: Soejima M]]
	[[Category: Soejima, M]]		[[Category: Suiko M]]
	[[Category: Suiko, M]]		[[Category: Teramoto T]]
	[[Category: Teramoto, T]]
	~~[[Category: Sulfotransferase fold]]~~
	~~[[Category: Transferase~~]]

OCA at 14:59, 29 December 2021

2021-12-29T14:59:38Z

← Older revision		Revision as of 14:59, 29 December 2021
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	==Crystal structure of human tyrosylprotein sulfotransferase-2 complexed with PAP and C4 peptide==		==Crystal structure of human tyrosylprotein sulfotransferase-2 complexed with PAP and C4 peptide==
	<StructureSection load='3ap1' size='340' side='right' caption='[[3ap1]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3ap1' size='340' side='right'caption='[[3ap1]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ap1]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AP1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3AP1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ap1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AP1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AP1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ap2\|3ap2]], [[3ap3\|3ap3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ap2\|3ap2]], [[3ap3\|3ap3]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TPST2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TPST2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Protein-tyrosine_sulfotransferase Protein-tyrosine sulfotransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.2.20 2.8.2.20] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Protein-tyrosine_sulfotransferase Protein-tyrosine sulfotransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.2.20 2.8.2.20] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ap1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ap1 OCA], [~~http~~://pdbe.org/3ap1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ap1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ap1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ap1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ap1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ap1 OCA], [https://pdbe.org/3ap1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ap1 RCSB], [https://www.ebi.ac.uk/pdbsum/3ap1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ap1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/TPST2_HUMAN TPST2_HUMAN]] Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides.		[[https://www.uniprot.org/uniprot/TPST2_HUMAN TPST2_HUMAN]] Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Protein-tyrosine sulfotransferase]]		[[Category: Protein-tyrosine sulfotransferase]]
	[[Category: Adachi, R]]		[[Category: Adachi, R]]

OCA at 20:45, 5 August 2016

2016-08-05T20:45:40Z

← Older revision		Revision as of 20:45, 5 August 2016
Line 1:		Line 1:

	==Crystal structure of human tyrosylprotein sulfotransferase-2 complexed with PAP and C4 peptide==		==Crystal structure of human tyrosylprotein sulfotransferase-2 complexed with PAP and C4 peptide==
	<StructureSection load='3ap1' size='340' side='right' caption='[[3ap1]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3ap1' size='340' side='right' caption='[[3ap1]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ap1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AP1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AP1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ap1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AP1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AP1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ap2\|3ap2]], [[3ap3\|3ap3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ap2\|3ap2]], [[3ap3\|3ap3]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TPST2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TPST2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine_sulfotransferase Protein-tyrosine sulfotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.2.20 2.8.2.20] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine_sulfotransferase Protein-tyrosine sulfotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.2.20 2.8.2.20] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ap1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ap1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ap1 RCSB], [http://www.ebi.ac.uk/pdbsum/3ap1 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ap1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ap1 OCA], [http://pdbe.org/3ap1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ap1 RCSB], [http://www.ebi.ac.uk/pdbsum/3ap1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ap1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3ap1" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Protein-tyrosine sulfotransferase]]		[[Category: Protein-tyrosine sulfotransferase]]
	[[Category: Adachi, R]]		[[Category: Adachi, R]]

OCA at 05:44, 25 December 2014

2014-12-25T05:44:11Z

← Older revision		Revision as of 05:44, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ap1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ap1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ap1 RCSB], [http://www.ebi.ac.uk/pdbsum/3ap1 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ap1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ap1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ap1 RCSB], [http://www.ebi.ac.uk/pdbsum/3ap1 PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/TPST2_HUMAN TPST2_HUMAN]] Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 14:17, 18 December 2014

2014-12-18T14:17:41Z

← Older revision		Revision as of 14:17, 18 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_3ap1~~\| ~~PDB~~=3ap1 \| ~~SCENE~~= }}		==Crystal structure of human tyrosylprotein sulfotransferase-2 complexed with PAP and C4 peptide==
	===~~Crystal~~ structure of human tyrosylprotein sulfotransferase-2 complexed with ~~PAP~~ and C4 peptide~~===~~		<StructureSection load='3ap1' size='340' side='right' caption='[[3ap1]], [[Resolution\|resolution]] 1.90Å' scene=''>
	~~{{ABSTRACT_PUBMED_23481380}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[3ap1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AP1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AP1 FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ap2\|3ap2]], [[3ap3\|3ap3]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TPST2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine_sulfotransferase Protein-tyrosine sulfotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.2.20 2.8.2.20] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ap1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ap1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ap1 RCSB], [http://www.ebi.ac.uk/pdbsum/3ap1 PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Post-translational protein modification by tyrosine sulfation has an important role in extracellular protein-protein interactions. The protein tyrosine sulfation reaction is catalysed by the Golgi enzyme called the tyrosylprotein sulfotransferase. To date, no crystal structure is available for tyrosylprotein sulfotransferase. Detailed mechanism of protein tyrosine sulfation reaction has thus remained unclear. Here we present the first crystal structure of the human tyrosylprotein sulfotransferase isoform 2 complexed with a substrate peptide (C4P5Y3) derived from complement C4 and 3'-phosphoadenosine-5'-phosphate at 1.9 A resolution. Structural and complementary mutational analyses revealed the molecular basis for catalysis being an S2-like in-line displacement mechanism. Tyrosylprotein sulfotransferase isoform 2 appeared to recognize the C4 peptide in a deep cleft by using a short parallel beta-sheet type interaction, and the bound C4P5Y3 forms an L-shaped structure. Surprisingly, the mode of substrate peptide recognition observed in the tyrosylprotein sulfotransferase isoform 2 structure resembles that observed for the receptor type tyrosine kinases.

	~~==Function==~~		Crystal structure of human tyrosylprotein sulfotransferase-2 reveals the mechanism of protein tyrosine sulfation reaction.,Teramoto T, Fujikawa Y, Kawaguchi Y, Kurogi K, Soejima M, Adachi R, Nakanishi Y, Mishiro-Sato E, Liu MC, Sakakibara Y, Suiko M, Kimura M, Kakuta Y Nat Commun. 2013;4:1572. doi: 10.1038/ncomms2593. PMID:23481380<ref>PMID:23481380</ref>
	~~[[http~~:~~//www~~.~~uniprot~~.~~org~~/~~uniprot~~/~~TPST2_HUMAN TPST2_HUMAN]] Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides.~~

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[3ap1]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:/~~/~~oca.weizmann.ac.il/oca-bin/ocashort?id=3AP1 OCA].~~		</div>

	==See Also==		==See Also==
	*[[Sulfotransferase\|Sulfotransferase]]		*[[Sulfotransferase\|Sulfotransferase]]
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Protein-tyrosine sulfotransferase]]		[[Category: Protein-tyrosine sulfotransferase]]
	[[Category: Adachi, R.]]		[[Category: Adachi, R]]
	[[Category: Fujikawa, Y.]]		[[Category: Fujikawa, Y]]
	[[Category: Kakuta, Y.]]		[[Category: Kakuta, Y]]
	[[Category: Kawaguchi, Y.]]		[[Category: Kawaguchi, Y]]
	[[Category: Kimura, M.]]		[[Category: Kimura, M]]
	[[Category: Kurogi, K.]]		[[Category: Kurogi, K]]
	[[Category: Liu, M C.]]		[[Category: Liu, M C]]
	[[Category: Mishiro-Sato, E.]]		[[Category: Mishiro-Sato, E]]
	[[Category: Nakanishi, Y.]]		[[Category: Nakanishi, Y]]
	[[Category: Sakakibara, Y.]]		[[Category: Sakakibara, Y]]
	[[Category: Soejima, M.]]		[[Category: Soejima, M]]
	[[Category: Suiko, M.]]		[[Category: Suiko, M]]
	[[Category: Teramoto, T.]]		[[Category: Teramoto, T]]
	[[Category: Sulfotransferase fold]]		[[Category: Sulfotransferase fold]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 07:36, 27 March 2013

2013-03-27T07:36:34Z

← Older revision		Revision as of 07:36, 27 March 2013
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	~~[[Image:3ap1.png\|left\|200px]]~~

	{{STRUCTURE_3ap1\| PDB=3ap1 \| SCENE= }}		{{STRUCTURE_3ap1\| PDB=3ap1 \| SCENE= }}

	===Crystal structure of human tyrosylprotein sulfotransferase-2 complexed with PAP and C4 peptide===		===Crystal structure of human tyrosylprotein sulfotransferase-2 complexed with PAP and C4 peptide===
			{{ABSTRACT_PUBMED_23481380}}

			==Function==
			[[http://www.uniprot.org/uniprot/TPST2_HUMAN TPST2_HUMAN]] Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides.

	==About this Structure==		==About this Structure==

OCA at 13:16, 20 October 2012

2012-10-20T13:16:52Z

← Older revision		Revision as of 13:16, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[3ap1]] is a 4 chain structure ~~of [[Sulfotransferase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AP1 OCA].		[[3ap1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AP1 OCA].

	==See Also==		==See Also==

OCA at 11:27, 26 July 2012

2012-07-26T11:27:51Z

← Older revision		Revision as of 11:27, 26 July 2012
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	[[Image:3ap1.png\|left\|200px]]		[[Image:3ap1.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3ap1", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3ap1\| PDB=3ap1 \| SCENE= }}		{{STRUCTURE_3ap1\| PDB=3ap1 \| SCENE= }}

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	==About this Structure==		==About this Structure==
	[[3ap1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AP1 OCA].		[[3ap1]] is a 4 chain structure of [[Sulfotransferase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AP1 OCA].

			==See Also==
			*[[Sulfotransferase\|Sulfotransferase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Protein-tyrosine sulfotransferase]]		[[Category: Protein-tyrosine sulfotransferase]]

OCA: Protected "3ap1" [edit=sysop:move=sysop]

2011-10-30T11:19:19Z

Protected "3ap1" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:19, 30 October 2011
(No difference)

OCA at 11:19, 30 October 2011

2011-10-30T11:19:11Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:3ap1.png|left|200px]]
-The entry 3ap1 is ON HOLD  until Paper Publication
+<!--
-Authors: Teramoto, T., Fujikawa, Y., Kawaguchi, Y., Kurogi, K., Soejima, M., Adachi, R., Nakanishi, Y., Mishiro-Sato, E., Liu, M.-C., Sakakibara, Y., Suiko, M., Kimura, M., Kakuta, Y.
+===Crystal structure of human tyrosylprotein sulfotransferase-2 complexed with PAP and C4 peptide===
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec  8 11:26:19 2010''
+==About this Structure==