3cap - Revision history

OCA at 01:40, 21 November 2024

2024-11-21T01:40:16Z

← Older revision		Revision as of 01:40, 21 November 2024
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ca/3cap_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ca/3cap_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 14:56, 1 November 2023

2023-11-01T14:56:47Z

← Older revision		Revision as of 14:56, 1 November 2023
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	<StructureSection load='3cap' size='340' side='right'caption='[[3cap]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='3cap' size='340' side='right'caption='[[3cap]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3cap]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CAP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3CAP FirstGlance]. <br>		<table><tr><td colspan='2'>[[3cap]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CAP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CAP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGL:B-2-OCTYLGLUCOSIDE'>BGL</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=~~PLM~~:~~PALMITIC+ACID~~'>~~PLM~~</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL-D-GLUCOSAMINE~~'>~~NAG~~</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3cap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cap OCA], [~~http~~://pdbe.org/3cap PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3cap RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3cap PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3cap ProSAT]</span></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGL:B-2-OCTYLGLUCOSIDE'>BGL</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cap OCA], [https://pdbe.org/3cap PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cap RCSB], [https://www.ebi.ac.uk/pdbsum/3cap PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cap ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/OPSD_BOVIN OPSD_BOVIN]] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).<ref>PMID:16908857</ref> <ref>PMID:17060607</ref>		[https://www.uniprot.org/uniprot/OPSD_BOVIN OPSD_BOVIN] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).<ref>PMID:16908857</ref> <ref>PMID:17060607</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 39:
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Choe, H W]]		[[Category: Choe H-W]]
	[[Category: Ernst~~, O P~~]]		[[Category: Ernst OP]]
	[[Category: Hofmann~~, K P~~]]		[[Category: Hofmann KP]]
	[[Category: Park~~, J H~~]]		[[Category: Park JH]]
	[[Category: Scheerer, P]]		[[Category: Scheerer P]]
	~~[[Category: Chromophore]]~~
	~~[[Category: G protein-coupled receptor]]~~
	~~[[Category: G-protein coupled receptor]]~~
	~~[[Category: Glycoprotein]]~~
	~~[[Category: Ligand-free state]]~~
	~~[[Category: Lipoprotein]]~~
	~~[[Category: Membrane protein]]~~
	~~[[Category: Opsin]]~~
	~~[[Category: Palmitate]]~~
	~~[[Category: Phosphoprotein]]~~
	~~[[Category: Photoreceptor]]~~
	~~[[Category: Photoreceptor protein]]~~
	~~[[Category: Retinal protein]]~~
	~~[[Category: Rhodopsin]]~~
	~~[[Category: Sensory transduction]]~~
	~~[[Category: Signaling protein]]~~
	~~[[Category: Transducer]]~~
	~~[[Category: Transmembrane]]~~
	~~[[Category: Vision~~]]

OCA at 10:25, 12 August 2020

2020-08-12T10:25:20Z

← Older revision		Revision as of 10:25, 12 August 2020
Line 1:		Line 1:

	==Crystal Structure of Native Opsin: the G Protein-Coupled Receptor Rhodopsin in its Ligand-free State==		==Crystal Structure of Native Opsin: the G Protein-Coupled Receptor Rhodopsin in its Ligand-free State==
	<StructureSection load='3cap' size='340' side='right' caption='[[3cap]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='3cap' size='340' side='right'caption='[[3cap]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3cap]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CAP OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3CAP FirstGlance]. <br>		<table><tr><td colspan='2'>[[3cap]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CAP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3CAP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGL:B-2-OCTYLGLUCOSIDE'>BGL</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL-D-GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=~~PLM~~:~~PALMITIC+ACID~~'>~~PLM~~</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGL:B-2-OCTYLGLUCOSIDE'>BGL</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3cap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cap OCA], [http://pdbe.org/3cap PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cap RCSB], [http://www.ebi.ac.uk/pdbsum/3cap PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cap ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3cap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cap OCA], [http://pdbe.org/3cap PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cap RCSB], [http://www.ebi.ac.uk/pdbsum/3cap PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cap ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	==See Also==		==See Also==
	*[[Rhodopsin\|Rhodopsin]]		*[[Rhodopsin\|Rhodopsin]]
			*[[Rhodopsin 3D structures\|Rhodopsin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
			[[Category: Large Structures]]
	[[Category: Choe, H W]]		[[Category: Choe, H W]]
	[[Category: Ernst, O P]]		[[Category: Ernst, O P]]

OCA at 13:33, 7 November 2018

2018-11-07T13:33:45Z

← Older revision		Revision as of 13:33, 7 November 2018
Line 1:		Line 1:

	==Crystal Structure of Native Opsin: the G Protein-Coupled Receptor Rhodopsin in its Ligand-free State==		==Crystal Structure of Native Opsin: the G Protein-Coupled Receptor Rhodopsin in its Ligand-free State==
	<StructureSection load='3cap' size='340' side='right' caption='[[3cap]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='3cap' size='340' side='right' caption='[[3cap]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3cap]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CAP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CAP FirstGlance]. <br>		<table><tr><td colspan='2'>[[3cap]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CAP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CAP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGL:B-2-OCTYLGLUCOSIDE'>BGL</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=~~PLM~~:~~PALMITIC+ACID~~'>~~PLM~~</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL-D-GLUCOSAMINE~~'>~~NAG~~</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGL:B-2-OCTYLGLUCOSIDE'>BGL</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cap OCA], [http://pdbe.org/3cap PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cap RCSB], [http://www.ebi.ac.uk/pdbsum/3cap PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cap OCA], [http://pdbe.org/3cap PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cap RCSB], [http://www.ebi.ac.uk/pdbsum/3cap PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cap ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ca/3cap_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ca/3cap_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 11:20, 8 February 2016

2016-02-08T11:20:31Z

← Older revision		Revision as of 11:20, 8 February 2016
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[3cap]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CAP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CAP FirstGlance]. <br>		<table><tr><td colspan='2'>[[3cap]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CAP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CAP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGL:B-2-OCTYLGLUCOSIDE'>BGL</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGL:B-2-OCTYLGLUCOSIDE'>BGL</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cap OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cap RCSB], [http://www.ebi.ac.uk/pdbsum/3cap PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cap OCA], [http://pdbe.org/3cap PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cap RCSB], [http://www.ebi.ac.uk/pdbsum/3cap PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cap ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3cap" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 22:57, 24 December 2014

2014-12-24T22:57:03Z

← Older revision		Revision as of 22:57, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3cap]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CAP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CAP FirstGlance]. <br>		<table><tr><td colspan='2'>[[3cap]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CAP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CAP FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGL:B-2-OCTYLGLUCOSIDE'>BGL</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGL:B-2-OCTYLGLUCOSIDE'>BGL</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cap OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cap RCSB], [http://www.ebi.ac.uk/pdbsum/3cap PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cap OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cap RCSB], [http://www.ebi.ac.uk/pdbsum/3cap PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/OPSD_BOVIN OPSD_BOVIN]] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).<ref>PMID:16908857</ref> <ref>PMID:17060607</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Choe, H W.]]		[[Category: Choe, H W]]
	[[Category: Ernst, O P.]]		[[Category: Ernst, O P]]
	[[Category: Hofmann, K P.]]		[[Category: Hofmann, K P]]
	[[Category: Park, J H.]]		[[Category: Park, J H]]
	[[Category: Scheerer, P.]]		[[Category: Scheerer, P]]
	[[Category: Chromophore]]		[[Category: Chromophore]]
	[[Category: G protein-coupled receptor]]		[[Category: G protein-coupled receptor]]

OCA at 07:44, 29 September 2014

2014-09-29T07:44:05Z

← Older revision		Revision as of 07:44, 29 September 2014
Line 1:		Line 1:
	[[Image:~~3cap~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal Structure of Native Opsin: the G Protein-Coupled Receptor Rhodopsin in its Ligand-free State==
			<StructureSection load='3cap' size='340' side='right' caption='[[3cap]], [[Resolution\|resolution]] 2.90Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3cap]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CAP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CAP FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGL:B-2-OCTYLGLUCOSIDE'>BGL</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cap OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cap RCSB], [http://www.ebi.ac.uk/pdbsum/3cap PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ca/3cap_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			In the G-protein-coupled receptor (GPCR) rhodopsin, the inactivating ligand 11-cis-retinal is bound in the seven-transmembrane helix (TM) bundle and is cis/trans isomerized by light to form active metarhodopsin II. With metarhodopsin II decay, all-trans-retinal is released, and opsin is reloaded with new 11-cis-retinal. Here we present the crystal structure of ligand-free native opsin from bovine retinal rod cells at 2.9 angstrom (A) resolution. Compared to rhodopsin, opsin shows prominent structural changes in the conserved E(D)RY and NPxxY(x)(5,6)F regions and in TM5-TM7. At the cytoplasmic side, TM6 is tilted outwards by 6-7 A, whereas the helix structure of TM5 is more elongated and close to TM6. These structural changes, some of which were attributed to an active GPCR state, reorganize the empty retinal-binding pocket to disclose two openings that may serve the entry and exit of retinal. The opsin structure sheds new light on ligand binding to GPCRs and on GPCR activation.

	~~{{STRUCTURE_3cap\| PDB=3cap \| SCENE= }}~~		Crystal structure of the ligand-free G-protein-coupled receptor opsin.,Park JH, Scheerer P, Hofmann KP, Choe HW, Ernst OP Nature. 2008 Jul 10;454(7201):183-7. Epub 2008 Jun 18. PMID:18563085<ref>PMID:18563085</ref>

	~~===Crystal Structure~~ of ~~Native Opsin:~~ the ~~G Protein-Coupled Receptor Rhodopsin in its Ligand-free State===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_18563085}}~~

	~~==About this Structure==~~
	~~[[3cap]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bos_taurus Bos taurus]~~. ~~Full crystallographic information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=3CAP OCA].~~

	==See Also==		==See Also==
	*[[Rhodopsin\|Rhodopsin]]		*[[Rhodopsin\|Rhodopsin]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:018563085<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Choe, H W.]]		[[Category: Choe, H W.]]

OCA at 09:58, 20 October 2012

2012-10-20T09:58:36Z

← Older revision		Revision as of 09:58, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[3cap]] is a 2 chain structure ~~of [[Rhodopsin]]~~ with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CAP OCA].		[[3cap]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CAP OCA].

	==See Also==		==See Also==

OCA: Protected "3cap" [edit=sysop:move=sysop]

2012-07-26T00:34:59Z

Protected "3cap" [edit=sysop:move=sysop]

← Older revision	Revision as of 00:34, 26 July 2012
(No difference)

OCA at 00:34, 26 July 2012

2012-07-26T00:34:58Z

← Older revision		Revision as of 00:34, 26 July 2012
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	~~{{Seed}}~~
	[[Image:3cap.png\|left\|200px]]		[[Image:3cap.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3cap", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3cap\| PDB=3cap \| SCENE= }}		{{STRUCTURE_3cap\| PDB=3cap \| SCENE= }}

	===Crystal Structure of Native Opsin: the G Protein-Coupled Receptor Rhodopsin in its Ligand-free State===		===Crystal Structure of Native Opsin: the G Protein-Coupled Receptor Rhodopsin in its Ligand-free State===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_18563085}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 18563085 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_18563085}}		{{ABSTRACT_PUBMED_18563085}}

	==About this Structure==		==About this Structure==
	~~3CAP~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CAP OCA].		[[3cap]] is a 2 chain structure of [[Rhodopsin]] with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CAP OCA].

			==See Also==
			*[[Rhodopsin\|Rhodopsin]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~18563085~~</ref><references group="xtra"/>		<ref group="xtra">PMID:018563085</ref><references group="xtra"/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Choe, H W.]]		[[Category: Choe, H W.]]
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	[[Category: Park, J H.]]		[[Category: Park, J H.]]
	[[Category: Scheerer, P.]]		[[Category: Scheerer, P.]]
	~~[[Category: Acetylation]]~~
	[[Category: Chromophore]]		[[Category: Chromophore]]
	[[Category: G protein-coupled receptor]]		[[Category: G protein-coupled receptor]]
Line 50:		Line 40:
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
	[[Category: Vision]]		[[Category: Vision]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 21:36:44 2009''~~