3ccd - Revision history

OCA at 12:25, 30 August 2023

2023-08-30T12:25:55Z

← Older revision		Revision as of 12:25, 30 August 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ccd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CCD FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ccd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CCD FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[1cm2\|1cm2]]~~<~~/div></td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></~~td><td class="sblockDat"~~>~~ptsH, hpr ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ccd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ccd OCA], [https://pdbe.org/3ccd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ccd RCSB], [https://www.ebi.ac.uk/pdbsum/3ccd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ccd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ccd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ccd OCA], [https://pdbe.org/3ccd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ccd RCSB], [https://www.ebi.ac.uk/pdbsum/3ccd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ccd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/PTHP_ECOLI PTHP_ECOLI]] General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the permease (enzymes II/III).		[https://www.uniprot.org/uniprot/PTHP_ECOLI PTHP_ECOLI] General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the permease (enzymes II/III).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Delbaere~~, L T.J~~]]		[[Category: Delbaere LTJ]]
	[[Category: Napper, S]]		[[Category: Napper S]]
	[[Category: Prasad, L]]		[[Category: Prasad L]]
	~~[[Category: Autophosphatase]]~~
	~~[[Category: Isoaspartate]]~~
	~~[[Category: Protein damage]]~~
	~~[[Category: Succinimide]]~~
	~~[[Category: Transferase~~]]

OCA at 19:08, 20 October 2021

2021-10-20T19:08:46Z

← Older revision		Revision as of 19:08, 20 October 2021
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	==1.0 A Structure of Post-Succinimide His15Asp HPr==		==1.0 A Structure of Post-Succinimide His15Asp HPr==
	<StructureSection load='3ccd' size='340' side='right' caption='[[3ccd]], [[Resolution\|resolution]] 1.00Å' scene=''>		<StructureSection load='3ccd' size='340' side='right'caption='[[3ccd]], [[Resolution\|resolution]] 1.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ccd]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CCD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3CCD FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ccd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CCD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cm2\|1cm2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1cm2\|1cm2]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ptsH, hpr ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ptsH, hpr ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ccd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ccd OCA], [~~http~~://pdbe.org/3ccd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ccd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ccd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ccd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ccd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ccd OCA], [https://pdbe.org/3ccd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ccd RCSB], [https://www.ebi.ac.uk/pdbsum/3ccd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ccd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/PTHP_ECOLI PTHP_ECOLI]] General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the permease (enzymes II/III).		[[https://www.uniprot.org/uniprot/PTHP_ECOLI PTHP_ECOLI]] General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the permease (enzymes II/III).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[Phosphocarrier protein\|Phosphocarrier protein]]		*[[Phosphocarrier protein HPr 3D structures\|Phosphocarrier protein HPr 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
			[[Category: Large Structures]]
	[[Category: Delbaere, L T.J]]		[[Category: Delbaere, L T.J]]
	[[Category: Napper, S]]		[[Category: Napper, S]]

OCA at 14:02, 7 November 2018

2018-11-07T14:02:49Z

← Older revision		Revision as of 14:02, 7 November 2018
Line 1:		Line 1:

	==1.0 A Structure of Post-Succinimide His15Asp HPr==		==1.0 A Structure of Post-Succinimide His15Asp HPr==
	<StructureSection load='3ccd' size='340' side='right' caption='[[3ccd]], [[Resolution\|resolution]] 1.00Å' scene=''>		<StructureSection load='3ccd' size='340' side='right' caption='[[3ccd]], [[Resolution\|resolution]] 1.00Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cm2\|1cm2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cm2\|1cm2]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ptsH, hpr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ptsH, hpr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ccd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ccd OCA], [http://pdbe.org/3ccd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ccd RCSB], [http://www.ebi.ac.uk/pdbsum/3ccd PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ccd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ccd OCA], [http://pdbe.org/3ccd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ccd RCSB], [http://www.ebi.ac.uk/pdbsum/3ccd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ccd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cc/3ccd_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cc/3ccd_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 31:		Line 32:

	==See Also==		==See Also==
	*[[Phosphocarrier protein ~~HPr~~\|Phosphocarrier protein ~~HPr~~]]		*[[Phosphocarrier protein\|Phosphocarrier protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:25, 9 February 2016

2016-02-09T10:25:32Z

← Older revision		Revision as of 10:25, 9 February 2016
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cm2\|1cm2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cm2\|1cm2]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ptsH, hpr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ptsH, hpr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ccd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ccd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ccd RCSB], [http://www.ebi.ac.uk/pdbsum/3ccd PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ccd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ccd OCA], [http://pdbe.org/3ccd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ccd RCSB], [http://www.ebi.ac.uk/pdbsum/3ccd PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ccd ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3ccd" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 06:15, 25 December 2014

2014-12-25T06:15:02Z

← Older revision		Revision as of 06:15, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ccd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CCD FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ccd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CCD FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cm2\|1cm2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cm2\|1cm2]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ptsH, hpr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ptsH, hpr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ccd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ccd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ccd RCSB], [http://www.ebi.ac.uk/pdbsum/3ccd PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ccd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ccd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ccd RCSB], [http://www.ebi.ac.uk/pdbsum/3ccd PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/PTHP_ECOLI PTHP_ECOLI]] General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the permease (enzymes II/III).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Delbaere, L T.J.]]		[[Category: Delbaere, L T.J]]
	[[Category: Napper, S.]]		[[Category: Napper, S]]
	[[Category: Prasad, L.]]		[[Category: Prasad, L]]
	[[Category: Autophosphatase]]		[[Category: Autophosphatase]]
	[[Category: Isoaspartate]]		[[Category: Isoaspartate]]

OCA at 21:35, 2 October 2014

2014-10-02T21:35:54Z

← Older revision		Revision as of 21:35, 2 October 2014
Line 1:		Line 1:
	[[Image:~~3ccd~~.~~png~~\|~~left~~\|~~200px~~]]		==1.0 A Structure of Post-Succinimide His15Asp HPr==
			<StructureSection load='3ccd' size='340' side='right' caption='[[3ccd]], [[Resolution\|resolution]] 1.00Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3ccd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CCD FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cm2\|1cm2]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ptsH, hpr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ccd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ccd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ccd RCSB], [http://www.ebi.ac.uk/pdbsum/3ccd PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cc/3ccd_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Aspartates and asparagines can spontaneously cyclize with neighboring main-chain amides to form succinimides. These succinimides hydrolyze to a mixture of isoaspartate and aspartate products. Phosphorylation of aspartates is a common mechanism of protein regulation and increases the propensity for succinimide formation. Although typically regarded as a form of protein damage, we hypothesize succinimides could represent an effective mechanism of phosphoaspartate autophosphatase activity, provided hydrolysis is limited to aspartate products. We previously reported the serendipitous creation of a protein, His15Asp histidine-containing protein (HPr), which undergoes phosphorylation-catalyzed formation of a succinimide whose hydrolysis is seemingly exclusive for aspartate formation. Here, through the high-resolution structure of postsuccinimide His15Asp HPr, we confirm the absence of isoaspartate residues and propose mechanisms for phosphorylation-catalyzed succinimide formation and its directed hydrolysis to aspartate. His15Asp HPr represents the first characterized protein example of an isoaspartate-free succinimide and lends credence to the hypothesis that intramolecular cyclization could represent a physiological mechanism of autophosphatase activity. Furthermore, this indicates that current strategies for succinimide evaluation, based on isoaspartate detection, underestimate the frequencies of these reactions. This is considerably significant for evaluation of protein stability and integrity.

	~~{{STRUCTURE_3ccd\| PDB=3ccd \| SCENE= }}~~		Structural investigation of a phosphorylation-catalyzed, isoaspartate-free, protein succinimide: crystallographic structure of post-succinimide His15Asp histidine-containing protein.,Napper S, Prasad L, Delbaere LT Biochemistry. 2008 Sep 9;47(36):9486-96. Epub 2008 Aug 15. PMID:18702519<ref>PMID:18702519</ref>

	~~===1~~.~~0 A Structure~~ of ~~Post-Succinimide His15Asp HPr===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	~~{{ABSTRACT_PUBMED_18702519}}~~		==See Also==
			*[[Phosphocarrier protein HPr\|Phosphocarrier protein HPr]]
	==~~About this Structure~~==		== References ==
	[[~~3ccd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli~~]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CCD OCA~~].		<references/>
			__TOC__
	==~~Reference~~==		</StructureSection>
	<~~ref group="xtra">PMID:018702519<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Delbaere, L T.J.]]		[[Category: Delbaere, L T.J.]]

OCA: Protected "3ccd" [edit=sysop:move=sysop]

2013-01-07T22:36:37Z

Protected "3ccd" [edit=sysop:move=sysop]

← Older revision	Revision as of 22:36, 7 January 2013
(No difference)

OCA at 22:36, 7 January 2013

2013-01-07T22:36:34Z

← Older revision		Revision as of 22:36, 7 January 2013
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	~~{{Seed}}~~
	[[Image:3ccd.png\|left\|200px]]		[[Image:3ccd.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3ccd", creates the "Structure Box" on the page.~~
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	{{STRUCTURE_3ccd\| PDB=3ccd \| SCENE= }}		{{STRUCTURE_3ccd\| PDB=3ccd \| SCENE= }}

	===1.0 A Structure of Post-Succinimide His15Asp HPr===		===1.0 A Structure of Post-Succinimide His15Asp HPr===


	~~<!--~~
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	{{ABSTRACT_PUBMED_18702519}}		{{ABSTRACT_PUBMED_18702519}}

	==About this Structure==		==About this Structure==
	~~3CCD~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CCD OCA].		[[3ccd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CCD OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~18702519~~</ref><references group="xtra"/>		<ref group="xtra">PMID:018702519</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Delbaere, L T.J.]]		[[Category: Delbaere, L T.J.]]
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	[[Category: Succinimide]]		[[Category: Succinimide]]
	[[Category: Transferase]]		[[Category: Transferase]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 09:07:37 2009''~~

OCA at 07:07, 17 February 2009

2009-02-17T07:07:39Z

← Older revision		Revision as of 07:07, 17 February 2009
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	{{Seed}}		{{Seed}}
	[[Image:3ccd.~~jpg~~\|left\|200px]]		[[Image:3ccd.png\|left\|200px]]

	<!--		<!--
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	==About this Structure==		==About this Structure==
	3CCD is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CCD OCA].		3CCD is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CCD OCA].

	==Reference==		==Reference==
	Structural investigation of a phosphorylation-catalyzed, isoaspartate-free, protein succinimide: crystallographic structure of post-succinimide His15Asp histidine-containing protein., Napper S, Prasad L, Delbaere LT, Biochemistry. 2008 Sep 9;47(36):9486-96. Epub 2008 Aug 15. PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~18702519 18702519]~~		<ref group="xtra">PMID:18702519</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	~~[[Category: Single protein]]~~
	[[Category: Delbaere, L T.J.]]		[[Category: Delbaere, L T.J.]]
	[[Category: Napper, S.]]		[[Category: Napper, S.]]
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	[[Category: Transferase]]		[[Category: Transferase]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Oct 22 10~~:43:~~04 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 09:07:37 2009''

OCA at 08:43, 22 October 2008

2008-10-22T08:43:04Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{Seed}}
-The entry 3ccd is ON HOLD  until Paper Publication
+<!--
-Authors: Napper, S., Prasad, L., Delbaere, L.T.J.
+===1.0 A Structure of Post-Succinimide His15Asp HPr===
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 11 09:31:10 2008''
+==About this Structure==