3cdc - Revision history

OCA at 08:53, 30 October 2024

2024-10-30T08:53:13Z

← Older revision		Revision as of 08:53, 30 October 2024
Line 8:		Line 8:
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/KV133_HUMAN KV133_HUMAN] V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:~~20176268~~, PubMed:~~17576170~~).<ref>PMID:17576170</ref> <ref>PMID:20176268</ref> <ref>PMID:22158414</ref> <ref>PMID:24600447</ref>		[https://www.uniprot.org/uniprot/KV133_HUMAN KV133_HUMAN] V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).<ref>PMID:17576170</ref> <ref>PMID:20176268</ref> <ref>PMID:22158414</ref> <ref>PMID:24600447</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 14:		Line 14:
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cd/3cdc_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cd/3cdc_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 12:26, 30 August 2023

2023-08-30T12:26:14Z

← Older revision		Revision as of 12:26, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='3cdc' size='340' side='right'caption='[[3cdc]], [[Resolution\|resolution]] 1.53Å' scene=''>		<StructureSection load='3cdc' size='340' side='right'caption='[[3cdc]], [[Resolution\|resolution]] 1.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3cdc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CDC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CDC FirstGlance]. <br>		<table><tr><td colspan='2'>[[3cdc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CDC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CDC FirstGlance]. <br>
	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3cdf\|3cdf]], [[3cdy\|3cdy]]</div></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.53Å</td></tr>
	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">kI O18/O8 germline ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cdc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cdc OCA], [https://pdbe.org/3cdc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cdc RCSB], [https://www.ebi.ac.uk/pdbsum/3cdc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cdc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cdc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cdc OCA], [https://pdbe.org/3cdc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cdc RCSB], [https://www.ebi.ac.uk/pdbsum/3cdc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cdc ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/KV133_HUMAN KV133_HUMAN] V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).<ref>PMID:17576170</ref> <ref>PMID:20176268</ref> <ref>PMID:22158414</ref> <ref>PMID:24600447</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Baden~~, E M~~]]		[[Category: Baden EM]]
	[[Category: Ramirez-Alvarado, M]]		[[Category: Ramirez-Alvarado M]]
	[[Category: Randles~~, E G~~]]		[[Category: Randles EG]]
	[[Category: Thompson~~, J R]]~~		[[Category: Thompson JR]]
	~~[[Category: Amyloid]]~~
	~~[[Category: Greek key beta barrel]]~~
	~~[[Category: Immune system]]~~
	~~[[Category: Immunoglobulin]]~~
	~~[[Category: Light chain]]~~
	~~[[Category: Variable domain~~]]

OCA at 07:51, 27 January 2022

2022-01-27T07:51:52Z

← Older revision		Revision as of 07:51, 27 January 2022
Line 1:		Line 1:

	==kI O18/O8 N34I/Y87H immunoglobulin light chain variable domain==		==kI O18/O8 N34I/Y87H immunoglobulin light chain variable domain==
	<StructureSection load='3cdc' size='340' side='right' caption='[[3cdc]], [[Resolution\|resolution]] 1.53Å' scene=''>		<StructureSection load='3cdc' size='340' side='right'caption='[[3cdc]], [[Resolution\|resolution]] 1.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3cdc]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CDC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3CDC FirstGlance]. <br>		<table><tr><td colspan='2'>[[3cdc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CDC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CDC FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cdf\|3cdf]], [[3cdy\|3cdy]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3cdf\|3cdf]], [[3cdy\|3cdy]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">kI O18/O8 germline ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">kI O18/O8 germline ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3cdc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cdc OCA], [~~http~~://pdbe.org/3cdc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3cdc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3cdc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3cdc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cdc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cdc OCA], [https://pdbe.org/3cdc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cdc RCSB], [https://www.ebi.ac.uk/pdbsum/3cdc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cdc ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Baden, E M]]		[[Category: Baden, E M]]
	[[Category: Ramirez-Alvarado, M]]		[[Category: Ramirez-Alvarado, M]]

OCA at 13:37, 7 November 2018

2018-11-07T13:37:13Z

← Older revision		Revision as of 13:37, 7 November 2018
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cd/3cdc_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cd/3cdc_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 09:22, 11 August 2016

2016-08-11T09:22:59Z

← Older revision		Revision as of 09:22, 11 August 2016
Line 1:		Line 1:

	==kI O18/O8 N34I/Y87H immunoglobulin light chain variable domain==		==kI O18/O8 N34I/Y87H immunoglobulin light chain variable domain==
	<StructureSection load='3cdc' size='340' side='right' caption='[[3cdc]], [[Resolution\|resolution]] 1.53Å' scene=''>		<StructureSection load='3cdc' size='340' side='right' caption='[[3cdc]], [[Resolution\|resolution]] 1.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3cdc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CDC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CDC FirstGlance]. <br>		<table><tr><td colspan='2'>[[3cdc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CDC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CDC FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cdf\|3cdf]], [[3cdy\|3cdy]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cdf\|3cdf]], [[3cdy\|3cdy]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">kI O18/O8 germline ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">kI O18/O8 germline ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cdc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cdc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cdc RCSB], [http://www.ebi.ac.uk/pdbsum/3cdc PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cdc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cdc OCA], [http://pdbe.org/3cdc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cdc RCSB], [http://www.ebi.ac.uk/pdbsum/3cdc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cdc ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cdc ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3cdc" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Baden, E M]]		[[Category: Baden, E M]]
	[[Category: Ramirez-Alvarado, M]]		[[Category: Ramirez-Alvarado, M]]

OCA at 10:25, 20 January 2015

2015-01-20T10:25:36Z

← Older revision		Revision as of 10:25, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3cdc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CDC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CDC FirstGlance]. <br>		<table><tr><td colspan='2'>[[3cdc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CDC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CDC FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cdf\|3cdf]], [[3cdy\|3cdy]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cdf\|3cdf]], [[3cdy\|3cdy]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">kI O18/O8 germline ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">kI O18/O8 germline ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cdc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cdc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cdc RCSB], [http://www.ebi.ac.uk/pdbsum/3cdc PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cdc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cdc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cdc RCSB], [http://www.ebi.ac.uk/pdbsum/3cdc PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Baden, E M.]]		[[Category: Baden, E M]]
	[[Category: Ramirez-Alvarado, M.]]		[[Category: Ramirez-Alvarado, M]]
	[[Category: Randles, E G.]]		[[Category: Randles, E G]]
	[[Category: Thompson, J R.]]		[[Category: Thompson, J R]]
	[[Category: Amyloid]]		[[Category: Amyloid]]
	[[Category: Greek key beta barrel]]		[[Category: Greek key beta barrel]]

OCA at 21:10, 2 October 2014

2014-10-02T21:10:28Z

← Older revision		Revision as of 21:10, 2 October 2014
Line 1:		Line 1:
	[[Image:~~3cdc~~.~~png~~\|~~left~~\|~~200px~~]]		==kI O18/O8 N34I/Y87H immunoglobulin light chain variable domain==
			<StructureSection load='3cdc' size='340' side='right' caption='[[3cdc]], [[Resolution\|resolution]] 1.53Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3cdc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CDC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CDC FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cdf\|3cdf]], [[3cdy\|3cdy]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">kI O18/O8 germline ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cdc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cdc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cdc RCSB], [http://www.ebi.ac.uk/pdbsum/3cdc PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cd/3cdc_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Mechanisms of amyloidogenesis are not well understood, including potential structural contributions of mutations in the process. Our previous research indicated that the dimer interface of amyloidogenic immunoglobulin light chain protein AL-09 is twisted 90 degrees relative to the protein from its germline sequence, kappaI O18/O8. Here we report a systematic restoration of AL-09 to its germline sequence by mutating the non-conservative somatic mutations located in the light chain dimer interface. Among these mutants, we find a correlation between increased thermodynamic stability and an increase in the lag time for fibril formation. The restorative mutant AL-09 H87Y completes the trifecta and restores the dimer interface observed in kappaI O18/O8, emphasizing the potential importance of the structural integrity of these proteins to protect against amyloidogenicity. We also find that adding amyloidogenic mutations into the germline protein illustrates mutational cooperativity in promoting amyloidogenesis.

	~~{{STRUCTURE_3cdc\| PDB=3cdc \| SCENE= }}~~		Structural insights into the role of mutations in amyloidogenesis.,Baden EM, Randles EG, Aboagye AK, Thompson JR, Ramirez-Alvarado M J Biol Chem. 2008 Nov 7;283(45):30950-6. Epub 2008 Sep 2. PMID:18768467<ref>PMID:18768467</ref>

	~~===kI O18/O8 N34I~~/~~Y87H immunoglobulin light chain variable domain===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_18768467}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[3cdc]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3CDC OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:018768467<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Baden, E M.]]		[[Category: Baden, E M.]]

OCA: Protected "3cdc" [edit=sysop:move=sysop]

2013-01-07T19:29:28Z

Protected "3cdc" [edit=sysop:move=sysop]

← Older revision	Revision as of 19:29, 7 January 2013
(No difference)

OCA at 19:29, 7 January 2013

2013-01-07T19:29:25Z

← Older revision		Revision as of 19:29, 7 January 2013
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	~~{{Seed}}~~
	[[Image:3cdc.png\|left\|200px]]		[[Image:3cdc.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3cdc", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3cdc\| PDB=3cdc \| SCENE= }}		{{STRUCTURE_3cdc\| PDB=3cdc \| SCENE= }}

	===kI O18/O8 N34I/Y87H immunoglobulin light chain variable domain===		===kI O18/O8 N34I/Y87H immunoglobulin light chain variable domain===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_18768467}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 18768467 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_18768467}}		{{ABSTRACT_PUBMED_18768467}}

	==About this Structure==		==About this Structure==
	~~3CDC~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CDC OCA].		[[3cdc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CDC OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~18768467~~</ref><references group="xtra"/>		<ref group="xtra">PMID:018768467</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Baden, E M.]]		[[Category: Baden, E M.]]
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	[[Category: Light chain]]		[[Category: Light chain]]
	[[Category: Variable domain]]		[[Category: Variable domain]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:31:32 2009''~~

OCA at 19:31, 17 February 2009

2009-02-17T19:31:33Z

← Older revision		Revision as of 19:31, 17 February 2009
Line 23:		Line 23:

	==Reference==		==Reference==
	~~Structural insights into the role of mutations in amyloidogenesis., Baden EM, Randles EG, Aboagye AK, Thompson JR, Ramirez-Alvarado M, J Biol Chem. 2008 Nov 7;283(45):30950-6. Epub 2008 Sep 2.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18768467 18768467]~~		<ref group="xtra">PMID:18768467</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Baden, E M.]]		[[Category: Baden, E M.]]
Line 36:		Line 36:
	[[Category: Variable domain]]		[[Category: Variable domain]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Dec 10 15~~:50:~~45 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:31:32 2009''