3csb - Revision history

OCA at 09:37, 21 February 2024

2024-02-21T09:37:57Z

← Older revision		Revision as of 09:37, 21 February 2024
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	<StructureSection load='3csb' size='340' side='right'caption='[[3csb]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3csb' size='340' side='right'caption='[[3csb]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3csb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CSB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CSB FirstGlance]. <br>		<table><tr><td colspan='2'>[[3csb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CSB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CSB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>~~</td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.999Å</td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2obg\|2obg]], [[3csg\|3csg]]</div></td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">malE ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3csb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3csb OCA], [https://pdbe.org/3csb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3csb RCSB], [https://www.ebi.ac.uk/pdbsum/3csb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3csb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3csb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3csb OCA], [https://pdbe.org/3csb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3csb RCSB], [https://www.ebi.ac.uk/pdbsum/3csb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3csb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.		[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3csb ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3csb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Recent studies have shown that highly simplified interaction surfaces consisting of combinations of just two amino acids, Tyr and Ser, exhibit high affinity and specificity. The high functional levels of such minimalist interfaces might thus indicate small contributions of greater amino acid diversity seen in natural interfaces. Toward addressing this issue, we have produced a pair of binding proteins built on the fibronectin type III scaffold, termed "monobodies." One monobody contains the Tyr/Ser binary-code interface (termed YS) and the other contains an expanded amino acid diversity interface (YSX), but both bind to an identical target, maltose-binding protein. The YSX monobody bound with higher affinity, a slower off rate and a more favorable enthalpic contribution than the YS monobody. High-resolution X-ray crystal structures revealed that both proteins bound to an essentially identical epitope, providing a unique opportunity to directly investigate the role of amino acid diversity in a protein interaction interface. Surprisingly, Tyr still dominates the YSX paratope and the additional amino acid types are primarily used to conformationally optimize contacts made by tyrosines. Scanning mutagenesis showed that while all contacting Tyr side chains are essential in the YS monobody, the YSX interface was more tolerant to mutations. These results suggest that the conformational, not chemical, diversity of additional types of amino acids provided higher functionality and evolutionary robustness, supporting the dominant role of Tyr and the importance of conformational diversity in forming protein interaction interfaces.

	A dominant conformational role for amino acid diversity in minimalist protein-protein interfaces.,Gilbreth RN, Esaki K, Koide A, Sidhu SS, Koide S J Mol Biol. 2008 Aug 29;381(2):407-18. Epub 2008 Jun 12. PMID:18602117<ref>PMID:18602117</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 3csb" style="background-color:#fffaf0;"></div>~~
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Ecoli~~]]		[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Gilbreth, R N~~]]		[[Category: Synthetic construct]]
	[[Category: ~~Koide, S~~]]		[[Category: Gilbreth RN]]
	[[Category: ~~Antibody mimic]]~~		[[Category: Koide S]]
	~~[[Category: De novo protein]]~~
	~~[[Category: Engineered binding protein]]~~
	~~[[Category: Minimalist protein interface]]~~
	~~[[Category: Sugar binding protein]]~~
	~~[[Category: Synthetic protein interface~~]]

OCA at 07:43, 2 February 2022

2022-02-02T07:43:26Z

← Older revision		Revision as of 07:43, 2 February 2022
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	<StructureSection load='3csb' size='340' side='right'caption='[[3csb]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3csb' size='340' side='right'caption='[[3csb]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3csb]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CSB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3CSB FirstGlance]. <br>		<table><tr><td colspan='2'>[[3csb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CSB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CSB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2obg\|2obg]], [[3csg\|3csg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2obg\|2obg]], [[3csg\|3csg]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">malE ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">malE ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3csb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3csb OCA], [~~http~~://pdbe.org/3csb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3csb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3csb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3csb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3csb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3csb OCA], [https://pdbe.org/3csb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3csb RCSB], [https://www.ebi.ac.uk/pdbsum/3csb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3csb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.		[[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:54, 24 July 2019

2019-07-24T07:54:12Z

← Older revision		Revision as of 07:54, 24 July 2019
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	==Crystal Structure of Monobody YSX1/Maltose Binding Protein Fusion Complex==		==Crystal Structure of Monobody YSX1/Maltose Binding Protein Fusion Complex==
	<StructureSection load='3csb' size='340' side='right' caption='[[3csb]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3csb' size='340' side='right'caption='[[3csb]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3csb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli,_synthetic Escherichia coli, synthetic~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CSB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CSB FirstGlance]. <br>		<table><tr><td colspan='2'>[[3csb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CSB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CSB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2obg\|2obg]], [[3csg\|3csg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2obg\|2obg]], [[3csg\|3csg]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">malE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= ~~Escherichia coli, synthetic~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">malE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3csb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3csb OCA], [http://pdbe.org/3csb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3csb RCSB], [http://www.ebi.ac.uk/pdbsum/3csb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3csb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3csb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3csb OCA], [http://pdbe.org/3csb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3csb RCSB], [http://www.ebi.ac.uk/pdbsum/3csb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3csb ProSAT]</span></td></tr>
	</table>		</table>
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cs/3csb_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cs/3csb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 34:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Escherichia coli, synthetic~~]]		[[Category: Ecoli]]
			[[Category: Large Structures]]
	[[Category: Gilbreth, R N]]		[[Category: Gilbreth, R N]]
	[[Category: Koide, S]]		[[Category: Koide, S]]

OCA at 08:34, 25 October 2017

2017-10-25T08:34:06Z

← Older revision		Revision as of 08:34, 25 October 2017
Line 1:		Line 1:

	==Crystal Structure of Monobody YSX1/Maltose Binding Protein Fusion Complex==		==Crystal Structure of Monobody YSX1/Maltose Binding Protein Fusion Complex==
	<StructureSection load='3csb' size='340' side='right' caption='[[3csb]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3csb' size='340' side='right' caption='[[3csb]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2obg\|2obg]], [[3csg\|3csg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2obg\|2obg]], [[3csg\|3csg]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">malE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= Escherichia coli, synthetic])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">malE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= Escherichia coli, synthetic])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3csb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3csb OCA], [http://pdbe.org/3csb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3csb RCSB], [http://www.ebi.ac.uk/pdbsum/3csb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3csb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3csb OCA], [http://pdbe.org/3csb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3csb RCSB], [http://www.ebi.ac.uk/pdbsum/3csb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3csb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 23:28, 9 February 2016

2016-02-09T23:28:31Z

← Older revision		Revision as of 23:28, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3csb' size='340' side='right' caption='[[3csb]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3csb' size='340' side='right' caption='[[3csb]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3csb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CSB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CSB FirstGlance]. <br>		<table><tr><td colspan='2'>[[3csb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli,_synthetic Escherichia coli, synthetic]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CSB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CSB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2obg\|2obg]], [[3csg\|3csg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2obg\|2obg]], [[3csg\|3csg]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">malE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~562~~ Escherichia coli])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">malE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= Escherichia coli, synthetic])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3csb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3csb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3csb RCSB], [http://www.ebi.ac.uk/pdbsum/3csb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3csb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3csb OCA], [http://pdbe.org/3csb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3csb RCSB], [http://www.ebi.ac.uk/pdbsum/3csb PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3csb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3csb" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli, synthetic]]
	[[Category: Gilbreth, R N]]		[[Category: Gilbreth, R N]]
	[[Category: Koide, S]]		[[Category: Koide, S]]

OCA at 10:14, 25 December 2014

2014-12-25T10:14:27Z

← Older revision		Revision as of 10:14, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3csb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CSB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CSB FirstGlance]. <br>		<table><tr><td colspan='2'>[[3csb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CSB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CSB FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2obg\|2obg]], [[3csg\|3csg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2obg\|2obg]], [[3csg\|3csg]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">malE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">malE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3csb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3csb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3csb RCSB], [http://www.ebi.ac.uk/pdbsum/3csb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3csb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3csb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3csb RCSB], [http://www.ebi.ac.uk/pdbsum/3csb PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Gilbreth, R N.]]		[[Category: Gilbreth, R N]]
	[[Category: Koide, S.]]		[[Category: Koide, S]]
	[[Category: Antibody mimic]]		[[Category: Antibody mimic]]
	[[Category: De novo protein]]		[[Category: De novo protein]]

OCA at 08:33, 29 September 2014

2014-09-29T08:33:18Z

@@ Line 1: / Line 1: @@
-[[Image:3csb.png|left|200px]]
+==Crystal Structure of Monobody YSX1/Maltose Binding Protein Fusion Complex==
-{{STRUCTURE_3csb|  PDB=3csb  |  SCENE=  }}
+A dominant conformational role for amino acid diversity in minimalist protein-protein interfaces.,Gilbreth RN, Esaki K, Koide A, Sidhu SS, Koide S J Mol Biol. 2008 Aug 29;381(2):407-18. Epub 2008 Jun 12. PMID:18602117<ref>PMID:18602117</ref>
-===Crystal Structure of Monobody YSX1/Maltose Binding Protein Fusion Complex===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_18602117}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[3csb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CSB OCA].
+</StructureSection>
 [[Category: Escherichia coli]]
 [[Category: Gilbreth, R N.]]

OCA at 15:31, 20 October 2012

2012-10-20T15:31:17Z

← Older revision		Revision as of 15:31, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[3csb]] is a 1 chain structure ~~of [[Maltose-binding protein]]~~ with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli~~,_synthetic~~ Escherichia coli~~, synthetic~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CSB OCA].		[[3csb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CSB OCA].

	==See Also==		==See Also==
Line 15:		Line 15:
	==Reference==		==Reference==
	<ref group="xtra">PMID:018602117</ref><references group="xtra"/>		<ref group="xtra">PMID:018602117</ref><references group="xtra"/>
	[[Category: Escherichia coli~~, synthetic~~]]		[[Category: Escherichia coli]]
	[[Category: Gilbreth, R N.]]		[[Category: Gilbreth, R N.]]
	[[Category: Koide, S.]]		[[Category: Koide, S.]]

OCA: Protected "3csb" [edit=sysop:move=sysop]

2012-07-26T18:38:24Z

Protected "3csb" [edit=sysop:move=sysop]

← Older revision	Revision as of 18:38, 26 July 2012
(No difference)

OCA at 18:38, 26 July 2012

2012-07-26T18:38:23Z

← Older revision		Revision as of 18:38, 26 July 2012
Line 1:		Line 1:
	~~{{Seed}}~~
	[[Image:3csb.png\|left\|200px]]		[[Image:3csb.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3csb", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3csb\| PDB=3csb \| SCENE= }}		{{STRUCTURE_3csb\| PDB=3csb \| SCENE= }}

	===Crystal Structure of Monobody YSX1/Maltose Binding Protein Fusion Complex===		===Crystal Structure of Monobody YSX1/Maltose Binding Protein Fusion Complex===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_18602117}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 18602117 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_18602117}}		{{ABSTRACT_PUBMED_18602117}}

	==About this Structure==		==About this Structure==
	~~3CSB~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli,_synthetic Escherichia coli, synthetic]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CSB OCA].		[[3csb]] is a 1 chain structure of [[Maltose-binding protein]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli,_synthetic Escherichia coli, synthetic]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CSB OCA].

			==See Also==
			*[[Maltose-binding protein\|Maltose-binding protein]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~18602117~~</ref><references group="xtra"/>		<ref group="xtra">PMID:018602117</ref><references group="xtra"/>
	[[Category: Escherichia coli, synthetic]]		[[Category: Escherichia coli, synthetic]]
	[[Category: Gilbreth, R N.]]		[[Category: Gilbreth, R N.]]
Line 33:		Line 24:
	[[Category: Sugar binding protein]]		[[Category: Sugar binding protein]]
	[[Category: Synthetic protein interface]]		[[Category: Synthetic protein interface]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 13:35:55 2009''~~