3daq - Revision history

OCA at 15:06, 1 November 2023

2023-11-01T15:06:23Z

← Older revision		Revision as of 15:06, 1 November 2023
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	<StructureSection load='3daq' size='340' side='right'caption='[[3daq]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='3daq' size='340' side='right'caption='[[3daq]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3daq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Staar Staar~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DAQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[3daq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_MRSA252 Staphylococcus aureus subsp. aureus MRSA252]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DAQ FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~, ~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.45Å</td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em~~;~~'>[[1yxc\|1yxc]], [[1dhp\|1dhp]], [[1xxx\|1xxx]]</div>~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>dapA, SAR1407 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~282458 STAAR])</td~~><~~/tr>~~
	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>[https://en.wikipedia.org/wiki/4-hydroxy-tetrahydrodipicolinate_synthase 4-hydroxy-tetrahydrodipicolinate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.7 4.3.3.7] </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3daq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3daq OCA], [https://pdbe.org/3daq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3daq RCSB], [https://www.ebi.ac.uk/pdbsum/3daq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3daq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3daq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3daq OCA], [https://pdbe.org/3daq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3daq RCSB], [https://www.ebi.ac.uk/pdbsum/3daq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3daq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/DAPA_STAAR DAPA_STAAR]] Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).<ref>PMID:18684709</ref>		[https://www.uniprot.org/uniprot/DAPA_STAAR DAPA_STAAR] Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).<ref>PMID:18684709</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: 4-hydroxy-tetrahydrodipicolinate synthase]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Staar~~]]		[[Category: Staphylococcus aureus subsp. aureus MRSA252]]
	[[Category: Burgess~~, B R~~]]		[[Category: Burgess BR]]
	[[Category: Dobson~~, R C.J~~]]		[[Category: Dobson RCJ]]
	[[Category: Gerrard~~, J A~~]]		[[Category: Gerrard JA]]
	[[Category: Jameson~~, G B~~]]		[[Category: Jameson GB]]
	[[Category: Parker~~, M W~~]]		[[Category: Parker MW]]
	[[Category: Perugini~~, M A]]~~		[[Category: Perugini MA]]
	~~[[Category: Amino-acid biosynthesis]]~~
	~~[[Category: Diaminopimelate biosynthesis]]~~
	~~[[Category: Dihydrodipicolinate synthase]]~~
	~~[[Category: Lyase]]~~
	~~[[Category: Lysine biosynthesis]]~~
	~~[[Category: Schiff base~~]]

OCA at 07:58, 2 February 2022

2022-02-02T07:58:56Z

← Older revision		Revision as of 07:58, 2 February 2022
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	==Crystal structure of dihydrodipicolinate synthase from methicillin-resistant Staphylococcus aureus==		==Crystal structure of dihydrodipicolinate synthase from methicillin-resistant Staphylococcus aureus==
	<StructureSection load='3daq' size='340' side='right' caption='[[3daq]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='3daq' size='340' side='right'caption='[[3daq]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3daq]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Staar Staar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3DAQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[3daq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staar Staar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DAQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1yxc\|1yxc]], [[1dhp\|1dhp]], [[1xxx\|1xxx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1yxc\|1yxc]], [[1dhp\|1dhp]], [[1xxx\|1xxx]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dapA, SAR1407 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=282458 STAAR])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dapA, SAR1407 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=282458 STAAR])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/4-hydroxy-tetrahydrodipicolinate_synthase 4-hydroxy-tetrahydrodipicolinate synthase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.7 4.3.3.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/4-hydroxy-tetrahydrodipicolinate_synthase 4-hydroxy-tetrahydrodipicolinate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.7 4.3.3.7] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3daq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3daq OCA], [~~http~~://pdbe.org/3daq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3daq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3daq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3daq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3daq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3daq OCA], [https://pdbe.org/3daq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3daq RCSB], [https://www.ebi.ac.uk/pdbsum/3daq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3daq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/DAPA_STAAR DAPA_STAAR]] Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).<ref>PMID:18684709</ref>		[[https://www.uniprot.org/uniprot/DAPA_STAAR DAPA_STAAR]] Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).<ref>PMID:18684709</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: 4-hydroxy-tetrahydrodipicolinate synthase]]		[[Category: 4-hydroxy-tetrahydrodipicolinate synthase]]
			[[Category: Large Structures]]
	[[Category: Staar]]		[[Category: Staar]]
	[[Category: Burgess, B R]]		[[Category: Burgess, B R]]

OCA at 09:24, 14 November 2018

2018-11-14T09:24:56Z

← Older revision		Revision as of 09:24, 14 November 2018
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/da/3daq_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/da/3daq_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 20:41, 11 August 2016

2016-08-11T20:41:21Z

← Older revision		Revision as of 20:41, 11 August 2016
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	==Crystal structure of dihydrodipicolinate synthase from methicillin-resistant Staphylococcus aureus==		==Crystal structure of dihydrodipicolinate synthase from methicillin-resistant Staphylococcus aureus==
	<StructureSection load='3daq' size='340' side='right' caption='[[3daq]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='3daq' size='340' side='right' caption='[[3daq]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3daq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Staphylococcus_aureus Staphylococcus aureus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DAQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[3daq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staar Staar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DAQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1yxc\|1yxc]], [[1dhp\|1dhp]], [[1xxx\|1xxx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1yxc\|1yxc]], [[1dhp\|1dhp]], [[1xxx\|1xxx]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dapA, SAR1407 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~1280 Staphylococcus aureus~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dapA, SAR1407 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=282458 STAAR])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~Dihydrodipicolinate_synthase Dihydrodipicolinate~~ synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.52 4.2.1.52] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-tetrahydrodipicolinate_synthase 4-hydroxy-tetrahydrodipicolinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.7 4.3.3.7] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3daq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3daq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3daq RCSB], [http://www.ebi.ac.uk/pdbsum/3daq PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3daq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3daq OCA], [http://pdbe.org/3daq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3daq RCSB], [http://www.ebi.ac.uk/pdbsum/3daq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3daq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3daq ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3daq" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Dihydrodipicolinate~~ synthase]]		[[Category: 4-hydroxy-tetrahydrodipicolinate synthase]]
	[[Category: ~~Staphylococcus aureus~~]]		[[Category: Staar]]
	[[Category: Burgess, B R]]		[[Category: Burgess, B R]]
	[[Category: Dobson, R C.J]]		[[Category: Dobson, R C.J]]
Line 46:		Line 48:
	[[Category: Amino-acid biosynthesis]]		[[Category: Amino-acid biosynthesis]]
	[[Category: Diaminopimelate biosynthesis]]		[[Category: Diaminopimelate biosynthesis]]
			[[Category: Dihydrodipicolinate synthase]]
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Lysine biosynthesis]]		[[Category: Lysine biosynthesis]]
	[[Category: Schiff base]]		[[Category: Schiff base]]

OCA at 12:35, 5 January 2015

2015-01-05T12:35:27Z

← Older revision		Revision as of 12:35, 5 January 2015
Line 1:		Line 1:
	[[Image:~~3daq~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of dihydrodipicolinate synthase from methicillin-resistant Staphylococcus aureus==
			<StructureSection load='3daq' size='340' side='right' caption='[[3daq]], [[Resolution\|resolution]] 1.45Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3daq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DAQ FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1yxc\|1yxc]], [[1dhp\|1dhp]], [[1xxx\|1xxx]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dapA, SAR1407 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrodipicolinate_synthase Dihydrodipicolinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.52 4.2.1.52] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3daq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3daq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3daq RCSB], [http://www.ebi.ac.uk/pdbsum/3daq PDBsum]</span></td></tr>
			</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/DAPA_STAAR DAPA_STAAR]] Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).<ref>PMID:18684709</ref>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/da/3daq_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Dihydrodipicolinate synthase (DHDPS) catalyzes the first committed step of the lysine biosynthetic pathway. The tetrameric structure of DHDPS is thought to be essential for enzymatic activity, as isolated dimeric mutants of Escherichia coli DHDPS possess less than 2.5% that of the activity of the wild-type tetramer. It has recently been proposed that the dimeric form lacks activity due to increased dynamics. Tetramerization, by buttressing two dimers together, reduces dynamics in the dimeric unit and explains why all active bacterial DHDPS enzymes to date have been shown to be homo-tetrameric. However, in this study we demonstrate for the first time that DHDPS from methicillin-resistant Staphylococcus aureus (MRSA) exists in a monomer-dimer equilibrium in solution. Fluorescence-detected analytical ultracentrifugation was employed to show that the dimerization dissociation constant of MRSA-DHDPS is 33 nm in the absence of substrates and 29 nm in the presence of (S)-aspartate semialdehyde (ASA), but is 20-fold tighter in the presence of the substrate pyruvate (1.6 nm). The MRSA-DHDPS dimer exhibits a ping-pong kinetic mechanism (k(cat)=70+/-2 s(-1), K(m)(Pyruvate)=0.11+/-0.01 mm, and K(m)(ASA)=0.22+/-0.02 mm) and shows ASA substrate inhibition with a K(si)(ASA) of 2.7+/-0.9 mm. We also demonstrate that unlike the E. coli tetramer, the MRSA-DHDPS dimer is insensitive to lysine inhibition. The near atomic resolution (1.45 A) crystal structure confirms the dimeric quaternary structure and reveals that the dimerization interface of the MRSA enzyme is more extensive in buried surface area and noncovalent contacts than the equivalent interface in tetrameric DHDPS enzymes from other bacterial species. These data provide a detailed mechanistic insight into DHDPS catalysis and the evolution of quaternary structure of this important bacterial enzyme.

	~~{{STRUCTURE_3daq\| PDB=3daq \| SCENE= }}~~		Structure and evolution of a novel dimeric enzyme from a clinically important bacterial pathogen.,Burgess BR, Dobson RC, Bailey MF, Atkinson SC, Griffin MD, Jameson GB, Parker MW, Gerrard JA, Perugini MA J Biol Chem. 2008 Oct 10;283(41):27598-603. Epub 2008 Aug 5. PMID:18684709<ref>PMID:18684709</ref>

	~~===Crystal structure~~ of ~~dihydrodipicolinate synthase from methicillin-resistant Staphylococcus aureus===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_18684709}}~~

	~~==About this Structure==~~
	~~[[3daq]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Staphylococcus_aureus Staphylococcus aureus]~~. ~~Full crystallographic information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=3DAQ OCA].~~

	==See Also==		==See Also==
	*[[Dihydrodipicolinate ~~Synthase~~\|Dihydrodipicolinate ~~Synthase~~]]		*[[Dihydrodipicolinate synthase\|Dihydrodipicolinate synthase]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:018684709<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Dihydrodipicolinate synthase]]		[[Category: Dihydrodipicolinate synthase]]
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Burgess, B R.]]		[[Category: Burgess, B R]]
	[[Category: Dobson, R C.J.]]		[[Category: Dobson, R C.J]]
	[[Category: Gerrard, J A.]]		[[Category: Gerrard, J A]]
	[[Category: Jameson, G B.]]		[[Category: Jameson, G B]]
	[[Category: Parker, M W.]]		[[Category: Parker, M W]]
	[[Category: Perugini, M A.]]		[[Category: Perugini, M A]]
	[[Category: Amino-acid biosynthesis]]		[[Category: Amino-acid biosynthesis]]
	[[Category: Diaminopimelate biosynthesis]]		[[Category: Diaminopimelate biosynthesis]]
	~~[[Category: Dihydrodipicolinate synthase]]~~
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Lysine biosynthesis]]		[[Category: Lysine biosynthesis]]
	[[Category: Schiff base]]		[[Category: Schiff base]]

OCA: Protected "3daq" [edit=sysop:move=sysop]

2012-10-20T22:24:07Z

Protected "3daq" [edit=sysop:move=sysop]

← Older revision	Revision as of 22:24, 20 October 2012
(No difference)

OCA at 22:24, 20 October 2012

2012-10-20T22:24:04Z

← Older revision		Revision as of 22:24, 20 October 2012
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	~~{{Seed}}~~
	[[Image:3daq.png\|left\|200px]]		[[Image:3daq.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3daq", creates the "Structure Box" on the page.~~
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	{{STRUCTURE_3daq\| PDB=3daq \| SCENE= }}		{{STRUCTURE_3daq\| PDB=3daq \| SCENE= }}

	===Crystal structure of dihydrodipicolinate synthase from methicillin-resistant Staphylococcus aureus===		===Crystal structure of dihydrodipicolinate synthase from methicillin-resistant Staphylococcus aureus===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_18684709}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 18684709 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_18684709}}		{{ABSTRACT_PUBMED_18684709}}

	==About this Structure==		==About this Structure==
	~~3DAQ~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAQ OCA].		[[3daq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAQ OCA].

			==See Also==
			*[[Dihydrodipicolinate Synthase\|Dihydrodipicolinate Synthase]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~18684709~~</ref><references group="xtra"/>		<ref group="xtra">PMID:018684709</ref><references group="xtra"/>
	[[Category: Dihydrodipicolinate synthase]]		[[Category: Dihydrodipicolinate synthase]]
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
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	[[Category: Perugini, M A.]]		[[Category: Perugini, M A.]]
	[[Category: Amino-acid biosynthesis]]		[[Category: Amino-acid biosynthesis]]
	~~[[Category: Cytoplasm]]~~
	[[Category: Diaminopimelate biosynthesis]]		[[Category: Diaminopimelate biosynthesis]]
	[[Category: Dihydrodipicolinate synthase]]		[[Category: Dihydrodipicolinate synthase]]
Line 39:		Line 29:
	[[Category: Lysine biosynthesis]]		[[Category: Lysine biosynthesis]]
	[[Category: Schiff base]]		[[Category: Schiff base]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:46:01 2009''~~

OCA at 07:46, 18 February 2009

2009-02-18T07:46:03Z

← Older revision		Revision as of 07:46, 18 February 2009
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	==About this Structure==		==About this Structure==
	3DAQ is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAQ OCA].		3DAQ is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAQ OCA].

	==Reference==		==Reference==
	Structure and evolution of a novel dimeric enzyme from a clinically-important bacterial pathogen., Burgess BR, Dobson RC, Bailey MF, Atkinson SC, Griffin MD, Jameson GB, Parker MW, Gerrard JA, Perugini MA, J Biol Chem. 2008 Aug 5. PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~18684709 18684709]~~		<ref group="xtra">PMID:18684709</ref><references group="xtra"/>
	[[Category: Dihydrodipicolinate synthase]]		[[Category: Dihydrodipicolinate synthase]]
	~~[[Category: Single protein]]~~
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Burgess, B R.]]		[[Category: Burgess, B R.]]
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	[[Category: Schiff base]]		[[Category: Schiff base]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Sep 17 13~~:11:~~43 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:46:01 2009''

OCA at 10:11, 17 September 2008

2008-09-17T10:11:44Z

← Older revision		Revision as of 10:11, 17 September 2008
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	{{Seed}}		{{Seed}}
	[[Image:3daq.~~jpg~~\|left\|200px]]		[[Image:3daq.png\|left\|200px]]

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	{{STRUCTURE_3daq\| PDB=3daq \| SCENE= }}		{{STRUCTURE_3daq\| PDB=3daq \| SCENE= }}

	===~~Structure~~ of dihydrodipicolinate synthase ~~at high resolution~~===		===Crystal structure of dihydrodipicolinate synthase from methicillin-resistant Staphylococcus aureus===


			<!--
			The line below this paragraph, {{ABSTRACT_PUBMED_18684709}}, adds the Publication Abstract to the page
			(as it appears on PubMed at http://www.pubmed.gov), where 18684709 is the PubMed ID number.
			-->
			{{ABSTRACT_PUBMED_18684709}}

	==About this Structure==		==About this Structure==
	3DAQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAQ OCA].		3DAQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAQ OCA].

			==Reference==
			Structure and evolution of a novel dimeric enzyme from a clinically-important bacterial pathogen., Burgess BR, Dobson RC, Bailey MF, Atkinson SC, Griffin MD, Jameson GB, Parker MW, Gerrard JA, Perugini MA, J Biol Chem. 2008 Aug 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18684709 18684709]
	[[Category: Dihydrodipicolinate synthase]]		[[Category: Dihydrodipicolinate synthase]]
	[[Category: Single protein]]		[[Category: Single protein]]
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: ~~Bugress~~, B J.]]		[[Category: Burgess, B R.]]
	[[Category: Dobson, R C.J.]]		[[Category: Dobson, R C.J.]]
	[[Category: Gerrard, J A.]]		[[Category: Gerrard, J A.]]
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	[[Category: Schiff base]]		[[Category: Schiff base]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Aug 6~~ 13:02:51 2008''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 17 13:11:43 2008''

OCA at 10:02, 6 August 2008

2008-08-06T10:02:54Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{Seed}}
-The entry 3daq is ON HOLD  until Paper Publication
+<!--
-Authors: Burgess, B.R., Dobson, R.C.J.
+===Structure of dihydrodipicolinate synthase at high resolution===
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Jul 11 13:05:55 2008''
+==About this Structure==