3dbd - Revision history

OCA at 12:44, 30 August 2023

2023-08-30T12:44:15Z

← Older revision		Revision as of 12:44, 30 August 2023
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	<StructureSection load='3dbd' size='340' side='right'caption='[[3dbd]], [[Resolution\|resolution]] 3.05Å' scene=''>		<StructureSection load='3dbd' size='340' side='right'caption='[[3dbd]], [[Resolution\|resolution]] 3.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3dbd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Brachidanio_rerio Brachidanio~~ rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DBD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DBD FirstGlance]. <br>		<table><tr><td colspan='2'>[[3dbd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DBD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DBD FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=3FR:3-CHLORO-5-(3-METHYL-6-{[(1S)-1-PHENYLETHYL]AMINO}-1H~~-~~PYRAZOLO[4~~,~~3-C]PYRIDIN-1-YL)BIPHENYL-2-CARBOXAMIDE'>3FR</scene></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.05Å</td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em~~;~~'>[[3d5w\|3d5w]], [[3db6\|3db6]], [[3db8\|3db8]], [[3dbc\|3dbc]], [[3dbe\|3dbe]], [[3dbf\|3dbf]]</div>~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3FR:3-CHLORO-5-(3-METHYL-6-{[(1S)-1-PHENYLETHYL]AMINO}-1H-PYRAZOLO[4,3-C]PYRIDIN-1-YL)BIPHENYL-2-CARBOXAMIDE'>3FR</scene></td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>plk1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~7955 Brachidanio rerio])</td~~><~~/tr>~~
	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks'>~~[~~https://en.wikipedia.org/wiki/Polo_kinase Polo kinase~~], ~~with EC number [https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=~~2~~.7.11.21 2.7.11.21]~~ </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dbd OCA], [https://pdbe.org/3dbd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dbd RCSB], [https://www.ebi.ac.uk/pdbsum/3dbd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dbd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dbd OCA], [https://pdbe.org/3dbd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dbd RCSB], [https://www.ebi.ac.uk/pdbsum/3dbd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dbd ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/Q4KMI8_DANRE Q4KMI8_DANRE]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Brachidanio~~ rerio]]		[[Category: Danio rerio]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Polo kinase]]~~		[[Category: Barr KJ]]
	[[Category: Barr~~, K J~~]]		[[Category: Elling RA]]
	[[Category: Elling~~, R A~~]]		[[Category: Romanowski MJ]]
	[[Category: Romanowski~~, M J]]~~
	~~[[Category: Catalytic domain]]~~
	~~[[Category: Kinase]]~~
	~~[[Category: Plk1]]~~
	~~[[Category: Polo-like kinase 1]]~~
	~~[[Category: Small-molecule inhibitor]]~~
	~~[[Category: Transferase~~]]

OCA at 19:21, 20 October 2021

2021-10-20T19:21:33Z

← Older revision		Revision as of 19:21, 20 October 2021
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	==Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 094==		==Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 094==
	<StructureSection load='3dbd' size='340' side='right' caption='[[3dbd]], [[Resolution\|resolution]] 3.05Å' scene=''>		<StructureSection load='3dbd' size='340' side='right'caption='[[3dbd]], [[Resolution\|resolution]] 3.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3dbd]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DBD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3DBD FirstGlance]. <br>		<table><tr><td colspan='2'>[[3dbd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DBD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DBD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3FR:3-CHLORO-5-(3-METHYL-6-{[(1S)-1-PHENYLETHYL]AMINO}-1H-PYRAZOLO[4,3-C]PYRIDIN-1-YL)BIPHENYL-2-CARBOXAMIDE'>3FR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3FR:3-CHLORO-5-(3-METHYL-6-{[(1S)-1-PHENYLETHYL]AMINO}-1H-PYRAZOLO[4,3-C]PYRIDIN-1-YL)BIPHENYL-2-CARBOXAMIDE'>3FR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3d5w\|3d5w]], [[3db6\|3db6]], [[3db8\|3db8]], [[3dbc\|3dbc]], [[3dbe\|3dbe]], [[3dbf\|3dbf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3d5w\|3d5w]], [[3db6\|3db6]], [[3db8\|3db8]], [[3dbc\|3dbc]], [[3dbe\|3dbe]], [[3dbf\|3dbf]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">plk1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">plk1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Polo_kinase Polo kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.21 2.7.11.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Polo_kinase Polo kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.21 2.7.11.21] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3dbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dbd OCA], [~~http~~://pdbe.org/3dbd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3dbd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3dbd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3dbd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dbd OCA], [https://pdbe.org/3dbd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dbd RCSB], [https://www.ebi.ac.uk/pdbsum/3dbd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dbd ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	==See Also==		==See Also==
	*[[Serine/threonine protein kinase\|Serine/threonine protein kinase]]		*[[Serine/threonine protein kinase 3D structures\|Serine/threonine protein kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Brachidanio rerio]]		[[Category: Brachidanio rerio]]
			[[Category: Large Structures]]
	[[Category: Polo kinase]]		[[Category: Polo kinase]]
	[[Category: Barr, K J]]		[[Category: Barr, K J]]

OCA at 09:34, 14 November 2018

2018-11-14T09:34:29Z

← Older revision		Revision as of 09:34, 14 November 2018
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/db/3dbd_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/db/3dbd_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 20:51, 11 August 2016

2016-08-11T20:51:27Z

← Older revision		Revision as of 20:51, 11 August 2016
Line 1:		Line 1:

	==Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 094==		==Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 094==
	<StructureSection load='3dbd' size='340' side='right' caption='[[3dbd]], [[Resolution\|resolution]] 3.05Å' scene=''>		<StructureSection load='3dbd' size='340' side='right' caption='[[3dbd]], [[Resolution\|resolution]] 3.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3dbd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Danio_rerio Danio~~ rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DBD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DBD FirstGlance]. <br>		<table><tr><td colspan='2'>[[3dbd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DBD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DBD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3FR:3-CHLORO-5-(3-METHYL-6-{[(1S)-1-PHENYLETHYL]AMINO}-1H-PYRAZOLO[4,3-C]PYRIDIN-1-YL)BIPHENYL-2-CARBOXAMIDE'>3FR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3FR:3-CHLORO-5-(3-METHYL-6-{[(1S)-1-PHENYLETHYL]AMINO}-1H-PYRAZOLO[4,3-C]PYRIDIN-1-YL)BIPHENYL-2-CARBOXAMIDE'>3FR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3d5w\|3d5w]], [[3db6\|3db6]], [[3db8\|3db8]], [[3dbc\|3dbc]], [[3dbe\|3dbe]], [[3dbf\|3dbf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3d5w\|3d5w]], [[3db6\|3db6]], [[3db8\|3db8]], [[3dbc\|3dbc]], [[3dbe\|3dbe]], [[3dbf\|3dbf]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">plk1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 ~~Danio~~ rerio])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">plk1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Polo_kinase Polo kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.21 2.7.11.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Polo_kinase Polo kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.21 2.7.11.21] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dbd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dbd RCSB], [http://www.ebi.ac.uk/pdbsum/3dbd PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dbd OCA], [http://pdbe.org/3dbd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dbd RCSB], [http://www.ebi.ac.uk/pdbsum/3dbd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3dbd ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dbd ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3dbd" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Danio~~ rerio]]		[[Category: Brachidanio rerio]]
	[[Category: Polo kinase]]		[[Category: Polo kinase]]
	[[Category: Barr, K J]]		[[Category: Barr, K J]]

OCA at 08:19, 12 November 2014

2014-11-12T08:19:34Z

← Older revision		Revision as of 08:19, 12 November 2014
Line 1:		Line 1:
	[[Image:~~3dbd~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 094==
			<StructureSection load='3dbd' size='340' side='right' caption='[[3dbd]], [[Resolution\|resolution]] 3.05Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3dbd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DBD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DBD FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3FR:3-CHLORO-5-(3-METHYL-6-{[(1S)-1-PHENYLETHYL]AMINO}-1H-PYRAZOLO[4,3-C]PYRIDIN-1-YL)BIPHENYL-2-CARBOXAMIDE'>3FR</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3d5w\|3d5w]], [[3db6\|3db6]], [[3db8\|3db8]], [[3dbc\|3dbc]], [[3dbe\|3dbe]], [[3dbf\|3dbf]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">plk1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Danio rerio])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Polo_kinase Polo kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.21 2.7.11.21] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dbd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dbd RCSB], [http://www.ebi.ac.uk/pdbsum/3dbd PDBsum]</span></td></tr>
			</table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/db/3dbd_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			A series of 2-amino-pyrazolopyridines was designed and synthesized as Polo-like kinase (Plk) inhibitors based on a low micromolar hit. The SAR was developed to provide compounds exhibiting low nanomolar inhibitory activity of Plk1; the phenotype of treated cells is consistent with Plk1 inhibition. A co-crystal structure of one of these compounds with zPlk1 confirms an ATP-competitive binding mode.

	~~{{STRUCTURE_3dbd\| PDB=3dbd \| SCENE= }}~~		Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors.,Fucini RV, Hanan EJ, Romanowski MJ, Elling RA, Lew W, Barr KJ, Zhu J, Yoburn JC, Liu Y, Fahr BT, Fan J, Lu Y, Pham P, Choong IC, VanderPorten EC, Bui M, Purkey HE, Evanchik MJ, Yang W Bioorg Med Chem Lett. 2008 Oct 15;18(20):5648-52. Epub 2008 Aug 29. PMID:18793847<ref>PMID:18793847</ref>

	~~===Crystal structure~~ of ~~an activated (Thr-~~>~~Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 094===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	~~{{ABSTRACT_PUBMED_18793847}}~~		==See Also==
			*[[Serine/threonine protein kinase\|Serine/threonine protein kinase]]
	==~~About this Structure~~==		== References ==
	[[~~3dbd]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Danio_rerio Danio rerio~~]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DBD OCA~~].		<references/>
			__TOC__
	==~~Reference~~==		</StructureSection>
	<~~ref group="xtra">PMID:018793847<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Danio rerio]]		[[Category: Danio rerio]]
	[[Category: Polo kinase]]		[[Category: Polo kinase]]
	[[Category: Barr, K J.]]		[[Category: Barr, K J]]
	[[Category: Elling, R A.]]		[[Category: Elling, R A]]
	[[Category: Romanowski, M J.]]		[[Category: Romanowski, M J]]
	[[Category: Catalytic domain]]		[[Category: Catalytic domain]]
	[[Category: Kinase]]		[[Category: Kinase]]

OCA: Protected "3dbd" [edit=sysop:move=sysop]

2013-01-07T22:56:11Z

Protected "3dbd" [edit=sysop:move=sysop]

← Older revision	Revision as of 22:56, 7 January 2013
(No difference)

OCA at 22:56, 7 January 2013

2013-01-07T22:56:08Z

← Older revision		Revision as of 22:56, 7 January 2013
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	~~{{Seed}}~~
	[[Image:3dbd.png\|left\|200px]]		[[Image:3dbd.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3dbd", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3dbd\| PDB=3dbd \| SCENE= }}		{{STRUCTURE_3dbd\| PDB=3dbd \| SCENE= }}

	===Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 094===		===Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 094===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_18793847}}, adds the Publication Abstract to the page~~
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	{{ABSTRACT_PUBMED_18793847}}		{{ABSTRACT_PUBMED_18793847}}

	==About this Structure==		==About this Structure==
	~~3DBD~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DBD OCA].		[[3dbd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DBD OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~18793847~~</ref><references group="xtra"/>		<ref group="xtra">PMID:018793847</ref><references group="xtra"/>
	[[Category: Danio rerio]]		[[Category: Danio rerio]]
	[[Category: Polo kinase]]		[[Category: Polo kinase]]
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	[[Category: Small-molecule inhibitor]]		[[Category: Small-molecule inhibitor]]
	[[Category: Transferase]]		[[Category: Transferase]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 19:07:56 2009''~~

OCA at 17:07, 17 February 2009

2009-02-17T17:07:57Z

← Older revision		Revision as of 17:07, 17 February 2009
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	==About this Structure==		==About this Structure==
	3DBD is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DBD OCA].		3DBD is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DBD OCA].

	==Reference==		==Reference==
	Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors., Fucini RV, Hanan EJ, Romanowski MJ, Elling RA, Lew W, Barr KJ, Zhu J, Yoburn JC, Liu Y, Fahr BT, Fan J, Lu Y, Pham P, Choong IC, Vanderporten EC, Bui M, Purkey HE, Evanchik MJ, Yang W, Bioorg Med Chem Lett. 2008 Aug 29. PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~18793847 18793847]~~		<ref group="xtra">PMID:18793847</ref><references group="xtra"/>
	[[Category: Danio rerio]]		[[Category: Danio rerio]]
	[[Category: Polo kinase]]		[[Category: Polo kinase]]
	~~[[Category: Single protein]]~~
	[[Category: Barr, K J.]]		[[Category: Barr, K J.]]
	[[Category: Elling, R A.]]		[[Category: Elling, R A.]]
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	[[Category: Transferase]]		[[Category: Transferase]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Nov 5 10~~:40:~~06 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 19:07:56 2009''

OCA at 08:40, 5 November 2008

2008-11-05T08:40:06Z

← Older revision		Revision as of 08:40, 5 November 2008
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	{{Seed}}		{{Seed}}
	[[Image:3dbd.~~jpg~~\|left\|200px]]		[[Image:3dbd.png\|left\|200px]]

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	[[Category: Transferase]]		[[Category: Transferase]]

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OCA at 07:29, 8 October 2008

2008-10-08T07:29:27Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{Seed}}
-The entry 3dbd is ON HOLD  until Paper Publication
+<!--
-Authors: Elling, R.A., Barr, K.J., Romanowski, M.J.
+===Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 094===
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Jul 11 13:06:05 2008''
+<!--