3dvm - Revision history

OCA at 09:43, 21 February 2024

2024-02-21T09:43:10Z

← Older revision		Revision as of 09:43, 21 February 2024
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	<StructureSection load='3dvm' size='340' side='right'caption='[[3dvm]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3dvm' size='340' side='right'caption='[[3dvm]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3dvm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~European_rabbit European rabbit~~] and [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DVM FirstGlance]. <br>		<table><tr><td colspan='2'>[[3dvm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DVM FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;'>[[3dve\|3dve]]~~, [[~~3dvj~~\|~~3dvj~~]]~~, [[3dvk\|3dvk]]</div>~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~CALM1, CALM, CAM, CAM1, CALM2, CAM2, CAMB, CALM3, CALML2, CAM3, CAMC, CAMIII ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN]), CACNA1A, CACH4, CACN3, CACNL1A4 ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dvm OCA], [https://pdbe.org/3dvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dvm RCSB], [https://www.ebi.ac.uk/pdbsum/3dvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dvm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dvm OCA], [https://pdbe.org/3dvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dvm RCSB], [https://www.ebi.ac.uk/pdbsum/3dvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dvm ProSAT]</span></td></tr>
	</table>		</table>
			== Disease ==
			[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4. The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of LQT14.
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/~~CAC1A_RABIT CAC1A_RABIT~~]~~] Voltage-sensitive calcium channels (VSCC) mediate~~ the ~~entry~~ of ~~calcium ions into excitable cells and are also involved in~~ a ~~variety~~ of ~~calcium-dependent processes~~, ~~including muscle contraction, hormone or neurotransmitter release~~, ~~gene expression, cell motility, cell division~~ and ~~cell death~~. ~~The isoform alpha-1A gives rise~~ to ~~P and/or Q~~-~~type~~ calcium ~~currents~~. ~~P/Q-type calcium channels belong to~~ the ~~'high-voltage activated' (HVA) group~~ and ~~are blocked by the funnel toxin~~ (~~Ftx~~) ~~and by the omega~~-~~agatoxin-IVA~~ (~~omega-Aga-IVA~~). ~~They are however insensitive to dihydropyridines (DHP), and omega~~-~~conotoxin-GVIA~~ (~~omega-CTx-GVIA~~).		[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).<ref>PMID:16760425</ref> <ref>PMID:23893133</ref> <ref>PMID:26969752</ref> <ref>PMID:27165696</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dvm ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dvm ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Calcium influx drives two opposing voltage-activated calcium channel (Ca(V)) self-modulatory processes: calcium-dependent inactivation (CDI) and calcium-dependent facilitation (CDF). Specific Ca(2+)/calmodulin (Ca(2+)/CaM) lobes produce CDI and CDF through interactions with the Ca(V)alpha(1) subunit IQ domain. Curiously, Ca(2+)/CaM lobe modulation polarity appears inverted between Ca(V)1s and Ca(V)2s. Here, we present crystal structures of Ca(V)2.1, Ca(V)2.2, and Ca(V)2.3 Ca(2+)/CaM-IQ domain complexes. All display binding orientations opposite to Ca(V)1.2 with a physical reversal of the CaM lobe positions relative to the IQ alpha-helix. Titration calorimetry reveals lobe competition for a high-affinity site common to Ca(V)1 and Ca(V)2 IQ domains that is occupied by the CDI lobe in the structures. Electrophysiological experiments demonstrate that the N-terminal Ca(V)2 Ca(2+)/C-lobe anchors affect CDF. Together, the data unveil the remarkable structural plasticity at the heart of Ca(V) feedback modulation and indicate that Ca(V)1 and Ca(V)2 IQ domains bear a dedicated CDF site that exchanges Ca(2+)/CaM lobe occupants.

	Structures of CaV2 Ca2+/CaM-IQ domain complexes reveal binding modes that underlie calcium-dependent inactivation and facilitation.,Kim EY, Rumpf CH, Fujiwara Y, Cooley ES, Van Petegem F, Minor DL Jr Structure. 2008 Oct 8;16(10):1455-67. PMID:18940602<ref>PMID:18940602</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 3dvm" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~European rabbit]]~~		[[Category: Homo sapiens]]
	~~[[Category: Human~~]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Cooley, E S~~]]		[[Category: Oryctolagus cuniculus]]
	[[Category: ~~Fujiwara, Y~~]]		[[Category: Cooley ES]]
	[[Category: ~~Kim, E~~ Y]]		[[Category: Fujiwara Y]]
	[[Category: ~~Minor, D L~~]]		[[Category: Kim EY]]
	[[Category: ~~Petegem, F Van~~]]		[[Category: Minor DL]]
	[[Category: Rumpf~~, C H~~]]		[[Category: Rumpf CH]]
	[[Category: ~~Calcium channel]]~~		[[Category: Van Petegem F]]
	~~[[Category: Calcium-dependent]]~~
	~~[[Category: Calmodulin]]~~
	~~[[Category: Facilitation]]~~
	~~[[Category: Inactivation]]~~
	~~[[Category: Iq domain]]~~
	~~[[Category: Membrane protein]]~~
	~~[[Category: Voltage-gated~~]]

OCA at 08:08, 9 February 2022

2022-02-09T08:08:57Z

← Older revision		Revision as of 08:08, 9 February 2022
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	==Crystal Structure of Ca2+/CaM-CaV2.1 IQ domain complex==		==Crystal Structure of Ca2+/CaM-CaV2.1 IQ domain complex==
	<StructureSection load='3dvm' size='340' side='right' caption='[[3dvm]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3dvm' size='340' side='right'caption='[[3dvm]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3dvm]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/European_rabbit European rabbit] and [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DVM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3DVM FirstGlance]. <br>		<table><tr><td colspan='2'>[[3dvm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/European_rabbit European rabbit] and [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DVM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3dve\|3dve]], [[3dvj\|3dvj]], [[3dvk\|3dvk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3dve\|3dve]], [[3dvj\|3dvj]], [[3dvk\|3dvk]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CALM1, CALM, CAM, CAM1, CALM2, CAM2, CAMB, CALM3, CALML2, CAM3, CAMC, CAMIII ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), CACNA1A, CACH4, CACN3, CACNL1A4 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CALM1, CALM, CAM, CAM1, CALM2, CAM2, CAMB, CALM3, CALML2, CAM3, CAMC, CAMIII ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), CACNA1A, CACH4, CACN3, CACNL1A4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3dvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dvm OCA], [~~http~~://pdbe.org/3dvm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3dvm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3dvm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3dvm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dvm OCA], [https://pdbe.org/3dvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dvm RCSB], [https://www.ebi.ac.uk/pdbsum/3dvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dvm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/CAC1A_RABIT CAC1A_RABIT]] Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin-IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).		[[https://www.uniprot.org/uniprot/CAC1A_RABIT CAC1A_RABIT]] Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin-IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dv/3dvm_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dv/3dvm_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 3dvm" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3dvm" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Calmodulin 3D structures\|Calmodulin 3D structures]]
			*[[Ion channels 3D structures\|Ion channels 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: European rabbit]]		[[Category: European rabbit]]
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Cooley, E S]]		[[Category: Cooley, E S]]
	[[Category: Fujiwara, Y]]		[[Category: Fujiwara, Y]]

OCA at 08:57, 25 October 2017

2017-10-25T08:57:30Z

← Older revision		Revision as of 08:57, 25 October 2017
Line 1:		Line 1:

	==Crystal Structure of Ca2+/CaM-CaV2.1 IQ domain complex==		==Crystal Structure of Ca2+/CaM-CaV2.1 IQ domain complex==
	<StructureSection load='3dvm' size='340' side='right' caption='[[3dvm]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3dvm' size='340' side='right' caption='[[3dvm]], [[Resolution\|resolution]] 2.60Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3dve\|3dve]], [[3dvj\|3dvj]], [[3dvk\|3dvk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3dve\|3dve]], [[3dvj\|3dvj]], [[3dvk\|3dvk]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CALM1, CALM, CAM, CAM1, CALM2, CAM2, CAMB, CALM3, CALML2, CAM3, CAMC, CAMIII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), CACNA1A, CACH4, CACN3, CACNL1A4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CALM1, CALM, CAM, CAM1, CALM2, CAM2, CAMB, CALM3, CALML2, CAM3, CAMC, CAMIII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), CACNA1A, CACH4, CACN3, CACNL1A4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dvm OCA], [http://pdbe.org/3dvm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dvm RCSB], [http://www.ebi.ac.uk/pdbsum/3dvm PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dvm OCA], [http://pdbe.org/3dvm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dvm RCSB], [http://www.ebi.ac.uk/pdbsum/3dvm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3dvm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 3dvm" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3dvm" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Calmodulin\|Calmodulin]]
	*[[Ion channels\|Ion channels]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 23:02, 7 February 2016

2016-02-07T23:02:35Z

← Older revision		Revision as of 23:02, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='3dvm' size='340' side='right' caption='[[3dvm]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3dvm' size='340' side='right' caption='[[3dvm]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3dvm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~] and [http://en.wikipedia.org/wiki/~~Oryctolagus_cuniculus Oryctolagus cuniculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DVM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DVM FirstGlance]. <br>		<table><tr><td colspan='2'>[[3dvm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DVM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DVM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3dve\|3dve]], [[3dvj\|3dvj]], [[3dvk\|3dvk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3dve\|3dve]], [[3dvj\|3dvj]], [[3dvk\|3dvk]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CALM1, CALM, CAM, CAM1, CALM2, CAM2, CAMB, CALM3, CALML2, CAM3, CAMC, CAMIII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~]), CACNA1A, CACH4, CACN3, CACNL1A4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 ~~Oryctolagus cuniculus~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CALM1, CALM, CAM, CAM1, CALM2, CAM2, CAMB, CALM3, CALML2, CAM3, CAMC, CAMIII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), CACNA1A, CACH4, CACN3, CACNL1A4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dvm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dvm RCSB], [http://www.ebi.ac.uk/pdbsum/3dvm PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dvm OCA], [http://pdbe.org/3dvm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dvm RCSB], [http://www.ebi.ac.uk/pdbsum/3dvm PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dvm ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3dvm" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: European rabbit]]
	[[Category: ~~Oryctolagus cuniculus~~]]		[[Category: Human]]
	[[Category: Cooley, E S]]		[[Category: Cooley, E S]]
	[[Category: Fujiwara, Y]]		[[Category: Fujiwara, Y]]

OCA at 18:48, 24 December 2014

2014-12-24T18:48:39Z

← Older revision		Revision as of 18:48, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3dvm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DVM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DVM FirstGlance]. <br>		<table><tr><td colspan='2'>[[3dvm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DVM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DVM FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3dve\|3dve]], [[3dvj\|3dvj]], [[3dvk\|3dvk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3dve\|3dve]], [[3dvj\|3dvj]], [[3dvk\|3dvk]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CALM1, CALM, CAM, CAM1, CALM2, CAM2, CAMB, CALM3, CALML2, CAM3, CAMC, CAMIII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), CACNA1A, CACH4, CACN3, CACNL1A4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 Oryctolagus cuniculus])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CALM1, CALM, CAM, CAM1, CALM2, CAM2, CAMB, CALM3, CALML2, CAM3, CAMC, CAMIII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), CACNA1A, CACH4, CACN3, CACNL1A4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 Oryctolagus cuniculus])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dvm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dvm RCSB], [http://www.ebi.ac.uk/pdbsum/3dvm PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dvm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dvm RCSB], [http://www.ebi.ac.uk/pdbsum/3dvm PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/CAC1A_RABIT CAC1A_RABIT]] Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin-IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
	[[Category: Cooley, E S.]]		[[Category: Cooley, E S]]
	[[Category: Fujiwara, Y.]]		[[Category: Fujiwara, Y]]
	[[Category: Kim, E Y.]]		[[Category: Kim, E Y]]
	[[Category: Minor, D L.]]		[[Category: Minor, D L]]
	[[Category: Petegem, F Van.]]		[[Category: Petegem, F Van]]
	[[Category: Rumpf, C H.]]		[[Category: Rumpf, C H]]
	[[Category: Calcium channel]]		[[Category: Calcium channel]]
	[[Category: Calcium-dependent]]		[[Category: Calcium-dependent]]

OCA at 12:26, 29 September 2014

2014-09-29T12:26:07Z

← Older revision		Revision as of 12:26, 29 September 2014
Line 1:		Line 1:
	[[Image:~~3dvm~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal Structure of Ca2+/CaM-CaV2.1 IQ domain complex==
			<StructureSection load='3dvm' size='340' side='right' caption='[[3dvm]], [[Resolution\|resolution]] 2.60Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3dvm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DVM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DVM FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3dve\|3dve]], [[3dvj\|3dvj]], [[3dvk\|3dvk]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CALM1, CALM, CAM, CAM1, CALM2, CAM2, CAMB, CALM3, CALML2, CAM3, CAMC, CAMIII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), CACNA1A, CACH4, CACN3, CACNL1A4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 Oryctolagus cuniculus])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dvm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dvm RCSB], [http://www.ebi.ac.uk/pdbsum/3dvm PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dv/3dvm_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Calcium influx drives two opposing voltage-activated calcium channel (Ca(V)) self-modulatory processes: calcium-dependent inactivation (CDI) and calcium-dependent facilitation (CDF). Specific Ca(2+)/calmodulin (Ca(2+)/CaM) lobes produce CDI and CDF through interactions with the Ca(V)alpha(1) subunit IQ domain. Curiously, Ca(2+)/CaM lobe modulation polarity appears inverted between Ca(V)1s and Ca(V)2s. Here, we present crystal structures of Ca(V)2.1, Ca(V)2.2, and Ca(V)2.3 Ca(2+)/CaM-IQ domain complexes. All display binding orientations opposite to Ca(V)1.2 with a physical reversal of the CaM lobe positions relative to the IQ alpha-helix. Titration calorimetry reveals lobe competition for a high-affinity site common to Ca(V)1 and Ca(V)2 IQ domains that is occupied by the CDI lobe in the structures. Electrophysiological experiments demonstrate that the N-terminal Ca(V)2 Ca(2+)/C-lobe anchors affect CDF. Together, the data unveil the remarkable structural plasticity at the heart of Ca(V) feedback modulation and indicate that Ca(V)1 and Ca(V)2 IQ domains bear a dedicated CDF site that exchanges Ca(2+)/CaM lobe occupants.

	~~{{STRUCTURE_3dvm\| PDB=3dvm \| SCENE= }}~~		Structures of CaV2 Ca2+/CaM-IQ domain complexes reveal binding modes that underlie calcium-dependent inactivation and facilitation.,Kim EY, Rumpf CH, Fujiwara Y, Cooley ES, Van Petegem F, Minor DL Jr Structure. 2008 Oct 8;16(10):1455-67. PMID:18940602<ref>PMID:18940602</ref>

	~~===Crystal Structure of Ca2+~~/~~CaM-CaV2.1 IQ domain complex===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_18940602}}~~

	~~==About this Structure==~~
	~~[[3dvm]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens] and [http://en~~.~~wikipedia.org~~/~~wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DVM OCA].~~

	==See Also==		==See Also==
	*[[Calmodulin\|Calmodulin]]		*[[Calmodulin\|Calmodulin]]
	*[[Ion channels\|Ion channels]]		*[[Ion channels\|Ion channels]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:018940602<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]

OCA at 08:06, 20 October 2012

2012-10-20T08:06:09Z

← Older revision		Revision as of 08:06, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[3dvm]] is a 2 chain structure ~~of [[]], [[Calmodulin]] and [[Ion channels]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DVM OCA].		[[3dvm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DVM OCA].

	==See Also==		==See Also==
	*[[\|]]
	*[[Calmodulin\|Calmodulin]]		*[[Calmodulin\|Calmodulin]]
	*[[Ion channels\|Ion channels]]		*[[Ion channels\|Ion channels]]

OCA at 18:56, 6 August 2012

2012-08-06T18:56:30Z

← Older revision		Revision as of 18:56, 6 August 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[3dvm]] is a 2 chain structure of [[~~Calmodulin~~]], [[~~Ion channels~~]] and [[Ion channels ~~(Part II)~~]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DVM OCA].		[[3dvm]] is a 2 chain structure of [[]], [[Calmodulin]] and [[Ion channels]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DVM OCA].

	==See Also==		==See Also==
			*[[\|]]
	*[[Calmodulin\|Calmodulin]]		*[[Calmodulin\|Calmodulin]]
	*[[Ion channels\|Ion channels]]		*[[Ion channels\|Ion channels]]
	*[[Ion channels (Part II)\|Ion channels (Part II)]]

	==Reference==		==Reference==

OCA at 18:26, 25 July 2012

2012-07-25T18:26:52Z

← Older revision		Revision as of 18:26, 25 July 2012
Line 1:		Line 1:
	[[Image:3dvm.png\|left\|200px]]		[[Image:3dvm.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3dvm", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3dvm\| PDB=3dvm \| SCENE= }}		{{STRUCTURE_3dvm\| PDB=3dvm \| SCENE= }}

	===Crystal Structure of Ca2+/CaM-CaV2.1 IQ domain complex===		===Crystal Structure of Ca2+/CaM-CaV2.1 IQ domain complex===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_18940602}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 18940602 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_18940602}}		{{ABSTRACT_PUBMED_18940602}}

	==About this Structure==		==About this Structure==
	[[3dvm]] is a 2 chain structure of [[Ion channels (Part II)]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DVM OCA].		[[3dvm]] is a 2 chain structure of [[Calmodulin]], [[Ion channels]] and [[Ion channels (Part II)]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DVM OCA].

	==See Also==		==See Also==
	*[[Ion channels (Part II)]]		*[[Calmodulin\|Calmodulin]]
			*[[Ion channels\|Ion channels]]
			*[[Ion channels (Part II)\|Ion channels (Part II)]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~18940602~~</ref><references group="xtra"/>		<ref group="xtra">PMID:018940602</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]

OCA: Protected "3dvm" [edit=sysop:move=sysop]

2010-12-26T21:31:52Z

Protected "3dvm" [edit=sysop:move=sysop]

← Older revision	Revision as of 21:31, 26 December 2010
(No difference)