3dwp - Revision history

OCA at 09:01, 30 October 2024

2024-10-30T09:01:23Z

← Older revision		Revision as of 09:01, 30 October 2024
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	<StructureSection load='3dwp' size='340' side='right'caption='[[3dwp]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3dwp' size='340' side='right'caption='[[3dwp]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3dwp]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DWP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DWP FirstGlance]. <br>		<table><tr><td colspan='2'>[[3dwp]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DWP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DWP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=NGC:3,5-DIDEOXY-5-[(HYDROXYACETYL)AMINO]-D-GLYCERO-ALPHA-D-GALACTO-NON-2-ULOPYRANOSONIC+ACID'>NGC</scene>~~</td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3dwa\|3dwa]], [[3dwq\|3dwq]]</div></td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=NGC:3,5-DIDEOXY-5-[(HYDROXYACETYL)AMINO]-D-GLYCERO-ALPHA-D-GALACTO-NON-2-ULOPYRANOSONIC+ACID'>NGC</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">subB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dwp OCA], [https://pdbe.org/3dwp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dwp RCSB], [https://www.ebi.ac.uk/pdbsum/3dwp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dwp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dwp OCA], [https://pdbe.org/3dwp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dwp RCSB], [https://www.ebi.ac.uk/pdbsum/3dwp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dwp ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/Q3ZTX8_ECOLX Q3ZTX8_ECOLX]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dw/3dwp_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dw/3dwp_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]		[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Beddoe, T]]		[[Category: Beddoe T]]
	[[Category: Byres, E]]		[[Category: Byres E]]
	[[Category: Chen, X]]		[[Category: Chen X]]
	[[Category: Chong~~, D C~~]]		[[Category: Chong DC]]
	[[Category: Huang, S]]		[[Category: Huang S]]
	[[Category: Lofling~~, J C~~]]		[[Category: Lofling JC]]
	[[Category: Paton~~, A W~~]]		[[Category: Paton AW]]
	[[Category: Paton~~, J C~~]]		[[Category: Paton JC]]
	[[Category: Rossjohn, J]]		[[Category: Rossjohn J]]
	[[Category: Smith~~, D F~~]]		[[Category: Smith DF]]
	[[Category: Talbot~~, U M~~]]		[[Category: Talbot UM]]
	[[Category: Varki, A]]		[[Category: Varki A]]
	[[Category: Varki~~, N M~~]]		[[Category: Varki NM]]
	[[Category: Wilce~~, M C.J~~]]		[[Category: Wilce MCJ]]
	[[Category: Yu, H]]		[[Category: Yu H]]
	~~[[Category: Toxin~~]]

OCA at 08:09, 9 February 2022

2022-02-09T08:09:36Z

← Older revision		Revision as of 08:09, 9 February 2022
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	==Crystal structure of the B-subunit of the AB5 toxin from E. Coli with Neu5Gc==		==Crystal structure of the B-subunit of the AB5 toxin from E. Coli with Neu5Gc==
	<StructureSection load='3dwp' size='340' side='right' caption='[[3dwp]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3dwp' size='340' side='right'caption='[[3dwp]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3dwp]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DWP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3DWP FirstGlance]. <br>		<table><tr><td colspan='2'>[[3dwp]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DWP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DWP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=NGC:3,5-DIDEOXY-5-[(HYDROXYACETYL)AMINO]-D-GLYCERO-ALPHA-D-GALACTO-NON-2-ULOPYRANOSONIC+ACID'>NGC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=NGC:3,5-DIDEOXY-5-[(HYDROXYACETYL)AMINO]-D-GLYCERO-ALPHA-D-GALACTO-NON-2-ULOPYRANOSONIC+ACID'>NGC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3dwa\|3dwa]], [[3dwq\|3dwq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3dwa\|3dwa]], [[3dwq\|3dwq]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">subB ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">subB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3dwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dwp OCA], [~~http~~://pdbe.org/3dwp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3dwp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3dwp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3dwp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dwp OCA], [https://pdbe.org/3dwp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dwp RCSB], [https://www.ebi.ac.uk/pdbsum/3dwp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dwp ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
			[[Category: Large Structures]]
	[[Category: Beddoe, T]]		[[Category: Beddoe, T]]
	[[Category: Byres, E]]		[[Category: Byres, E]]

OCA at 09:44, 14 November 2018

2018-11-14T09:44:31Z

← Older revision		Revision as of 09:44, 14 November 2018
Line 1:		Line 1:

	==Crystal structure of the B-subunit of the AB5 toxin from E. Coli with Neu5Gc==		==Crystal structure of the B-subunit of the AB5 toxin from E. Coli with Neu5Gc==
	<StructureSection load='3dwp' size='340' side='right' caption='[[3dwp]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3dwp' size='340' side='right' caption='[[3dwp]], [[Resolution\|resolution]] 2.20Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3dwa\|3dwa]], [[3dwq\|3dwq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3dwa\|3dwa]], [[3dwq\|3dwq]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">subB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">subB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dwp OCA], [http://pdbe.org/3dwp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dwp RCSB], [http://www.ebi.ac.uk/pdbsum/3dwp PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dwp OCA], [http://pdbe.org/3dwp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dwp RCSB], [http://www.ebi.ac.uk/pdbsum/3dwp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3dwp ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dw/3dwp_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dw/3dwp_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 09:16, 7 February 2016

2016-02-07T09:16:37Z

← Older revision		Revision as of 09:16, 7 February 2016
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	<StructureSection load='3dwp' size='340' side='right' caption='[[3dwp]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3dwp' size='340' side='right' caption='[[3dwp]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3dwp]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DWP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DWP FirstGlance]. <br>		<table><tr><td colspan='2'>[[3dwp]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DWP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DWP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=NGC:3,5-DIDEOXY-5-[(HYDROXYACETYL)AMINO]-D-GLYCERO-ALPHA-D-GALACTO-NON-2-ULOPYRANOSONIC+ACID'>NGC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=NGC:3,5-DIDEOXY-5-[(HYDROXYACETYL)AMINO]-D-GLYCERO-ALPHA-D-GALACTO-NON-2-ULOPYRANOSONIC+ACID'>NGC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3dwa\|3dwa]], [[3dwq\|3dwq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3dwa\|3dwa]], [[3dwq\|3dwq]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">subB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 ~~Escherichia~~ coli])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">subB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dwp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dwp RCSB], [http://www.ebi.ac.uk/pdbsum/3dwp PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dwp OCA], [http://pdbe.org/3dwp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dwp RCSB], [http://www.ebi.ac.uk/pdbsum/3dwp PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dwp ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3dwp" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Escherichia~~ coli]]		[[Category: Bacillus coli migula 1895]]
	[[Category: Beddoe, T]]		[[Category: Beddoe, T]]
	[[Category: Byres, E]]		[[Category: Byres, E]]

OCA at 13:18, 19 November 2014

2014-11-19T13:18:52Z

← Older revision		Revision as of 13:18, 19 November 2014
Line 1:		Line 1:
	[[Image:~~3dwp~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of the B-subunit of the AB5 toxin from E. Coli with Neu5Gc==
			<StructureSection load='3dwp' size='340' side='right' caption='[[3dwp]], [[Resolution\|resolution]] 2.20Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3dwp]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DWP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DWP FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=NGC:3,5-DIDEOXY-5-[(HYDROXYACETYL)AMINO]-D-GLYCERO-ALPHA-D-GALACTO-NON-2-ULOPYRANOSONIC+ACID'>NGC</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3dwa\|3dwa]], [[3dwq\|3dwq]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">subB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dwp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dwp RCSB], [http://www.ebi.ac.uk/pdbsum/3dwp PDBsum]</span></td></tr>
			</table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dw/3dwp_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			AB(5) toxins comprise an A subunit that corrupts essential eukaryotic cell functions, and pentameric B subunits that direct target-cell uptake after binding surface glycans. Subtilase cytotoxin (SubAB) is an AB(5) toxin secreted by Shiga toxigenic Escherichia coli (STEC), which causes serious gastrointestinal disease in humans. SubAB causes haemolytic uraemic syndrome-like pathology in mice through SubA-mediated cleavage of BiP/GRP78, an essential endoplasmic reticulum chaperone. Here we show that SubB has a strong preference for glycans terminating in the sialic acid N-glycolylneuraminic acid (Neu5Gc), a monosaccharide not synthesized in humans. Structures of SubB-Neu5Gc complexes revealed the basis for this specificity, and mutagenesis of key SubB residues abrogated in vitro glycan recognition, cell binding and cytotoxicity. SubAB specificity for Neu5Gc was confirmed using mouse tissues with a human-like deficiency of Neu5Gc and human cell lines fed with Neu5Gc. Despite lack of Neu5Gc biosynthesis in humans, assimilation of dietary Neu5Gc creates high-affinity receptors on human gut epithelia and kidney vasculature. This, and the lack of Neu5Gc-containing body fluid competitors in humans, confers susceptibility to the gastrointestinal and systemic toxicities of SubAB. Ironically, foods rich in Neu5Gc are the most common source of STEC contamination. Thus a bacterial toxin's receptor is generated by metabolic incorporation of an exogenous factor derived from food.

	~~{{STRUCTURE_3dwp\| PDB=3dwp \| SCENE= }}~~		Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin.,Byres E, Paton AW, Paton JC, Lofling JC, Smith DF, Wilce MC, Talbot UM, Chong DC, Yu H, Huang S, Chen X, Varki NM, Varki A, Rossjohn J, Beddoe T Nature. 2008 Dec 4;456(7222):648-52. Epub 2008 Oct 29. PMID:18971931<ref>PMID:18971931</ref>

	~~===Crystal structure~~ of the ~~B-subunit~~ of ~~the AB5 toxin from E~~. ~~Coli with Neu5Gc===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_18971931}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[3dwp]] is a 5 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DWP OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:018971931<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Beddoe, T.]]		[[Category: Beddoe, T]]
	[[Category: Byres, E.]]		[[Category: Byres, E]]
	[[Category: Chen, X.]]		[[Category: Chen, X]]
	[[Category: Chong, D C.]]		[[Category: Chong, D C]]
	[[Category: Huang, S.]]		[[Category: Huang, S]]
	[[Category: Lofling, J C.]]		[[Category: Lofling, J C]]
	[[Category: Paton, A W.]]		[[Category: Paton, A W]]
	[[Category: Paton, J C.]]		[[Category: Paton, J C]]
	[[Category: Rossjohn, J.]]		[[Category: Rossjohn, J]]
	[[Category: Smith, D F.]]		[[Category: Smith, D F]]
	[[Category: Talbot, U M.]]		[[Category: Talbot, U M]]
	[[Category: Varki, A.]]		[[Category: Varki, A]]
	[[Category: Varki, N M.]]		[[Category: Varki, N M]]
	[[Category: Wilce, M C.J.]]		[[Category: Wilce, M C.J]]
	[[Category: Yu, H.]]		[[Category: Yu, H]]
	[[Category: Toxin]]		[[Category: Toxin]]

OCA: Protected "3dwp" [edit=sysop:move=sysop]

2013-01-09T08:44:11Z

Protected "3dwp" [edit=sysop:move=sysop]

← Older revision	Revision as of 08:44, 9 January 2013
(No difference)

OCA at 08:44, 9 January 2013

2013-01-09T08:44:09Z

← Older revision		Revision as of 08:44, 9 January 2013
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	~~{{Seed}}~~
	[[Image:3dwp.png\|left\|200px]]		[[Image:3dwp.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3dwp", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3dwp\| PDB=3dwp \| SCENE= }}		{{STRUCTURE_3dwp\| PDB=3dwp \| SCENE= }}

	===Crystal structure of the B-subunit of the AB5 toxin from E. Coli with Neu5Gc===		===Crystal structure of the B-subunit of the AB5 toxin from E. Coli with Neu5Gc===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_18971931}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 18971931 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_18971931}}		{{ABSTRACT_PUBMED_18971931}}

	==About this Structure==		==About this Structure==
	~~3DWP~~ is a 5 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DWP OCA].		[[3dwp]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DWP OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~18971931~~</ref><references group="xtra"/>		<ref group="xtra">PMID:018971931</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Beddoe, T.]]		[[Category: Beddoe, T.]]
Line 41:		Line 29:
	[[Category: Yu, H.]]		[[Category: Yu, H.]]
	[[Category: Toxin]]		[[Category: Toxin]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:50:03 2009''~~

OCA at 10:50, 16 February 2009

2009-02-16T10:50:03Z

← Older revision		Revision as of 10:50, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
	3DWP is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DWP OCA].		3DWP is a 5 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DWP OCA].

	==Reference==		==Reference==
	Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin., Byres E, Paton AW, Paton JC, Lofling JC, Smith DF, Wilce MC, Talbot UM, Chong DC, Yu H, Huang S, Chen X, Varki NM, Varki A, Rossjohn J, Beddoe T, Nature. 2008 Dec 4;456(7222):648-52. Epub 2008 Oct 29. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18971931 18971931]~~		<ref group="xtra">PMID:18971931</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: ~~Single protein~~]]		[[Category: Beddoe, T.]]
	[[Category: ~~Pdbx_ordinal=~~, ~~<PDBx~~:~~audit_author~~.]]		[[Category: Byres, E.]]
			[[Category: Chen, X.]]
			[[Category: Chong, D C.]]
			[[Category: Huang, S.]]
			[[Category: Lofling, J C.]]
			[[Category: Paton, A W.]]
			[[Category: Paton, J C.]]
			[[Category: Rossjohn, J.]]
			[[Category: Smith, D F.]]
			[[Category: Talbot, U M.]]
			[[Category: Varki, A.]]
			[[Category: Varki, N M.]]
			[[Category: Wilce, M C.J.]]
			[[Category: Yu, H.]]
	[[Category: Toxin]]		[[Category: Toxin]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Dec 10 20~~:35:~~30 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:50:03 2009''

OCA at 06:35, 11 December 2008

2008-12-11T06:35:58Z

← Older revision		Revision as of 06:35, 11 December 2008
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
	3DWP is a ~~5 chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DWP OCA].		3DWP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DWP OCA].

	==Reference==		==Reference==
	Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin., Byres E, Paton AW, Paton JC, Lofling JC, Smith DF, Wilce MC, Talbot UM, Chong DC, Yu H, Huang S, Chen X, Varki NM, Varki A, Rossjohn J, Beddoe T, Nature. 2008 Dec 4;456(7222):648-52. Epub 2008 Oct 29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18971931 18971931]		Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin., Byres E, Paton AW, Paton JC, Lofling JC, Smith DF, Wilce MC, Talbot UM, Chong DC, Yu H, Huang S, Chen X, Varki NM, Varki A, Rossjohn J, Beddoe T, Nature. 2008 Dec 4;456(7222):648-52. Epub 2008 Oct 29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18971931 18971931]
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: ~~Beddoe, T.]]~~		[[Category: Single protein]]
	~~[[Category: Byres, E.]]~~		[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
	~~[[Category: Chen, X.]]~~
	~~[[Category: Chong, D C.]]~~
	~~[[Category: Huang, S.]]~~
	~~[[Category: Lofling, J C.]]~~
	~~[[Category: Paton, A W.]]~~
	~~[[Category: Paton, J C.]]~~
	~~[[Category: Rossjohn, J.]]~~
	~~[[Category: Smith, D F.]]~~
	~~[[Category: Talbot, U M.]]~~
	~~[[Category: Varki, A.]]~~
	~~[[Category: Varki, N M.~~]]
	[[Category: ~~Wilce~~, ~~M C.J.]]~~
	~~[[Category~~: ~~Yu, H~~.]]
	[[Category: Toxin]]		[[Category: Toxin]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 10 15:26:00 2008''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 10 20:35:30 2008''

OCA at 13:26, 10 December 2008

2008-12-10T13:26:01Z

← Older revision		Revision as of 13:26, 10 December 2008
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	{{Seed}}		{{Seed}}
	[[Image:3dwp.~~jpg~~\|left\|200px]]		[[Image:3dwp.png\|left\|200px]]

	<!--		<!--
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	===Crystal structure of the B-subunit of the AB5 toxin from E. Coli with Neu5Gc===		===Crystal structure of the B-subunit of the AB5 toxin from E. Coli with Neu5Gc===


			<!--
			The line below this paragraph, {{ABSTRACT_PUBMED_18971931}}, adds the Publication Abstract to the page
			(as it appears on PubMed at http://www.pubmed.gov), where 18971931 is the PubMed ID number.
			-->
			{{ABSTRACT_PUBMED_18971931}}

	==About this Structure==		==About this Structure==
	3DWP is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DWP OCA].		3DWP is a 5 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DWP OCA].

			==Reference==
			Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin., Byres E, Paton AW, Paton JC, Lofling JC, Smith DF, Wilce MC, Talbot UM, Chong DC, Yu H, Huang S, Chen X, Varki NM, Varki A, Rossjohn J, Beddoe T, Nature. 2008 Dec 4;456(7222):648-52. Epub 2008 Oct 29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18971931 18971931]
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	~~[[Category: Single protein]]~~
	[[Category: Beddoe, T.]]		[[Category: Beddoe, T.]]
	[[Category: Byres, E.]]		[[Category: Byres, E.]]
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	[[Category: Toxin]]		[[Category: Toxin]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Nov 5 12~~:47:56 2008''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 10 15:26:00 2008''