3e2b - Revision history

OCA at 12:57, 30 August 2023

2023-08-30T12:57:17Z

← Older revision		Revision as of 12:57, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='3e2b' size='340' side='right'caption='[[3e2b]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3e2b' size='340' side='right'caption='[[3e2b]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3e2b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Drome Drome~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2p1k 2p1k]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E2B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E2B FirstGlance]. <br>		<table><tr><td colspan='2'>[[3e2b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2p1k 2p1k]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E2B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E2B FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[2p1k\|2p1k]]~~<~~/div></td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">ctp, Cdlc1, ddlc1, CG6998 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e2b OCA], [https://pdbe.org/3e2b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e2b RCSB], [https://www.ebi.ac.uk/pdbsum/3e2b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e2b ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e2b OCA], [https://pdbe.org/3e2b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e2b RCSB], [https://www.ebi.ac.uk/pdbsum/3e2b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e2b ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/DYL1_DROME DYL1_DROME]] Acts as a non-catalytic accessory component of a dynein complex (By similarity). [[https://www.uniprot.org/uniprot/SWA_DROME SWA_DROME]] Has a role in localizing bicoid mRNA at the anterior margin of the oocyte during oogenesis, and a poorly characterized role in nuclear divisions in early embryogenesis.<ref>PMID:1806330</ref>		[https://www.uniprot.org/uniprot/DYL1_DROME DYL1_DROME] Acts as a non-catalytic accessory component of a dynein complex (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Drome~~]]		[[Category: Drosophila melanogaster]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Barbar, E]]		[[Category: Barbar E]]
	[[Category: Benison, G]]		[[Category: Benison G]]
	[[Category: Karplus~~, P A]]~~		[[Category: Karplus PA]]
	~~[[Category: Cytoplasm]]~~
	~~[[Category: Dynein]]~~
	~~[[Category: Microtubule]]~~
	~~[[Category: Motor protein]]~~
	~~[[Category: Protein-peptide complex]]~~
	~~[[Category: Transport protein~~]]

OCA at 08:13, 9 February 2022

2022-02-09T08:13:43Z

← Older revision		Revision as of 08:13, 9 February 2022
Line 1:		Line 1:

	==Crystal structure of Dynein Light chain LC8 in complex with a peptide derived from Swallow==		==Crystal structure of Dynein Light chain LC8 in complex with a peptide derived from Swallow==
	<StructureSection load='3e2b' size='340' side='right' caption='[[3e2b]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3e2b' size='340' side='right'caption='[[3e2b]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3e2b]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Drome Drome]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2p1k 2p1k]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E2B OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3E2B FirstGlance]. <br>		<table><tr><td colspan='2'>[[3e2b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2p1k 2p1k]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E2B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E2B FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p1k\|2p1k]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2p1k\|2p1k]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ctp, Cdlc1, ddlc1, CG6998 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ctp, Cdlc1, ddlc1, CG6998 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3e2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e2b OCA], [~~http~~://pdbe.org/3e2b PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3e2b RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3e2b PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3e2b ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e2b OCA], [https://pdbe.org/3e2b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e2b RCSB], [https://www.ebi.ac.uk/pdbsum/3e2b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e2b ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/DYL1_DROME DYL1_DROME]] Acts as a non-catalytic accessory component of a dynein complex (By similarity). [[~~http~~://www.uniprot.org/uniprot/SWA_DROME SWA_DROME]] Has a role in localizing bicoid mRNA at the anterior margin of the oocyte during oogenesis, and a poorly characterized role in nuclear divisions in early embryogenesis.<ref>PMID:1806330</ref>		[[https://www.uniprot.org/uniprot/DYL1_DROME DYL1_DROME]] Acts as a non-catalytic accessory component of a dynein complex (By similarity). [[https://www.uniprot.org/uniprot/SWA_DROME SWA_DROME]] Has a role in localizing bicoid mRNA at the anterior margin of the oocyte during oogenesis, and a poorly characterized role in nuclear divisions in early embryogenesis.<ref>PMID:1806330</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:

	==See Also==		==See Also==
	*[[Dynein\|Dynein]]		*[[Dynein 3D structures\|Dynein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 38:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Drome]]		[[Category: Drome]]
			[[Category: Large Structures]]
	[[Category: Barbar, E]]		[[Category: Barbar, E]]
	[[Category: Benison, G]]		[[Category: Benison, G]]

OCA at 21:54, 2 December 2018

2018-12-02T21:54:55Z

← Older revision		Revision as of 21:54, 2 December 2018
Line 1:		Line 1:

	==Crystal structure of Dynein Light chain LC8 in complex with a peptide derived from Swallow==		==Crystal structure of Dynein Light chain LC8 in complex with a peptide derived from Swallow==
	<StructureSection load='3e2b' size='340' side='right' caption='[[3e2b]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3e2b' size='340' side='right' caption='[[3e2b]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p1k\|2p1k]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p1k\|2p1k]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ctp, Cdlc1, ddlc1, CG6998 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ctp, Cdlc1, ddlc1, CG6998 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e2b OCA], [http://pdbe.org/3e2b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3e2b RCSB], [http://www.ebi.ac.uk/pdbsum/3e2b PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e2b OCA], [http://pdbe.org/3e2b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3e2b RCSB], [http://www.ebi.ac.uk/pdbsum/3e2b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3e2b ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e2/3e2b_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e2/3e2b_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 40:		Line 41:
	[[Category: Benison, G]]		[[Category: Benison, G]]
	[[Category: Karplus, P A]]		[[Category: Karplus, P A]]
			[[Category: Cytoplasm]]
	[[Category: Dynein]]		[[Category: Dynein]]
	[[Category: Microtubule]]		[[Category: Microtubule]]

OCA at 08:09, 9 February 2016

2016-02-09T08:09:41Z

← Older revision		Revision as of 08:09, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3e2b' size='340' side='right' caption='[[3e2b]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3e2b' size='340' side='right' caption='[[3e2b]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3e2b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Drosophila_melanogaster Drosophila melanogaster~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2p1k 2p1k]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E2B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3E2B FirstGlance]. <br>		<table><tr><td colspan='2'>[[3e2b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2p1k 2p1k]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E2B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3E2B FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p1k\|2p1k]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p1k\|2p1k]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ctp, Cdlc1, ddlc1, CG6998 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 ~~Drosophila melanogaster~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ctp, Cdlc1, ddlc1, CG6998 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e2b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3e2b RCSB], [http://www.ebi.ac.uk/pdbsum/3e2b PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e2b OCA], [http://pdbe.org/3e2b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3e2b RCSB], [http://www.ebi.ac.uk/pdbsum/3e2b PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e2b ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3e2b" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Drosophila melanogaster~~]]		[[Category: Drome]]
	[[Category: Barbar, E]]		[[Category: Barbar, E]]
	[[Category: Benison, G]]		[[Category: Benison, G]]

OCA at 05:36, 25 December 2014

2014-12-25T05:36:18Z

← Older revision		Revision as of 05:36, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3e2b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2p1k 2p1k]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E2B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3E2B FirstGlance]. <br>		<table><tr><td colspan='2'>[[3e2b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2p1k 2p1k]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E2B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3E2B FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p1k\|2p1k]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p1k\|2p1k]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ctp, Cdlc1, ddlc1, CG6998 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ctp, Cdlc1, ddlc1, CG6998 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e2b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3e2b RCSB], [http://www.ebi.ac.uk/pdbsum/3e2b PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e2b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3e2b RCSB], [http://www.ebi.ac.uk/pdbsum/3e2b PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/DYL1_DROME DYL1_DROME]] Acts as a non-catalytic accessory component of a dynein complex (By similarity). [[http://www.uniprot.org/uniprot/SWA_DROME SWA_DROME]] Has a role in localizing bicoid mRNA at the anterior margin of the oocyte during oogenesis, and a poorly characterized role in nuclear divisions in early embryogenesis.<ref>PMID:1806330</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Drosophila melanogaster]]		[[Category: Drosophila melanogaster]]
	[[Category: Barbar, E.]]		[[Category: Barbar, E]]
	[[Category: Benison, G.]]		[[Category: Benison, G]]
	[[Category: Karplus, P A.]]		[[Category: Karplus, P A]]
	[[Category: Dynein]]		[[Category: Dynein]]
	[[Category: Microtubule]]		[[Category: Microtubule]]

OCA at 13:17, 29 September 2014

2014-09-29T13:17:40Z

← Older revision		Revision as of 13:17, 29 September 2014
Line 1:		Line 1:
	[[Image:~~3e2b~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of Dynein Light chain LC8 in complex with a peptide derived from Swallow==
			<StructureSection load='3e2b' size='340' side='right' caption='[[3e2b]], [[Resolution\|resolution]] 2.00Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3e2b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2p1k 2p1k]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E2B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3E2B FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p1k\|2p1k]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ctp, Cdlc1, ddlc1, CG6998 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e2b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3e2b RCSB], [http://www.ebi.ac.uk/pdbsum/3e2b PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e2/3e2b_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Dynein light chain LC8 is a small, dimeric, and very highly conserved globular protein that is an integral part of the dynein and myosin molecular motors but appears to have a broader role in multiple protein complexes unrelated to molecular motors. LC8 binds to two families of targets: those having a KXTQT sequence fingerprint and those having a GIQVD fingerprint. All known LC8 binding partners containing these fingerprints share a common binding site on LC8 that raises the question of what determines binding specificity. Here, we present the crystal structure of apo-LC8 at 1.7-A resolution, which, when compared with the crystal structures of several LC8 complexes, gives insight into the mechanism underlying the binding diversity of LC8. Peptide binding is associated with a shift in quaternary structure that expands the hydrophobic binding surface available to the ligand, in addition to changes in tertiary structure and ordering of LC8 around the binding groove. The observed quaternary shift suggests a mechanism by which binding at one of the two identical sites can influence binding at the other. NMR spectra of titrations with peptides from each fingerprint family show evidence of allosteric interaction between the two binding sites, to a differing degree in the two ligand families. Allosteric interaction between the binding sites may be a mechanism to promote simultaneous binding of ligands from the same family, providing a physiological role for the two fingerprints.

	~~{{STRUCTURE_3e2b\| PDB=3e2b \| SCENE= }}~~		The interplay of ligand binding and quaternary structure in the diverse interactions of dynein light chain LC8.,Benison G, Karplus PA, Barbar E J Mol Biol. 2008 Dec 26;384(4):954-66. Epub 2008 Oct 11. PMID:18948118<ref>PMID:18948118</ref>

	~~===Crystal structure~~ of ~~Dynein Light chain LC8 in complex with a peptide derived from Swallow===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_18948118}}~~

	~~==About this Structure==~~
	~~[[3e2b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. This structure supersedes~~ the ~~now removed PDB entry [http://oca~~.~~weizmann~~.ac.~~il/oca-bin/send-pdb?obs=1&id=2p1k 2p1k]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin~~/~~ocashort?id=3E2B OCA].~~

	==See Also==		==See Also==
	*[[Dynein\|Dynein]]		*[[Dynein\|Dynein]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:018948118<~~/~~ref~~><~~ref group="xtra">PMID:017570393</ref><references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Drosophila melanogaster]]		[[Category: Drosophila melanogaster]]
	[[Category: Barbar, E.]]		[[Category: Barbar, E.]]

OCA at 13:13, 20 October 2012

2012-10-20T13:13:35Z

← Older revision		Revision as of 13:13, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[3e2b]] is a 2 chain structure ~~of [[Dynein]]~~ with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2p1k 2p1k]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E2B OCA].		[[3e2b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2p1k 2p1k]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E2B OCA].

	==See Also==		==See Also==

OCA at 11:17, 26 July 2012

2012-07-26T11:17:37Z

← Older revision		Revision as of 11:17, 26 July 2012
Line 1:		Line 1:
	[[Image:3e2b.png\|left\|200px]]		[[Image:3e2b.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3e2b", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3e2b\| PDB=3e2b \| SCENE= }}		{{STRUCTURE_3e2b\| PDB=3e2b \| SCENE= }}

	===Crystal structure of Dynein Light chain LC8 in complex with a peptide derived from Swallow===		===Crystal structure of Dynein Light chain LC8 in complex with a peptide derived from Swallow===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_18948118}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 18948118 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_18948118}}		{{ABSTRACT_PUBMED_18948118}}

	==About this Structure==		==About this Structure==
	[[3e2b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2p1k 2p1k]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E2B OCA].		[[3e2b]] is a 2 chain structure of [[Dynein]] with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2p1k 2p1k]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E2B OCA].

			==See Also==
			*[[Dynein\|Dynein]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~18948118~~</ref><ref group="xtra">PMID:~~17570393~~</ref><references group="xtra"/>		<ref group="xtra">PMID:018948118</ref><ref group="xtra">PMID:017570393</ref><references group="xtra"/>
	[[Category: Drosophila melanogaster]]		[[Category: Drosophila melanogaster]]
	[[Category: Barbar, E.]]		[[Category: Barbar, E.]]
	[[Category: Benison, G.]]		[[Category: Benison, G.]]
	[[Category: Karplus, P A.]]		[[Category: Karplus, P A.]]
	~~[[Category: Cytoplasm]]~~
	[[Category: Dynein]]		[[Category: Dynein]]
	[[Category: Microtubule]]		[[Category: Microtubule]]

OCA: Protected "3e2b" [edit=sysop:move=sysop]

2011-03-14T20:35:34Z

Protected "3e2b" [edit=sysop:move=sysop]

← Older revision	Revision as of 20:35, 14 March 2011
(No difference)

OCA at 20:35, 14 March 2011

2011-03-14T20:35:32Z

← Older revision		Revision as of 20:35, 14 March 2011
Line 1:		Line 1:
	~~{{Seed}}~~
	[[Image:3e2b.png\|left\|200px]]		[[Image:3e2b.png\|left\|200px]]

Line 20:		Line 19:

	==About this Structure==		==About this Structure==
	~~3E2B~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2p1k 2p1k]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E2B OCA].		[[3e2b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2p1k 2p1k]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E2B OCA].

	==Reference==		==Reference==
Line 34:		Line 33:
	[[Category: Protein-peptide complex]]		[[Category: Protein-peptide complex]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 08:14:34 2009''~~