3ech - Revision history

OCA at 13:00, 30 August 2023

2023-08-30T13:00:45Z

← Older revision		Revision as of 13:00, 30 August 2023
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	<StructureSection load='3ech' size='340' side='right'caption='[[3ech]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3ech' size='340' side='right'caption='[[3ech]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ech]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ECH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ECH FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ech]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ECH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ECH FirstGlance]. <br>
	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>mexR, PA0424 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~287~~ "~~Bacillus aeruginosus~~" ~~(Schroeter 1872) Trevisan 1885])~~, ~~PA3719 (~~[~~https://www.ncbi.nlm~~.~~nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5~~&~~id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.802Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ech FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ech OCA], [https://pdbe.org/3ech PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ech RCSB], [https://www.ebi.ac.uk/pdbsum/3ech PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ech ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ech FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ech OCA], [https://pdbe.org/3ech PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ech RCSB], [https://www.ebi.ac.uk/pdbsum/3ech PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ech ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/MEXR_PSEAE MEXR_PSEAE]] Repressor of the mexAB-oprM multidrug resistance operon. Also represses its own expression. Many variants lead to increased expression of the mexAB-oprM operon.		[https://www.uniprot.org/uniprot/MEXR_PSEAE MEXR_PSEAE] Repressor of the mexAB-oprM multidrug resistance operon. Also represses its own expression. Many variants lead to increased expression of the mexAB-oprM operon.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Strynadka, N C.J~~]]		[[Category: Pseudomonas aeruginosa]]
	[[Category: ~~Wilke, M S~~]]		[[Category: Strynadka NCJ]]
	[[Category: ~~Dna-binding]]~~		[[Category: Wilke MS]]
	~~[[Category: Helix-turn-helix]]~~
	~~[[Category: Protein-peptide complex]]~~
	~~[[Category: Repressor]]~~
	~~[[Category: Transcription]]~~
	~~[[Category: Transcription regulation]]~~
	~~[[Category: Winged helix~~]]

OCA at 19:38, 20 October 2021

2021-10-20T19:38:34Z

← Older revision		Revision as of 19:38, 20 October 2021
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	==The MarR-family repressor MexR in complex with its antirepressor ArmR==		==The MarR-family repressor MexR in complex with its antirepressor ArmR==
	<StructureSection load='3ech' size='340' side='right' caption='[[3ech]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3ech' size='340' side='right'caption='[[3ech]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ech]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ECH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ECH FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ech]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ECH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ECH FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mexR, PA0424 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885]), PA3719 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mexR, PA0424 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885]), PA3719 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ech FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ech OCA], [~~http~~://pdbe.org/3ech PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ech RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ech PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ech ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ech FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ech OCA], [https://pdbe.org/3ech PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ech RCSB], [https://www.ebi.ac.uk/pdbsum/3ech PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ech ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/MEXR_PSEAE MEXR_PSEAE]] Repressor of the mexAB-oprM multidrug resistance operon. Also represses its own expression. Many variants lead to increased expression of the mexAB-oprM operon.		[[https://www.uniprot.org/uniprot/MEXR_PSEAE MEXR_PSEAE]] Repressor of the mexAB-oprM multidrug resistance operon. Also represses its own expression. Many variants lead to increased expression of the mexAB-oprM operon.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ec/3ech_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ec/3ech_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Strynadka, N C.J]]		[[Category: Strynadka, N C.J]]
	[[Category: Wilke, M S]]		[[Category: Wilke, M S]]

OCA at 09:08, 25 October 2017

2017-10-25T09:08:20Z

← Older revision		Revision as of 09:08, 25 October 2017
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	==The MarR-family repressor MexR in complex with its antirepressor ArmR==		==The MarR-family repressor MexR in complex with its antirepressor ArmR==
	<StructureSection load='3ech' size='340' side='right' caption='[[3ech]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3ech' size='340' side='right' caption='[[3ech]], [[Resolution\|resolution]] 1.80Å' scene=''>
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	<table><tr><td colspan='2'>[[3ech]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ECH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ECH FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ech]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ECH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ECH FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mexR, PA0424 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885]), PA3719 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mexR, PA0424 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885]), PA3719 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ech FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ech OCA], [http://pdbe.org/3ech PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ech RCSB], [http://www.ebi.ac.uk/pdbsum/3ech PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ech FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ech OCA], [http://pdbe.org/3ech PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ech RCSB], [http://www.ebi.ac.uk/pdbsum/3ech PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ech ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 05:36, 8 February 2016

2016-02-08T05:36:18Z

← Older revision		Revision as of 05:36, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3ech' size='340' side='right' caption='[[3ech]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3ech' size='340' side='right' caption='[[3ech]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ech]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pseudomonas_aeruginosa Pseudomonas aeruginosa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ECH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ECH FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ech]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ECH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ECH FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mexR, PA0424 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 ~~Pseudomonas aeruginosa~~]), PA3719 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 ~~Pseudomonas aeruginosa~~])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mexR, PA0424 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885]), PA3719 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ech FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ech OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ech RCSB], [http://www.ebi.ac.uk/pdbsum/3ech PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ech FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ech OCA], [http://pdbe.org/3ech PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ech RCSB], [http://www.ebi.ac.uk/pdbsum/3ech PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ech ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3ech" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Pseudomonas aeruginosa]]~~
	[[Category: Strynadka, N C.J]]		[[Category: Strynadka, N C.J]]
	[[Category: Wilke, M S]]		[[Category: Wilke, M S]]

OCA at 21:00, 24 December 2014

2014-12-24T21:00:54Z

← Older revision		Revision as of 21:00, 24 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ech FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ech OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ech RCSB], [http://www.ebi.ac.uk/pdbsum/3ech PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ech FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ech OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ech RCSB], [http://www.ebi.ac.uk/pdbsum/3ech PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/MEXR_PSEAE MEXR_PSEAE]] Repressor of the mexAB-oprM multidrug resistance operon. Also represses its own expression. Many variants lead to increased expression of the mexAB-oprM operon.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 13:22, 19 November 2014

2014-11-19T13:22:25Z

← Older revision		Revision as of 13:22, 19 November 2014
Line 1:		Line 1:
	[[Image:~~3ech~~.~~png~~\|~~left~~\|~~200px~~]]		==The MarR-family repressor MexR in complex with its antirepressor ArmR==
			<StructureSection load='3ech' size='340' side='right' caption='[[3ech]], [[Resolution\|resolution]] 1.80Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3ech]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ECH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ECH FirstGlance]. <br>
			</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mexR, PA0424 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 Pseudomonas aeruginosa]), PA3719 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 Pseudomonas aeruginosa])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ech FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ech OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ech RCSB], [http://www.ebi.ac.uk/pdbsum/3ech PDBsum]</span></td></tr>
			</table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ec/3ech_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The intrinsic antimicrobial resistance of the opportunistic human pathogen Pseudomonas aeruginosa is compounded in mutant strains that overexpress multidrug efflux pumps such as the prominent drug-proton antiporter, MexAB-OprM. The primary regulator of the mexAB-oprM operon is the MarR family repressor, MexR. An additional repressor, NalC, also regulates mexAB-oprM by controlling expression of ArmR, an antirepressor peptide that is hypothesized to prevent the binding of MexR to its cognate DNA operator via an allosteric protein-peptide interaction. To better understand how ArmR modulates MexR, we determined the MexR-binding region of ArmR as its C-terminal 25 residues and solved the crystal structure of MexR in a 2:1 complex with this ArmR fragment at 1.8 A resolution. This structure reveals that the C-terminal residues of ArmR form a kinked alpha-helix, which occupies a pseudosymmetrical and largely hydrophobic binding cavity located at the centre of the MexR dimer. Although the ArmR-binding cavity partially overlaps with the small molecule effector-binding sites of other MarR family members, it possesses a larger and more complex binding surface to accommodate the greater size and specific physicochemical properties of a peptide effector. Comparison with the structure of apo-MexR reveals that ArmR stabilizes a dramatic conformational change that is incompatible with DNA-binding. Thus, this work defines the structural mechanism by which ArmR allosterically derepresses MexR-controlled gene expression in P. aeruginosa and reveals important insights into the regulation of multidrug resistance.

	~~{{STRUCTURE_3ech\| PDB=3ech \| SCENE= }}~~		The crystal structure of MexR from Pseudomonas aeruginosa in complex with its antirepressor ArmR.,Wilke MS, Heller M, Creagh AL, Haynes CA, McIntosh LP, Poole K, Strynadka NC Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):14832-7. Epub 2008 Sep 23. PMID:18812515<ref>PMID:18812515</ref>

	~~===The MarR-family repressor MexR in complex with its antirepressor ArmR===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_18812515}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[3ech]] is~~ a ~~3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3ECH OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:018812515<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Pseudomonas aeruginosa]]		[[Category: Pseudomonas aeruginosa]]
	[[Category: Strynadka, N C.J.]]		[[Category: Strynadka, N C.J]]
	[[Category: Wilke, M S.]]		[[Category: Wilke, M S]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
	[[Category: Helix-turn-helix]]		[[Category: Helix-turn-helix]]

OCA: Protected "3ech" [edit=sysop:move=sysop]

2013-01-09T08:48:13Z

Protected "3ech" [edit=sysop:move=sysop]

← Older revision	Revision as of 08:48, 9 January 2013
(No difference)

OCA at 08:48, 9 January 2013

2013-01-09T08:48:11Z

← Older revision		Revision as of 08:48, 9 January 2013
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	~~{{Seed}}~~
	[[Image:3ech.png\|left\|200px]]		[[Image:3ech.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3ech", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3ech\| PDB=3ech \| SCENE= }}		{{STRUCTURE_3ech\| PDB=3ech \| SCENE= }}

	===The MarR-family repressor MexR in complex with its antirepressor ArmR===		===The MarR-family repressor MexR in complex with its antirepressor ArmR===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_18812515}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 18812515 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_18812515}}		{{ABSTRACT_PUBMED_18812515}}

	==About this Structure==		==About this Structure==
	~~3ECH~~ is a 3 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ECH OCA].		[[3ech]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ECH OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~18812515~~</ref><references group="xtra"/>		<ref group="xtra">PMID:018812515</ref><references group="xtra"/>
	[[Category: Pseudomonas aeruginosa]]		[[Category: Pseudomonas aeruginosa]]
	[[Category: Strynadka, N C.J.]]		[[Category: Strynadka, N C.J.]]
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	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
	[[Category: Winged helix]]		[[Category: Winged helix]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 19:12:27 2009''~~

OCA at 17:12, 16 February 2009

2009-02-16T17:12:28Z

← Older revision		Revision as of 17:12, 16 February 2009
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
	[[Image:3ech.~~jpg~~\|left\|200px]]		[[Image:3ech.png\|left\|200px]]

	<!--		<!--
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
	3ECH is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ECH OCA].		3ECH is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ECH OCA].

	==Reference==		==Reference==
	The crystal structure of MexR from Pseudomonas aeruginosa in complex with its antirepressor ArmR., Wilke MS, Heller M, Creagh AL, Haynes CA, McIntosh LP, Poole K, Strynadka NC, Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):14832-7. Epub 2008 Sep 23. PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~18812515 18812515]~~		<ref group="xtra">PMID:18812515</ref><references group="xtra"/>
	~~[[Category: Protein complex]]~~
	[[Category: Pseudomonas aeruginosa]]		[[Category: Pseudomonas aeruginosa]]
	[[Category: Strynadka, N C.J.]]		[[Category: Strynadka, N C.J.]]
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	[[Category: Winged helix]]		[[Category: Winged helix]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Oct 22 10~~:52:~~53 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 19:12:27 2009''

OCA at 08:52, 22 October 2008

2008-10-22T08:52:53Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{Seed}}
-The entry 3ech is ON HOLD  until Paper Publication
+<!--
-Authors: Wilke, M.S., Strynadka, N.C.J.
+===The MarR-family repressor MexR in complex with its antirepressor ArmR===
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct  8 09:19:11 2008''
+<!--