3eec - Revision history

OCA at 15:21, 1 November 2023

2023-11-01T15:21:01Z

← Older revision		Revision as of 15:21, 1 November 2023
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	<StructureSection load='3eec' size='340' side='right'caption='[[3eec]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='3eec' size='340' side='right'caption='[[3eec]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3eec]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EEC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EEC FirstGlance]. <br>		<table><tr><td colspan='2'>[[3eec]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EEC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EEC FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[1ubq\|1ubq]], [[1yj1\|1yj1]]~~<~~/div></td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">RPS27A, UBA80, UBCEP1, UBA52, UBCEP2, UBB, UBC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eec OCA], [https://pdbe.org/3eec PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eec RCSB], [https://www.ebi.ac.uk/pdbsum/3eec PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eec ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eec OCA], [https://pdbe.org/3eec PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eec RCSB], [https://www.ebi.ac.uk/pdbsum/3eec PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eec ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/UBC_HUMAN UBC_HUMAN] Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.<ref>PMID:16543144</ref> <ref>PMID:19754430</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Arnesano, F]]		[[Category: Arnesano F]]
	[[Category: Falini, G]]		[[Category: Falini G]]
	[[Category: Fermani, S]]		[[Category: Fermani S]]
	[[Category: Natile, G]]		[[Category: Natile G]]
	[[Category: Tosi, G]]		[[Category: Tosi G]]
	~~[[Category: 3d structure]]~~
	~~[[Category: Adduct]]~~
	~~[[Category: Cadmium]]~~
	~~[[Category: Cytoplasm]]~~
	~~[[Category: Nucleus]]~~
	~~[[Category: Phosphoprotein]]~~
	~~[[Category: Ubiquitin]]~~
	~~[[Category: Ubl conjugation]]~~
	~~[[Category: Unknown function~~]]

OCA at 11:47, 16 February 2022

2022-02-16T11:47:45Z

← Older revision		Revision as of 11:47, 16 February 2022
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	<StructureSection load='3eec' size='340' side='right'caption='[[3eec]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='3eec' size='340' side='right'caption='[[3eec]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3eec]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EEC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3EEC FirstGlance]. <br>		<table><tr><td colspan='2'>[[3eec]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EEC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EEC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ubq\|1ubq]], [[1yj1\|1yj1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ubq\|1ubq]], [[1yj1\|1yj1]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RPS27A, UBA80, UBCEP1, UBA52, UBCEP2, UBB, UBC ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RPS27A, UBA80, UBCEP1, UBA52, UBCEP2, UBB, UBC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3eec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eec OCA], [~~http~~://pdbe.org/3eec PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3eec RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3eec PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3eec ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eec OCA], [https://pdbe.org/3eec PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eec RCSB], [https://www.ebi.ac.uk/pdbsum/3eec PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eec ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	==See Also==		==See Also==
	*[[~~Ubiquitin~~\|~~Ubiquitin~~]]		*[[3D structures of ubiquitin\|3D structures of ubiquitin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:32, 11 December 2019

2019-12-11T15:32:20Z

← Older revision		Revision as of 15:32, 11 December 2019
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	==X-ray structure of human ubiquitin Cd(II) adduct==		==X-ray structure of human ubiquitin Cd(II) adduct==
	<StructureSection load='3eec' size='340' side='right' caption='[[3eec]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='3eec' size='340' side='right'caption='[[3eec]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3eec]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EEC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EEC FirstGlance]. <br>		<table><tr><td colspan='2'>[[3eec]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EEC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EEC FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Arnesano, F]]		[[Category: Arnesano, F]]
	[[Category: Falini, G]]		[[Category: Falini, G]]

OCA at 21:49, 2 December 2018

2018-12-02T21:49:51Z

← Older revision		Revision as of 21:49, 2 December 2018
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ee/3eec_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ee/3eec_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	[[Category: Adduct]]		[[Category: Adduct]]
	[[Category: Cadmium]]		[[Category: Cadmium]]
			[[Category: Cytoplasm]]
	[[Category: Nucleus]]		[[Category: Nucleus]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
	[[Category: Ubiquitin]]		[[Category: Ubiquitin]]
			[[Category: Ubl conjugation]]
	[[Category: Unknown function]]		[[Category: Unknown function]]

OCA at 11:11, 5 August 2016

2016-08-05T11:11:00Z

← Older revision		Revision as of 11:11, 5 August 2016
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	==X-ray structure of human ubiquitin Cd(II) adduct==		==X-ray structure of human ubiquitin Cd(II) adduct==
	<StructureSection load='3eec' size='340' side='right' caption='[[3eec]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='3eec' size='340' side='right' caption='[[3eec]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3eec]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EEC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EEC FirstGlance]. <br>		<table><tr><td colspan='2'>[[3eec]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EEC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EEC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ubq\|1ubq]], [[1yj1\|1yj1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ubq\|1ubq]], [[1yj1\|1yj1]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RPS27A, UBA80, UBCEP1, UBA52, UBCEP2, UBB, UBC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RPS27A, UBA80, UBCEP1, UBA52, UBCEP2, UBB, UBC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eec OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3eec RCSB], [http://www.ebi.ac.uk/pdbsum/3eec PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eec OCA], [http://pdbe.org/3eec PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3eec RCSB], [http://www.ebi.ac.uk/pdbsum/3eec PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3eec ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3eec ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3eec" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Arnesano, F]]		[[Category: Arnesano, F]]
	[[Category: Falini, G]]		[[Category: Falini, G]]

OCA at 18:19, 25 December 2014

2014-12-25T18:19:24Z

← Older revision		Revision as of 18:19, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3eec]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EEC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EEC FirstGlance]. <br>		<table><tr><td colspan='2'>[[3eec]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EEC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EEC FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ubq\|1ubq]], [[1yj1\|1yj1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ubq\|1ubq]], [[1yj1\|1yj1]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RPS27A, UBA80, UBCEP1, UBA52, UBCEP2, UBB, UBC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RPS27A, UBA80, UBCEP1, UBA52, UBCEP2, UBB, UBC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eec OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3eec RCSB], [http://www.ebi.ac.uk/pdbsum/3eec PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eec OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3eec RCSB], [http://www.ebi.ac.uk/pdbsum/3eec PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arnesano, F.]]		[[Category: Arnesano, F]]
	[[Category: Falini, G.]]		[[Category: Falini, G]]
	[[Category: Fermani, S.]]		[[Category: Fermani, S]]
	[[Category: Natile, G.]]		[[Category: Natile, G]]
	[[Category: Tosi, G.]]		[[Category: Tosi, G]]
	[[Category: 3d structure]]		[[Category: 3d structure]]
	[[Category: Adduct]]		[[Category: Adduct]]

OCA at 12:27, 29 September 2014

2014-09-29T12:27:21Z

← Older revision		Revision as of 12:27, 29 September 2014
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	[[Image:~~3eec~~.~~png~~\|~~left~~\|~~200px~~]]		==X-ray structure of human ubiquitin Cd(II) adduct==
			<StructureSection load='3eec' size='340' side='right' caption='[[3eec]], [[Resolution\|resolution]] 3.00Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3eec]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EEC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EEC FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ubq\|1ubq]], [[1yj1\|1yj1]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RPS27A, UBA80, UBCEP1, UBA52, UBCEP2, UBB, UBC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eec OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3eec RCSB], [http://www.ebi.ac.uk/pdbsum/3eec PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ee/3eec_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			A structural investigation performed on adducts of human ubiquitin with group-12 metal ions reveals common preferential anchoring sites, the most populated one being His68; at higher metal ion concentration a second and a third site, close to the N-terminus of the protein, become populated and promote a polymorphic transition from orthorhombic to cubic form; Glu16 and Glu18, involved in the latter metal binding, undergo a remarkable displacement from their position in native ubiquitin; the aggregate stereochemistry appears to be driven by the clustering of deshielded backbone hydrogen-bond patches, and metal ions foster this process.

	~~{{STRUCTURE_3eec\| PDB=3eec \| SCENE= }}~~		Structural probing of Zn(ii), Cd(ii) and Hg(ii) binding to human ubiquitin.,Falini G, Fermani S, Tosi G, Arnesano F, Natile G Chem Commun (Camb). 2008 Dec 7;(45):5960-2. Epub 2008 Oct 9. PMID:19030552<ref>PMID:19030552</ref>

	~~===X-ray structure~~ of ~~human ubiquitin Cd(II) adduct===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_19030552}}~~

	~~==About this Structure==~~
	~~[[3eec]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=3EEC OCA].~~

	==See Also==		==See Also==
	*[[Ubiquitin\|Ubiquitin]]		*[[Ubiquitin\|Ubiquitin]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:019030552<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arnesano, F.]]		[[Category: Arnesano, F.]]

OCA at 19:53, 20 October 2012

2012-10-20T19:53:56Z

← Older revision		Revision as of 19:53, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[3eec]] is a 2 chain structure ~~of [[Ubiquitin]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EEC OCA].		[[3eec]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EEC OCA].

	==See Also==		==See Also==

OCA: Protected "3eec" [edit=sysop:move=sysop]

2012-07-27T08:49:37Z

Protected "3eec" [edit=sysop:move=sysop]

← Older revision	Revision as of 08:49, 27 July 2012
(No difference)

OCA at 08:49, 27 July 2012

2012-07-27T08:49:33Z

← Older revision		Revision as of 08:49, 27 July 2012
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	~~{{Seed}}~~		[[Image:3eec.png\|left\|200px]]
	[[Image:3eec.~~jpg~~\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3eec", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3eec\| PDB=3eec \| SCENE= }}		{{STRUCTURE_3eec\| PDB=3eec \| SCENE= }}

	===X-ray structure of human ubiquitin Cd(II) adduct===		===X-ray structure of human ubiquitin Cd(II) adduct===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_19030552}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 19030552 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_19030552}}		{{ABSTRACT_PUBMED_19030552}}

	==About this Structure==		==About this Structure==
	~~3EEC~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EEC OCA].		[[3eec]] is a 2 chain structure of [[Ubiquitin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EEC OCA].

			==See Also==
			*[[Ubiquitin\|Ubiquitin]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~19030552~~</ref><references group="xtra"/>		<ref group="xtra">PMID:019030552</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arnesano, F.]]		[[Category: Arnesano, F.]]
Line 33:		Line 24:
	[[Category: Adduct]]		[[Category: Adduct]]
	[[Category: Cadmium]]		[[Category: Cadmium]]
	~~[[Category: Cytoplasm]]~~
	[[Category: Nucleus]]		[[Category: Nucleus]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
	[[Category: Ubiquitin]]		[[Category: Ubiquitin]]
	~~[[Category: Ubl conjugation]]~~
	[[Category: Unknown function]]		[[Category: Unknown function]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 11 11:15:45 2009''~~