3ejs - Revision history

OCA at 10:45, 7 February 2016

2016-02-07T10:45:20Z

← Older revision		Revision as of 10:45, 7 February 2016
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	<StructureSection load='3ejs' size='340' side='right' caption='[[3ejs]], [[Resolution\|resolution]] 1.35Å' scene=''>		<StructureSection load='3ejs' size='340' side='right' caption='[[3ejs]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ejs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Drosophila_melanogaster Drosophila melanogaster~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EJS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EJS FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ejs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EJS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EJS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HN5:(1S,2R,5S,8R,8AR)-5-[2-(4-TERT-BUTYLPHENYL)ETHYL]OCTAHYDROINDOLIZINE-1,2,8-TRIOL'>HN5</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HN5:(1S,2R,5S,8R,8AR)-5-[2-(4-TERT-BUTYLPHENYL)ETHYL]OCTAHYDROINDOLIZINE-1,2,8-TRIOL'>HN5</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hty\|1hty]], [[1hww\|1hww]], [[1hxk\|1hxk]], [[1ps2\|1ps2]], [[1qwn\|1qwn]], [[1r33\|1r33]], [[1r34\|1r34]], [[1tqv\|1tqv]], [[2alw\|2alw]], [[2f7o\|2f7o]], [[2f7p\|2f7p]], [[2f7q\|2f7q]], [[2f7r\|2f7r]], [[2fyv\|2fyv]], [[3bub\|3bub]], [[3bup\|3bup]], [[3czn\|3czn]], [[3ejp\|3ejp]], [[3ejq\|3ejq]], [[3ejr\|3ejr]], [[3ejt\|3ejt]], [[3eju\|3eju]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hty\|1hty]], [[1hww\|1hww]], [[1hxk\|1hxk]], [[1ps2\|1ps2]], [[1qwn\|1qwn]], [[1r33\|1r33]], [[1r34\|1r34]], [[1tqv\|1tqv]], [[2alw\|2alw]], [[2f7o\|2f7o]], [[2f7p\|2f7p]], [[2f7q\|2f7q]], [[2f7r\|2f7r]], [[2fyv\|2fyv]], [[3bub\|3bub]], [[3bup\|3bup]], [[3czn\|3czn]], [[3ejp\|3ejp]], [[3ejq\|3ejq]], [[3ejr\|3ejr]], [[3ejt\|3ejt]], [[3eju\|3eju]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">alpha-Man-II, GmII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 ~~Drosophila melanogaster~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">alpha-Man-II, GmII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-oligosaccharide_1,3-1,6-alpha-mannosidase Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.114 3.2.1.114] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-oligosaccharide_1,3-1,6-alpha-mannosidase Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.114 3.2.1.114] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ejs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ejs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ejs RCSB], [http://www.ebi.ac.uk/pdbsum/3ejs PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ejs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ejs OCA], [http://pdbe.org/3ejs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ejs RCSB], [http://www.ebi.ac.uk/pdbsum/3ejs PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ejs ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3ejs" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Drosophila melanogaster~~]]		[[Category: Drome]]
	[[Category: Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase]]		[[Category: Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase]]
	[[Category: Kuntz, D A]]		[[Category: Kuntz, D A]]

OCA at 14:30, 24 December 2014

2014-12-24T14:30:51Z

← Older revision		Revision as of 14:30, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ejs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EJS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EJS FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ejs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EJS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EJS FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HN5:(1S,2R,5S,8R,8AR)-5-[2-(4-TERT-BUTYLPHENYL)ETHYL]OCTAHYDROINDOLIZINE-1,2,8-TRIOL'>HN5</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HN5:(1S,2R,5S,8R,8AR)-5-[2-(4-TERT-BUTYLPHENYL)ETHYL]OCTAHYDROINDOLIZINE-1,2,8-TRIOL'>HN5</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hty\|1hty]], [[1hww\|1hww]], [[1hxk\|1hxk]], [[1ps2\|1ps2]], [[1qwn\|1qwn]], [[1r33\|1r33]], [[1r34\|1r34]], [[1tqv\|1tqv]], [[2alw\|2alw]], [[2f7o\|2f7o]], [[2f7p\|2f7p]], [[2f7q\|2f7q]], [[2f7r\|2f7r]], [[2fyv\|2fyv]], [[3bub\|3bub]], [[3bup\|3bup]], [[3czn\|3czn]], [[3ejp\|3ejp]], [[3ejq\|3ejq]], [[3ejr\|3ejr]], [[3ejt\|3ejt]], [[3eju\|3eju]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hty\|1hty]], [[1hww\|1hww]], [[1hxk\|1hxk]], [[1ps2\|1ps2]], [[1qwn\|1qwn]], [[1r33\|1r33]], [[1r34\|1r34]], [[1tqv\|1tqv]], [[2alw\|2alw]], [[2f7o\|2f7o]], [[2f7p\|2f7p]], [[2f7q\|2f7q]], [[2f7r\|2f7r]], [[2fyv\|2fyv]], [[3bub\|3bub]], [[3bup\|3bup]], [[3czn\|3czn]], [[3ejp\|3ejp]], [[3ejq\|3ejq]], [[3ejr\|3ejr]], [[3ejt\|3ejt]], [[3eju\|3eju]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">alpha-Man-II, GmII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">alpha-Man-II, GmII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-oligosaccharide_1,3-1,6-alpha-mannosidase Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.114 3.2.1.114] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-oligosaccharide_1,3-1,6-alpha-mannosidase Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.114 3.2.1.114] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ejs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ejs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ejs RCSB], [http://www.ebi.ac.uk/pdbsum/3ejs PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ejs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ejs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ejs RCSB], [http://www.ebi.ac.uk/pdbsum/3ejs PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/MAN2_DROME MAN2_DROME]] Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Drosophila melanogaster]]		[[Category: Drosophila melanogaster]]
	[[Category: Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase]]		[[Category: Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase]]
	[[Category: Kuntz, D A.]]		[[Category: Kuntz, D A]]
	[[Category: Rose, D R.]]		[[Category: Rose, D R]]
	[[Category: Shea, K.]]		[[Category: Shea, K]]
	[[Category: Gh38 glycosidase]]		[[Category: Gh38 glycosidase]]
	[[Category: Glycosidase]]		[[Category: Glycosidase]]

OCA at 11:01, 29 September 2014

2014-09-29T11:01:08Z

← Older revision		Revision as of 11:01, 29 September 2014
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	[[Image:~~3ejs~~.~~png~~\|~~left~~\|~~200px~~]]		==Golgi alpha-Mannosidase II in complex with 5-substituted swainsonine analog: (5S)-5-[2'-(4-tert-butylphenyl)ethyl]-swainsonine==
			<StructureSection load='3ejs' size='340' side='right' caption='[[3ejs]], [[Resolution\|resolution]] 1.35Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3ejs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EJS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EJS FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HN5:(1S,2R,5S,8R,8AR)-5-[2-(4-TERT-BUTYLPHENYL)ETHYL]OCTAHYDROINDOLIZINE-1,2,8-TRIOL'>HN5</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hty\|1hty]], [[1hww\|1hww]], [[1hxk\|1hxk]], [[1ps2\|1ps2]], [[1qwn\|1qwn]], [[1r33\|1r33]], [[1r34\|1r34]], [[1tqv\|1tqv]], [[2alw\|2alw]], [[2f7o\|2f7o]], [[2f7p\|2f7p]], [[2f7q\|2f7q]], [[2f7r\|2f7r]], [[2fyv\|2fyv]], [[3bub\|3bub]], [[3bup\|3bup]], [[3czn\|3czn]], [[3ejp\|3ejp]], [[3ejq\|3ejq]], [[3ejr\|3ejr]], [[3ejt\|3ejt]], [[3eju\|3eju]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">alpha-Man-II, GmII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-oligosaccharide_1,3-1,6-alpha-mannosidase Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.114 3.2.1.114] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ejs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ejs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ejs RCSB], [http://www.ebi.ac.uk/pdbsum/3ejs PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ej/3ejs_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Golgi alpha-mannosidase II (GMII) is a key enzyme in the N-glycosylation pathway and is a potential target for cancer chemotherapy. The natural product swainsonine is a potent inhibitor of GMII. In this paper we characterize the binding of 5alpha-substituted swainsonine analogues to the soluble catalytic domain of Drosophila GMII by X-ray crystallography. These inhibitors enjoy an advantage over previously reported GMII inhibitors in that they did not significantly decrease the inhibitory potential of the swainsonine head-group. The phenyl groups of these analogues occupy a portion of the binding site not previously seen to be populated with either substrate analogues or other inhibitors and they form novel hydrophobic interactions. They displace a well-organized water cluster, but the presence of a C(10) carbonyl allows the reestablishment of important hydrogen bonds. Already approximately tenfold more active against the Golgi enzyme than the lysosomal enzyme, these inhibitors offer the potential of being extended into the N-acetylglucosamine binding site of GMII for the creation of even more potent and selective GMII inhibitors.

	~~{{STRUCTURE_3ejs\| PDB=3ejs \| SCENE= }}~~		Structural Investigation of the Binding of 5-Substituted Swainsonine Analogues to Golgi alpha-Mannosidase II.,Kuntz DA, Nakayama S, Shea K, Hori H, Uto Y, Nagasawa H, Rose DR Chembiochem. 2010 Mar 5;11(5):673-680. PMID:20209559<ref>PMID:20209559</ref>

	~~===Golgi alpha-Mannosidase II in complex with 5-substituted swainsonine analog: (5S)-5-[2'-(4-tert-butylphenyl)ethyl]-swainsonine===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_20209559}}~~

	~~==About this Structure==~~
	~~[[3ejs]] is~~ a ~~1 chain structure with sequence from [http://en.wikipedia~~.~~org/wiki/Drosophila_melanogaster Drosophila melanogaster]~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann.ac.il/oca-bin~~/~~ocashort?id=3EJS OCA].~~

	==See Also==		==See Also==
	*[[Mannosidase\|Mannosidase]]		*[[Mannosidase\|Mannosidase]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:020209559<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Drosophila melanogaster]]		[[Category: Drosophila melanogaster]]
	[[Category: Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase]]		[[Category: Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase]]

OCA at 06:24, 20 October 2012

2012-10-20T06:24:13Z

← Older revision		Revision as of 06:24, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[3ejs]] is a 1 chain structure ~~of [[Mannosidase]]~~ with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EJS OCA].		[[3ejs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EJS OCA].

	==See Also==		==See Also==

OCA: Protected "3ejs" [edit=sysop:move=sysop]

2012-07-25T13:04:32Z

Protected "3ejs" [edit=sysop:move=sysop]

← Older revision	Revision as of 13:04, 25 July 2012
(No difference)

OCA at 13:04, 25 July 2012

2012-07-25T13:04:31Z

← Older revision		Revision as of 13:04, 25 July 2012
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	~~{{Seed}}~~
	[[Image:3ejs.png\|left\|200px]]		[[Image:3ejs.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3ejs", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3ejs\| PDB=3ejs \| SCENE= }}		{{STRUCTURE_3ejs\| PDB=3ejs \| SCENE= }}

	===Golgi alpha-Mannosidase II in complex with 5-substituted swainsonine analog: (5S)-5-[2'-(4-tert-butylphenyl)ethyl]-swainsonine===		===Golgi alpha-Mannosidase II in complex with 5-substituted swainsonine analog: (5S)-5-[2'-(4-tert-butylphenyl)ethyl]-swainsonine===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_20209559}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 20209559 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_20209559}}		{{ABSTRACT_PUBMED_20209559}}

	==About this Structure==		==About this Structure==
	~~3EJS~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EJS OCA].		[[3ejs]] is a 1 chain structure of [[Mannosidase]] with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EJS OCA].

			==See Also==
			*[[Mannosidase\|Mannosidase]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~20209559~~</ref><references group="xtra"/>		<ref group="xtra">PMID:020209559</ref><references group="xtra"/>
	[[Category: Drosophila melanogaster]]		[[Category: Drosophila melanogaster]]
	[[Category: Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase]]		[[Category: Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase]]
Line 37:		Line 28:
	[[Category: Signal-anchor]]		[[Category: Signal-anchor]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
	~~[[Category: Zinc]]~~

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 31 13:09:04 2010''~~

OCA at 10:09, 31 March 2010

2010-03-31T10:09:05Z

← Older revision		Revision as of 10:09, 31 March 2010
Line 12:		Line 12:
	===Golgi alpha-Mannosidase II in complex with 5-substituted swainsonine analog: (5S)-5-[2'-(4-tert-butylphenyl)ethyl]-swainsonine===		===Golgi alpha-Mannosidase II in complex with 5-substituted swainsonine analog: (5S)-5-[2'-(4-tert-butylphenyl)ethyl]-swainsonine===


			<!--
			The line below this paragraph, {{ABSTRACT_PUBMED_20209559}}, adds the Publication Abstract to the page
			(as it appears on PubMed at http://www.pubmed.gov), where 20209559 is the PubMed ID number.
			-->
			{{ABSTRACT_PUBMED_20209559}}

	==About this Structure==		==About this Structure==
	3EJS is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EJS OCA].		3EJS is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EJS OCA].

			==Reference==
			<ref group="xtra">PMID:20209559</ref><references group="xtra"/>
	[[Category: Drosophila melanogaster]]		[[Category: Drosophila melanogaster]]
	[[Category: Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase]]		[[Category: Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase]]
Line 30:		Line 39:
	[[Category: Zinc]]		[[Category: Zinc]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Jan 28 15~~:00:12 2010''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 31 13:09:04 2010''

OCA at 13:00, 28 January 2010

2010-01-28T13:00:13Z

← Older revision		Revision as of 13:00, 28 January 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
	[[Image:3ejs.~~jpg~~\|left\|200px]]		[[Image:3ejs.png\|left\|200px]]

	<!--		<!--
Line 14:		Line 14:

	==About this Structure==		==About this Structure==
	3EJS is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EJS OCA].		3EJS is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EJS OCA].
	[[Category: Drosophila melanogaster]]		[[Category: Drosophila melanogaster]]
	[[Category: Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase]]		[[Category: Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase]]
Line 30:		Line 30:
	[[Category: Zinc]]		[[Category: Zinc]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Oct 14 10~~:30:~~57 2009~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jan 28 15:00:12 2010''

OCA at 08:30, 14 October 2009

2009-10-14T08:30:59Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{Seed}}
-The entry 3ejs is ON HOLD
+<!--
-Authors: Kuntz, D.A., Shea, K., Rose, D.R.
+===Golgi alpha-Mannosidase II in complex with 5-substituted swainsonine analog: (5S)-5-[2'-(4-tert-butylphenyl)ethyl]-swainsonine===
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct  7 13:39:59 2009''
+==About this Structure==

OCA at 11:39, 7 October 2009

2009-10-07T11:39:59Z

← Older revision		Revision as of 11:39, 7 October 2009
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 3ejs is ON HOLD ~~until Paper Publication~~		The entry 3ejs is ON HOLD

	Authors: Kuntz, D.A., Shea, K., Rose, D.R.		Authors: Kuntz, D.A., Shea, K., Rose, D.R.
Line 7:		Line 7:
	Description: Golgi alpha-Mannosidase II in complex with 5-substituted swainsonine analog: (5R)-5-[2'-(4-tert-butylphenyl)ethyl]-swainsonine		Description: Golgi alpha-Mannosidase II in complex with 5-substituted swainsonine analog: (5R)-5-[2'-(4-tert-butylphenyl)ethyl]-swainsonine

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Mar 22 10~~:23:16 2009''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 7 13:39:59 2009''