3err - Revision history

OCA at 06:32, 6 September 2023

2023-09-06T06:32:09Z

← Older revision		Revision as of 06:32, 6 September 2023
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	<StructureSection load='3err' size='340' side='right'caption='[[3err]], [[Resolution\|resolution]] 2.27Å' scene=''>		<StructureSection load='3err' size='340' side='right'caption='[[3err]], [[Resolution\|resolution]] 2.27Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3err]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ERR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ERR FirstGlance]. <br>		<table><tr><td colspan='2'>[[3err]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB27 Thermus thermophilus HB27]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ERR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ERR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.27Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3err FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3err OCA], [https://pdbe.org/3err PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3err RCSB], [https://www.ebi.ac.uk/pdbsum/3err PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3err ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3err FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3err OCA], [https://pdbe.org/3err PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3err RCSB], [https://www.ebi.ac.uk/pdbsum/3err PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3err ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[https://www.uniprot.org/uniprot/DYHC1_MOUSE DYHC1_MOUSE]] Defects in Dync1h1 are the cause of the 'Legs at odd angles' (LOA) phenotype, an autosomal dominant trait where affected animals display unusual twisting of the body and clenching of the hindlimbs when suspended by the tail. Heterozygotes suffer age-related progressive loss of muscle tone and locomotor ability without major reduction in life-span while homozygotes show a more severe phenotype with an inability to move or feed, and die within 24 hours of birth. LOA mutants display defects in migration of facial motor neuron cell bodies and impaired retrograde transport in spinal cord motor neurons. Defects in Dync1h1 are the cause of the Cramping 1 (Cra1) phenotype, an autosomal dominant trait where affected animals display unusual twisting of the body and clenching of the hindlimbs when suspended by the tail. Heterozygotes suffer age-related progressive loss of muscle tone and locomotor ability without major reduction in life-span while homozygotes show a more severe phenotype with an inability to move or feed, and die within 24 hours of birth.		[https://www.uniprot.org/uniprot/DYHC1_MOUSE DYHC1_MOUSE] Defects in Dync1h1 are the cause of the 'Legs at odd angles' (LOA) phenotype, an autosomal dominant trait where affected animals display unusual twisting of the body and clenching of the hindlimbs when suspended by the tail. Heterozygotes suffer age-related progressive loss of muscle tone and locomotor ability without major reduction in life-span while homozygotes show a more severe phenotype with an inability to move or feed, and die within 24 hours of birth. LOA mutants display defects in migration of facial motor neuron cell bodies and impaired retrograde transport in spinal cord motor neurons. Defects in Dync1h1 are the cause of the Cramping 1 (Cra1) phenotype, an autosomal dominant trait where affected animals display unusual twisting of the body and clenching of the hindlimbs when suspended by the tail. Heterozygotes suffer age-related progressive loss of muscle tone and locomotor ability without major reduction in life-span while homozygotes show a more severe phenotype with an inability to move or feed, and die within 24 hours of birth.
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/DYHC1_MOUSE DYHC1_MOUSE]] Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.		[https://www.uniprot.org/uniprot/DYHC1_MOUSE DYHC1_MOUSE] Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.[https://www.uniprot.org/uniprot/SYS_THET8 SYS_THET8] Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).[HAMAP-Rule:MF_00176]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Lk3 transgenic mice~~]]		[[Category: Mus musculus]]
	[[Category: ~~Carter, A P~~]]		[[Category: Thermus thermophilus HB27]]
	[[Category: ~~Coiled coil]]~~		[[Category: Carter AP]]
	~~[[Category: Dynein]]~~
	~~[[Category: Fusion protein]]~~
	~~[[Category: Ligase]]~~
	~~[[Category: Microtubule binding domain~~]]

OCA at 19:45, 20 October 2021

2021-10-20T19:45:37Z

← Older revision		Revision as of 19:45, 20 October 2021
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	<StructureSection load='3err' size='340' side='right'caption='[[3err]], [[Resolution\|resolution]] 2.27Å' scene=''>		<StructureSection load='3err' size='340' side='right'caption='[[3err]], [[Resolution\|resolution]] 2.27Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3err]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ERR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ERR FirstGlance]. <br>		<table><tr><td colspan='2'>[[3err]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ERR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ERR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3err FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3err OCA], [~~http~~://pdbe.org/3err PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3err RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3err PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3err ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3err FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3err OCA], [https://pdbe.org/3err PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3err RCSB], [https://www.ebi.ac.uk/pdbsum/3err PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3err ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[~~http~~://www.uniprot.org/uniprot/DYHC1_MOUSE DYHC1_MOUSE]] Defects in Dync1h1 are the cause of the 'Legs at odd angles' (LOA) phenotype, an autosomal dominant trait where affected animals display unusual twisting of the body and clenching of the hindlimbs when suspended by the tail. Heterozygotes suffer age-related progressive loss of muscle tone and locomotor ability without major reduction in life-span while homozygotes show a more severe phenotype with an inability to move or feed, and die within 24 hours of birth. LOA mutants display defects in migration of facial motor neuron cell bodies and impaired retrograde transport in spinal cord motor neurons. Defects in Dync1h1 are the cause of the Cramping 1 (Cra1) phenotype, an autosomal dominant trait where affected animals display unusual twisting of the body and clenching of the hindlimbs when suspended by the tail. Heterozygotes suffer age-related progressive loss of muscle tone and locomotor ability without major reduction in life-span while homozygotes show a more severe phenotype with an inability to move or feed, and die within 24 hours of birth.		[[https://www.uniprot.org/uniprot/DYHC1_MOUSE DYHC1_MOUSE]] Defects in Dync1h1 are the cause of the 'Legs at odd angles' (LOA) phenotype, an autosomal dominant trait where affected animals display unusual twisting of the body and clenching of the hindlimbs when suspended by the tail. Heterozygotes suffer age-related progressive loss of muscle tone and locomotor ability without major reduction in life-span while homozygotes show a more severe phenotype with an inability to move or feed, and die within 24 hours of birth. LOA mutants display defects in migration of facial motor neuron cell bodies and impaired retrograde transport in spinal cord motor neurons. Defects in Dync1h1 are the cause of the Cramping 1 (Cra1) phenotype, an autosomal dominant trait where affected animals display unusual twisting of the body and clenching of the hindlimbs when suspended by the tail. Heterozygotes suffer age-related progressive loss of muscle tone and locomotor ability without major reduction in life-span while homozygotes show a more severe phenotype with an inability to move or feed, and die within 24 hours of birth.
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/DYHC1_MOUSE DYHC1_MOUSE]] Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.		[[https://www.uniprot.org/uniprot/DYHC1_MOUSE DYHC1_MOUSE]] Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:45, 21 August 2019

2019-08-21T07:45:55Z

← Older revision		Revision as of 07:45, 21 August 2019
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	==Microtubule binding domain from mouse cytoplasmic dynein as a fusion with seryl-tRNA synthetase==		==Microtubule binding domain from mouse cytoplasmic dynein as a fusion with seryl-tRNA synthetase==
	<StructureSection load='3err' size='340' side='right' caption='[[3err]], [[Resolution\|resolution]] 2.27Å' scene=''>		<StructureSection load='3err' size='340' side='right'caption='[[3err]], [[Resolution\|resolution]] 2.27Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3err]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ERR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ERR FirstGlance]. <br>		<table><tr><td colspan='2'>[[3err]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ERR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ERR FirstGlance]. <br>
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/er/3err_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/er/3err_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 3err" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3err" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Aminoacyl tRNA synthetase 3D structures\|Aminoacyl tRNA synthetase 3D structures]]
			*[[Dynein 3D structures\|Dynein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Carter, A P]]		[[Category: Carter, A P]]

OCA at 02:20, 16 November 2017

2017-11-16T02:20:01Z

← Older revision		Revision as of 02:20, 16 November 2017
Line 1:		Line 1:

	==Microtubule binding domain from mouse cytoplasmic dynein as a fusion with seryl-tRNA synthetase==		==Microtubule binding domain from mouse cytoplasmic dynein as a fusion with seryl-tRNA synthetase==
	<StructureSection load='3err' size='340' side='right' caption='[[3err]], [[Resolution\|resolution]] 2.27Å' scene=''>		<StructureSection load='3err' size='340' side='right' caption='[[3err]], [[Resolution\|resolution]] 2.27Å' scene=''>
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	<table><tr><td colspan='2'>[[3err]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ERR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ERR FirstGlance]. <br>		<table><tr><td colspan='2'>[[3err]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ERR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ERR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3err FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3err OCA], [http://pdbe.org/3err PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3err RCSB], [http://www.ebi.ac.uk/pdbsum/3err PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3err FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3err OCA], [http://pdbe.org/3err PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3err RCSB], [http://www.ebi.ac.uk/pdbsum/3err PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3err ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	</div>		</div>
	<div class="pdbe-citations 3err" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3err" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Aminoacyl tRNA Synthetase\|Aminoacyl tRNA Synthetase]]
	*[[Dynein\|Dynein]]
	== References ==		== References ==
	<references/>		<references/>
Line 39:		Line 36:
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Carter, A P]]		[[Category: Carter, A P]]
			[[Category: Coiled coil]]
	[[Category: Dynein]]		[[Category: Dynein]]
	[[Category: Fusion protein]]		[[Category: Fusion protein]]
	[[Category: Ligase]]		[[Category: Ligase]]
	[[Category: Microtubule binding domain]]		[[Category: Microtubule binding domain]]

OCA at 02:10, 10 February 2016

2016-02-10T02:10:41Z

← Older revision		Revision as of 02:10, 10 February 2016
Line 2:		Line 2:
	<StructureSection load='3err' size='340' side='right' caption='[[3err]], [[Resolution\|resolution]] 2.27Å' scene=''>		<StructureSection load='3err' size='340' side='right' caption='[[3err]], [[Resolution\|resolution]] 2.27Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3err]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ERR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ERR FirstGlance]. <br>		<table><tr><td colspan='2'>[[3err]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ERR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ERR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3err FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3err OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3err RCSB], [http://www.ebi.ac.uk/pdbsum/3err PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3err FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3err OCA], [http://pdbe.org/3err PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3err RCSB], [http://www.ebi.ac.uk/pdbsum/3err PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3err ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3err" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Mus musculus~~]]		[[Category: Lk3 transgenic mice]]
	[[Category: Carter, A P]]		[[Category: Carter, A P]]
	[[Category: Dynein]]		[[Category: Dynein]]

OCA at 11:47, 20 January 2015

2015-01-20T11:47:26Z

← Older revision		Revision as of 11:47, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3err]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ERR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ERR FirstGlance]. <br>		<table><tr><td colspan='2'>[[3err]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ERR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ERR FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3err FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3err OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3err RCSB], [http://www.ebi.ac.uk/pdbsum/3err PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3err FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3err OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3err RCSB], [http://www.ebi.ac.uk/pdbsum/3err PDBsum]</span></td></tr>
	<table>		</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/DYHC1_MOUSE DYHC1_MOUSE]] Defects in Dync1h1 are the cause of the 'Legs at odd angles' (LOA) phenotype, an autosomal dominant trait where affected animals display unusual twisting of the body and clenching of the hindlimbs when suspended by the tail. Heterozygotes suffer age-related progressive loss of muscle tone and locomotor ability without major reduction in life-span while homozygotes show a more severe phenotype with an inability to move or feed, and die within 24 hours of birth. LOA mutants display defects in migration of facial motor neuron cell bodies and impaired retrograde transport in spinal cord motor neurons. Defects in Dync1h1 are the cause of the Cramping 1 (Cra1) phenotype, an autosomal dominant trait where affected animals display unusual twisting of the body and clenching of the hindlimbs when suspended by the tail. Heterozygotes suffer age-related progressive loss of muscle tone and locomotor ability without major reduction in life-span while homozygotes show a more severe phenotype with an inability to move or feed, and die within 24 hours of birth.		[[http://www.uniprot.org/uniprot/DYHC1_MOUSE DYHC1_MOUSE]] Defects in Dync1h1 are the cause of the 'Legs at odd angles' (LOA) phenotype, an autosomal dominant trait where affected animals display unusual twisting of the body and clenching of the hindlimbs when suspended by the tail. Heterozygotes suffer age-related progressive loss of muscle tone and locomotor ability without major reduction in life-span while homozygotes show a more severe phenotype with an inability to move or feed, and die within 24 hours of birth. LOA mutants display defects in migration of facial motor neuron cell bodies and impaired retrograde transport in spinal cord motor neurons. Defects in Dync1h1 are the cause of the Cramping 1 (Cra1) phenotype, an autosomal dominant trait where affected animals display unusual twisting of the body and clenching of the hindlimbs when suspended by the tail. Heterozygotes suffer age-related progressive loss of muscle tone and locomotor ability without major reduction in life-span while homozygotes show a more severe phenotype with an inability to move or feed, and die within 24 hours of birth.
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Carter, A P.]]		[[Category: Carter, A P]]
	[[Category: Dynein]]		[[Category: Dynein]]
	[[Category: Fusion protein]]		[[Category: Fusion protein]]
	[[Category: Ligase]]		[[Category: Ligase]]
	[[Category: Microtubule binding domain]]		[[Category: Microtubule binding domain]]

OCA at 13:32, 29 September 2014

2014-09-29T13:32:55Z

← Older revision		Revision as of 13:32, 29 September 2014
Line 1:		Line 1:
	[[Image:~~3err~~.~~png~~\|~~left~~\|~~200px~~]]		==Microtubule binding domain from mouse cytoplasmic dynein as a fusion with seryl-tRNA synthetase==
			<StructureSection load='3err' size='340' side='right' caption='[[3err]], [[Resolution\|resolution]] 2.27Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3err]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ERR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ERR FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene><br>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3err FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3err OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3err RCSB], [http://www.ebi.ac.uk/pdbsum/3err PDBsum]</span></td></tr>
			<table>
			== Disease ==
			[[http://www.uniprot.org/uniprot/DYHC1_MOUSE DYHC1_MOUSE]] Defects in Dync1h1 are the cause of the 'Legs at odd angles' (LOA) phenotype, an autosomal dominant trait where affected animals display unusual twisting of the body and clenching of the hindlimbs when suspended by the tail. Heterozygotes suffer age-related progressive loss of muscle tone and locomotor ability without major reduction in life-span while homozygotes show a more severe phenotype with an inability to move or feed, and die within 24 hours of birth. LOA mutants display defects in migration of facial motor neuron cell bodies and impaired retrograde transport in spinal cord motor neurons. Defects in Dync1h1 are the cause of the Cramping 1 (Cra1) phenotype, an autosomal dominant trait where affected animals display unusual twisting of the body and clenching of the hindlimbs when suspended by the tail. Heterozygotes suffer age-related progressive loss of muscle tone and locomotor ability without major reduction in life-span while homozygotes show a more severe phenotype with an inability to move or feed, and die within 24 hours of birth.
			== Function ==
			[[http://www.uniprot.org/uniprot/DYHC1_MOUSE DYHC1_MOUSE]] Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/er/3err_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Dynein motors move various cargos along microtubules within the cytoplasm and power the beating of cilia and flagella. An unusual feature of dynein is that its microtubule-binding domain (MTBD) is separated from its ring-shaped AAA+ adenosine triphosphatase (ATPase) domain by a 15-nanometer coiled-coil stalk. We report the crystal structure of the mouse cytoplasmic dynein MTBD and a portion of the coiled coil, which supports a mechanism by which the ATPase domain and MTBD may communicate through a shift in the heptad registry of the coiled coil. Surprisingly, functional data suggest that the MTBD, and not the ATPase domain, is the main determinant of the direction of dynein motility.

	~~{{STRUCTURE_3err\| PDB=3err \| SCENE= }}~~		Structure and functional role of dynein's microtubule-binding domain.,Carter AP, Garbarino JE, Wilson-Kubalek EM, Shipley WE, Cho C, Milligan RA, Vale RD, Gibbons IR Science. 2008 Dec 12;322(5908):1691-5. PMID:19074350<ref>PMID:19074350</ref>

	~~===Microtubule binding domain from mouse cytoplasmic dynein as a fusion with seryl-tRNA synthetase===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_19074350}}~~

	~~==About this Structure==~~
	~~[[3err]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3ERR OCA].~~

	==See Also==		==See Also==
	*[[Aminoacyl tRNA Synthetase\|Aminoacyl tRNA Synthetase]]		*[[Aminoacyl tRNA Synthetase\|Aminoacyl tRNA Synthetase]]
	*[[Dynein\|Dynein]]		*[[Dynein\|Dynein]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:019074350<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Carter, A P.]]		[[Category: Carter, A P.]]

OCA at 15:57, 20 October 2012

2012-10-20T15:57:19Z

← Older revision		Revision as of 15:57, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[3err]] is a 2 chain structure ~~of [[Aminoacyl tRNA Synthetase]] and [[Dynein]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus~~,_thermus_thermophilus~~ Mus musculus~~, thermus thermophilus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ERR OCA].		[[3err]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ERR OCA].

	==See Also==		==See Also==
Line 16:		Line 16:
	==Reference==		==Reference==
	<ref group="xtra">PMID:019074350</ref><references group="xtra"/>		<ref group="xtra">PMID:019074350</ref><references group="xtra"/>
	[[Category: Mus musculus~~, thermus thermophilus~~]]		[[Category: Mus musculus]]
	[[Category: Carter, A P.]]		[[Category: Carter, A P.]]
	[[Category: Dynein]]		[[Category: Dynein]]

OCA: Protected "3err" [edit=sysop:move=sysop]

2012-07-26T20:02:09Z

Protected "3err" [edit=sysop:move=sysop]

← Older revision	Revision as of 20:02, 26 July 2012
(No difference)

OCA at 20:02, 26 July 2012

2012-07-26T20:02:07Z

← Older revision		Revision as of 20:02, 26 July 2012
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	~~{{Seed}}~~
	[[Image:3err.png\|left\|200px]]		[[Image:3err.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3err", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3err\| PDB=3err \| SCENE= }}		{{STRUCTURE_3err\| PDB=3err \| SCENE= }}

	===Microtubule binding domain from mouse cytoplasmic dynein as a fusion with seryl-tRNA synthetase===		===Microtubule binding domain from mouse cytoplasmic dynein as a fusion with seryl-tRNA synthetase===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_19074350}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 19074350 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_19074350}}		{{ABSTRACT_PUBMED_19074350}}

	==About this Structure==		==About this Structure==
	~~3ERR~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus,_thermus_thermophilus Mus musculus, thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ERR OCA].		[[3err]] is a 2 chain structure of [[Aminoacyl tRNA Synthetase]] and [[Dynein]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus,_thermus_thermophilus Mus musculus, thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ERR OCA].

			==See Also==
			*[[Aminoacyl tRNA Synthetase\|Aminoacyl tRNA Synthetase]]
			*[[Dynein\|Dynein]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~19074350~~</ref><references group="xtra"/>		<ref group="xtra">PMID:019074350</ref><references group="xtra"/>
	[[Category: Mus musculus, thermus thermophilus]]		[[Category: Mus musculus, thermus thermophilus]]
	[[Category: Carter, A P.]]		[[Category: Carter, A P.]]
	~~[[Category: Coiled coil]]~~
	[[Category: Dynein]]		[[Category: Dynein]]
	[[Category: Fusion protein]]		[[Category: Fusion protein]]
	[[Category: Ligase]]		[[Category: Ligase]]
	[[Category: Microtubule binding domain]]		[[Category: Microtubule binding domain]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 6 09:18:50 2009''~~