3eth - Revision history

OCA at 06:33, 6 September 2023

2023-09-06T06:33:41Z

← Older revision		Revision as of 06:33, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3eth' size='340' side='right'caption='[[3eth]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='3eth' size='340' side='right'caption='[[3eth]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3eth]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ETH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ETH FirstGlance]. <br>		<table><tr><td colspan='2'>[[3eth]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ETH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ETH FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ATP:ADENOSINE-5~~-~~TRIPHOSPHATE'>ATP</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[3etj\|3etj]]</div>~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>b0522, JW0511, purK, PURK_ECOLI ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~83333 ECOLI])</td~~><~~/tr>~~
	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>[https://en.wikipedia.org/wiki/Phosphoribosylaminoimidazole_carboxylase Phosphoribosylaminoimidazole carboxylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.21 4.1.1.21] </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eth OCA], [https://pdbe.org/3eth PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eth RCSB], [https://www.ebi.ac.uk/pdbsum/3eth PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eth ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eth OCA], [https://pdbe.org/3eth PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eth RCSB], [https://www.ebi.ac.uk/pdbsum/3eth PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eth ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/PURK_ECOLI PURK_ECOLI]] Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).		[https://www.uniprot.org/uniprot/PURK_ECOLI PURK_ECOLI] Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Ecoli~~]]		[[Category: Escherichia coli K-12]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Phosphoribosylaminoimidazole carboxylase]]~~		[[Category: Holden HM]]
	[[Category: Holden~~, H M~~]]		[[Category: Thoden JB]]
	[[Category: Thoden~~, J B]]~~
	~~[[Category: Antimicrobial]]~~
	~~[[Category: Atp-binding]]~~
	~~[[Category: Atp-grasp]]~~
	~~[[Category: Decarboxylase]]~~
	~~[[Category: Lyase]]~~
	~~[[Category: Nucleotide-binding]]~~
	~~[[Category: Purine biosynthesis~~]]

OCA at 19:45, 20 October 2021

2021-10-20T19:45:59Z

← Older revision		Revision as of 19:45, 20 October 2021
Line 1:		Line 1:

	==Crystal structure of E. coli Purk in complex with MgATP==		==Crystal structure of E. coli Purk in complex with MgATP==
	<StructureSection load='3eth' size='340' side='right' caption='[[3eth]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='3eth' size='340' side='right'caption='[[3eth]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3eth]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ETH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ETH FirstGlance]. <br>		<table><tr><td colspan='2'>[[3eth]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ETH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ETH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3etj\|3etj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3etj\|3etj]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b0522, JW0511, purK, PURK_ECOLI ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b0522, JW0511, purK, PURK_ECOLI ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Phosphoribosylaminoimidazole_carboxylase Phosphoribosylaminoimidazole carboxylase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.21 4.1.1.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phosphoribosylaminoimidazole_carboxylase Phosphoribosylaminoimidazole carboxylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.21 4.1.1.21] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3eth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eth OCA], [~~http~~://pdbe.org/3eth PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3eth RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3eth PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3eth ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eth OCA], [https://pdbe.org/3eth PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eth RCSB], [https://www.ebi.ac.uk/pdbsum/3eth PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eth ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/PURK_ECOLI PURK_ECOLI]] Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).		[[https://www.uniprot.org/uniprot/PURK_ECOLI PURK_ECOLI]] Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/et/3eth_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/et/3eth_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 31:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 3eth" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3eth" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Phosphoribosylaminoimidazole carboxylase 3D structures\|Phosphoribosylaminoimidazole carboxylase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Ecoli]]		[[Category: Ecoli]]
			[[Category: Large Structures]]
	[[Category: Phosphoribosylaminoimidazole carboxylase]]		[[Category: Phosphoribosylaminoimidazole carboxylase]]
	[[Category: Holden, H M]]		[[Category: Holden, H M]]

OCA at 09:19, 25 October 2017

2017-10-25T09:19:18Z

← Older revision		Revision as of 09:19, 25 October 2017
Line 31:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 3eth" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3eth" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Phosphoribosylaminoimidazole carboxylase\|Phosphoribosylaminoimidazole carboxylase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 22:39, 4 August 2016

2016-08-04T22:39:13Z

← Older revision		Revision as of 22:39, 4 August 2016
Line 1:		Line 1:

	==Crystal structure of E. coli Purk in complex with MgATP==		==Crystal structure of E. coli Purk in complex with MgATP==
	<StructureSection load='3eth' size='340' side='right' caption='[[3eth]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='3eth' size='340' side='right' caption='[[3eth]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3eth]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia coli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ETH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ETH FirstGlance]. <br>		<table><tr><td colspan='2'>[[3eth]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ETH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ETH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3etj\|3etj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3etj\|3etj]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b0522, JW0511, purK, PURK_ECOLI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~562 Escherichia coli~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b0522, JW0511, purK, PURK_ECOLI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylaminoimidazole_carboxylase Phosphoribosylaminoimidazole carboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.21 4.1.1.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylaminoimidazole_carboxylase Phosphoribosylaminoimidazole carboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.21 4.1.1.21] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eth OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3eth RCSB], [http://www.ebi.ac.uk/pdbsum/3eth PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eth OCA], [http://pdbe.org/3eth PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3eth RCSB], [http://www.ebi.ac.uk/pdbsum/3eth PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3eth ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3eth ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 30:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3eth" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Phosphoribosylaminoimidazole carboxylase\|Phosphoribosylaminoimidazole carboxylase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Escherichia coli~~]]		[[Category: Ecoli]]
	[[Category: Phosphoribosylaminoimidazole carboxylase]]		[[Category: Phosphoribosylaminoimidazole carboxylase]]
	[[Category: Holden, H M]]		[[Category: Holden, H M]]

OCA at 13:42, 25 December 2014

2014-12-25T13:42:16Z

← Older revision		Revision as of 13:42, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eth OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3eth RCSB], [http://www.ebi.ac.uk/pdbsum/3eth PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eth OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3eth RCSB], [http://www.ebi.ac.uk/pdbsum/3eth PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/PURK_ECOLI PURK_ECOLI]] Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:36, 26 November 2014

2014-11-26T08:36:38Z

← Older revision		Revision as of 08:36, 26 November 2014
Line 1:		Line 1:
	[[Image:~~3eth~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of E. coli Purk in complex with MgATP==
			<StructureSection load='3eth' size='340' side='right' caption='[[3eth]], [[Resolution\|resolution]] 1.60Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3eth]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ETH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ETH FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3etj\|3etj]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b0522, JW0511, purK, PURK_ECOLI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylaminoimidazole_carboxylase Phosphoribosylaminoimidazole carboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.21 4.1.1.21] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eth OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3eth RCSB], [http://www.ebi.ac.uk/pdbsum/3eth PDBsum]</span></td></tr>
			</table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/et/3eth_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			N(5)-Carboxyaminoimidazole ribonucleotide synthetase (N(5)-CAIR synthetase) converts 5-aminoimidazole ribonucleotide (AIR), MgATP, and bicarbonate into N(5)-CAIR, MgADP, and P(i). The enzyme is required for de novo purine biosynthesis in microbes yet is not found in humans suggesting that it represents an ideal and unexplored target for antimicrobial drug design. Here we report the X-ray structures of N(5)-CAIR synthetase from Escherichia coli with either MgATP or MgADP/P(i) bound in the active site cleft. These structures, determined to 1.6-A resolution, provide detailed information regarding the active site geometry before and after ATP hydrolysis. In both structures, two magnesium ions are observed. Each of these is octahedrally coordinated, and the carboxylate side chain of Glu238 bridges them. For the structure of the MgADP/P(i) complex, crystals were grown in the presence of AIR and MgATP. No electron density was observed for AIR, and the electron density corresponding to the nucleotide clearly revealed the presence of ADP and P(i) rather than ATP. The bound P(i) shifts by approximately 3 A relative to the gamma-phosphoryl group of ATP and forms electrostatic interactions with the side chains of Arg242 and His244. Since the reaction mechanism of N(5)-CAIR synthetase is believed to proceed via a carboxyphosphate intermediate, we propose that the location of the inorganic phosphate represents the binding site for stabilization of this reactive species. Using the information derived from the two structures reported here, coupled with molecular modeling, we propose a catalytic mechanism for N(5)-CAIR synthetase.

	~~{{STRUCTURE_3eth\| PDB=3eth \| SCENE= }}~~		Structural analysis of the active site geometry of N(5)-Carboxyaminoimidazole ribonucleotide synthetase from Escherichia coli.,Thoden JB, Holden HM, Firestine SM Biochemistry. 2008 Dec 16;47(50):13346-53. PMID:19053251<ref>PMID:19053251</ref>

	~~===Crystal structure~~ of E. ~~coli Purk in complex with MgATP===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_19053251}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[3eth]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org~~/~~wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ETH OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:019053251<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Phosphoribosylaminoimidazole carboxylase]]		[[Category: Phosphoribosylaminoimidazole carboxylase]]
	[[Category: Holden, H M.]]		[[Category: Holden, H M]]
	[[Category: Thoden, J B.]]		[[Category: Thoden, J B]]
	[[Category: Antimicrobial]]		[[Category: Antimicrobial]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]

OCA: Protected "3eth" [edit=sysop:move=sysop]

2013-02-06T13:19:46Z

Protected "3eth" [edit=sysop:move=sysop]

← Older revision	Revision as of 13:19, 6 February 2013
(No difference)

OCA at 13:19, 6 February 2013

2013-02-06T13:19:43Z

← Older revision		Revision as of 13:19, 6 February 2013
Line 1:		Line 1:
	~~{{Seed}}~~
	[[Image:3eth.png\|left\|200px]]		[[Image:3eth.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3eth", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3eth\| PDB=3eth \| SCENE= }}		{{STRUCTURE_3eth\| PDB=3eth \| SCENE= }}

	===Crystal structure of E. coli Purk in complex with MgATP===		===Crystal structure of E. coli Purk in complex with MgATP===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_19053251}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 19053251 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_19053251}}		{{ABSTRACT_PUBMED_19053251}}

	==About this Structure==		==About this Structure==
	~~3ETH~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ETH OCA].		[[3eth]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ETH OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~19053251~~</ref><references group="xtra"/>		<ref group="xtra">PMID:019053251</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Phosphoribosylaminoimidazole carboxylase]]		[[Category: Phosphoribosylaminoimidazole carboxylase]]
Line 35:		Line 23:
	[[Category: Nucleotide-binding]]		[[Category: Nucleotide-binding]]
	[[Category: Purine biosynthesis]]		[[Category: Purine biosynthesis]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:42:45 2009''~~

OCA at 15:42, 17 February 2009

2009-02-17T15:42:47Z

← Older revision		Revision as of 15:42, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
	3ETH is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ETH OCA].		3ETH is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ETH OCA].

	==Reference==		==Reference==
	Structural analysis of the active site geometry of N(5)-Carboxyaminoimidazole ribonucleotide synthetase from Escherichia coli., Thoden JB, Holden HM, Firestine SM, Biochemistry. 2008 Dec 16;47(50):13346-53. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/19053251 19053251]~~		<ref group="xtra">PMID:19053251</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Phosphoribosylaminoimidazole carboxylase]]		[[Category: Phosphoribosylaminoimidazole carboxylase]]
	[[Category: ~~Single protein~~]]		[[Category: Holden, H M.]]
	[[Category: ~~Pdbx_ordinal=~~, ~~<PDBx:audit_author~~.]]		[[Category: Thoden, J B.]]
	[[Category: Antimicrobial]]		[[Category: Antimicrobial]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
Line 36:		Line 36:
	[[Category: Purine biosynthesis]]		[[Category: Purine biosynthesis]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Dec 31 20~~:14:~~49 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:42:45 2009''

OCA at 14:52, 1 January 2009

2009-01-01T14:52:45Z

← Older revision		Revision as of 14:52, 1 January 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
	3ETH is a ~~2 chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ETH OCA].		3ETH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ETH OCA].

	==Reference==		==Reference==
Line 26:		Line 26:
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Phosphoribosylaminoimidazole carboxylase]]		[[Category: Phosphoribosylaminoimidazole carboxylase]]
	[[Category: ~~Holden, H M.~~]]		[[Category: Single protein]]
	[[Category: ~~Thoden~~, ~~J B~~.]]		[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
	[[Category: Antimicrobial]]		[[Category: Antimicrobial]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
Line 36:		Line 36:
	[[Category: Purine biosynthesis]]		[[Category: Purine biosynthesis]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 31 09:07:17 2008''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 31 20:14:49 2008''