3fa2 - Revision history

OCA at 09:07, 30 October 2024

2024-10-30T09:07:16Z

← Older revision		Revision as of 09:07, 30 October 2024
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fa/3fa2_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fa/3fa2_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 06:43, 6 September 2023

2023-09-06T06:43:44Z

← Older revision		Revision as of 06:43, 6 September 2023
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	<StructureSection load='3fa2' size='340' side='right'caption='[[3fa2]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3fa2' size='340' side='right'caption='[[3fa2]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3fa2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FA2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3fa2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FA2 FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~, ~~<scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~BARD1 ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fa2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fa2 OCA], [https://pdbe.org/3fa2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fa2 RCSB], [https://www.ebi.ac.uk/pdbsum/3fa2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fa2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fa2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fa2 OCA], [https://pdbe.org/3fa2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fa2 RCSB], [https://www.ebi.ac.uk/pdbsum/3fa2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fa2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/BARD1_HUMAN BARD1_HUMAN]] Probable E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.<ref>PMID:10477523</ref> <ref>PMID:12890688</ref> <ref>PMID:14976165</ref> <ref>PMID:20351172</ref>		[https://www.uniprot.org/uniprot/BARD1_HUMAN BARD1_HUMAN] Probable E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.<ref>PMID:10477523</ref> <ref>PMID:12890688</ref> <ref>PMID:14976165</ref> <ref>PMID:20351172</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: III, D ~~Fox~~]]		[[Category: Fox III D]]
	[[Category: Klevit~~, R E]]~~		[[Category: Klevit RE]]
	~~[[Category: Stenkamp, R E~~]]		[[Category: Le Trong I]]
	[[Category: Trong, I Le]]		[[Category: Stenkamp RE]]
	[[Category: ~~Ank repeat]]~~
	~~[[Category: Bard1]]~~
	~~[[Category: Brca1]]~~
	~~[[Category: Brca1 c-terminal domain]]~~
	~~[[Category: Brct]]~~
	~~[[Category: Disease mutation]]~~
	~~[[Category: Metal-binding]]~~
	~~[[Category: Nucleus]]~~
	~~[[Category: Protein binding]]~~
	~~[[Category: Tandem]]~~
	~~[[Category: Zinc-finger~~]]

OCA at 09:27, 23 February 2022

2022-02-23T09:27:20Z

← Older revision		Revision as of 09:27, 23 February 2022
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	==Crystal Structure of the BRCA1 Associated Ring Domain (BARD1) Tandem BRCT Domains==		==Crystal Structure of the BRCA1 Associated Ring Domain (BARD1) Tandem BRCT Domains==
	<StructureSection load='3fa2' size='340' side='right' caption='[[3fa2]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3fa2' size='340' side='right'caption='[[3fa2]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3fa2]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FA2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3FA2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3fa2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FA2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BARD1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BARD1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3fa2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fa2 OCA], [~~http~~://pdbe.org/3fa2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3fa2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3fa2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3fa2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fa2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fa2 OCA], [https://pdbe.org/3fa2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fa2 RCSB], [https://www.ebi.ac.uk/pdbsum/3fa2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fa2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/BARD1_HUMAN BARD1_HUMAN]] Probable E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.<ref>PMID:10477523</ref> <ref>PMID:12890688</ref> <ref>PMID:14976165</ref> <ref>PMID:20351172</ref>		[[https://www.uniprot.org/uniprot/BARD1_HUMAN BARD1_HUMAN]] Probable E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.<ref>PMID:10477523</ref> <ref>PMID:12890688</ref> <ref>PMID:14976165</ref> <ref>PMID:20351172</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: III, D Fox]]		[[Category: III, D Fox]]
	[[Category: Klevit, R E]]		[[Category: Klevit, R E]]

OCA at 19:17, 24 January 2018

2018-01-24T19:17:34Z

← Older revision		Revision as of 19:17, 24 January 2018
Line 1:		Line 1:

	==Crystal Structure of the BRCA1 Associated Ring Domain (BARD1) Tandem BRCT Domains==		==Crystal Structure of the BRCA1 Associated Ring Domain (BARD1) Tandem BRCT Domains==
	<StructureSection load='3fa2' size='340' side='right' caption='[[3fa2]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3fa2' size='340' side='right' caption='[[3fa2]], [[Resolution\|resolution]] 2.20Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BARD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BARD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fa2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fa2 OCA], [http://pdbe.org/3fa2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fa2 RCSB], [http://www.ebi.ac.uk/pdbsum/3fa2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fa2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fa2 OCA], [http://pdbe.org/3fa2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fa2 RCSB], [http://www.ebi.ac.uk/pdbsum/3fa2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3fa2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fa/3fa2_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fa/3fa2_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
	[[Category: ~~3rd~~, D Fox]]		[[Category: III, D Fox]]
	[[Category: Klevit, R E]]		[[Category: Klevit, R E]]
	[[Category: Stenkamp, R E]]		[[Category: Stenkamp, R E]]

OCA at 13:45, 9 February 2016

2016-02-09T13:45:48Z

← Older revision		Revision as of 13:45, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3fa2' size='340' side='right' caption='[[3fa2]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3fa2' size='340' side='right' caption='[[3fa2]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3fa2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FA2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FA2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3fa2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FA2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FA2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BARD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BARD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fa2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fa2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fa2 RCSB], [http://www.ebi.ac.uk/pdbsum/3fa2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fa2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fa2 OCA], [http://pdbe.org/3fa2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fa2 RCSB], [http://www.ebi.ac.uk/pdbsum/3fa2 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fa2 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	== References ==		== References ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: 3rd, D Fox]]		[[Category: 3rd, D Fox]]
	[[Category: Klevit, R E]]		[[Category: Klevit, R E]]

OCA at 07:10, 25 December 2014

2014-12-25T07:10:43Z

← Older revision		Revision as of 07:10, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fa2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fa2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fa2 RCSB], [http://www.ebi.ac.uk/pdbsum/3fa2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fa2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fa2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fa2 RCSB], [http://www.ebi.ac.uk/pdbsum/3fa2 PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/BARD1_HUMAN BARD1_HUMAN]] Probable E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.<ref>PMID:10477523</ref> <ref>PMID:12890688</ref> <ref>PMID:14976165</ref> <ref>PMID:20351172</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 17:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:43, 26 November 2014

2014-11-26T08:43:54Z

← Older revision		Revision as of 08:43, 26 November 2014
Line 1:		Line 1:
	~~[[Image:3fa2.png\|left\|200px]]~~		==Crystal Structure of the BRCA1 Associated Ring Domain (BARD1) Tandem BRCT Domains==
			<StructureSection load='3fa2' size='340' side='right' caption='[[3fa2]], [[Resolution\|resolution]] 2.20Å' scene=''>
	~~{{STRUCTURE_3fa2\| PDB=3fa2 \| SCENE= }}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[3fa2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FA2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FA2 FirstGlance]. <br>
	===Crystal Structure of the BRCA1 Associated Ring Domain (BARD1) Tandem BRCT Domains===		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BARD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fa2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fa2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fa2 RCSB], [http://www.ebi.ac.uk/pdbsum/3fa2 PDBsum]</span></td></tr>
	==~~About this Structure~~==		</table>
	[[3fa2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FA2 OCA].		== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fa/3fa2_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: 3rd, D Fox.]]		[[Category: 3rd, D Fox]]
	[[Category: Klevit, R E.]]		[[Category: Klevit, R E]]
	[[Category: Stenkamp, R E.]]		[[Category: Stenkamp, R E]]
	[[Category: Trong, I Le.]]		[[Category: Trong, I Le]]
	[[Category: Ank repeat]]		[[Category: Ank repeat]]
	[[Category: Bard1]]		[[Category: Bard1]]

OCA: Protected "3fa2" [edit=sysop:move=sysop]

2013-02-13T11:03:45Z

Protected "3fa2" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:03, 13 February 2013
(No difference)

OCA at 11:03, 13 February 2013

2013-02-13T11:03:38Z

← Older revision		Revision as of 11:03, 13 February 2013
Line 1:		Line 1:
	~~{{Seed}}~~		[[Image:3fa2.png\|left\|200px]]
	[[Image:3fa2.~~jpg~~\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3fa2", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3fa2\| PDB=3fa2 \| SCENE= }}		{{STRUCTURE_3fa2\| PDB=3fa2 \| SCENE= }}

	===Crystal Structure of the BRCA1 Associated Ring Domain (BARD1) Tandem BRCT Domains===		===Crystal Structure of the BRCA1 Associated Ring Domain (BARD1) Tandem BRCT Domains===


	~~==Disease==~~
	~~Known disease associated with this structure: Breast cancer, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601593 601593]]~~

	==About this Structure==		==About this Structure==
	~~3FA2~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FA2 OCA].		[[3fa2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FA2 OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: 3rd, D Fox.]]		[[Category: 3rd, D Fox.]]
Line 31:		Line 21:
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
	[[Category: Nucleus]]		[[Category: Nucleus]]
	~~[[Category: Polymorphism]]~~
	[[Category: Protein binding]]		[[Category: Protein binding]]
	[[Category: Tandem]]		[[Category: Tandem]]
	~~[[Category: Ubl conjugation]]~~
	~~[[Category: Zinc]]~~
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 24 11:36:13 2008''~~

OCA at 09:36, 24 December 2008

2008-12-24T09:36:15Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{Seed}}
-The entry 3fa2 is ON HOLD
+<!--
-Authors: Fox 3rd, D., Le Trong, I., Stenkamp, R.E., Klevit, R.E.
+===Crystal Structure of the BRCA1 Associated Ring Domain (BARD1) Tandem BRCT Domains===
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec  3 23:17:39 2008''
+==Disease==