3fc0 - Revision history

OCA at 05:48, 17 October 2024

2024-10-17T05:48:52Z

← Older revision		Revision as of 05:48, 17 October 2024
Line 15:		Line 15:
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fc/3fc0_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fc/3fc0_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 06:44, 6 September 2023

2023-09-06T06:44:19Z

← Older revision		Revision as of 06:44, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3fc0' size='340' side='right'caption='[[3fc0]], [[Resolution\|resolution]] 1.76Å' scene=''>		<StructureSection load='3fc0' size='340' side='right'caption='[[3fc0]], [[Resolution\|resolution]] 1.76Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3fc0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FC0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FC0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3fc0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FC0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FC0 FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.76Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[2qdn\|2qdn]]~~<~~/div></td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></~~td><td class="sblockDat"~~>~~Tnfsf18, Gitrl ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fc0 OCA], [https://pdbe.org/3fc0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fc0 RCSB], [https://www.ebi.ac.uk/pdbsum/3fc0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fc0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fc0 OCA], [https://pdbe.org/3fc0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fc0 RCSB], [https://www.ebi.ac.uk/pdbsum/3fc0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fc0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/TNF18_MOUSE TNF18_MOUSE]] Cytokine that binds to TNFRSF18/AITR/GITR (PubMed:14521928, PubMed:14647196). Regulates T-cell responses (PubMed:14647196). Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation (PubMed:14608036, PubMed:15128759). Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B (PubMed:14521928, PubMed:14647196, PubMed:18178614). Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (By similarity). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (PubMed:24107315).[UniProtKB:Q9UNG2]<ref>PMID:14521928</ref> <ref>PMID:14608036</ref> <ref>PMID:14647196</ref> <ref>PMID:15128759</ref> <ref>PMID:18178614</ref> <ref>PMID:23892569</ref> <ref>PMID:24107315</ref>		[https://www.uniprot.org/uniprot/TNF18_MOUSE TNF18_MOUSE] Cytokine that binds to TNFRSF18/AITR/GITR (PubMed:14521928, PubMed:14647196). Regulates T-cell responses (PubMed:14647196). Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation (PubMed:14608036, PubMed:15128759). Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B (PubMed:14521928, PubMed:14647196, PubMed:18178614). Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (By similarity). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (PubMed:24107315).[UniProtKB:Q9UNG2]<ref>PMID:14521928</ref> <ref>PMID:14608036</ref> <ref>PMID:14647196</ref> <ref>PMID:15128759</ref> <ref>PMID:18178614</ref> <ref>PMID:23892569</ref> <ref>PMID:24107315</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Lk3 transgenic mice~~]]		[[Category: Mus musculus]]
	[[Category: Almo~~, S C~~]]		[[Category: Almo SC]]
	[[Category: Chattopadhyay, K]]		[[Category: Chattopadhyay K]]
	[[Category: Nathenson~~, S G~~]]		[[Category: Nathenson SG]]
	[[Category: Ramagopal~~, U A]]~~		[[Category: Ramagopal UA]]
	~~[[Category: Gitrl]]~~
	~~[[Category: Glucocorticoid-induced tnf receptor ligand]]~~
	~~[[Category: Protein binding]]~~
	~~[[Category: Receptor~~]]

OCA at 07:57, 2 March 2022

2022-03-02T07:57:22Z

← Older revision		Revision as of 07:57, 2 March 2022
Line 1:		Line 1:

	==1.8 A crystal structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells==		==1.8 A crystal structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells==
	<StructureSection load='3fc0' size='340' side='right' caption='[[3fc0]], [[Resolution\|resolution]] 1.76Å' scene=''>		<StructureSection load='3fc0' size='340' side='right'caption='[[3fc0]], [[Resolution\|resolution]] 1.76Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3fc0]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FC0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3FC0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3fc0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FC0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FC0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qdn\|2qdn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2qdn\|2qdn]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tnfsf18, Gitrl ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tnfsf18, Gitrl ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3fc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fc0 OCA], [~~http~~://pdbe.org/3fc0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3fc0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3fc0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3fc0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fc0 OCA], [https://pdbe.org/3fc0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fc0 RCSB], [https://www.ebi.ac.uk/pdbsum/3fc0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fc0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/TNF18_MOUSE TNF18_MOUSE]] Cytokine that binds to TNFRSF18/AITR/GITR (PubMed:14521928, PubMed:14647196). Regulates T-cell responses (PubMed:14647196). Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation (PubMed:14608036, PubMed:15128759). Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B (PubMed:14521928, PubMed:14647196, PubMed:18178614). Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (By similarity). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (PubMed:24107315).[UniProtKB:Q9UNG2]<ref>PMID:14521928</ref> <ref>PMID:14608036</ref> <ref>PMID:14647196</ref> <ref>PMID:15128759</ref> <ref>PMID:18178614</ref> <ref>PMID:23892569</ref> <ref>PMID:24107315</ref>		[[https://www.uniprot.org/uniprot/TNF18_MOUSE TNF18_MOUSE]] Cytokine that binds to TNFRSF18/AITR/GITR (PubMed:14521928, PubMed:14647196). Regulates T-cell responses (PubMed:14647196). Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation (PubMed:14608036, PubMed:15128759). Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B (PubMed:14521928, PubMed:14647196, PubMed:18178614). Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (By similarity). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (PubMed:24107315).[UniProtKB:Q9UNG2]<ref>PMID:14521928</ref> <ref>PMID:14608036</ref> <ref>PMID:14647196</ref> <ref>PMID:15128759</ref> <ref>PMID:18178614</ref> <ref>PMID:23892569</ref> <ref>PMID:24107315</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fc/3fc0_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fc/3fc0_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:

	==See Also==		==See Also==
	*[[Tumor necrosis factor receptor\|Tumor necrosis factor receptor]]		*[[Tumor necrosis factor receptor 3D structures\|Tumor necrosis factor receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Almo, S C]]		[[Category: Almo, S C]]

OCA at 06:38, 1 November 2017

2017-11-01T06:38:23Z

← Older revision		Revision as of 06:38, 1 November 2017
Line 1:		Line 1:

	==1.8 A crystal structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells==		==1.8 A crystal structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells==
	<StructureSection load='3fc0' size='340' side='right' caption='[[3fc0]], [[Resolution\|resolution]] 1.76Å' scene=''>		<StructureSection load='3fc0' size='340' side='right' caption='[[3fc0]], [[Resolution\|resolution]] 1.76Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qdn\|2qdn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qdn\|2qdn]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tnfsf18, Gitrl ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tnfsf18, Gitrl ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fc0 OCA], [http://pdbe.org/3fc0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fc0 RCSB], [http://www.ebi.ac.uk/pdbsum/3fc0 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fc0 OCA], [http://pdbe.org/3fc0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fc0 RCSB], [http://www.ebi.ac.uk/pdbsum/3fc0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3fc0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 19:00, 7 February 2016

2016-02-07T19:00:00Z

← Older revision		Revision as of 19:00, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='3fc0' size='340' side='right' caption='[[3fc0]], [[Resolution\|resolution]] 1.76Å' scene=''>		<StructureSection load='3fc0' size='340' side='right' caption='[[3fc0]], [[Resolution\|resolution]] 1.76Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3fc0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FC0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3fc0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FC0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qdn\|2qdn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qdn\|2qdn]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tnfsf18, Gitrl ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tnfsf18, Gitrl ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fc0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fc0 RCSB], [http://www.ebi.ac.uk/pdbsum/3fc0 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fc0 OCA], [http://pdbe.org/3fc0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fc0 RCSB], [http://www.ebi.ac.uk/pdbsum/3fc0 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/~~Q7TS55_MOUSE Q7TS55_MOUSE~~]] Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B.<ref>PMID:14521928</ref> <ref>PMID:~~14647196~~</ref> <ref>PMID:~~14608036~~</ref> <ref>PMID:15128759</ref> <ref>PMID:18178614</ref>		[[http://www.uniprot.org/uniprot/TNF18_MOUSE TNF18_MOUSE]] Cytokine that binds to TNFRSF18/AITR/GITR (PubMed:14521928, PubMed:14647196). Regulates T-cell responses (PubMed:14647196). Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation (PubMed:14608036, PubMed:15128759). Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B (PubMed:14521928, PubMed:14647196, PubMed:18178614). Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (By similarity). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (PubMed:24107315).[UniProtKB:Q9UNG2]<ref>PMID:14521928</ref> <ref>PMID:14608036</ref> <ref>PMID:14647196</ref> <ref>PMID:15128759</ref> <ref>PMID:18178614</ref> <ref>PMID:23892569</ref> <ref>PMID:24107315</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fc0 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3fc0" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Mus musculus~~]]		[[Category: Lk3 transgenic mice]]
	[[Category: Almo, S C]]		[[Category: Almo, S C]]
	[[Category: Chattopadhyay, K]]		[[Category: Chattopadhyay, K]]

OCA at 17:37, 24 December 2014

2014-12-24T17:37:09Z

← Older revision		Revision as of 17:37, 24 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fc0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fc0 RCSB], [http://www.ebi.ac.uk/pdbsum/3fc0 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fc0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fc0 RCSB], [http://www.ebi.ac.uk/pdbsum/3fc0 PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/Q7TS55_MOUSE Q7TS55_MOUSE]] Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B.<ref>PMID:14521928</ref> <ref>PMID:14647196</ref> <ref>PMID:14608036</ref> <ref>PMID:15128759</ref> <ref>PMID:18178614</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:38, 26 November 2014

2014-11-26T08:38:48Z

← Older revision		Revision as of 08:38, 26 November 2014
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	[[Image:~~3fc0~~.~~png~~\|~~left~~\|~~200px~~]]		==1.8 A crystal structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells==
			<StructureSection load='3fc0' size='340' side='right' caption='[[3fc0]], [[Resolution\|resolution]] 1.76Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3fc0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FC0 FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qdn\|2qdn]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tnfsf18, Gitrl ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fc0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fc0 RCSB], [http://www.ebi.ac.uk/pdbsum/3fc0 PDBsum]</span></td></tr>
			</table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fc/3fc0_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Glucocorticoid-induced TNF receptor ligand (GITRL), a prominent member of the TNF superfamily, activates its receptor on both effector and regulatory T cells to generate critical costimulatory signals that have been implicated in a wide range of T-cell immune functions. The crystal structures of murine and human orthologs of GITRL recombinantly expressed in Escherichia coli have previously been determined. In contrast to all classical TNF structures, including the human GITRL structure, murine GITRL demonstrated a unique ;strand-exchanged' dimeric organization. Such a novel assembly behavior indicated a dramatic impact on receptor activation as well as on the signaling mechanism associated with the murine GITRL costimulatory system. In this present work, the 1.8 A resolution crystal structure of murine GITRL expressed in Drosophila melanogaster S2 cells is reported. The eukaryotic protein-expression system allows transport of the recombinant protein into the extracellular culture medium, thus maximizing the possibility of obtaining correctly folded material devoid of any folding/assembly artifacts that are often suspected with E. coli-expressed proteins. The S2 cell-expressed murine GITRL adopts an identical ;strand-exchanged' dimeric structure to that observed for the E. coli-expressed protein, thus conclusively demonstrating the novel quaternary structure assembly behavior of murine GITRL.

	~~{{STRUCTURE_3fc0\| PDB=3fc0 \| SCENE= }}~~		1.8 A structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells.,Chattopadhyay K, Ramagopal UA, Nathenson SG, Almo SC Acta Crystallogr D Biol Crystallogr. 2009 May;65(Pt 5):434-9. Epub 2009, Apr 18. PMID:19390148<ref>PMID:19390148</ref>

	~~===1~~.~~8 A crystal structure~~ of ~~murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	~~{{ABSTRACT_PUBMED_19390148}}~~		==See Also==
			*[[Tumor necrosis factor receptor\|Tumor necrosis factor receptor]]
	==~~About this Structure~~==		== References ==
	[[~~3fc0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus~~]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FC0 OCA~~].		<references/>
			__TOC__
	==~~Reference~~==		</StructureSection>
	<~~ref group="xtra">PMID:019390148<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Almo, S C.]]		[[Category: Almo, S C]]
	[[Category: Chattopadhyay, K.]]		[[Category: Chattopadhyay, K]]
	[[Category: Nathenson, S G.]]		[[Category: Nathenson, S G]]
	[[Category: Ramagopal, U A.]]		[[Category: Ramagopal, U A]]
	[[Category: Gitrl]]		[[Category: Gitrl]]
	[[Category: Glucocorticoid-induced tnf receptor ligand]]		[[Category: Glucocorticoid-induced tnf receptor ligand]]
	[[Category: Protein binding]]		[[Category: Protein binding]]
	[[Category: Receptor]]		[[Category: Receptor]]

OCA: Protected "3fc0" [edit=sysop:move=sysop]

2013-02-13T10:56:36Z

Protected "3fc0" [edit=sysop:move=sysop]

← Older revision	Revision as of 10:56, 13 February 2013
(No difference)

OCA at 10:56, 13 February 2013

2013-02-13T10:56:34Z

← Older revision		Revision as of 10:56, 13 February 2013
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	~~{{Seed}}~~
	[[Image:3fc0.png\|left\|200px]]		[[Image:3fc0.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3fc0", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3fc0\| PDB=3fc0 \| SCENE= }}		{{STRUCTURE_3fc0\| PDB=3fc0 \| SCENE= }}

	===1.8 A crystal structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells===		===1.8 A crystal structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_19390148}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 19390148 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_19390148}}		{{ABSTRACT_PUBMED_19390148}}

	==About this Structure==		==About this Structure==
	~~3FC0~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FC0 OCA].		[[3fc0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FC0 OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~19390148~~</ref><references group="xtra"/>		<ref group="xtra">PMID:019390148</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Almo, S C.]]		[[Category: Almo, S C.]]
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	[[Category: Protein binding]]		[[Category: Protein binding]]
	[[Category: Receptor]]		[[Category: Receptor]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat Jul 4 18:09:40 2009''~~

OCA at 15:09, 4 July 2009

2009-07-04T15:09:40Z

← Older revision		Revision as of 15:09, 4 July 2009
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	===1.8 A crystal structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells===		===1.8 A crystal structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells===


			<!--
			The line below this paragraph, {{ABSTRACT_PUBMED_19390148}}, adds the Publication Abstract to the page
			(as it appears on PubMed at http://www.pubmed.gov), where 19390148 is the PubMed ID number.
			-->
			{{ABSTRACT_PUBMED_19390148}}

	==About this Structure==		==About this Structure==
	3FC0 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FC0 OCA].		3FC0 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FC0 OCA].

			==Reference==
			<ref group="xtra">PMID:19390148</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Almo, S C.]]		[[Category: Almo, S C.]]
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	[[Category: Receptor]]		[[Category: Receptor]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed~~ Jul ~~1 20~~:19:02 2009''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat Jul 4 18:09:40 2009''