3fe2 - Revision history

OCA at 15:28, 1 November 2023

2023-11-01T15:28:58Z

← Older revision		Revision as of 15:28, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3fe2' size='340' side='right'caption='[[3fe2]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3fe2' size='340' side='right'caption='[[3fe2]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3fe2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FE2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FE2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3fe2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FE2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FE2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DDX5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fe2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fe2 OCA], [https://pdbe.org/3fe2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fe2 RCSB], [https://www.ebi.ac.uk/pdbsum/3fe2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fe2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fe2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fe2 OCA], [https://pdbe.org/3fe2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fe2 RCSB], [https://www.ebi.ac.uk/pdbsum/3fe2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fe2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/DDX5_HUMAN DDX5_HUMAN]] Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specicic manner; the function probbaly involves association with histone deacetylases, such as HDAC1.<ref>PMID:10409727</ref> <ref>PMID:11250900</ref> <ref>PMID:12527917</ref> <ref>PMID:15298701</ref> <ref>PMID:15660129</ref> <ref>PMID:17011493</ref> <ref>PMID:18829551</ref> <ref>PMID:17960593</ref> <ref>PMID:19718048</ref> <ref>PMID:21343338</ref>		[https://www.uniprot.org/uniprot/DDX5_HUMAN DDX5_HUMAN] Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specicic manner; the function probbaly involves association with histone deacetylases, such as HDAC1.<ref>PMID:10409727</ref> <ref>PMID:11250900</ref> <ref>PMID:12527917</ref> <ref>PMID:15298701</ref> <ref>PMID:15660129</ref> <ref>PMID:17011493</ref> <ref>PMID:18829551</ref> <ref>PMID:17960593</ref> <ref>PMID:19718048</ref> <ref>PMID:21343338</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 3fe2" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3fe2" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Helicase 3D structures\|Helicase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Arrowsmith~~, C H]]~~		[[Category: Arrowsmith CH]]
	~~[[Category: Berg, S Van Den~~]]		[[Category: Berglund H]]
	[[Category: Berglund, H]]		[[Category: Bountra C]]
	[[Category: Bountra, C]]		[[Category: Collins R]]
	[[Category: Collins, R]]		[[Category: Dahlgren LG]]
	[[Category: Dahlgren~~, L G~~]]		[[Category: Edwards AM]]
	[[Category: Edwards~~, A M~~]]		[[Category: Flodin S]]
	[[Category: Flodin, S]]		[[Category: Flores A]]
	[[Category: Flores, A]]		[[Category: Graslund S]]
	[[Category: Graslund, S]]		[[Category: Hammarstrom M]]
	[[Category: Hammarstrom, M]]		[[Category: Johansson A]]
	[[Category: Johansson, A]]		[[Category: Johansson I]]
	[[Category: Johansson, I]]		[[Category: Karlberg T]]
	[[Category: Karlberg, T]]		[[Category: Kotenyova T]]
	[[Category: Kotenyova, T]]		[[Category: Lehtio L]]
	[[Category: Lehtio, L]]		[[Category: Moche M]]
	[[Category: Moche, M]]		[[Category: Nilsson ME]]
	[[Category: Nilsson~~, M E~~]]		[[Category: Nordlund P]]
	[[Category: Nordlund, P]]		[[Category: Nyman T]]
	[[Category: Nyman, T]]		[[Category: Persson C]]
	[[Category: Persson, C]]		[[Category: Sagemark J]]
	~~[[Category: Structural genomic~~]]		[[Category: Schuler H]]
	[[Category: Sagemark, J]]		[[Category: Siponen MI]]
	[[Category: Schuler, H]]		[[Category: Thorsell AG]]
	[[Category: Siponen~~, M I~~]]		[[Category: Tresaugues L]]
	[[Category: Thorsell~~, A G~~]]		[[Category: Van Den Berg S]]
	[[Category: Tresaugues, L]]		[[Category: Weigelt J]]
	[[Category: ~~Weigelt, J~~]]		[[Category: Welin M]]
	[[Category: ~~Welin, M~~]]		[[Category: Wikstrom M]]
	[[Category: ~~Wikstrom,~~ M]]		[[Category: Wisniewska M]]
	[[Category: ~~Wisniewska,~~ M]]
	[[Category: ~~Adp]]~~
	~~[[Category: Atp-binding]]~~
	~~[[Category: Dead]]~~
	~~[[Category: Helicase]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: Methylation]]~~
	~~[[Category: Mrna processing]]~~
	~~[[Category: Mrna splicing]]~~
	~~[[Category: Nucleotide-binding]]~~
	~~[[Category: Nucleus]]~~
	~~[[Category: Phosphoprotein]]~~
	~~[[Category: Rna helicase]]~~
	~~[[Category: Rna-binding]]~~
	~~[[Category: Sgc]]~~
	~~[[Category: Spliceosome~~]]

OCA at 07:58, 2 March 2022

2022-03-02T07:58:54Z

← Older revision		Revision as of 07:58, 2 March 2022
Line 1:		Line 1:

	==Human DEAD-BOX RNA helicase DDX5 (P68), conserved domain I in complex with ADP==		==Human DEAD-BOX RNA helicase DDX5 (P68), conserved domain I in complex with ADP==
	<StructureSection load='3fe2' size='340' side='right' caption='[[3fe2]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3fe2' size='340' side='right'caption='[[3fe2]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3fe2]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FE2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3FE2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3fe2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FE2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FE2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DDX5 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DDX5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3fe2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fe2 OCA], [~~http~~://pdbe.org/3fe2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3fe2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3fe2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3fe2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fe2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fe2 OCA], [https://pdbe.org/3fe2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fe2 RCSB], [https://www.ebi.ac.uk/pdbsum/3fe2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fe2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/DDX5_HUMAN DDX5_HUMAN]] Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specicic manner; the function probbaly involves association with histone deacetylases, such as HDAC1.<ref>PMID:10409727</ref> <ref>PMID:11250900</ref> <ref>PMID:12527917</ref> <ref>PMID:15298701</ref> <ref>PMID:15660129</ref> <ref>PMID:17011493</ref> <ref>PMID:18829551</ref> <ref>PMID:17960593</ref> <ref>PMID:19718048</ref> <ref>PMID:21343338</ref>		[[https://www.uniprot.org/uniprot/DDX5_HUMAN DDX5_HUMAN]] Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specicic manner; the function probbaly involves association with histone deacetylases, such as HDAC1.<ref>PMID:10409727</ref> <ref>PMID:11250900</ref> <ref>PMID:12527917</ref> <ref>PMID:15298701</ref> <ref>PMID:15660129</ref> <ref>PMID:17011493</ref> <ref>PMID:18829551</ref> <ref>PMID:17960593</ref> <ref>PMID:19718048</ref> <ref>PMID:21343338</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Berg, S Van Den]]		[[Category: Berg, S Van Den]]

OCA at 14:56, 5 August 2016

2016-08-05T14:56:12Z

← Older revision		Revision as of 14:56, 5 August 2016
Line 1:		Line 1:

	==Human DEAD-BOX RNA helicase DDX5 (P68), conserved domain I in complex with ADP==		==Human DEAD-BOX RNA helicase DDX5 (P68), conserved domain I in complex with ADP==
	<StructureSection load='3fe2' size='340' side='right' caption='[[3fe2]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3fe2' size='340' side='right' caption='[[3fe2]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3fe2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FE2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FE2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3fe2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FE2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FE2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DDX5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DDX5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fe2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fe2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fe2 RCSB], [http://www.ebi.ac.uk/pdbsum/3fe2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fe2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fe2 OCA], [http://pdbe.org/3fe2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fe2 RCSB], [http://www.ebi.ac.uk/pdbsum/3fe2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3fe2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3fe2" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Berg, S Van Den]]		[[Category: Berg, S Van Den]]

OCA at 03:26, 25 December 2014

2014-12-25T03:26:40Z

← Older revision		Revision as of 03:26, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fe2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fe2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fe2 RCSB], [http://www.ebi.ac.uk/pdbsum/3fe2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fe2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fe2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fe2 RCSB], [http://www.ebi.ac.uk/pdbsum/3fe2 PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/DDX5_HUMAN DDX5_HUMAN]] Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specicic manner; the function probbaly involves association with histone deacetylases, such as HDAC1.<ref>PMID:10409727</ref> <ref>PMID:11250900</ref> <ref>PMID:12527917</ref> <ref>PMID:15298701</ref> <ref>PMID:15660129</ref> <ref>PMID:17011493</ref> <ref>PMID:18829551</ref> <ref>PMID:17960593</ref> <ref>PMID:19718048</ref> <ref>PMID:21343338</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 08:35, 26 November 2014

2014-11-26T08:35:26Z

← Older revision		Revision as of 08:35, 26 November 2014
Line 1:		Line 1:
	[[~~Image~~:~~3fe2~~.~~png~~\|~~left~~\|~~200px~~]]		==Human DEAD-BOX RNA helicase DDX5 (P68), conserved domain I in complex with ADP==
			<StructureSection load='3fe2' size='340' side='right' caption='[[3fe2]], [[Resolution\|resolution]] 2.60Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3fe2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FE2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FE2 FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DDX5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fe2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fe2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fe2 RCSB], [http://www.ebi.ac.uk/pdbsum/3fe2 PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			DEAD-box RNA helicases play various, often critical, roles in all processes where RNAs are involved. Members of this family of proteins are linked to human disease, including cancer and viral infections. DEAD-box proteins contain two conserved domains that both contribute to RNA and ATP binding. Despite recent advances the molecular details of how these enzymes convert chemical energy into RNA remodeling is unknown. We present crystal structures of the isolated DEAD-domains of human DDX2A/eIF4A1, DDX2B/eIF4A2, DDX5, DDX10/DBP4, DDX18/myc-regulated DEAD-box protein, DDX20, DDX47, DDX52/ROK1, and DDX53/CAGE, and of the helicase domains of DDX25 and DDX41. Together with prior knowledge this enables a family-wide comparative structural analysis. We propose a general mechanism for opening of the RNA binding site. This analysis also provides insights into the diversity of DExD/H- proteins, with implications for understanding the functions of individual family members.

	~~{{STRUCTURE_3fe2\| PDB=3fe2 \| SCENE= }}~~		Comparative structural analysis of human DEAD-box RNA helicases.,Schutz P, Karlberg T, van den Berg S, Collins R, Lehtio L, Hogbom M, Holmberg-Schiavone L, Tempel W, Park HW, Hammarstrom M, Moche M, Thorsell AG, Schuler H PLoS One. 2010 Sep 30;5(9). pii: e12791. PMID:20941364<ref>PMID:20941364</ref>

	~~===Human DEAD-BOX RNA helicase DDX5 (P68)~~, ~~conserved domain I in complex with ADP===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_20941364}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[3fe2]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3FE2 OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:020941364<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H]]
	[[Category: Berg, S Van Den.]]		[[Category: Berg, S Van Den]]
	[[Category: Berglund, H.]]		[[Category: Berglund, H]]
	[[Category: Bountra, C.]]		[[Category: Bountra, C]]
	[[Category: Collins, R.]]		[[Category: Collins, R]]
	[[Category: Dahlgren, L G.]]		[[Category: Dahlgren, L G]]
	[[Category: Edwards, A M.]]		[[Category: Edwards, A M]]
	[[Category: Flodin, S.]]		[[Category: Flodin, S]]
	[[Category: Flores, A.]]		[[Category: Flores, A]]
	[[Category: Graslund, S.]]		[[Category: Graslund, S]]
	[[Category: Hammarstrom, M.]]		[[Category: Hammarstrom, M]]
	[[Category: Johansson, A.]]		[[Category: Johansson, A]]
	[[Category: Johansson, I.]]		[[Category: Johansson, I]]
	[[Category: Karlberg, T.]]		[[Category: Karlberg, T]]
	[[Category: Kotenyova, T.]]		[[Category: Kotenyova, T]]
	[[Category: Lehtio, L.]]		[[Category: Lehtio, L]]
	[[Category: Moche, M.]]		[[Category: Moche, M]]
	[[Category: Nilsson, M E.]]		[[Category: Nilsson, M E]]
	[[Category: Nordlund, P.]]		[[Category: Nordlund, P]]
	[[Category: Nyman, T.]]		[[Category: Nyman, T]]
	[[Category: Persson, C.]]		[[Category: Persson, C]]
	[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]		[[Category: Structural genomic]]
	[[Category: Sagemark, J.]]		[[Category: Sagemark, J]]
	[[Category: Schuler, H.]]		[[Category: Schuler, H]]
	[[Category: Siponen, M I.]]		[[Category: Siponen, M I]]
	[[Category: Thorsell, A G.]]		[[Category: Thorsell, A G]]
	[[Category: Tresaugues, L.]]		[[Category: Tresaugues, L]]
	[[Category: Weigelt, J.]]		[[Category: Weigelt, J]]
	[[Category: Welin, M.]]		[[Category: Welin, M]]
	[[Category: Wikstrom, M.]]		[[Category: Wikstrom, M]]
	[[Category: Wisniewska, M.]]		[[Category: Wisniewska, M]]
	[[Category: Adp]]		[[Category: Adp]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
Line 59:		Line 66:
	[[Category: Sgc]]		[[Category: Sgc]]
	[[Category: Spliceosome]]		[[Category: Spliceosome]]
	~~[[Category: Structural genomic]]~~
	~~[[Category: Structural genomics consortium]]~~

OCA: Protected "3fe2" [edit=sysop:move=sysop]

2013-02-13T10:53:23Z

Protected "3fe2" [edit=sysop:move=sysop]

← Older revision	Revision as of 10:53, 13 February 2013
(No difference)

OCA at 10:53, 13 February 2013

2013-02-13T10:53:21Z

← Older revision		Revision as of 10:53, 13 February 2013
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	~~{{Seed}}~~
	[[Image:3fe2.png\|left\|200px]]		[[Image:3fe2.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3fe2", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3fe2\| PDB=3fe2 \| SCENE= }}		{{STRUCTURE_3fe2\| PDB=3fe2 \| SCENE= }}

	===Human DEAD-BOX RNA helicase DDX5 (P68), conserved domain I in complex with ADP===		===Human DEAD-BOX RNA helicase DDX5 (P68), conserved domain I in complex with ADP===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_20941364}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 20941364 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_20941364}}		{{ABSTRACT_PUBMED_20941364}}

	==About this Structure==		==About this Structure==
	~~3FE2~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FE2 OCA].		[[3fe2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FE2 OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~20941364~~</ref><references group="xtra"/>		<ref group="xtra">PMID:020941364</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H.]]
Line 73:		Line 61:
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Structural genomics consortium]]		[[Category: Structural genomics consortium]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 27 11:26:55 2010''~~

OCA at 08:16, 27 October 2010

2010-10-27T08:16:33Z

← Older revision		Revision as of 08:16, 27 October 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
	[[Image:3fe2.~~jpg~~\|left\|200px]]		[[Image:3fe2.png\|left\|200px]]

	<!--		<!--
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	===Human DEAD-BOX RNA helicase DDX5 (P68), conserved domain I in complex with ADP===		===Human DEAD-BOX RNA helicase DDX5 (P68), conserved domain I in complex with ADP===


			<!--
			The line below this paragraph, {{ABSTRACT_PUBMED_20941364}}, adds the Publication Abstract to the page
			(as it appears on PubMed at http://www.pubmed.gov), where 20941364 is the PubMed ID number.
			-->
			{{ABSTRACT_PUBMED_20941364}}

	==About this Structure==		==About this Structure==
	3FE2 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FE2 OCA].		3FE2 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FE2 OCA].

			==Reference==
			<ref group="xtra">PMID:20941364</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H.]]
Line 58:		Line 67:
	[[Category: Nucleus]]		[[Category: Nucleus]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
	~~[[Category: Polymorphism]]~~
	[[Category: Rna helicase]]		[[Category: Rna helicase]]
	[[Category: Rna-binding]]		[[Category: Rna-binding]]
Line 66:		Line 74:
	[[Category: Structural genomics consortium]]		[[Category: Structural genomics consortium]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Dec 17 13~~:49:~~03 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 27 11:26:55 2010''

OCA at 11:49, 17 December 2008

2008-12-17T11:49:04Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{Seed}}
-The entry 3fe2 is ON HOLD
+<!--
-Authors: Karlberg, T., Siponen, M.I., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Dahlgren, L.G., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Kotenyova, T., Lehtio, L., Moche, M., Nilsson, M.E.,
+===Human DEAD-BOX RNA helicase DDX5 (P68), conserved domain I in complex with ADP===
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 10 14:42:26 2008''
+==About this Structure==

OCA: New page: '''Unreleased structure''' The entry 3fe2 is ON HOLD Authors: Karlberg, T., Siponen, M.I., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Dahlgren, L.G., Edwards, A.M., Flodi...

2008-12-10T12:42:26Z

New page: '''Unreleased structure''' The entry 3fe2 is ON HOLD Authors: Karlberg, T., Siponen, M.I., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Dahlgren, L.G., Edwards, A.M., Flodi...

New page

'''Unreleased structure'''

The entry 3fe2 is ON HOLD

Authors: Karlberg, T., Siponen, M.I., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Dahlgren, L.G., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Kotenyova, T., Lehtio, L., Moche, M., Nilsson, M.E.,

Description: Human DEAD-BOX RNA helicase DDX5 (P68), conserved domain I in complex with ADP

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 10 14:42:26 2008''