3ffd - Revision history

OCA at 15:29, 1 November 2023

2023-11-01T15:29:16Z

← Older revision		Revision as of 15:29, 1 November 2023
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	<StructureSection load='3ffd' size='340' side='right'caption='[[3ffd]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3ffd' size='340' side='right'caption='[[3ffd]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ffd]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~] and [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3FFD FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ffd]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FFD FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3ffd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ffd OCA], [~~http~~://pdbe.org/3ffd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ffd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ffd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ffd ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ffd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ffd OCA], [https://pdbe.org/3ffd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ffd RCSB], [https://www.ebi.ac.uk/pdbsum/3ffd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ffd ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[~~[http~~://www.uniprot.org/uniprot/PTHR_HUMAN PTHR_HUMAN]] Defects in PTHLH are the cause of brachydactyly type E2 (BDE2) [MIM:[~~http~~://omim.org/entry/613382 613382]]. BDE2 is a form of brachydactyly. Brachydactyly defines a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. Brachydactyly type E is characterized by shortening of the fingers mainly in the metacarpals and metatarsals. Wide variability in the number of digits affected occurs from person to person, even in the same family. Some individuals are moderately short of stature. In brachydactyly type E2 variable combinations of metacarpals are involved, with shortening also of the first and third distal and the second and fifth middle phalanges.<ref>PMID:20170896</ref>		[https://www.uniprot.org/uniprot/PTHR_HUMAN PTHR_HUMAN] Defects in PTHLH are the cause of brachydactyly type E2 (BDE2) [MIM:[https://omim.org/entry/613382 613382]. BDE2 is a form of brachydactyly. Brachydactyly defines a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. Brachydactyly type E is characterized by shortening of the fingers mainly in the metacarpals and metatarsals. Wide variability in the number of digits affected occurs from person to person, even in the same family. Some individuals are moderately short of stature. In brachydactyly type E2 variable combinations of metacarpals are involved, with shortening also of the first and third distal and the second and fifth middle phalanges.<ref>PMID:20170896</ref>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/PTHR_HUMAN PTHR_HUMAN]] Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1.<ref>PMID:20637541</ref> Osteostatin is a potent inhibitor of osteoclastic bone resorption.<ref>PMID:20637541</ref>		[https://www.uniprot.org/uniprot/PTHR_HUMAN PTHR_HUMAN] Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1.<ref>PMID:20637541</ref> Osteostatin is a potent inhibitor of osteoclastic bone resorption.<ref>PMID:20637541</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Lk3 transgenic mice~~]]		[[Category: Mus musculus]]
	[[Category: Diefenbach-Jagger, H]]		[[Category: Diefenbach-Jagger H]]
	[[Category: Gillespie~~, M T~~]]		[[Category: Gillespie MT]]
	[[Category: Ho~~, P W.M~~]]		[[Category: Ho PWM]]
	[[Category: Martin~~, T J~~]]		[[Category: Martin TJ]]
	[[Category: Mckinstry~~, W J~~]]		[[Category: Mckinstry WJ]]
	[[Category: Onuma, E]]		[[Category: Onuma E]]
	[[Category: Parker~~, M W~~]]		[[Category: Parker MW]]
	[[Category: Polekhina, G]]		[[Category: Polekhina G]]
	[[Category: Sato, K]]		[[Category: Sato K]]
	~~[[Category: Cleavage on pair of basic residue]]~~
	~~[[Category: Hormone]]~~
	~~[[Category: Immune system-hormone complex]]~~
	~~[[Category: Nucleus]]~~
	~~[[Category: Pthrp complexed to fab]]~~
	~~[[Category: Secreted~~]]

OCA at 10:29, 9 September 2020

2020-09-09T10:29:53Z

← Older revision		Revision as of 10:29, 9 September 2020
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	==Structure of parathyroid hormone-related protein complexed to a neutralizing monoclonal antibody==		==Structure of parathyroid hormone-related protein complexed to a neutralizing monoclonal antibody==
	<StructureSection load='3ffd' size='340' side='right' caption='[[3ffd]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3ffd' size='340' side='right'caption='[[3ffd]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ffd]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFD OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3FFD FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ffd]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3FFD FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca.weizmann~~.~~ac.il/oca-docs~~/fgij/fg.htm?mol=3ffd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ffd OCA], [http://pdbe.org/3ffd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ffd RCSB], [http://www.ebi.ac.uk/pdbsum/3ffd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ffd ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3ffd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ffd OCA], [http://pdbe.org/3ffd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ffd RCSB], [http://www.ebi.ac.uk/pdbsum/3ffd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ffd ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Diefenbach-Jagger, H]]		[[Category: Diefenbach-Jagger, H]]

OCA at 07:23, 5 December 2018

2018-12-05T07:23:08Z

← Older revision		Revision as of 07:23, 5 December 2018
Line 1:		Line 1:

	==Structure of parathyroid hormone-related protein complexed to a neutralizing monoclonal antibody==		==Structure of parathyroid hormone-related protein complexed to a neutralizing monoclonal antibody==
	<StructureSection load='3ffd' size='340' side='right' caption='[[3ffd]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3ffd' size='340' side='right' caption='[[3ffd]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ffd]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FFD FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ffd]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FFD FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ffd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ffd OCA], [http://pdbe.org/3ffd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ffd RCSB], [http://www.ebi.ac.uk/pdbsum/3ffd PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ffd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ffd OCA], [http://pdbe.org/3ffd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ffd RCSB], [http://www.ebi.ac.uk/pdbsum/3ffd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ffd ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ff/3ffd_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ff/3ffd_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 31:

	==See Also==		==See Also==
	*[[Monoclonal ~~Antibody~~\|Monoclonal ~~Antibody~~]]		*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:30, 10 February 2016

2016-02-10T07:30:43Z

← Older revision		Revision as of 07:30, 10 February 2016
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ffd]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FFD FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ffd]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FFD FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ffd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ffd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ffd RCSB], [http://www.ebi.ac.uk/pdbsum/3ffd PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ffd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ffd OCA], [http://pdbe.org/3ffd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ffd RCSB], [http://www.ebi.ac.uk/pdbsum/3ffd PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ffd ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3ffd" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 22:39, 3 January 2015

2015-01-03T22:39:59Z

← Older revision		Revision as of 22:39, 3 January 2015
Line 1:		Line 1:
	~~{{STRUCTURE_3ffd\| PDB=3ffd \| SCENE= }}~~		==Structure of parathyroid hormone-related protein complexed to a neutralizing monoclonal antibody==
	===Structure of parathyroid hormone-related protein complexed to a neutralizing monoclonal antibody===		<StructureSection load='3ffd' size='340' side='right' caption='[[3ffd]], [[Resolution\|resolution]] 2.00Å' scene=''>
	~~{{ABSTRACT_PUBMED_19346515}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[3ffd]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FFD FirstGlance]. <br>
	==Disease==		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ffd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ffd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ffd RCSB], [http://www.ebi.ac.uk/pdbsum/3ffd PDBsum]</span></td></tr>
			</table>
			== Disease ==
	[[http://www.uniprot.org/uniprot/PTHR_HUMAN PTHR_HUMAN]] Defects in PTHLH are the cause of brachydactyly type E2 (BDE2) [MIM:[http://omim.org/entry/613382 613382]]. BDE2 is a form of brachydactyly. Brachydactyly defines a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. Brachydactyly type E is characterized by shortening of the fingers mainly in the metacarpals and metatarsals. Wide variability in the number of digits affected occurs from person to person, even in the same family. Some individuals are moderately short of stature. In brachydactyly type E2 variable combinations of metacarpals are involved, with shortening also of the first and third distal and the second and fifth middle phalanges.<ref>PMID:20170896</ref>		[[http://www.uniprot.org/uniprot/PTHR_HUMAN PTHR_HUMAN]] Defects in PTHLH are the cause of brachydactyly type E2 (BDE2) [MIM:[http://omim.org/entry/613382 613382]]. BDE2 is a form of brachydactyly. Brachydactyly defines a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. Brachydactyly type E is characterized by shortening of the fingers mainly in the metacarpals and metatarsals. Wide variability in the number of digits affected occurs from person to person, even in the same family. Some individuals are moderately short of stature. In brachydactyly type E2 variable combinations of metacarpals are involved, with shortening also of the first and third distal and the second and fifth middle phalanges.<ref>PMID:20170896</ref>
			== Function ==
			[[http://www.uniprot.org/uniprot/PTHR_HUMAN PTHR_HUMAN]] Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1.<ref>PMID:20637541</ref> Osteostatin is a potent inhibitor of osteoclastic bone resorption.<ref>PMID:20637541</ref>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ff/3ffd_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Parathyroid hormone-related protein (PTHrP) plays a vital role in the embryonic development of the skeleton and other tissues. When it is produced in excess by cancers it can cause hypercalcemia, and its local production by breast cancer cells has been implicated in the pathogenesis of bone metastasis formation in that disease. Antibodies have been developed that neutralize the action of PTHrP through its receptor, parathyroid hormone receptor 1, without influencing parathyroid hormone action through the same receptor. Such neutralizing antibodies against PTHrP are therapeutically effective in animal models of the humoral hypercalcemia of malignancy and of bone metastasis formation. We have determined the crystal structure of the complex between PTHrP (residues 1-108) and a neutralizing monoclonal anti-PTHrP antibody that reveals the only point of contact is an alpha-helical structure extending from residues 14-29. Another striking feature is that the same residues that interact with the antibody also interact with parathyroid hormone receptor 1, showing that the antibody and the receptor binding site on the hormone closely overlap. The structure explains how the antibody discriminates between the two hormones and provides information that could be used in the development of novel agonists and antagonists of their common receptor.

	~~==Function==~~		Structural basis for antibody discrimination between two hormones that recognize the parathyroid hormone receptor.,McKinstry WJ, Polekhina G, Diefenbach-Jagger H, Ho PW, Sato K, Onuma E, Gillespie MT, Martin TJ, Parker MW J Biol Chem. 2009 Jun 5;284(23):15557-63. doi: 10.1074/jbc.M900044200. Epub 2009 , Apr 4. PMID:19346515<ref>PMID:19346515</ref>
	~~[[http://www~~.~~uniprot.org/uniprot/PTHR_HUMAN PTHR_HUMAN]] Neuroendocrine peptide which is a critical regulator of cellular and organ growth~~, ~~development~~, ~~migration~~, ~~differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial~~-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, ~~in turn~~, ~~triggers epithelial outgrowth and augments MSX2 expression~~, ~~which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath~~ (~~By similarity~~). ~~Promotes colon cancer cell migration and invasion in an integrin alpha-6~~/~~beta-1-dependent manner through activation of Rac1~~.~~<ref>~~PMID:~~20637541</ref> Osteostatin is a potent inhibitor of osteoclastic bone resorption.~~<ref>PMID:~~20637541~~</ref>

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[3ffd]] is~~ a ~~3 chain structure with sequence from [http://en.wikipedia~~.~~org/wiki/Human Human] and [http://en~~.~~wikipedia~~.~~org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=3FFD OCA].~~		</div>

	==See Also==		==See Also==
	*[[Monoclonal Antibody\|Monoclonal Antibody]]		*[[Monoclonal Antibody\|Monoclonal Antibody]]
			== References ==
	==~~Reference~~==		<references/>
	~~<ref group="xtra">PMID:019346515</ref>~~<references ~~group="xtra"~~/><~~references~~/>		__TOC__
			</StructureSection>
	[[Category: Human]]		[[Category: Human]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Diefenbach-Jagger, H.]]		[[Category: Diefenbach-Jagger, H]]
	[[Category: Gillespie, M T.]]		[[Category: Gillespie, M T]]
	[[Category: Ho, P W.M.]]		[[Category: Ho, P W.M]]
	[[Category: Martin, T J.]]		[[Category: Martin, T J]]
	[[Category: Mckinstry, W J.]]		[[Category: Mckinstry, W J]]
	[[Category: Onuma, E.]]		[[Category: Onuma, E]]
	[[Category: Parker, M W.]]		[[Category: Parker, M W]]
	[[Category: Polekhina, G.]]		[[Category: Polekhina, G]]
	[[Category: Sato, K.]]		[[Category: Sato, K]]
	[[Category: Cleavage on pair of basic residue]]		[[Category: Cleavage on pair of basic residue]]
	[[Category: Hormone]]		[[Category: Hormone]]

OCA at 08:10, 5 February 2014

2014-02-05T08:10:12Z

← Older revision		Revision as of 08:10, 5 February 2014
Line 1:		Line 1:
	{{STRUCTURE_3ffd\| PDB=3ffd \| SCENE= }}		{{STRUCTURE_3ffd\| PDB=3ffd \| SCENE= }}
	===Structure of parathyroid hormone-related protein complexed to a neutralizing monoclonal antibody===		===Structure of parathyroid hormone-related protein complexed to a neutralizing monoclonal antibody===
	{{~~ABSTRACT_PUBMED_11356832~~}}		{{ABSTRACT_PUBMED_19346515}}

	==Disease==		==Disease==
	[[http://www.uniprot.org/uniprot/PTHR_HUMAN PTHR_HUMAN]] Defects in PTHLH are the cause of brachydactyly type E2 (BDE2) [MIM:[http://omim.org/entry/613382 613382]]. BDE2 is a form of brachydactyly. Brachydactyly defines a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. Brachydactyly type E is characterized by shortening of the fingers mainly in the metacarpals and metatarsals. Wide variability in the number of digits affected occurs from person to person, even in the same family. Some individuals are moderately short of stature. In brachydactyly type E2 variable combinations of metacarpals are involved, with shortening also of the first and third distal and the second and fifth middle phalanges.<ref>PMID:20170896</ref>		[[http://www.uniprot.org/uniprot/PTHR_HUMAN PTHR_HUMAN]] Defects in PTHLH are the cause of brachydactyly type E2 (BDE2) [MIM:[http://omim.org/entry/613382 613382]]. BDE2 is a form of brachydactyly. Brachydactyly defines a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. Brachydactyly type E is characterized by shortening of the fingers mainly in the metacarpals and metatarsals. Wide variability in the number of digits affected occurs from person to person, even in the same family. Some individuals are moderately short of stature. In brachydactyly type E2 variable combinations of metacarpals are involved, with shortening also of the first and third distal and the second and fifth middle phalanges.<ref>PMID:20170896</ref>

	==Function==		==Function==
	[[http://www.uniprot.org/uniprot/PTHR_HUMAN PTHR_HUMAN]] Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1.<ref>PMID:20637541</ref> Osteostatin is a potent inhibitor of osteoclastic bone resorption.<ref>PMID:20637541</ref>		[[http://www.uniprot.org/uniprot/PTHR_HUMAN PTHR_HUMAN]] Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1.<ref>PMID:20637541</ref> Osteostatin is a potent inhibitor of osteoclastic bone resorption.<ref>PMID:20637541</ref>

	==About this Structure==		==About this Structure==
	[[3ffd]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~] and [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFD OCA].		[[3ffd]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFD OCA].

	==See Also==		==See Also==
Line 16:		Line 16:

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~011356832</ref><ref group="xtra">PMID:011397646~~</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:019346515</ref><references group="xtra"/><references/>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: ~~Mus musculus~~]]		[[Category: Lk3 transgenic mice]]
	[[Category: Diefenbach-Jagger, H.]]		[[Category: Diefenbach-Jagger, H.]]
	[[Category: Gillespie, M T.]]		[[Category: Gillespie, M T.]]

OCA at 02:09, 25 March 2013

2013-03-25T02:09:35Z

← Older revision		Revision as of 02:09, 25 March 2013
Line 1:		Line 1:
	~~[[Image:3ffd.png\|left\|200px]]~~

	{{STRUCTURE_3ffd\| PDB=3ffd \| SCENE= }}		{{STRUCTURE_3ffd\| PDB=3ffd \| SCENE= }}
			===Structure of parathyroid hormone-related protein complexed to a neutralizing monoclonal antibody===
			{{ABSTRACT_PUBMED_11356832}}

	===~~Structure~~ of ~~parathyroid hormone-related protein complexed~~ to ~~a neutralizing monoclonal antibody===~~		==Disease==
			[[http://www.uniprot.org/uniprot/PTHR_HUMAN PTHR_HUMAN]] Defects in PTHLH are the cause of brachydactyly type E2 (BDE2) [MIM:[http://omim.org/entry/613382 613382]]. BDE2 is a form of brachydactyly. Brachydactyly defines a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. Brachydactyly type E is characterized by shortening of the fingers mainly in the metacarpals and metatarsals. Wide variability in the number of digits affected occurs from person to person, even in the same family. Some individuals are moderately short of stature. In brachydactyly type E2 variable combinations of metacarpals are involved, with shortening also of the first and third distal and the second and fifth middle phalanges.<ref>PMID:20170896</ref>

	~~{{ABSTRACT_PUBMED_11356832}}~~		==Function==
			[[http://www.uniprot.org/uniprot/PTHR_HUMAN PTHR_HUMAN]] Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1.<ref>PMID:20637541</ref> Osteostatin is a potent inhibitor of osteoclastic bone resorption.<ref>PMID:20637541</ref>

	==About this Structure==		==About this Structure==
Line 14:		Line 16:

	==Reference==		==Reference==
	<ref group="xtra">PMID:011356832</ref><ref group="xtra">PMID:011397646</ref><references group="xtra"/>		<ref group="xtra">PMID:011356832</ref><ref group="xtra">PMID:011397646</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]

OCA at 16:49, 20 October 2012

2012-10-20T16:49:11Z

← Older revision		Revision as of 16:49, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[3ffd]] is a 3 chain structure ~~of [[Monoclonal Antibody]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFD OCA].		[[3ffd]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFD OCA].

	==See Also==		==See Also==

OCA at 22:55, 26 July 2012

2012-07-26T22:55:36Z

← Older revision		Revision as of 22:55, 26 July 2012
Line 1:		Line 1:
	[[Image:3ffd.png\|left\|200px]]		[[Image:3ffd.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3ffd", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3ffd\| PDB=3ffd \| SCENE= }}		{{STRUCTURE_3ffd\| PDB=3ffd \| SCENE= }}

	===Structure of parathyroid hormone-related protein complexed to a neutralizing monoclonal antibody===		===Structure of parathyroid hormone-related protein complexed to a neutralizing monoclonal antibody===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_11356832}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 11356832 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_11356832}}		{{ABSTRACT_PUBMED_11356832}}

	==About this Structure==		==About this Structure==
	[[3ffd]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFD OCA].		[[3ffd]] is a 3 chain structure of [[Monoclonal Antibody]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFD OCA].

			==See Also==
			*[[Monoclonal Antibody\|Monoclonal Antibody]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~11356832~~</ref><ref group="xtra">PMID:~~11397646~~</ref><references group="xtra"/>		<ref group="xtra">PMID:011356832</ref><ref group="xtra">PMID:011397646</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
Line 34:		Line 26:
	[[Category: Polekhina, G.]]		[[Category: Polekhina, G.]]
	[[Category: Sato, K.]]		[[Category: Sato, K.]]
	~~[[Category: Alternative splicing]]~~
	~~[[Category: Calcium]]~~
	[[Category: Cleavage on pair of basic residue]]		[[Category: Cleavage on pair of basic residue]]
	~~[[Category: Cytoplasm]]~~
	[[Category: Hormone]]		[[Category: Hormone]]
	[[Category: Immune system/hormone complex]]		[[Category: Immune system-hormone complex]]
	[[Category: Nucleus]]		[[Category: Nucleus]]
	~~[[Category: Polymorphism]]~~
	[[Category: Pthrp complexed to fab]]		[[Category: Pthrp complexed to fab]]
	[[Category: Secreted]]		[[Category: Secreted]]

OCA: Protected "3ffd" [edit=sysop:move=sysop]

2011-03-14T23:17:44Z

Protected "3ffd" [edit=sysop:move=sysop]

← Older revision	Revision as of 23:17, 14 March 2011
(No difference)