3flu - Revision history

OCA at 15:30, 1 November 2023

2023-11-01T15:30:30Z

← Older revision		Revision as of 15:30, 1 November 2023
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	<StructureSection load='3flu' size='340' side='right'caption='[[3flu]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3flu' size='340' side='right'caption='[[3flu]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3flu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Neimi Neimi~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FLU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FLU FirstGlance]. <br>		<table><tr><td colspan='2'>[[3flu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_meningitidis_serogroup_B Neisseria meningitidis serogroup B]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FLU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FLU FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em~~;~~'>[[1yxc\|1yxc]], [[1yxd\|1yxd]]</div>~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>dapA, NMB0929 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~491 NEIMI])</td~~><~~/tr>~~
	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>[https://en.wikipedia.org/wiki/4-hydroxy-tetrahydrodipicolinate_synthase 4-hydroxy-tetrahydrodipicolinate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.7 4.3.3.7] </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3flu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3flu OCA], [https://pdbe.org/3flu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3flu RCSB], [https://www.ebi.ac.uk/pdbsum/3flu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3flu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3flu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3flu OCA], [https://pdbe.org/3flu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3flu RCSB], [https://www.ebi.ac.uk/pdbsum/3flu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3flu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/DAPA_NEIMB DAPA_NEIMB]] Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).<ref>PMID:19236959</ref>		[https://www.uniprot.org/uniprot/DAPA_NEIMB DAPA_NEIMB] Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).<ref>PMID:19236959</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: 4-hydroxy-tetrahydrodipicolinate synthase]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Neimi~~]]		[[Category: Neisseria meningitidis serogroup B]]
	[[Category: Devenish~~, S R.A~~]]		[[Category: Devenish SRA]]
	[[Category: Hadfield~~, A T]]~~		[[Category: Hadfield AT]]
	~~[[Category: Amino-acid biosynthesis]]~~
	~~[[Category: Beta-alpha-barrel]]~~
	~~[[Category: Diaminopimelate biosynthesis]]~~
	~~[[Category: Lyase]]~~
	~~[[Category: Lysine biosynthesis]]~~
	~~[[Category: Schiff base]]~~
	~~[[Category: Tim barrel~~]]

OCA at 08:04, 2 March 2022

2022-03-02T08:04:27Z

← Older revision		Revision as of 08:04, 2 March 2022
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	==Crystal structure of dihydrodipicolinate synthase from the pathogen Neisseria meningitidis==		==Crystal structure of dihydrodipicolinate synthase from the pathogen Neisseria meningitidis==
	<StructureSection load='3flu' size='340' side='right' caption='[[3flu]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3flu' size='340' side='right'caption='[[3flu]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3flu]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Neimi Neimi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FLU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3FLU FirstGlance]. <br>		<table><tr><td colspan='2'>[[3flu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Neimi Neimi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FLU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FLU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1yxc\|1yxc]], [[1yxd\|1yxd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1yxc\|1yxc]], [[1yxd\|1yxd]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dapA, NMB0929 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=491 NEIMI])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dapA, NMB0929 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=491 NEIMI])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/4-hydroxy-tetrahydrodipicolinate_synthase 4-hydroxy-tetrahydrodipicolinate synthase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.7 4.3.3.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/4-hydroxy-tetrahydrodipicolinate_synthase 4-hydroxy-tetrahydrodipicolinate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.7 4.3.3.7] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3flu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3flu OCA], [~~http~~://pdbe.org/3flu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3flu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3flu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3flu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3flu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3flu OCA], [https://pdbe.org/3flu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3flu RCSB], [https://www.ebi.ac.uk/pdbsum/3flu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3flu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/DAPA_NEIMB DAPA_NEIMB]] Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).<ref>PMID:19236959</ref>		[[https://www.uniprot.org/uniprot/DAPA_NEIMB DAPA_NEIMB]] Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).<ref>PMID:19236959</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fl/3flu_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fl/3flu_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 3flu" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3flu" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Dihydrodipicolinate synthase\|Dihydrodipicolinate synthase]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: 4-hydroxy-tetrahydrodipicolinate synthase]]		[[Category: 4-hydroxy-tetrahydrodipicolinate synthase]]
			[[Category: Large Structures]]
	[[Category: Neimi]]		[[Category: Neimi]]
	[[Category: Devenish, S R.A]]		[[Category: Devenish, S R.A]]

OCA at 06:44, 1 November 2017

2017-11-01T06:44:43Z

← Older revision		Revision as of 06:44, 1 November 2017
Line 1:		Line 1:

	==Crystal structure of dihydrodipicolinate synthase from the pathogen Neisseria meningitidis==		==Crystal structure of dihydrodipicolinate synthase from the pathogen Neisseria meningitidis==
	<StructureSection load='3flu' size='340' side='right' caption='[[3flu]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3flu' size='340' side='right' caption='[[3flu]], [[Resolution\|resolution]] 2.00Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dapA, NMB0929 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=491 NEIMI])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dapA, NMB0929 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=491 NEIMI])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-tetrahydrodipicolinate_synthase 4-hydroxy-tetrahydrodipicolinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.7 4.3.3.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-tetrahydrodipicolinate_synthase 4-hydroxy-tetrahydrodipicolinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.7 4.3.3.7] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3flu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3flu OCA], [http://pdbe.org/3flu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3flu RCSB], [http://www.ebi.ac.uk/pdbsum/3flu PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3flu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3flu OCA], [http://pdbe.org/3flu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3flu RCSB], [http://www.ebi.ac.uk/pdbsum/3flu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3flu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 3flu" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3flu" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Dihydrodipicolinate synthase\|Dihydrodipicolinate synthase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:07, 8 February 2016

2016-02-08T15:07:24Z

← Older revision		Revision as of 15:07, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3flu' size='340' side='right' caption='[[3flu]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3flu' size='340' side='right' caption='[[3flu]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3flu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Neisseria_meningitidis_serogroup_b Neisseria meningitidis serogroup b~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FLU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FLU FirstGlance]. <br>		<table><tr><td colspan='2'>[[3flu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Neimi Neimi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FLU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FLU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1yxc\|1yxc]], [[1yxd\|1yxd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1yxc\|1yxc]], [[1yxd\|1yxd]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dapA, NMB0929 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=491 ~~Neisseria meningitidis serogroup B~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dapA, NMB0929 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=491 NEIMI])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~Dihydrodipicolinate_synthase Dihydrodipicolinate~~ synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.52 4.2.1.52] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-tetrahydrodipicolinate_synthase 4-hydroxy-tetrahydrodipicolinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.7 4.3.3.7] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3flu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3flu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3flu RCSB], [http://www.ebi.ac.uk/pdbsum/3flu PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3flu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3flu OCA], [http://pdbe.org/3flu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3flu RCSB], [http://www.ebi.ac.uk/pdbsum/3flu PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3flu ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3flu" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Dihydrodipicolinate~~ synthase]]		[[Category: 4-hydroxy-tetrahydrodipicolinate synthase]]
	[[Category: ~~Neisseria meningitidis serogroup b~~]]		[[Category: Neimi]]
	[[Category: Devenish, S R.A]]		[[Category: Devenish, S R.A]]
	[[Category: Hadfield, A T]]		[[Category: Hadfield, A T]]

OCA at 12:54, 5 January 2015

2015-01-05T12:54:40Z

← Older revision		Revision as of 12:54, 5 January 2015
Line 1:		Line 1:
	[[Image:~~3flu~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of dihydrodipicolinate synthase from the pathogen Neisseria meningitidis==
			<StructureSection load='3flu' size='340' side='right' caption='[[3flu]], [[Resolution\|resolution]] 2.00Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3flu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_meningitidis_serogroup_b Neisseria meningitidis serogroup b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FLU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FLU FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1yxc\|1yxc]], [[1yxd\|1yxd]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dapA, NMB0929 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=491 Neisseria meningitidis serogroup B])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrodipicolinate_synthase Dihydrodipicolinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.52 4.2.1.52] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3flu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3flu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3flu RCSB], [http://www.ebi.ac.uk/pdbsum/3flu PDBsum]</span></td></tr>
			</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/DAPA_NEIMB DAPA_NEIMB]] Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).<ref>PMID:19236959</ref>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fl/3flu_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Neisseria meningitidis is an obligate commensal bacterium of humans, and also an important human pathogen. To facilitate future drug studies, we report here the biochemical and structural characterisation of a key enzyme in (S)-lysine biosynthesis, dihydrodipicolinate synthase (DHDPS), from N. meningitidis (NmeDHDPS). X-ray crystallography revealed only minor structural differences between NmeDHDPS and the enzyme from E. coli at the active and allosteric effector sites. The catalytic capabilities of NmeDHDPS are similar to those of the enzyme from E. coli, but intriguingly NmeDHDPS is subject to substrate inhibition by high concentrations of the second substrate, (S)-aspartate semialdehyde, and is also significantly more sensitive to feedback inhibition by (S)-lysine. This heightened sensitivity to inhibition at both active and allosteric sites suggests that it may be possible to target DHDPS from N. meningitidis for antibiotic development.

	~~{{STRUCTURE_3flu\| PDB=3flu \| SCENE= }}~~		Cloning and characterisation of dihydrodipicolinate synthase from the pathogen Neisseria meningitidis.,Devenish SR, Huisman FH, Parker EJ, Hadfield AT, Gerrard JA Biochim Biophys Acta. 2009 Aug;1794(8):1168-74. Epub 2009 Feb 21. PMID:19236959<ref>PMID:19236959</ref>

	~~===Crystal structure~~ of ~~dihydrodipicolinate synthase from~~ the ~~pathogen Neisseria meningitidis===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_19236959}}~~

	~~==About this Structure==~~
	~~[[3flu]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Neisseria_meningitidis_serogroup_b Neisseria meningitidis serogroup b]~~. ~~Full crystallographic information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=3FLU OCA].~~

	==See Also==		==See Also==
	*[[Dihydrodipicolinate ~~Synthase~~\|Dihydrodipicolinate ~~Synthase~~]]		*[[Dihydrodipicolinate synthase\|Dihydrodipicolinate synthase]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:019236959<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Dihydrodipicolinate synthase]]		[[Category: Dihydrodipicolinate synthase]]
	[[Category: Neisseria meningitidis serogroup b]]		[[Category: Neisseria meningitidis serogroup b]]
	[[Category: Devenish, S R.A.]]		[[Category: Devenish, S R.A]]
	[[Category: Hadfield, A T.]]		[[Category: Hadfield, A T]]
	[[Category: Amino-acid biosynthesis]]		[[Category: Amino-acid biosynthesis]]
	[[Category: Beta-alpha-barrel]]		[[Category: Beta-alpha-barrel]]

OCA: Protected "3flu" [edit=sysop:move=sysop]

2012-10-20T10:33:44Z

Protected "3flu" [edit=sysop:move=sysop]

← Older revision	Revision as of 10:33, 20 October 2012
(No difference)

OCA at 10:33, 20 October 2012

2012-10-20T10:33:42Z

← Older revision		Revision as of 10:33, 20 October 2012
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	~~{{Seed}}~~		[[Image:3flu.png\|left\|200px]]
	[[Image:3flu.~~jpg~~\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3flu", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3flu\| PDB=3flu \| SCENE= }}		{{STRUCTURE_3flu\| PDB=3flu \| SCENE= }}

	===Crystal structure of dihydrodipicolinate synthase from the pathogen Neisseria meningitidis===		===Crystal structure of dihydrodipicolinate synthase from the pathogen Neisseria meningitidis===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_19236959}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 19236959 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_19236959}}		{{ABSTRACT_PUBMED_19236959}}

	==About this Structure==		==About this Structure==
	~~3FLU~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Neisseria_meningitidis_serogroup_b Neisseria meningitidis serogroup b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FLU OCA].		[[3flu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_meningitidis_serogroup_b Neisseria meningitidis serogroup b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FLU OCA].

			==See Also==
			*[[Dihydrodipicolinate Synthase\|Dihydrodipicolinate Synthase]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~19236959~~</ref><references group="xtra"/>		<ref group="xtra">PMID:019236959</ref><references group="xtra"/>
	[[Category: Dihydrodipicolinate synthase]]		[[Category: Dihydrodipicolinate synthase]]
	[[Category: Neisseria meningitidis serogroup b]]		[[Category: Neisseria meningitidis serogroup b]]
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	[[Category: Amino-acid biosynthesis]]		[[Category: Amino-acid biosynthesis]]
	[[Category: Beta-alpha-barrel]]		[[Category: Beta-alpha-barrel]]
	~~[[Category: Cytoplasm]]~~
	[[Category: Diaminopimelate biosynthesis]]		[[Category: Diaminopimelate biosynthesis]]
	[[Category: Lyase]]		[[Category: Lyase]]
Line 36:		Line 26:
	[[Category: Schiff base]]		[[Category: Schiff base]]
	[[Category: Tim barrel]]		[[Category: Tim barrel]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 25 09:10:02 2009''~~

OCA at 06:10, 25 June 2009

2009-06-25T06:10:04Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{Seed}}
-The entry 3flu is ON HOLD  until Paper Publication
+<!--
-Authors: Devenish, S.R.A., Huisman, F.H.A., Parker, E.J., Hadfield, A.T., Gerrard, J.A.
+===Crystal structure of dihydrodipicolinate synthase from the pathogen Neisseria meningitidis===
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 21 10:38:36 2009''
+<!--

OCA at 08:38, 21 January 2009

2009-01-21T08:38:36Z

← Older revision		Revision as of 08:38, 21 January 2009
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 3flu is ON HOLD		The entry 3flu is ON HOLD until Paper Publication

	Authors: Devenish, S.R.A., Huisman, F.H.A., Parker, E.J., Hadfield, A.T., Gerrard, J.A.		Authors: Devenish, S.R.A., Huisman, F.H.A., Parker, E.J., Hadfield, A.T., Gerrard, J.A.
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	Description: Crystal structure of dihydrodipicolinate synthase from the pathogen Neisseria meningitidis		Description: Crystal structure of dihydrodipicolinate synthase from the pathogen Neisseria meningitidis

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan ~~7 09~~:35:44 2009''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 21 10:38:36 2009''

OCA: New page: '''Unreleased structure''' The entry 3flu is ON HOLD Authors: Devenish, S.R.A., Huisman, F.H.A., Parker, E.J., Hadfield, A.T., Gerrard, J.A. Description: Crystal structure of dihydrodi...

2009-01-07T07:35:44Z

New page: '''Unreleased structure''' The entry 3flu is ON HOLD Authors: Devenish, S.R.A., Huisman, F.H.A., Parker, E.J., Hadfield, A.T., Gerrard, J.A. Description: Crystal structure of dihydrodi...

New page

'''Unreleased structure'''

The entry 3flu is ON HOLD

Authors: Devenish, S.R.A., Huisman, F.H.A., Parker, E.J., Hadfield, A.T., Gerrard, J.A.

Description: Crystal structure of dihydrodipicolinate synthase from the pathogen Neisseria meningitidis

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 7 09:35:44 2009''