3fmo - Revision history

OCA at 06:48, 6 September 2023

2023-09-06T06:48:24Z

← Older revision		Revision as of 06:48, 6 September 2023
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	<StructureSection load='3fmo' size='340' side='right'caption='[[3fmo]], [[Resolution\|resolution]] 2.51Å' scene=''>		<StructureSection load='3fmo' size='340' side='right'caption='[[3fmo]], [[Resolution\|resolution]] 2.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3fmo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FMO FirstGlance]. <br>		<table><tr><td colspan='2'>[[3fmo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FMO FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ADP:ADENOSINE-5~~-~~DIPHOSPHATE'>ADP</scene>~~, ~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.51Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[3fmp\|3fmp]]~~</~~div~~><~~/td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></~~td><td class="sblockDat"~~>NUP214, CAIN, CAN, KIAA0023 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), DDX19B, DBP5, DDX19 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fmo OCA], [https://pdbe.org/3fmo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fmo RCSB], [https://www.ebi.ac.uk/pdbsum/3fmo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fmo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fmo OCA], [https://pdbe.org/3fmo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fmo RCSB], [https://www.ebi.ac.uk/pdbsum/3fmo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fmo ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[https://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN]] Note=A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene. Note=A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET.		[https://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN] Note=A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene. Note=A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET.
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN]] May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex. [[https://www.uniprot.org/uniprot/DD19B_HUMAN DD19B_HUMAN]] ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins.		[https://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN] May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Blobel, G]]		[[Category: Blobel G]]
	[[Category: Debler~~, E W~~]]		[[Category: Debler EW]]
	[[Category: Hoelz, A]]		[[Category: Hoelz A]]
	[[Category: Napetschnig, J]]		[[Category: Napetschnig J]]
	~~[[Category: Atp-binding]]~~
	~~[[Category: Beta-propeller]]~~
	~~[[Category: Dead box]]~~
	~~[[Category: Glycoprotein]]~~
	~~[[Category: Helicase]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: Membrane]]~~
	~~[[Category: Mrna export]]~~
	~~[[Category: Mrna transport]]~~
	~~[[Category: Nuclear pore complex]]~~
	~~[[Category: Nuclear porin]]~~
	~~[[Category: Nucleocytoplasmic transport]]~~
	~~[[Category: Nucleotide-binding]]~~
	~~[[Category: Nucleus]]~~
	~~[[Category: Oncoprotein-hydrolase complex]]~~
	~~[[Category: Phosphoprotein]]~~
	~~[[Category: Protein interaction]]~~
	~~[[Category: Protein transport]]~~
	~~[[Category: Protein transport-hydrolase complex]]~~
	~~[[Category: Proto-oncogene]]~~
	~~[[Category: Rna-binding]]~~
	~~[[Category: Translocation]]~~
	~~[[Category: Transport~~]]

OCA at 08:05, 2 March 2022

2022-03-02T08:05:21Z

← Older revision		Revision as of 08:05, 2 March 2022
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	==Crystal structure of the nucleoporin Nup214 in complex with the DEAD-box helicase Ddx19==		==Crystal structure of the nucleoporin Nup214 in complex with the DEAD-box helicase Ddx19==
	<StructureSection load='3fmo' size='340' side='right' caption='[[3fmo]], [[Resolution\|resolution]] 2.51Å' scene=''>		<StructureSection load='3fmo' size='340' side='right'caption='[[3fmo]], [[Resolution\|resolution]] 2.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3fmo]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FMO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3FMO FirstGlance]. <br>		<table><tr><td colspan='2'>[[3fmo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FMO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3fmp\|3fmp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3fmp\|3fmp]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NUP214, CAIN, CAN, KIAA0023 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), DDX19B, DBP5, DDX19 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NUP214, CAIN, CAN, KIAA0023 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), DDX19B, DBP5, DDX19 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3fmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fmo OCA], [~~http~~://pdbe.org/3fmo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3fmo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3fmo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3fmo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fmo OCA], [https://pdbe.org/3fmo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fmo RCSB], [https://www.ebi.ac.uk/pdbsum/3fmo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fmo ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[~~http~~://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN]] Note=A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene. Note=A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET.		[[https://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN]] Note=A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene. Note=A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET.
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN]] May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex. [[~~http~~://www.uniprot.org/uniprot/DD19B_HUMAN DD19B_HUMAN]] ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins.		[[https://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN]] May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex. [[https://www.uniprot.org/uniprot/DD19B_HUMAN DD19B_HUMAN]] ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fm/3fmo_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fm/3fmo_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 3fmo" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3fmo" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Helicase 3D structures\|Helicase 3D structures]]
			*[[Nucleoporin 3D structures\|Nucleoporin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Blobel, G]]		[[Category: Blobel, G]]
	[[Category: Debler, E W]]		[[Category: Debler, E W]]

OCA at 06:45, 1 November 2017

2017-11-01T06:45:04Z

← Older revision		Revision as of 06:45, 1 November 2017
Line 1:		Line 1:

	==Crystal structure of the nucleoporin Nup214 in complex with the DEAD-box helicase Ddx19==		==Crystal structure of the nucleoporin Nup214 in complex with the DEAD-box helicase Ddx19==
	<StructureSection load='3fmo' size='340' side='right' caption='[[3fmo]], [[Resolution\|resolution]] 2.51Å' scene=''>		<StructureSection load='3fmo' size='340' side='right' caption='[[3fmo]], [[Resolution\|resolution]] 2.51Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3fmp\|3fmp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3fmp\|3fmp]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NUP214, CAIN, CAN, KIAA0023 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), DDX19B, DBP5, DDX19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NUP214, CAIN, CAN, KIAA0023 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), DDX19B, DBP5, DDX19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fmo OCA], [http://pdbe.org/3fmo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fmo RCSB], [http://www.ebi.ac.uk/pdbsum/3fmo PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fmo OCA], [http://pdbe.org/3fmo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fmo RCSB], [http://www.ebi.ac.uk/pdbsum/3fmo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3fmo ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	</div>		</div>
	<div class="pdbe-citations 3fmo" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3fmo" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Helicase\|Helicase]]
	*[[Nucleoporin\|Nucleoporin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:28, 8 February 2016

2016-02-08T19:28:09Z

← Older revision		Revision as of 19:28, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3fmo' size='340' side='right' caption='[[3fmo]], [[Resolution\|resolution]] 2.51Å' scene=''>		<StructureSection load='3fmo' size='340' side='right' caption='[[3fmo]], [[Resolution\|resolution]] 2.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3fmo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FMO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FMO FirstGlance]. <br>		<table><tr><td colspan='2'>[[3fmo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FMO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FMO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3fmp\|3fmp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3fmp\|3fmp]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NUP214, CAIN, CAN, KIAA0023 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~]), DDX19B, DBP5, DDX19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NUP214, CAIN, CAN, KIAA0023 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), DDX19B, DBP5, DDX19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fmo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fmo RCSB], [http://www.ebi.ac.uk/pdbsum/3fmo PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fmo OCA], [http://pdbe.org/3fmo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fmo RCSB], [http://www.ebi.ac.uk/pdbsum/3fmo PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fmo ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3fmo" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Blobel, G]]		[[Category: Blobel, G]]
	[[Category: Debler, E W]]		[[Category: Debler, E W]]

OCA at 09:58, 20 January 2015

2015-01-20T09:58:38Z

← Older revision		Revision as of 09:58, 20 January 2015
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	~~{{STRUCTURE_3fmo\| PDB=3fmo \| SCENE= }}~~		==Crystal structure of the nucleoporin Nup214 in complex with the DEAD-box helicase Ddx19==
	===Crystal structure of the nucleoporin Nup214 in complex with the DEAD-box helicase Ddx19===		<StructureSection load='3fmo' size='340' side='right' caption='[[3fmo]], [[Resolution\|resolution]] 2.51Å' scene=''>
	~~{{ABSTRACT_PUBMED_19208808}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[3fmo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FMO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FMO FirstGlance]. <br>
	==Disease==		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3fmp\|3fmp]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NUP214, CAIN, CAN, KIAA0023 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), DDX19B, DBP5, DDX19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fmo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fmo RCSB], [http://www.ebi.ac.uk/pdbsum/3fmo PDBsum]</span></td></tr>
			</table>
			== Disease ==
	[[http://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN]] Note=A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene. Note=A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET.		[[http://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN]] Note=A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene. Note=A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET.
			== Function ==
			[[http://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN]] May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex. [[http://www.uniprot.org/uniprot/DD19B_HUMAN DD19B_HUMAN]] ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins.
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fm/3fmo_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Key steps in the export of mRNA from the nucleus to the cytoplasm are the transport through the nuclear pore complex (NPC) and the subsequent remodeling of messenger RNA-protein (mRNP) complexes that occurs at the cytoplasmic side of the NPC. Crucial for these events is the recruitment of the DEAD-box helicase Ddx19 to the cytoplasmic filaments of the NPC that is mediated by the nucleoporin Nup214. Here, we present the crystal structure of the Nup214 N-terminal domain in complex with Ddx19 in its ADP-bound state at 2.5 A resolution. Strikingly, the interaction surfaces are not only evolutionarily conserved but also exhibit strongly opposing surface potentials, with the helicase surface being positively and the Nup214 surface being negatively charged. We speculate that the positively charged surface of the interacting ADP-helicase binds competitively to a segment of mRNA of a linearized mRNP, passing through the NPC on its way to the cytoplasm. As a result, the ADP-helicase would dissociate from Nup214 and replace a single bound protein from the mRNA. One cycle of protein replacement would be accompanied, cooperatively, by nucleotide exchange, ATP hydrolysis, release of the ADP-helicase from mRNA and its rebinding to Nup214. Repeat of these cycles would remove proteins from a mRNP, one at a time, akin to a ratchet mechanism for mRNA export.

	~~==Function==~~		Structural and functional analysis of the interaction between the nucleoporin Nup214 and the DEAD-box helicase Ddx19.,Napetschnig J, Kassube SA, Debler EW, Wong RW, Blobel G, Hoelz A Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3089-94. Epub 2009 Feb 10. PMID:19208808<ref>PMID:19208808</ref>
	~~[[http://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN]] May serve as a docking site in~~ the ~~receptor-mediated import of substrates across~~ the ~~nuclear pore complex. [[http://www.uniprot.org/uniprot/DD19B_HUMAN DD19B_HUMAN]] ATP~~-~~dependent RNA~~ helicase ~~involved in mRNA export from the nucleus~~. ~~Rather than unwinding RNA duplexes~~, ~~DDX19B functions as a remodeler of ribonucleoprotein particles~~, ~~whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins~~.

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[3fmo]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:/~~/~~oca.weizmann.ac.il/oca-bin/ocashort?id=3FMO OCA].~~		</div>

	==See Also==		==See Also==
	*[[Helicase\|Helicase]]		*[[Helicase\|Helicase]]
	*[[Nucleoporin\|Nucleoporin]]		*[[Nucleoporin\|Nucleoporin]]
			== References ==
	==~~Reference~~==		<references/>
	~~<ref group="xtra">PMID:019208808</ref>~~<references ~~group="xtra"~~/><~~references~~/>		__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Blobel, G.]]		[[Category: Blobel, G]]
	[[Category: Debler, E W.]]		[[Category: Debler, E W]]
	[[Category: Hoelz, A.]]		[[Category: Hoelz, A]]
	[[Category: Napetschnig, J.]]		[[Category: Napetschnig, J]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Beta-propeller]]		[[Category: Beta-propeller]]

OCA at 20:30, 24 March 2013

2013-03-24T20:30:01Z

← Older revision		Revision as of 20:30, 24 March 2013
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	~~[[Image:3fmo.png\|left\|200px]]~~

	{{STRUCTURE_3fmo\| PDB=3fmo \| SCENE= }}		{{STRUCTURE_3fmo\| PDB=3fmo \| SCENE= }}
			===Crystal structure of the nucleoporin Nup214 in complex with the DEAD-box helicase Ddx19===
			{{ABSTRACT_PUBMED_19208808}}

	===~~Crystal structure~~ of ~~the nucleoporin Nup214~~ in ~~complex with~~ the ~~DEAD~~-~~box helicase Ddx19==~~=		==Disease==
			[[http://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN]] Note=A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene. Note=A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET.

	~~{{ABSTRACT_PUBMED_19208808}}~~		==Function==
			[[http://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN]] May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex. [[http://www.uniprot.org/uniprot/DD19B_HUMAN DD19B_HUMAN]] ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins.

	==About this Structure==		==About this Structure==
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	==Reference==		==Reference==
	<ref group="xtra">PMID:019208808</ref><references group="xtra"/>		<ref group="xtra">PMID:019208808</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Blobel, G.]]		[[Category: Blobel, G.]]

OCA at 11:13, 20 October 2012

2012-10-20T11:13:40Z

← Older revision		Revision as of 11:13, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[3fmo]] is a 2 chain structure ~~of [[Helicase]] and [[Nucleoporin]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FMO OCA].		[[3fmo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FMO OCA].

	==See Also==		==See Also==

OCA at 04:39, 26 July 2012

2012-07-26T04:39:12Z

← Older revision		Revision as of 04:39, 26 July 2012
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	[[Image:3fmo.png\|left\|200px]]		[[Image:3fmo.png\|left\|200px]]

	~~<!--~~
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	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
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	{{STRUCTURE_3fmo\| PDB=3fmo \| SCENE= }}		{{STRUCTURE_3fmo\| PDB=3fmo \| SCENE= }}

	===Crystal structure of the nucleoporin Nup214 in complex with the DEAD-box helicase Ddx19===		===Crystal structure of the nucleoporin Nup214 in complex with the DEAD-box helicase Ddx19===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_19208808}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 19208808 is the PubMed ID number.~~
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	{{ABSTRACT_PUBMED_19208808}}		{{ABSTRACT_PUBMED_19208808}}

	==About this Structure==		==About this Structure==
	[[3fmo]] is a 2 chain structure of [[Nucleoporin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FMO OCA].		[[3fmo]] is a 2 chain structure of [[Helicase]] and [[Nucleoporin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FMO OCA].

	==See Also==		==See Also==
	*[[Nucleoporin]]		*[[Helicase\|Helicase]]
			*[[Nucleoporin\|Nucleoporin]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~19208808~~</ref><references group="xtra"/>		<ref group="xtra">PMID:019208808</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Blobel, G.]]		[[Category: Blobel, G.]]
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	[[Category: Hoelz, A.]]		[[Category: Hoelz, A.]]
	[[Category: Napetschnig, J.]]		[[Category: Napetschnig, J.]]
	~~[[Category: Alternative splicing]]~~
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Beta-propeller]]		[[Category: Beta-propeller]]
	~~[[Category: Chromosomal rearrangement]]~~
	~~[[Category: Cytoplasm]]~~
	[[Category: Dead box]]		[[Category: Dead box]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
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	[[Category: Nucleotide-binding]]		[[Category: Nucleotide-binding]]
	[[Category: Nucleus]]		[[Category: Nucleus]]
	[[Category: Oncoprotein/hydrolase complex]]		[[Category: Oncoprotein-hydrolase complex]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
	~~[[Category: Polymorphism]]~~
	[[Category: Protein interaction]]		[[Category: Protein interaction]]
	[[Category: Protein transport]]		[[Category: Protein transport]]
	[[Category: Protein transport/hydrolase complex]]		[[Category: Protein transport-hydrolase complex]]
	[[Category: Proto-oncogene]]		[[Category: Proto-oncogene]]
	[[Category: Rna-binding]]		[[Category: Rna-binding]]
	[[Category: Translocation]]		[[Category: Translocation]]
	[[Category: Transport]]		[[Category: Transport]]

OCA: Protected "3fmo" [edit=sysop:move=sysop]

2010-12-27T02:12:11Z

Protected "3fmo" [edit=sysop:move=sysop]

← Older revision	Revision as of 02:12, 27 December 2010
(No difference)

OCA at 02:12, 27 December 2010

2010-12-27T02:12:09Z

← Older revision		Revision as of 02:12, 27 December 2010
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	~~{{Seed}}~~		[[Image:3fmo.png\|left\|200px]]
	[[Image:3fmo.~~jpg~~\|left\|200px]]

	<!--		<!--
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	==About this Structure==		==About this Structure==
	~~3FMO~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FMO OCA].		[[3fmo]] is a 2 chain structure of [[Nucleoporin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FMO OCA].

			==See Also==
			*[[Nucleoporin]]

	==Reference==		==Reference==
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	[[Category: Translocation]]		[[Category: Translocation]]
	[[Category: Transport]]		[[Category: Transport]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 20 17:03:34 2009''~~