3fqa - Revision history

OCA at 06:50, 6 September 2023

2023-09-06T06:50:14Z

← Older revision		Revision as of 06:50, 6 September 2023
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	<StructureSection load='3fqa' size='340' side='right'caption='[[3fqa]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='3fqa' size='340' side='right'caption='[[3fqa]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3fqa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Anacystis_nidulans Anacystis nidulans~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FQA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FQA FirstGlance]. <br>		<table><tr><td colspan='2'>[[3fqa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synechococcus_elongatus_PCC_6301 Synechococcus elongatus PCC 6301]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FQA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FQA FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GAB:3~~-~~AMINOBENZOIC+ACID'>GAB</scene>~~, ~~<scene name='pdbligand=PMP:4-DEOXY-4-AMINOPYRIDOXAL-5-PHOSPHATE'>PMP</scene></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.35Å</td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[3fq7\|3fq7]], [[3fq8\|3fq8]], [[2hp1\|2hp1]], [[2hp2\|2hp2]]</div>~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAB:3-AMINOBENZOIC+ACID'>GAB</scene>, <scene name='pdbligand=PMP:4-DEOXY-4-AMINOPYRIDOXAL-5-PHOSPHATE'>PMP</scene></td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>hemL, gsa, syc0881_c ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~269084 Anacystis nidulans])</td~~><~~/tr>~~
	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/Glutamate~~-1-~~semialdehyde_2,1~~-~~aminomutase Glutamate~~-1-~~semialdehyde 2,1-aminomutase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.3.8 5.4.3.8]~~ </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fqa OCA], [https://pdbe.org/3fqa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fqa RCSB], [https://www.ebi.ac.uk/pdbsum/3fqa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fqa ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fqa OCA], [https://pdbe.org/3fqa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fqa RCSB], [https://www.ebi.ac.uk/pdbsum/3fqa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fqa ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/GSA_SYNP6 GSA_SYNP6]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Anacystis nidulans]]~~
	~~[[Category: Glutamate-1-semialdehyde 2,1-aminomutase]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Stetefeld, J~~]]		[[Category: Synechococcus elongatus PCC 6301]]
	[[Category: ~~Chlorophyll biosynthesis]]~~		[[Category: Stetefeld J]]
	~~[[Category: Cytoplasm]]~~
	~~[[Category: Drug resistance]]~~
	~~[[Category: Integrated approach]]~~
	~~[[Category: Isomerase]]~~
	~~[[Category: Microevilution]]~~
	~~[[Category: Porphyrin biosynthesis]]~~
	~~[[Category: Pyridoxal phosphate~~]]

OCA at 19:57, 20 October 2021

2021-10-20T19:57:38Z

← Older revision		Revision as of 19:57, 20 October 2021
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	==Gabaculien complex of gabaculine resistant GSAM version==		==Gabaculien complex of gabaculine resistant GSAM version==
	<StructureSection load='3fqa' size='340' side='right' caption='[[3fqa]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='3fqa' size='340' side='right'caption='[[3fqa]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3fqa]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Anacystis_nidulans Anacystis nidulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FQA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3FQA FirstGlance]. <br>		<table><tr><td colspan='2'>[[3fqa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Anacystis_nidulans Anacystis nidulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FQA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FQA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAB:3-AMINOBENZOIC+ACID'>GAB</scene>, <scene name='pdbligand=PMP:4-DEOXY-4-AMINOPYRIDOXAL-5-PHOSPHATE'>PMP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAB:3-AMINOBENZOIC+ACID'>GAB</scene>, <scene name='pdbligand=PMP:4-DEOXY-4-AMINOPYRIDOXAL-5-PHOSPHATE'>PMP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3fq7\|3fq7]], [[3fq8\|3fq8]], [[2hp1\|2hp1]], [[2hp2\|2hp2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3fq7\|3fq7]], [[3fq8\|3fq8]], [[2hp1\|2hp1]], [[2hp2\|2hp2]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hemL, gsa, syc0881_c ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=269084 Anacystis nidulans])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hemL, gsa, syc0881_c ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=269084 Anacystis nidulans])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Glutamate-1-semialdehyde_2,1-aminomutase Glutamate-1-semialdehyde 2,1-aminomutase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.3.8 5.4.3.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glutamate-1-semialdehyde_2,1-aminomutase Glutamate-1-semialdehyde 2,1-aminomutase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.3.8 5.4.3.8] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3fqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fqa OCA], [~~http~~://pdbe.org/3fqa PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3fqa RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3fqa PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3fqa ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fqa OCA], [https://pdbe.org/3fqa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fqa RCSB], [https://www.ebi.ac.uk/pdbsum/3fqa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fqa ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	==See Also==		==See Also==
	*[[Aminomutase\|Aminomutase]]		*[[Aminomutase 3D structures\|Aminomutase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Anacystis nidulans]]		[[Category: Anacystis nidulans]]
	[[Category: Glutamate-1-semialdehyde 2,1-aminomutase]]		[[Category: Glutamate-1-semialdehyde 2,1-aminomutase]]
			[[Category: Large Structures]]
	[[Category: Stetefeld, J]]		[[Category: Stetefeld, J]]
	[[Category: Chlorophyll biosynthesis]]		[[Category: Chlorophyll biosynthesis]]

OCA at 07:30, 5 December 2018

2018-12-05T07:30:12Z

← Older revision		Revision as of 07:30, 5 December 2018
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fq/3fqa_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fq/3fqa_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 40:		Line 40:
	[[Category: Stetefeld, J]]		[[Category: Stetefeld, J]]
	[[Category: Chlorophyll biosynthesis]]		[[Category: Chlorophyll biosynthesis]]
			[[Category: Cytoplasm]]
	[[Category: Drug resistance]]		[[Category: Drug resistance]]
	[[Category: Integrated approach]]		[[Category: Integrated approach]]

OCA at 20:28, 9 December 2016

2016-12-09T20:28:15Z

← Older revision		Revision as of 20:28, 9 December 2016
Line 1:		Line 1:

	==Gabaculien complex of gabaculine resistant GSAM version==		==Gabaculien complex of gabaculine resistant GSAM version==
	<StructureSection load='3fqa' size='340' side='right' caption='[[3fqa]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='3fqa' size='340' side='right' caption='[[3fqa]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3fqa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Synechococcus_elongatus_pcc_6301 Synechococcus elongatus pcc 6301~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FQA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FQA FirstGlance]. <br>		<table><tr><td colspan='2'>[[3fqa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Anacystis_nidulans Anacystis nidulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FQA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FQA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAB:3-AMINOBENZOIC+ACID'>GAB</scene>, <scene name='pdbligand=PMP:4-DEOXY-4-AMINOPYRIDOXAL-5-PHOSPHATE'>PMP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAB:3-AMINOBENZOIC+ACID'>GAB</scene>, <scene name='pdbligand=PMP:4-DEOXY-4-AMINOPYRIDOXAL-5-PHOSPHATE'>PMP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3fq7\|3fq7]], [[3fq8\|3fq8]], [[2hp1\|2hp1]], [[2hp2\|2hp2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3fq7\|3fq7]], [[3fq8\|3fq8]], [[2hp1\|2hp1]], [[2hp2\|2hp2]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hemL, gsa, syc0881_c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=269084 ~~Synechococcus elongatus PCC 6301~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hemL, gsa, syc0881_c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=269084 Anacystis nidulans])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate-1-semialdehyde_2,1-aminomutase Glutamate-1-semialdehyde 2,1-aminomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.3.8 5.4.3.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate-1-semialdehyde_2,1-aminomutase Glutamate-1-semialdehyde 2,1-aminomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.3.8 5.4.3.8] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fqa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fqa RCSB], [http://www.ebi.ac.uk/pdbsum/3fqa PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fqa OCA], [http://pdbe.org/3fqa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fqa RCSB], [http://www.ebi.ac.uk/pdbsum/3fqa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3fqa ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fqa ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3fqa" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Aminomutase\|Aminomutase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Anacystis nidulans]]
	[[Category: Glutamate-1-semialdehyde 2,1-aminomutase]]		[[Category: Glutamate-1-semialdehyde 2,1-aminomutase]]
	~~[[Category: Synechococcus elongatus pcc 6301]]~~
	[[Category: Stetefeld, J]]		[[Category: Stetefeld, J]]
	[[Category: Chlorophyll biosynthesis]]		[[Category: Chlorophyll biosynthesis]]

OCA at 10:17, 3 December 2014

2014-12-03T10:17:13Z

← Older revision		Revision as of 10:17, 3 December 2014
Line 1:		Line 1:
	[[Image:~~3fqa~~.~~png~~\|~~left~~\|~~200px~~]]		==Gabaculien complex of gabaculine resistant GSAM version==
			<StructureSection load='3fqa' size='340' side='right' caption='[[3fqa]], [[Resolution\|resolution]] 2.35Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3fqa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Synechococcus_elongatus_pcc_6301 Synechococcus elongatus pcc 6301]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FQA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FQA FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAB:3-AMINOBENZOIC+ACID'>GAB</scene>, <scene name='pdbligand=PMP:4-DEOXY-4-AMINOPYRIDOXAL-5-PHOSPHATE'>PMP</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3fq7\|3fq7]], [[3fq8\|3fq8]], [[2hp1\|2hp1]], [[2hp2\|2hp2]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hemL, gsa, syc0881_c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=269084 Synechococcus elongatus PCC 6301])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate-1-semialdehyde_2,1-aminomutase Glutamate-1-semialdehyde 2,1-aminomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.3.8 5.4.3.8] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fqa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fqa RCSB], [http://www.ebi.ac.uk/pdbsum/3fqa PDBsum]</span></td></tr>
			</table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fq/3fqa_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Gabaculine is a potent inhibitor of the vitamin B6-dependent key enzyme in chlorophyll biosynthesis, glutamate-1-semialdehyde aminomutase (GSAM). The inhibition effect is caused by an enzymatic deprotonation of the neurotoxin and requires the aldimine (PLP) form of the cofactor at the active site. In this study, we show that a single-point mutation confers resistance to gabaculine. A combined functional and structural analysis of wild-type GSAM in complex with gabaculine and the GSAM(M248I) form allowed us to decipher in atomic detail the molecular basis of this unique resistance. Interestingly, the gabaculine tolerance is caused by the absence of an essential water molecule that has a dual functional role. It serves as a nucleophilic shuttle for the hydroxyl anion along the reaction pathway and holds active-site Lys273 in a catalytically competent conformation. The single-point mutant is not able to fix this catalytic water between the beta-branched side chain of Ile248 and Lys273. As a consequence, the mutant enzyme is trapped in a gabaculine-insensitive but still enzymatically active amine (PMP) form.

	~~{{STRUCTURE_3fqa\| PDB=3fqa \| SCENE= }}~~		Absence of a catalytic water confers resistance to the neurotoxin gabaculine.,Orriss GL, Patel TR, Sorensen J, Stetefeld J FASEB J. 2010 Feb;24(2):404-14. Epub 2009 Sep 28. PMID:19786580<ref>PMID:19786580</ref>

	~~===Gabaculien complex~~ of ~~gabaculine resistant GSAM version===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_19786580}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[3fqa]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Synechococcus_elongatus_pcc_6301 Synechococcus elongatus pcc 6301]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3FQA OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:019786580<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Glutamate-1-semialdehyde 2,1-aminomutase]]		[[Category: Glutamate-1-semialdehyde 2,1-aminomutase]]
	[[Category: Synechococcus elongatus pcc 6301]]		[[Category: Synechococcus elongatus pcc 6301]]
	[[Category: Stetefeld, J.]]		[[Category: Stetefeld, J]]
	[[Category: Chlorophyll biosynthesis]]		[[Category: Chlorophyll biosynthesis]]
	[[Category: Drug resistance]]		[[Category: Drug resistance]]

OCA: Protected "3fqa" [edit=sysop:move=sysop]

2013-02-20T14:35:47Z

Protected "3fqa" [edit=sysop:move=sysop]

← Older revision	Revision as of 14:35, 20 February 2013
(No difference)

OCA at 14:35, 20 February 2013

2013-02-20T14:35:43Z

← Older revision		Revision as of 14:35, 20 February 2013
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	~~{{Seed}}~~
	[[Image:3fqa.png\|left\|200px]]		[[Image:3fqa.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3fqa", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
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	{{STRUCTURE_3fqa\| PDB=3fqa \| SCENE= }}		{{STRUCTURE_3fqa\| PDB=3fqa \| SCENE= }}

	===Gabaculien complex of gabaculine resistant GSAM version===		===Gabaculien complex of gabaculine resistant GSAM version===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_19786580}}, adds the Publication Abstract to the page~~
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	{{ABSTRACT_PUBMED_19786580}}		{{ABSTRACT_PUBMED_19786580}}

	==About this Structure==		==About this Structure==
	~~3FQA~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Synechococcus_elongatus_pcc_6301 Synechococcus elongatus pcc 6301]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FQA OCA].		[[3fqa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Synechococcus_elongatus_pcc_6301 Synechococcus elongatus pcc 6301]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FQA OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~19786580~~</ref><references group="xtra"/>		<ref group="xtra">PMID:019786580</ref><references group="xtra"/>
	[[Category: Glutamate-1-semialdehyde 2,1-aminomutase]]		[[Category: Glutamate-1-semialdehyde 2,1-aminomutase]]
	[[Category: Synechococcus elongatus pcc 6301]]		[[Category: Synechococcus elongatus pcc 6301]]
	[[Category: Stetefeld, J.]]		[[Category: Stetefeld, J.]]
	[[Category: Chlorophyll biosynthesis]]		[[Category: Chlorophyll biosynthesis]]
	~~[[Category: Cytoplasm]]~~
	[[Category: Drug resistance]]		[[Category: Drug resistance]]
	[[Category: Integrated approach]]		[[Category: Integrated approach]]
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	[[Category: Porphyrin biosynthesis]]		[[Category: Porphyrin biosynthesis]]
	[[Category: Pyridoxal phosphate]]		[[Category: Pyridoxal phosphate]]

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OCA at 12:52, 28 January 2010

2010-01-28T12:52:56Z

← Older revision		Revision as of 12:52, 28 January 2010
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	[[Image:3fqa.~~jpg~~\|left\|200px]]		[[Image:3fqa.png\|left\|200px]]

	<!--		<!--
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	==About this Structure==		==About this Structure==
	3FQA is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Synechococcus_elongatus_pcc_6301 Synechococcus elongatus pcc 6301]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FQA OCA].		3FQA is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Synechococcus_elongatus_pcc_6301 Synechococcus elongatus pcc 6301]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FQA OCA].

	==Reference==		==Reference==
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	[[Category: Pyridoxal phosphate]]		[[Category: Pyridoxal phosphate]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Nov 25 09~~:31:~~58 2009~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jan 28 14:52:55 2010''

OCA at 07:31, 25 November 2009

2009-11-25T07:31:58Z

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-'''Unreleased structure'''
+{{Seed}}
-The entry 3fqa is ON HOLD  until Paper Publication
+<!--
-Authors: Stetefeld, J.
+===Gabaculien complex of gabaculine resistant GSAM version===
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OCA at 14:56, 10 June 2009

2009-06-10T14:56:07Z

← Older revision		Revision as of 14:56, 10 June 2009
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 3fqa is ON HOLD		The entry 3fqa is ON HOLD until Paper Publication

	Authors: Stetefeld, J.		Authors: Stetefeld, J.
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	Description: Gabaculien complex of gabaculine resistant GSAM version		Description: Gabaculien complex of gabaculine resistant GSAM version

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jan 21~~ 10:39:10 2009''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 10 17:56:07 2009''