3fth - Revision history

OCA at 09:50, 21 February 2024

2024-02-21T09:50:56Z

@@ Line 10: / Line 10: @@
 == Function ==
 [https://www.uniprot.org/uniprot/IAPP_HUMAN IAPP_HUMAN] Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
 __TOC__
 </StructureSection>

OCA at 09:33, 6 December 2023

2023-12-06T09:33:34Z

← Older revision		Revision as of 09:33, 6 December 2023
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	<StructureSection load='3fth' size='340' side='right'caption='[[3fth]], [[Resolution\|resolution]] 1.84Å' scene=''>		<StructureSection load='3fth' size='340' side='right'caption='[[3fth]], [[Resolution\|resolution]] 1.84Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3fth]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FTH FirstGlance]. <br>		<table><tr><td colspan='2'>[[3fth]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FTH FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.84Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[3fod\|3fod]], [[3fpo\|3fpo]], [[3fqp\|3fqp]], [[3fr1\|3fr1]], [[3ftk\|3ftk]], [[3ftl\|3ftl]]~~</~~div~~></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fth OCA], [https://pdbe.org/3fth PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fth RCSB], [https://www.ebi.ac.uk/pdbsum/3fth PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fth ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fth OCA], [https://pdbe.org/3fth PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fth RCSB], [https://www.ebi.ac.uk/pdbsum/3fth PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fth ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/IAPP_HUMAN IAPP_HUMAN] Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Eisenberg, D]]		[[Category: Eisenberg D]]
	[[Category: Sawaya~~, M R~~]]		[[Category: Sawaya MR]]
	[[Category: Wiltzius~~, J J.W]]~~		[[Category: Wiltzius JJW]]
	~~[[Category: Amyloid-like protofibril]]~~
	~~[[Category: Protein fibril~~]]

OCA at 08:10, 2 March 2022

2022-03-02T08:10:29Z

← Older revision		Revision as of 08:10, 2 March 2022
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	<StructureSection load='3fth' size='340' side='right'caption='[[3fth]], [[Resolution\|resolution]] 1.84Å' scene=''>		<StructureSection load='3fth' size='340' side='right'caption='[[3fth]], [[Resolution\|resolution]] 1.84Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3fth]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3FTH FirstGlance]. <br>		<table><tr><td colspan='2'>[[3fth]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FTH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3fod\|3fod]], [[3fpo\|3fpo]], [[3fqp\|3fqp]], [[3fr1\|3fr1]], [[3ftk\|3ftk]], [[3ftl\|3ftl]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3fod\|3fod]], [[3fpo\|3fpo]], [[3fqp\|3fqp]], [[3fr1\|3fr1]], [[3ftk\|3ftk]], [[3ftl\|3ftl]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3fth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fth OCA], [~~http~~://pdbe.org/3fth PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3fth RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3fth PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3fth ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fth OCA], [https://pdbe.org/3fth PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fth RCSB], [https://www.ebi.ac.uk/pdbsum/3fth PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fth ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:07, 7 August 2019

2019-08-07T07:07:24Z

← Older revision		Revision as of 07:07, 7 August 2019
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	==NFLVHSS segment from Islet Amyloid Polypeptide (IAPP or Amylin)==		==NFLVHSS segment from Islet Amyloid Polypeptide (IAPP or Amylin)==
	<StructureSection load='3fth' size='340' side='right' caption='[[3fth]], [[Resolution\|resolution]] 1.84Å' scene=''>		<StructureSection load='3fth' size='340' side='right'caption='[[3fth]], [[Resolution\|resolution]] 1.84Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3fth]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FTH FirstGlance]. <br>		<table><tr><td colspan='2'>[[3fth]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FTH FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Eisenberg, D]]		[[Category: Eisenberg, D]]
	[[Category: Sawaya, M R]]		[[Category: Sawaya, M R]]

OCA at 20:24, 9 December 2016

2016-12-09T20:24:24Z

← Older revision		Revision as of 20:24, 9 December 2016
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	==NFLVHSS segment from Islet Amyloid Polypeptide (IAPP or Amylin)==		==NFLVHSS segment from Islet Amyloid Polypeptide (IAPP or Amylin)==
	<StructureSection load='3fth' size='340' side='right' caption='[[3fth]], [[Resolution\|resolution]] 1.84Å' scene=''>		<StructureSection load='3fth' size='340' side='right' caption='[[3fth]], [[Resolution\|resolution]] 1.84Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3fod\|3fod]], [[3fpo\|3fpo]], [[3fqp\|3fqp]], [[3fr1\|3fr1]], [[3ftk\|3ftk]], [[3ftl\|3ftl]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3fod\|3fod]], [[3fpo\|3fpo]], [[3fqp\|3fqp]], [[3fr1\|3fr1]], [[3ftk\|3ftk]], [[3ftl\|3ftl]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fth OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fth RCSB], [http://www.ebi.ac.uk/pdbsum/3fth PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fth OCA], [http://pdbe.org/3fth PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fth RCSB], [http://www.ebi.ac.uk/pdbsum/3fth PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3fth ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3fth" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:14, 3 December 2014

2014-12-03T10:14:21Z

← Older revision		Revision as of 10:14, 3 December 2014
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	[[~~Image~~:~~3fth~~.~~png~~\|~~left~~\|~~200px~~]]		==NFLVHSS segment from Islet Amyloid Polypeptide (IAPP or Amylin)==
			<StructureSection load='3fth' size='340' side='right' caption='[[3fth]], [[Resolution\|resolution]] 1.84Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3fth]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FTH FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3fod\|3fod]], [[3fpo\|3fpo]], [[3fqp\|3fqp]], [[3fr1\|3fr1]], [[3ftk\|3ftk]], [[3ftl\|3ftl]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fth OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fth RCSB], [http://www.ebi.ac.uk/pdbsum/3fth PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			In prion inheritance and transmission, strains are phenotypic variants encoded by protein 'conformations'. However, it is unclear how a protein conformation can be stable enough to endure transmission between cells or organisms. Here we describe new polymorphic crystal structures of segments of prion and other amyloid proteins, which offer two structural mechanisms for the encoding of prion strains. In packing polymorphism, prion strains are encoded by alternative packing arrangements (polymorphs) of beta-sheets formed by the same segment of a protein; in segmental polymorphism, prion strains are encoded by distinct beta-sheets built from different segments of a protein. Both forms of polymorphism can produce enduring conformations capable of encoding strains. These molecular mechanisms for transfer of protein-encoded information into prion strains share features with the familiar mechanism for transfer of nucleic acid-encoded information into microbial strains, including sequence specificity and recognition by noncovalent bonds.

	~~{{STRUCTURE_3fth\| PDB=3fth \| SCENE= }}~~		Molecular mechanisms for protein-encoded inheritance.,Wiltzius JJ, Landau M, Nelson R, Sawaya MR, Apostol MI, Goldschmidt L, Soriaga AB, Cascio D, Rajashankar K, Eisenberg D Nat Struct Mol Biol. 2009 Sep;16(9):973-8. Epub 2009 Aug 16. PMID:19684598<ref>PMID:19684598</ref>

	~~===NFLVHSS segment from Islet Amyloid Polypeptide (IAPP or Amylin)===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_19684598}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[3fth]] is~~ a ~~2 chain structure. Full crystallographic information is available from [http://oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=3FTH OCA].~~		</StructureSection>
			[[Category: Eisenberg, D]]
	==~~Reference~~==		[[Category: Sawaya, M R]]
	<~~ref group="xtra">PMID:019684598<~~/~~ref~~><~~references group="xtra"~~/>		[[Category: Wiltzius, J J.W]]
	[[Category: Eisenberg, D.]]
	[[Category: Sawaya, M R.]]
	[[Category: Wiltzius, J J.W.]]
	[[Category: Amyloid-like protofibril]]		[[Category: Amyloid-like protofibril]]
	[[Category: Protein fibril]]		[[Category: Protein fibril]]

OCA: Protected "3fth" [edit=sysop:move=sysop]

2013-02-20T14:29:51Z

Protected "3fth" [edit=sysop:move=sysop]

← Older revision	Revision as of 14:29, 20 February 2013
(No difference)

OCA at 14:29, 20 February 2013

2013-02-20T14:29:48Z

← Older revision		Revision as of 14:29, 20 February 2013
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	~~{{Seed}}~~
	[[Image:3fth.png\|left\|200px]]		[[Image:3fth.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3fth", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3fth\| PDB=3fth \| SCENE= }}		{{STRUCTURE_3fth\| PDB=3fth \| SCENE= }}

	===NFLVHSS segment from Islet Amyloid Polypeptide (IAPP or Amylin)===		===NFLVHSS segment from Islet Amyloid Polypeptide (IAPP or Amylin)===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_19684598}}, adds the Publication Abstract to the page~~
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	~~-->~~
	{{ABSTRACT_PUBMED_19684598}}		{{ABSTRACT_PUBMED_19684598}}

	==About this Structure==		==About this Structure==
	~~3FTH~~ is a 2 ~~chains~~ structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTH OCA].		[[3fth]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTH OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~19684598~~</ref><references group="xtra"/>		<ref group="xtra">PMID:019684598</ref><references group="xtra"/>
	[[Category: Eisenberg, D.]]		[[Category: Eisenberg, D.]]
	[[Category: Sawaya, M R.]]		[[Category: Sawaya, M R.]]
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	[[Category: Amyloid-like protofibril]]		[[Category: Amyloid-like protofibril]]
	[[Category: Protein fibril]]		[[Category: Protein fibril]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 16 08:35:05 2009''~~

OCA at 05:35, 16 September 2009

2009-09-16T05:35:06Z

← Older revision		Revision as of 05:35, 16 September 2009
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	===NFLVHSS segment from Islet Amyloid Polypeptide (IAPP or Amylin)===		===NFLVHSS segment from Islet Amyloid Polypeptide (IAPP or Amylin)===


			<!--
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			{{ABSTRACT_PUBMED_19684598}}

	==About this Structure==		==About this Structure==
	3FTH is a 2 chains structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTH OCA].		3FTH is a 2 chains structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTH OCA].

			==Reference==
			<ref group="xtra">PMID:19684598</ref><references group="xtra"/>
	[[Category: Eisenberg, D.]]		[[Category: Eisenberg, D.]]
	[[Category: Sawaya, M R.]]		[[Category: Sawaya, M R.]]
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	[[Category: Protein fibril]]		[[Category: Protein fibril]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Aug 19 13~~:57:00 2009''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 16 08:35:05 2009''

OCA at 10:57, 19 August 2009

2009-08-19T10:57:04Z

← Older revision		Revision as of 10:57, 19 August 2009
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	{{Seed}}		{{Seed}}
	[[Image:3fth.~~jpg~~\|left\|200px]]		[[Image:3fth.png\|left\|200px]]

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	[[Category: Protein fibril]]		[[Category: Protein fibril]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jul 1 09~~:38:23 2009''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 19 13:57:00 2009''