3fty - Revision history

OCA at 06:51, 6 September 2023

2023-09-06T06:51:47Z

← Older revision		Revision as of 06:51, 6 September 2023
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	<StructureSection load='3fty' size='340' side='right'caption='[[3fty]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='3fty' size='340' side='right'caption='[[3fty]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3fty]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FTY FirstGlance]. <br>		<table><tr><td colspan='2'>[[3fty]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FTY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3IP:3-(BENZYLOXY)PYRIDIN-2-AMINE'>3IP</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.15Å</td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3fh7\|3fh7]], [[3fts\|3fts]], [[3ftu\|3ftu]], [[3ftv\|3ftv]], [[3ftw\|3ftw]], [[3ftx\|3ftx]], [[3ftz\|3ftz]], [[3fu0\|3fu0]], [[3fu3\|3fu3]], [[3fu5\|3fu5]], [[3fu6\|3fu6]], [[3fud\|3fud]], [[3fue\|3fue]], [[3fuf\|3fuf]], [[3fuh\|3fuh]], [[3fui\|3fui]], [[3fuj\|3fuj]], [[3fuk\|3fuk]], [[3ful\|3ful]], [[3fum\|3fum]], [[3fun\|3fun]]</div></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3IP:3-(BENZYLOXY)PYRIDIN-2-AMINE'>3IP</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LTA4H, LTA4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Leukotriene-A(4)_hydrolase Leukotriene-A(4) hydrolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.2.6 3.3.2.6] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fty OCA], [https://pdbe.org/3fty PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fty RCSB], [https://www.ebi.ac.uk/pdbsum/3fty PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fty ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fty OCA], [https://pdbe.org/3fty PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fty RCSB], [https://www.ebi.ac.uk/pdbsum/3fty PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fty ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/LKHA4_HUMAN LKHA4_HUMAN]] Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.<ref>PMID:1897988</ref> <ref>PMID:1975494</ref> <ref>PMID:2244921</ref> <ref>PMID:12207002</ref> <ref>PMID:11917124</ref> <ref>PMID:15078870</ref> <ref>PMID:18804029</ref>		[https://www.uniprot.org/uniprot/LKHA4_HUMAN LKHA4_HUMAN] Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.<ref>PMID:1897988</ref> <ref>PMID:1975494</ref> <ref>PMID:2244921</ref> <ref>PMID:12207002</ref> <ref>PMID:11917124</ref> <ref>PMID:15078870</ref> <ref>PMID:18804029</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Davies~~, D R]]~~		[[Category: Davies DR]]
	~~[[Category: Alternative splicing]]~~
	~~[[Category: Cytoplasm]]~~
	~~[[Category: Fol]]~~
	~~[[Category: Fragment crystallography]]~~
	~~[[Category: Fragments of life]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: Leukotriene a4 hydrolase]]~~
	~~[[Category: Leukotriene biosynthesis]]~~
	~~[[Category: Lta4h]]~~
	~~[[Category: Metal-binding]]~~
	~~[[Category: Metalloprotease]]~~
	~~[[Category: Multifunctional enzyme]]~~
	~~[[Category: Polymorphism]]~~
	~~[[Category: Protease]]~~
	~~[[Category: Zinc~~]]

OCA at 08:10, 2 March 2022

2022-03-02T08:10:53Z

← Older revision		Revision as of 08:10, 2 March 2022
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	==Leukotriene A4 hydrolase in complex with fragment 3-(benzyloxy)pyridin-2-amine==		==Leukotriene A4 hydrolase in complex with fragment 3-(benzyloxy)pyridin-2-amine==
	<StructureSection load='3fty' size='340' side='right' caption='[[3fty]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='3fty' size='340' side='right'caption='[[3fty]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3fty]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3FTY FirstGlance]. <br>		<table><tr><td colspan='2'>[[3fty]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FTY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3IP:3-(BENZYLOXY)PYRIDIN-2-AMINE'>3IP</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3IP:3-(BENZYLOXY)PYRIDIN-2-AMINE'>3IP</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3fh7\|3fh7]], [[3fts\|3fts]], [[3ftu\|3ftu]], [[3ftv\|3ftv]], [[3ftw\|3ftw]], [[3ftx\|3ftx]], [[3ftz\|3ftz]], [[3fu0\|3fu0]], [[3fu3\|3fu3]], [[3fu5\|3fu5]], [[3fu6\|3fu6]], [[3fud\|3fud]], [[3fue\|3fue]], [[3fuf\|3fuf]], [[3fuh\|3fuh]], [[3fui\|3fui]], [[3fuj\|3fuj]], [[3fuk\|3fuk]], [[3ful\|3ful]], [[3fum\|3fum]], [[3fun\|3fun]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3fh7\|3fh7]], [[3fts\|3fts]], [[3ftu\|3ftu]], [[3ftv\|3ftv]], [[3ftw\|3ftw]], [[3ftx\|3ftx]], [[3ftz\|3ftz]], [[3fu0\|3fu0]], [[3fu3\|3fu3]], [[3fu5\|3fu5]], [[3fu6\|3fu6]], [[3fud\|3fud]], [[3fue\|3fue]], [[3fuf\|3fuf]], [[3fuh\|3fuh]], [[3fui\|3fui]], [[3fuj\|3fuj]], [[3fuk\|3fuk]], [[3ful\|3ful]], [[3fum\|3fum]], [[3fun\|3fun]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LTA4H, LTA4 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LTA4H, LTA4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Leukotriene-A(4)_hydrolase Leukotriene-A(4) hydrolase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.2.6 3.3.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Leukotriene-A(4)_hydrolase Leukotriene-A(4) hydrolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.2.6 3.3.2.6] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3fty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fty OCA], [~~http~~://pdbe.org/3fty PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3fty RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3fty PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3fty ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fty OCA], [https://pdbe.org/3fty PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fty RCSB], [https://www.ebi.ac.uk/pdbsum/3fty PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fty ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/LKHA4_HUMAN LKHA4_HUMAN]] Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.<ref>PMID:1897988</ref> <ref>PMID:1975494</ref> <ref>PMID:2244921</ref> <ref>PMID:12207002</ref> <ref>PMID:11917124</ref> <ref>PMID:15078870</ref> <ref>PMID:18804029</ref>		[[https://www.uniprot.org/uniprot/LKHA4_HUMAN LKHA4_HUMAN]] Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.<ref>PMID:1897988</ref> <ref>PMID:1975494</ref> <ref>PMID:2244921</ref> <ref>PMID:12207002</ref> <ref>PMID:11917124</ref> <ref>PMID:15078870</ref> <ref>PMID:18804029</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ft/3fty_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ft/3fty_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 3fty" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3fty" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Leukotriene A4 Hydrolase\|Leukotriene A4 Hydrolase]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Davies, D R]]		[[Category: Davies, D R]]
	[[Category: Alternative splicing]]		[[Category: Alternative splicing]]

OCA at 06:49, 1 November 2017

2017-11-01T06:49:44Z

← Older revision		Revision as of 06:49, 1 November 2017
Line 31:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 3fty" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3fty" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Leukotriene A4 Hydrolase\|Leukotriene A4 Hydrolase]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Human]]		[[Category: Human]]
	[[Category: Davies, D R]]		[[Category: Davies, D R]]
			[[Category: Alternative splicing]]
			[[Category: Cytoplasm]]
	[[Category: Fol]]		[[Category: Fol]]
	[[Category: Fragment crystallography]]		[[Category: Fragment crystallography]]
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	[[Category: Metalloprotease]]		[[Category: Metalloprotease]]
	[[Category: Multifunctional enzyme]]		[[Category: Multifunctional enzyme]]
			[[Category: Polymorphism]]
	[[Category: Protease]]		[[Category: Protease]]
			[[Category: Zinc]]

OCA at 06:52, 5 August 2016

2016-08-05T06:52:44Z

← Older revision		Revision as of 06:52, 5 August 2016
Line 1:		Line 1:

	==Leukotriene A4 hydrolase in complex with fragment 3-(benzyloxy)pyridin-2-amine==		==Leukotriene A4 hydrolase in complex with fragment 3-(benzyloxy)pyridin-2-amine==
	<StructureSection load='3fty' size='340' side='right' caption='[[3fty]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='3fty' size='340' side='right' caption='[[3fty]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3fty]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FTY FirstGlance]. <br>		<table><tr><td colspan='2'>[[3fty]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FTY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3IP:3-(BENZYLOXY)PYRIDIN-2-AMINE'>3IP</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3IP:3-(BENZYLOXY)PYRIDIN-2-AMINE'>3IP</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3fh7\|3fh7]], [[3fts\|3fts]], [[3ftu\|3ftu]], [[3ftv\|3ftv]], [[3ftw\|3ftw]], [[3ftx\|3ftx]], [[3ftz\|3ftz]], [[3fu0\|3fu0]], [[3fu3\|3fu3]], [[3fu5\|3fu5]], [[3fu6\|3fu6]], [[3fud\|3fud]], [[3fue\|3fue]], [[3fuf\|3fuf]], [[3fuh\|3fuh]], [[3fui\|3fui]], [[3fuj\|3fuj]], [[3fuk\|3fuk]], [[3ful\|3ful]], [[3fum\|3fum]], [[3fun\|3fun]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3fh7\|3fh7]], [[3fts\|3fts]], [[3ftu\|3ftu]], [[3ftv\|3ftv]], [[3ftw\|3ftw]], [[3ftx\|3ftx]], [[3ftz\|3ftz]], [[3fu0\|3fu0]], [[3fu3\|3fu3]], [[3fu5\|3fu5]], [[3fu6\|3fu6]], [[3fud\|3fud]], [[3fue\|3fue]], [[3fuf\|3fuf]], [[3fuh\|3fuh]], [[3fui\|3fui]], [[3fuj\|3fuj]], [[3fuk\|3fuk]], [[3ful\|3ful]], [[3fum\|3fum]], [[3fun\|3fun]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LTA4H, LTA4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LTA4H, LTA4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leukotriene-A(4)_hydrolase Leukotriene-A(4) hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.2.6 3.3.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leukotriene-A(4)_hydrolase Leukotriene-A(4) hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.2.6 3.3.2.6] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fty OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fty RCSB], [http://www.ebi.ac.uk/pdbsum/3fty PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fty OCA], [http://pdbe.org/3fty PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fty RCSB], [http://www.ebi.ac.uk/pdbsum/3fty PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3fty ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fty ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3fty" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Davies, D R]]		[[Category: Davies, D R]]
	[[Category: Fol]]		[[Category: Fol]]

OCA at 16:39, 25 December 2014

2014-12-25T16:39:30Z

← Older revision		Revision as of 16:39, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3fty]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FTY FirstGlance]. <br>		<table><tr><td colspan='2'>[[3fty]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FTY FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3IP:3-(BENZYLOXY)PYRIDIN-2-AMINE'>3IP</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3IP:3-(BENZYLOXY)PYRIDIN-2-AMINE'>3IP</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3fh7\|3fh7]], [[3fts\|3fts]], [[3ftu\|3ftu]], [[3ftv\|3ftv]], [[3ftw\|3ftw]], [[3ftx\|3ftx]], [[3ftz\|3ftz]], [[3fu0\|3fu0]], [[3fu3\|3fu3]], [[3fu5\|3fu5]], [[3fu6\|3fu6]], [[3fud\|3fud]], [[3fue\|3fue]], [[3fuf\|3fuf]], [[3fuh\|3fuh]], [[3fui\|3fui]], [[3fuj\|3fuj]], [[3fuk\|3fuk]], [[3ful\|3ful]], [[3fum\|3fum]], [[3fun\|3fun]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3fh7\|3fh7]], [[3fts\|3fts]], [[3ftu\|3ftu]], [[3ftv\|3ftv]], [[3ftw\|3ftw]], [[3ftx\|3ftx]], [[3ftz\|3ftz]], [[3fu0\|3fu0]], [[3fu3\|3fu3]], [[3fu5\|3fu5]], [[3fu6\|3fu6]], [[3fud\|3fud]], [[3fue\|3fue]], [[3fuf\|3fuf]], [[3fuh\|3fuh]], [[3fui\|3fui]], [[3fuj\|3fuj]], [[3fuk\|3fuk]], [[3ful\|3ful]], [[3fum\|3fum]], [[3fun\|3fun]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LTA4H, LTA4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LTA4H, LTA4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leukotriene-A(4)_hydrolase Leukotriene-A(4) hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.2.6 3.3.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leukotriene-A(4)_hydrolase Leukotriene-A(4) hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.2.6 3.3.2.6] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fty OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fty RCSB], [http://www.ebi.ac.uk/pdbsum/3fty PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fty OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fty RCSB], [http://www.ebi.ac.uk/pdbsum/3fty PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/LKHA4_HUMAN LKHA4_HUMAN]] Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.<ref>PMID:1897988</ref> <ref>PMID:1975494</ref> <ref>PMID:2244921</ref> <ref>PMID:12207002</ref> <ref>PMID:11917124</ref> <ref>PMID:15078870</ref> <ref>PMID:18804029</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Davies, D R.]]		[[Category: Davies, D R]]
	[[Category: Fol]]		[[Category: Fol]]
	[[Category: Fragment crystallography]]		[[Category: Fragment crystallography]]

OCA at 12:53, 29 September 2014

2014-09-29T12:53:11Z

← Older revision		Revision as of 12:53, 29 September 2014
Line 1:		Line 1:
	[[Image:~~3fty~~.~~png~~\|~~left~~\|~~200px~~]]		==Leukotriene A4 hydrolase in complex with fragment 3-(benzyloxy)pyridin-2-amine==
			<StructureSection load='3fty' size='340' side='right' caption='[[3fty]], [[Resolution\|resolution]] 2.15Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3fty]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FTY FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3IP:3-(BENZYLOXY)PYRIDIN-2-AMINE'>3IP</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3fh7\|3fh7]], [[3fts\|3fts]], [[3ftu\|3ftu]], [[3ftv\|3ftv]], [[3ftw\|3ftw]], [[3ftx\|3ftx]], [[3ftz\|3ftz]], [[3fu0\|3fu0]], [[3fu3\|3fu3]], [[3fu5\|3fu5]], [[3fu6\|3fu6]], [[3fud\|3fud]], [[3fue\|3fue]], [[3fuf\|3fuf]], [[3fuh\|3fuh]], [[3fui\|3fui]], [[3fuj\|3fuj]], [[3fuk\|3fuk]], [[3ful\|3ful]], [[3fum\|3fum]], [[3fun\|3fun]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LTA4H, LTA4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leukotriene-A(4)_hydrolase Leukotriene-A(4) hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.2.6 3.3.2.6] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fty OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fty RCSB], [http://www.ebi.ac.uk/pdbsum/3fty PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ft/3fty_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			We describe a novel fragment library termed fragments of life (FOL) for structure-based drug discovery. The FOL library includes natural small molecules of life, derivatives thereof, and biaryl protein architecture mimetics. The choice of fragments facilitates the interrogation of protein active sites, allosteric binding sites, and protein-protein interaction surfaces for fragment binding. We screened the FOL library against leukotriene A4 hydrolase (LTA4H) by X-ray crystallography. A diverse set of fragments including derivatives of resveratrol, nicotinamide, and indole were identified as efficient ligands for LTA4H. These fragments were elaborated in a small number of synthetic cycles into potent inhibitors of LTA4H representing multiple novel chemotypes for modulating leukotriene biosynthesis. Analysis of the fragment-bound structures also showed that the fragments comprehensively recapitulated key chemical features and binding modes of several reported LTA4H inhibitors.

	~~{{STRUCTURE_3fty\| PDB=3fty \| SCENE= }}~~		Discovery of Leukotriene A4 Hydrolase Inhibitors Using Metabolomics Biased Fragment Crystallography (dagger).,Davies DR, Mamat B, Magnusson OT, Christensen J, Haraldsson MH, Mishra R, Pease B, Hansen E, Singh J, Zembower D, Kim H, Kiselyov AS, Burgin AB, Gurney ME, Stewart LJ J Med Chem. 2009 Jul 20. PMID:19618939<ref>PMID:19618939</ref>

	~~===Leukotriene A4 hydrolase in complex with fragment 3-(benzyloxy)pyridin-2-amine===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_19618939}}~~

	~~==About this Structure==~~
	~~[[3fty]] is~~ a ~~1 chain structure with sequence from [http://en.wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann.ac.il/oca-bin~~/~~ocashort?id=3FTY OCA].~~

	==See Also==		==See Also==
	*[[Leukotriene A4 Hydrolase\|Leukotriene A4 Hydrolase]]		*[[Leukotriene A4 Hydrolase\|Leukotriene A4 Hydrolase]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:019618939<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Davies, D R.]]		[[Category: Davies, D R.]]

OCA at 19:00, 20 October 2012

2012-10-20T19:00:24Z

← Older revision		Revision as of 19:00, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[3fty]] is a 1 chain structure ~~of [[Leukotriene A4 Hydrolase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTY OCA].		[[3fty]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTY OCA].

	==See Also==		==See Also==

OCA at 05:58, 27 July 2012

2012-07-27T05:58:59Z

← Older revision		Revision as of 05:58, 27 July 2012
Line 1:		Line 1:
	[[Image:3fty.png\|left\|200px]]		[[Image:3fty.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3fty", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3fty\| PDB=3fty \| SCENE= }}		{{STRUCTURE_3fty\| PDB=3fty \| SCENE= }}

	===Leukotriene A4 hydrolase in complex with fragment 3-(benzyloxy)pyridin-2-amine===		===Leukotriene A4 hydrolase in complex with fragment 3-(benzyloxy)pyridin-2-amine===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_19618939}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 19618939 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_19618939}}		{{ABSTRACT_PUBMED_19618939}}

Line 22:		Line 11:

	==See Also==		==See Also==
	*[[Leukotriene A4 Hydrolase]]		*[[Leukotriene A4 Hydrolase\|Leukotriene A4 Hydrolase]]

	==Reference==		==Reference==
Line 28:		Line 17:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Davies, D R.]]		[[Category: Davies, D R.]]
	~~[[Category: Alternative splicing]]~~
	~~[[Category: Cytoplasm]]~~
	[[Category: Fol]]		[[Category: Fol]]
	[[Category: Fragment crystallography]]		[[Category: Fragment crystallography]]
Line 40:		Line 27:
	[[Category: Metalloprotease]]		[[Category: Metalloprotease]]
	[[Category: Multifunctional enzyme]]		[[Category: Multifunctional enzyme]]
	~~[[Category: Polymorphism]]~~
	[[Category: Protease]]		[[Category: Protease]]
	~~[[Category: Zinc]]~~

OCA: Protected "3fty" [edit=sysop:move=sysop]

2011-05-26T11:49:00Z

Protected "3fty" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:49, 26 May 2011
(No difference)

OCA at 11:48, 26 May 2011

2011-05-26T11:48:58Z

← Older revision		Revision as of 11:48, 26 May 2011
Line 1:		Line 1:
	~~{{Seed}}~~
	[[Image:3fty.png\|left\|200px]]		[[Image:3fty.png\|left\|200px]]

Line 20:		Line 19:

	==About this Structure==		==About this Structure==
	~~3FTY~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTY OCA].		[[3fty]] is a 1 chain structure of [[Leukotriene A4 Hydrolase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTY OCA].

			==See Also==
			*[[Leukotriene A4 Hydrolase]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~19618939~~</ref><references group="xtra"/>		<ref group="xtra">PMID:019618939</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Davies, D R.]]		[[Category: Davies, D R.]]
Line 41:		Line 43:
	[[Category: Protease]]		[[Category: Protease]]
	[[Category: Zinc]]		[[Category: Zinc]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 16 08:35:58 2009''~~