3fvx - Revision history

OCA at 06:52, 6 September 2023

2023-09-06T06:52:54Z

← Older revision		Revision as of 06:52, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3fvx' size='340' side='right'caption='[[3fvx]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='3fvx' size='340' side='right'caption='[[3fvx]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3fvx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FVX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FVX FirstGlance]. <br>		<table><tr><td colspan='2'>[[3fvx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FVX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FVX FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~, ~~<scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-~~1~~,3-DIOL'>TRS</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene><~~/td~~></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">CCBL1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fvx OCA], [https://pdbe.org/3fvx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fvx RCSB], [https://www.ebi.ac.uk/pdbsum/3fvx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fvx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fvx OCA], [https://pdbe.org/3fvx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fvx RCSB], [https://www.ebi.ac.uk/pdbsum/3fvx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fvx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/KAT1_HUMAN KAT1_HUMAN]] Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond.<ref>PMID:19338303</ref>		[https://www.uniprot.org/uniprot/KAT1_HUMAN KAT1_HUMAN] Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond.<ref>PMID:19338303</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Cai, T]]		[[Category: Cai T]]
	[[Category: Han, Q]]		[[Category: Han Q]]
	[[Category: Li, J]]		[[Category: Li J]]
	[[Category: Robinson, H]]		[[Category: Robinson H]]
	[[Category: Tagle~~, D A]]~~		[[Category: Tagle DA]]
	~~[[Category: Alpha beta protein plp dependent protein aminotransferase lyase pyridoxal phosphate transferase]]~~
	~~[[Category: Alternative splicing]]~~
	~~[[Category: Aminotransferase]]~~
	~~[[Category: Cytoplasm]]~~
	~~[[Category: Lyase]]~~
	~~[[Category: Pyridoxal phosphate]]~~
	~~[[Category: Transferase~~]]

OCA at 08:13, 2 March 2022

2022-03-02T08:13:03Z

← Older revision		Revision as of 08:13, 2 March 2022
Line 1:		Line 1:

	==Human kynurenine aminotransferase I in complex with tris==		==Human kynurenine aminotransferase I in complex with tris==
	<StructureSection load='3fvx' size='340' side='right' caption='[[3fvx]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='3fvx' size='340' side='right'caption='[[3fvx]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3fvx]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FVX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3FVX FirstGlance]. <br>		<table><tr><td colspan='2'>[[3fvx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FVX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FVX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CCBL1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CCBL1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3fvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fvx OCA], [~~http~~://pdbe.org/3fvx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3fvx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3fvx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3fvx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fvx OCA], [https://pdbe.org/3fvx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fvx RCSB], [https://www.ebi.ac.uk/pdbsum/3fvx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fvx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/KAT1_HUMAN KAT1_HUMAN]] Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond.<ref>PMID:19338303</ref>		[[https://www.uniprot.org/uniprot/KAT1_HUMAN KAT1_HUMAN]] Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond.<ref>PMID:19338303</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Cai, T]]		[[Category: Cai, T]]
	[[Category: Han, Q]]		[[Category: Han, Q]]

OCA at 07:49, 5 December 2018

2018-12-05T07:49:16Z

← Older revision		Revision as of 07:49, 5 December 2018
Line 1:		Line 1:

	==Human kynurenine aminotransferase I in complex with tris==		==Human kynurenine aminotransferase I in complex with tris==
	<StructureSection load='3fvx' size='340' side='right' caption='[[3fvx]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='3fvx' size='340' side='right' caption='[[3fvx]], [[Resolution\|resolution]] 1.50Å' scene=''>
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CCBL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CCBL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fvx OCA], [http://pdbe.org/3fvx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fvx RCSB], [http://www.ebi.ac.uk/pdbsum/3fvx PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fvx OCA], [http://pdbe.org/3fvx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fvx RCSB], [http://www.ebi.ac.uk/pdbsum/3fvx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3fvx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fv/3fvx_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fv/3fvx_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 40:		Line 41:
	[[Category: Tagle, D A]]		[[Category: Tagle, D A]]
	[[Category: Alpha beta protein plp dependent protein aminotransferase lyase pyridoxal phosphate transferase]]		[[Category: Alpha beta protein plp dependent protein aminotransferase lyase pyridoxal phosphate transferase]]
			[[Category: Alternative splicing]]
	[[Category: Aminotransferase]]		[[Category: Aminotransferase]]
			[[Category: Cytoplasm]]
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Pyridoxal phosphate]]		[[Category: Pyridoxal phosphate]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 15:17, 7 February 2016

2016-02-07T15:17:52Z

← Older revision		Revision as of 15:17, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='3fvx' size='340' side='right' caption='[[3fvx]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='3fvx' size='340' side='right' caption='[[3fvx]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3fvx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FVX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FVX FirstGlance]. <br>		<table><tr><td colspan='2'>[[3fvx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FVX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FVX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:2-~~LYSINE(~~3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-~~YLMETHANE)~~'>LLP</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CCBL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CCBL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fvx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fvx RCSB], [http://www.ebi.ac.uk/pdbsum/3fvx PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fvx OCA], [http://pdbe.org/3fvx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fvx RCSB], [http://www.ebi.ac.uk/pdbsum/3fvx PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fvx ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3fvx" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Cai, T]]		[[Category: Cai, T]]
	[[Category: Han, Q]]		[[Category: Han, Q]]

OCA at 16:13, 24 December 2014

2014-12-24T16:13:21Z

← Older revision		Revision as of 16:13, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fvx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fvx RCSB], [http://www.ebi.ac.uk/pdbsum/3fvx PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fvx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fvx RCSB], [http://www.ebi.ac.uk/pdbsum/3fvx PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/KAT1_HUMAN KAT1_HUMAN]] Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond.<ref>PMID:19338303</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:10, 3 December 2014

2014-12-03T10:10:26Z

← Older revision		Revision as of 10:10, 3 December 2014
Line 1:		Line 1:
	[[Image:~~3fvx~~.~~png~~\|~~left~~\|~~200px~~]]		==Human kynurenine aminotransferase I in complex with tris==
			<StructureSection load='3fvx' size='340' side='right' caption='[[3fvx]], [[Resolution\|resolution]] 1.50Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3fvx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FVX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FVX FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
			<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE)'>LLP</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CCBL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fvx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fvx RCSB], [http://www.ebi.ac.uk/pdbsum/3fvx PDBsum]</span></td></tr>
			</table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fv/3fvx_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Human kynurenine aminotransferase I (hKAT I) catalyzes the formation of kynurenic acid, a neuroactive compound. Here, we report three high-resolution crystal structures (1.50-1.55 A) of hKAT I that are in complex with glycerol and each of two inhibitors of hKAT I: indole-3-acetic acid (IAC) and Tris. Because Tris is able to occupy the substrate binding position, we speculate that this may be the basis for hKAT I inhibition. Furthermore, the hKAT/IAC complex structure reveals that the binding moieties of the inhibitor are its indole ring and a carboxyl group. Six chemicals with both binding moieties were tested for their ability to inhibit hKAT I activity; 3-indolepropionic acid and DL-indole-3-lactic acid demonstrated the highest level of inhibition, and as they cannot be considered as substrates of the enzyme, these two inhibitors are promising candidates for future study. Perhaps even more significantly, we report the discovery of two different ligands located simultaneously in the hKAT I active center for the first time.

	~~{{STRUCTURE_3fvx\| PDB=3fvx \| SCENE= }}~~		Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K.,Han Q, Robinson H, Cai T, Tagle DA, Li J J Med Chem. 2009 May 14;52(9):2786-93. PMID:19338303<ref>PMID:19338303</ref>

	~~===Human kynurenine aminotransferase I in complex with tris===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_19338303}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[3fvx]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3FVX OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:019338303<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Cai, T.]]		[[Category: Cai, T]]
	[[Category: Han, Q.]]		[[Category: Han, Q]]
	[[Category: Li, J.]]		[[Category: Li, J]]
	[[Category: Robinson, H.]]		[[Category: Robinson, H]]
	[[Category: Tagle, D A.]]		[[Category: Tagle, D A]]
	[[Category: Alpha beta protein plp dependent protein aminotransferase lyase pyridoxal phosphate transferase]]		[[Category: Alpha beta protein plp dependent protein aminotransferase lyase pyridoxal phosphate transferase]]
	[[Category: Aminotransferase]]		[[Category: Aminotransferase]]

OCA: Protected "3fvx" [edit=sysop:move=sysop]

2013-02-20T14:25:30Z

Protected "3fvx" [edit=sysop:move=sysop]

← Older revision	Revision as of 14:25, 20 February 2013
(No difference)

OCA at 14:25, 20 February 2013

2013-02-20T14:25:25Z

← Older revision		Revision as of 14:25, 20 February 2013
Line 1:		Line 1:
	~~{{Seed}}~~		[[Image:3fvx.png\|left\|200px]]
	[[Image:3fvx.~~jpg~~\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3fvx", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3fvx\| PDB=3fvx \| SCENE= }}		{{STRUCTURE_3fvx\| PDB=3fvx \| SCENE= }}

	===Human kynurenine aminotransferase I in complex with tris===		===Human kynurenine aminotransferase I in complex with tris===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_19338303}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 19338303 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_19338303}}		{{ABSTRACT_PUBMED_19338303}}

	==About this Structure==		==About this Structure==
	~~3FVX~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FVX OCA].		[[3fvx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FVX OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~19338303~~</ref><references group="xtra"/>		<ref group="xtra">PMID:019338303</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Cai, T.]]		[[Category: Cai, T.]]
Line 31:		Line 19:
	[[Category: Tagle, D A.]]		[[Category: Tagle, D A.]]
	[[Category: Alpha beta protein plp dependent protein aminotransferase lyase pyridoxal phosphate transferase]]		[[Category: Alpha beta protein plp dependent protein aminotransferase lyase pyridoxal phosphate transferase]]
	~~[[Category: Alternative splicing]]~~
	[[Category: Aminotransferase]]		[[Category: Aminotransferase]]
	~~[[Category: Cytoplasm]]~~
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Pyridoxal phosphate]]		[[Category: Pyridoxal phosphate]]
	[[Category: Transferase]]		[[Category: Transferase]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 20 17:07:45 2009''~~

OCA at 14:07, 20 May 2009

2009-05-20T14:07:46Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{Seed}}
-The entry 3fvx is ON HOLD  until Paper Publication
+<!--
-Authors: Han, Q., Robinson, H., Cai, T., Tagle, D.A., Li, J.
+===Human kynurenine aminotransferase I in complex with tris===
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 25 09:25:03 2009''
+<!--

OCA at 07:25, 25 February 2009

2009-02-25T07:25:03Z

← Older revision		Revision as of 07:25, 25 February 2009
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 3fvx is ON HOLD		The entry 3fvx is ON HOLD until Paper Publication

	Authors: Han, Q., Robinson, H., Cai, T., Tagle, D. A., Li, J.		Authors: Han, Q., Robinson, H., Cai, T., Tagle, D.A., Li, J.

	Description: Human kynurenine aminotransferase I in complex with tris		Description: Human kynurenine aminotransferase I in complex with tris

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb ~~4 11~~:26:37 2009''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 25 09:25:03 2009''