3g4e - Revision history

OCA at 06:59, 6 September 2023

2023-09-06T06:59:14Z

← Older revision		Revision as of 06:59, 6 September 2023
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	<StructureSection load='3g4e' size='340' side='right'caption='[[3g4e]], [[Resolution\|resolution]] 1.42Å' scene=''>		<StructureSection load='3g4e' size='340' side='right'caption='[[3g4e]], [[Resolution\|resolution]] 1.42Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3g4e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[3g4e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G4E FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.42Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[3g4h\|3g4h]]~~<~~/div></td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></~~td><td class="sblockDat"~~>~~RGN, SMP30 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g4e OCA], [https://pdbe.org/3g4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g4e RCSB], [https://www.ebi.ac.uk/pdbsum/3g4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g4e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g4e OCA], [https://pdbe.org/3g4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g4e RCSB], [https://www.ebi.ac.uk/pdbsum/3g4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g4e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/RGN_HUMAN RGN_HUMAN]] Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity).		[https://www.uniprot.org/uniprot/RGN_HUMAN RGN_HUMAN] Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Bahnson~~, B J~~]]		[[Category: Bahnson BJ]]
	[[Category: Chakraborti, S]]		[[Category: Chakraborti S]]
	~~[[Category: Alternative splicing]]~~
	~~[[Category: Calcium]]~~
	~~[[Category: Calcium bound]]~~
	~~[[Category: Cytoplasm]]~~
	~~[[Category: Gluconolcatonase]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: Organophosphate hydrolase]]~~
	~~[[Category: Phosphoprotein]]~~
	~~[[Category: Regucalcin]]~~
	~~[[Category: Six bladed beta-propeller~~]]

OCA at 07:55, 9 March 2022

2022-03-09T07:55:29Z

← Older revision		Revision as of 07:55, 9 March 2022
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	==Crystal structure of human senescence marker protein-30(SMP30)(Calcium bound)==		==Crystal structure of human senescence marker protein-30(SMP30)(Calcium bound)==
	<StructureSection load='3g4e' size='340' side='right' caption='[[3g4e]], [[Resolution\|resolution]] 1.42Å' scene=''>		<StructureSection load='3g4e' size='340' side='right'caption='[[3g4e]], [[Resolution\|resolution]] 1.42Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3g4e]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G4E OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3G4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[3g4e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G4E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g4h\|3g4h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3g4h\|3g4h]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RGN, SMP30 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RGN, SMP30 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3g4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g4e OCA], [~~http~~://pdbe.org/3g4e PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3g4e RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3g4e PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3g4e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g4e OCA], [https://pdbe.org/3g4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g4e RCSB], [https://www.ebi.ac.uk/pdbsum/3g4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g4e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/RGN_HUMAN RGN_HUMAN]] Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity).		[[https://www.uniprot.org/uniprot/RGN_HUMAN RGN_HUMAN]] Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g4/3g4e_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g4/3g4e_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 38:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Bahnson, B J]]		[[Category: Bahnson, B J]]
	[[Category: Chakraborti, S]]		[[Category: Chakraborti, S]]

OCA at 06:56, 1 November 2017

2017-11-01T06:56:42Z

← Older revision		Revision as of 06:56, 1 November 2017
Line 40:		Line 40:
	[[Category: Bahnson, B J]]		[[Category: Bahnson, B J]]
	[[Category: Chakraborti, S]]		[[Category: Chakraborti, S]]
			[[Category: Alternative splicing]]
			[[Category: Calcium]]
	[[Category: Calcium bound]]		[[Category: Calcium bound]]
			[[Category: Cytoplasm]]
	[[Category: Gluconolcatonase]]		[[Category: Gluconolcatonase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 22:14, 4 August 2016

2016-08-04T22:14:12Z

← Older revision		Revision as of 22:14, 4 August 2016
Line 1:		Line 1:

	==Crystal structure of human senescence marker protein-30(SMP30)(Calcium bound)==		==Crystal structure of human senescence marker protein-30(SMP30)(Calcium bound)==
	<StructureSection load='3g4e' size='340' side='right' caption='[[3g4e]], [[Resolution\|resolution]] 1.42Å' scene=''>		<StructureSection load='3g4e' size='340' side='right' caption='[[3g4e]], [[Resolution\|resolution]] 1.42Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3g4e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[3g4e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G4E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g4h\|3g4h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g4h\|3g4h]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RGN, SMP30 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RGN, SMP30 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g4e RCSB], [http://www.ebi.ac.uk/pdbsum/3g4e PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g4e OCA], [http://pdbe.org/3g4e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3g4e RCSB], [http://www.ebi.ac.uk/pdbsum/3g4e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3g4e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3g4e ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3g4e" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Bahnson, B J]]		[[Category: Bahnson, B J]]
	[[Category: Chakraborti, S]]		[[Category: Chakraborti, S]]

OCA at 13:35, 25 December 2014

2014-12-25T13:35:03Z

← Older revision		Revision as of 13:35, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3g4e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[3g4e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G4E FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g4h\|3g4h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g4h\|3g4h]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RGN, SMP30 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RGN, SMP30 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g4e RCSB], [http://www.ebi.ac.uk/pdbsum/3g4e PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g4e RCSB], [http://www.ebi.ac.uk/pdbsum/3g4e PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/RGN_HUMAN RGN_HUMAN]] Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bahnson, B J.]]		[[Category: Bahnson, B J]]
	[[Category: Chakraborti, S.]]		[[Category: Chakraborti, S]]
	[[Category: Calcium bound]]		[[Category: Calcium bound]]
	[[Category: Gluconolcatonase]]		[[Category: Gluconolcatonase]]

OCA at 11:16, 29 September 2014

2014-09-29T11:16:31Z

← Older revision		Revision as of 11:16, 29 September 2014
Line 1:		Line 1:
	[[Image:~~3g4e~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of human senescence marker protein-30(SMP30)(Calcium bound)==
			<StructureSection load='3g4e' size='340' side='right' caption='[[3g4e]], [[Resolution\|resolution]] 1.42Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3g4e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G4E FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g4h\|3g4h]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RGN, SMP30 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g4e RCSB], [http://www.ebi.ac.uk/pdbsum/3g4e PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g4/3g4e_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Human senescence marker protein 30 (SMP30), which functions enzymatically as a lactonase, hydrolyzes various carbohydrate lactones. The penultimate step in vitamin-C biosynthesis is catalyzed by this enzyme in nonprimate mammals. It has also been implicated as an organophosphate hydrolase, with the ability to hydrolyze diisopropyl phosphofluoridate and other nerve agents. SMP30 was originally identified as an aging marker protein, whose expression decreased androgen independently in aging cells. SMP30 is also referred to as regucalcin and has been suggested to have functions in calcium homeostasis. The crystal structure of the human enzyme has been solved from X-ray diffraction data collected to a resolution of 1.4 A. The protein has a 6-bladed beta-propeller fold, and it contains a single metal ion. Crystal structures have been solved with the metal site bound with either a Ca(2+) or a Zn(2+) atom. The catalytic role of the metal ion has been confirmed by mutagenesis of the metal coordinating residues. Kinetic studies using the substrate gluconolactone showed a k(cat) preference of divalent cations in the order Zn(2+) > Mn(2+) > Ca(2+) > Mg(2+). Notably, the Ca(2+) had a significantly higher value of K(d) compared to those of the other metal ions tested (566, 82, 7, and 0.6 mum for Ca(2+), Mg(2+), Zn(2+), and Mn(2+), respectively), suggesting that the Ca(2+)-bound form may be physiologically relevant for stressed cells with an elevated free calcium level.

	~~{{STRUCTURE_3g4e\| PDB=3g4e \| SCENE= }}~~		Crystal structure of human senescence marker protein 30: insights linking structural, enzymatic, and physiological functions .,Chakraborti S, Bahnson BJ Biochemistry. 2010 Apr 27;49(16):3436-44. PMID:20329768<ref>PMID:20329768</ref>

	~~===Crystal structure~~ of ~~human senescence marker protein-30(SMP30)(Calcium bound)===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_20329768}}~~

	~~==About this Structure==~~
	~~[[3g4e]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=3G4E OCA].~~

	==See Also==		==See Also==
	*[[~~Ribosomal protein L11~~\|~~Ribosomal protein L11~~]]		*[[Ribosome 3D structures\|Ribosome 3D structures]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:020329768<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bahnson, B J.]]		[[Category: Bahnson, B J.]]

OCA at 17:18, 20 October 2012

2012-10-20T17:18:09Z

← Older revision		Revision as of 17:18, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[3g4e]] is a 2 chain structure ~~of [[Ribosomal protein L11]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G4E OCA].		[[3g4e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G4E OCA].

	==See Also==		==See Also==

OCA: Protected "3g4e" [edit=sysop:move=sysop]

2012-07-27T00:27:56Z

Protected "3g4e" [edit=sysop:move=sysop]

← Older revision	Revision as of 00:27, 27 July 2012
(No difference)

OCA at 00:27, 27 July 2012

2012-07-27T00:27:55Z

← Older revision		Revision as of 00:27, 27 July 2012
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	~~{{Seed}}~~
	[[Image:3g4e.png\|left\|200px]]		[[Image:3g4e.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3g4e", creates the "Structure Box" on the page.~~
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	{{STRUCTURE_3g4e\| PDB=3g4e \| SCENE= }}		{{STRUCTURE_3g4e\| PDB=3g4e \| SCENE= }}

	===Crystal structure of human senescence marker protein-30(SMP30)(Calcium bound)===		===Crystal structure of human senescence marker protein-30(SMP30)(Calcium bound)===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_20329768}}, adds the Publication Abstract to the page~~
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	~~-->~~
	{{ABSTRACT_PUBMED_20329768}}		{{ABSTRACT_PUBMED_20329768}}

	==About this Structure==		==About this Structure==
	~~3G4E~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G4E OCA].		[[3g4e]] is a 2 chain structure of [[Ribosomal protein L11]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G4E OCA].

			==See Also==
			*[[Ribosomal protein L11\|Ribosomal protein L11]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~20329768~~</ref><references group="xtra"/>		<ref group="xtra">PMID:020329768</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bahnson, B J.]]		[[Category: Bahnson, B J.]]
	[[Category: Chakraborti, S.]]		[[Category: Chakraborti, S.]]
	~~[[Category: Alternative splicing]]~~
	~~[[Category: Calcium]]~~
	[[Category: Calcium bound]]		[[Category: Calcium bound]]
	~~[[Category: Cytoplasm]]~~
	[[Category: Gluconolcatonase]]		[[Category: Gluconolcatonase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
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	[[Category: Regucalcin]]		[[Category: Regucalcin]]
	[[Category: Six bladed beta-propeller]]		[[Category: Six bladed beta-propeller]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 5 11:08:24 2010''~~

OCA at 08:08, 5 May 2010

2010-05-05T08:08:25Z

← Older revision		Revision as of 08:08, 5 May 2010
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	{{Seed}}		{{Seed}}
	[[Image:3g4e.~~jpg~~\|left\|200px]]		[[Image:3g4e.png\|left\|200px]]

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	===Crystal structure of human senescence marker protein-30(SMP30)(Calcium bound)===		===Crystal structure of human senescence marker protein-30(SMP30)(Calcium bound)===


			<!--
			The line below this paragraph, {{ABSTRACT_PUBMED_20329768}}, adds the Publication Abstract to the page
			(as it appears on PubMed at http://www.pubmed.gov), where 20329768 is the PubMed ID number.
			-->
			{{ABSTRACT_PUBMED_20329768}}

	==About this Structure==		==About this Structure==
	3G4E is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G4E OCA].		3G4E is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G4E OCA].

			==Reference==
			<ref group="xtra">PMID:20329768</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bahnson, B J.]]		[[Category: Bahnson, B J.]]
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	[[Category: Cytoplasm]]		[[Category: Cytoplasm]]
	[[Category: Gluconolcatonase]]		[[Category: Gluconolcatonase]]
			[[Category: Hydrolase]]
	[[Category: Organophosphate hydrolase]]		[[Category: Organophosphate hydrolase]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
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	[[Category: Six bladed beta-propeller]]		[[Category: Six bladed beta-propeller]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Feb~~ ~~3 09~~:52:34 2010''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 5 11:08:24 2010''