3ga3 - Revision history

OCA at 09:53, 21 February 2024

2024-02-21T09:53:21Z

← Older revision		Revision as of 09:53, 21 February 2024
Line 3:		Line 3:
	<StructureSection load='3ga3' size='340' side='right'caption='[[3ga3]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='3ga3' size='340' side='right'caption='[[3ga3]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ga3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GA3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GA3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ga3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GA3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GA3 FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.45Å</td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~IFIH1, IFIH1 or MDA5, MDA5, RH116 ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ga3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ga3 OCA], [https://pdbe.org/3ga3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ga3 RCSB], [https://www.ebi.ac.uk/pdbsum/3ga3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ga3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ga3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ga3 OCA], [https://pdbe.org/3ga3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ga3 RCSB], [https://www.ebi.ac.uk/pdbsum/3ga3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ga3 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[https://www.uniprot.org/uniprot/IFIH1_HUMAN IFIH1_HUMAN]] Genetic variation in IFIH1 is associated with diabetes mellitus insulin-dependent type 19 (IDDM19) [MIM:[https://omim.org/entry/610155 610155]]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:16699517</ref> Note=IFIH1 is the CADM-140 autoantigen, involved in clinically amyopathic dermatomyositis (CADM). This is a chronic inflammatory disorder that shows typical skin manifestations of dermatomyositis but has no or little evidence of clinical myositis. Anti-CADM-140 antibodies appear to be specific to dermatomyositis, especially CADM. Patients with anti-CADM-140 antibodies frequently develop life-threatening acute progressive interstitial lung disease (ILD).<ref>PMID:19565506</ref> <ref>PMID:20015976</ref>		[https://www.uniprot.org/uniprot/IFIH1_HUMAN IFIH1_HUMAN] Genetic variation in IFIH1 is associated with diabetes mellitus insulin-dependent type 19 (IDDM19) [MIM:[https://omim.org/entry/610155 610155]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:16699517</ref> Note=IFIH1 is the CADM-140 autoantigen, involved in clinically amyopathic dermatomyositis (CADM). This is a chronic inflammatory disorder that shows typical skin manifestations of dermatomyositis but has no or little evidence of clinical myositis. Anti-CADM-140 antibodies appear to be specific to dermatomyositis, especially CADM. Patients with anti-CADM-140 antibodies frequently develop life-threatening acute progressive interstitial lung disease (ILD).<ref>PMID:19565506</ref> <ref>PMID:20015976</ref>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/IFIH1_HUMAN IFIH1_HUMAN]] Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines.<ref>PMID:14645903</ref> <ref>PMID:19211564</ref> <ref>PMID:19656871</ref> <ref>PMID:21742966</ref> <ref>PMID:21217758</ref>		[https://www.uniprot.org/uniprot/IFIH1_HUMAN IFIH1_HUMAN] Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines.<ref>PMID:14645903</ref> <ref>PMID:19211564</ref> <ref>PMID:19656871</ref> <ref>PMID:21742966</ref> <ref>PMID:21217758</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Li, P]]		[[Category: Li P]]
	~~[[Category: Alternative splicing]]~~
	~~[[Category: Antiviral defense]]~~
	~~[[Category: Atp-binding]]~~
	~~[[Category: Cytoplasm]]~~
	~~[[Category: Diabetes mellitus]]~~
	~~[[Category: Helicase]]~~
	~~[[Category: Host-virus interaction]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: Immune response]]~~
	~~[[Category: Innate immune receptor]]~~
	~~[[Category: Innate immunity]]~~
	~~[[Category: Nucleotide-binding]]~~
	~~[[Category: Nucleus]]~~
	~~[[Category: Phosphoprotein]]~~
	~~[[Category: Polymorphism]]~~
	~~[[Category: Rlr]]~~
	~~[[Category: Rna biniding]]~~
	~~[[Category: Rna-binding~~]]

OCA at 07:59, 9 March 2022

2022-03-09T07:59:44Z

← Older revision		Revision as of 07:59, 9 March 2022
Line 1:		Line 1:

	==Crystal structure of the C-terminal domain of human MDA5==		==Crystal structure of the C-terminal domain of human MDA5==
	<StructureSection load='3ga3' size='340' side='right' caption='[[3ga3]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='3ga3' size='340' side='right'caption='[[3ga3]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ga3]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GA3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3GA3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ga3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GA3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GA3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IFIH1, IFIH1 or MDA5, MDA5, RH116 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IFIH1, IFIH1 or MDA5, MDA5, RH116 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ga3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ga3 OCA], [~~http~~://pdbe.org/3ga3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ga3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ga3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ga3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ga3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ga3 OCA], [https://pdbe.org/3ga3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ga3 RCSB], [https://www.ebi.ac.uk/pdbsum/3ga3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ga3 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[~~http~~://www.uniprot.org/uniprot/IFIH1_HUMAN IFIH1_HUMAN]] Genetic variation in IFIH1 is associated with diabetes mellitus insulin-dependent type 19 (IDDM19) [MIM:[~~http~~://omim.org/entry/610155 610155]]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:16699517</ref> Note=IFIH1 is the CADM-140 autoantigen, involved in clinically amyopathic dermatomyositis (CADM). This is a chronic inflammatory disorder that shows typical skin manifestations of dermatomyositis but has no or little evidence of clinical myositis. Anti-CADM-140 antibodies appear to be specific to dermatomyositis, especially CADM. Patients with anti-CADM-140 antibodies frequently develop life-threatening acute progressive interstitial lung disease (ILD).<ref>PMID:19565506</ref> <ref>PMID:20015976</ref>		[[https://www.uniprot.org/uniprot/IFIH1_HUMAN IFIH1_HUMAN]] Genetic variation in IFIH1 is associated with diabetes mellitus insulin-dependent type 19 (IDDM19) [MIM:[https://omim.org/entry/610155 610155]]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:16699517</ref> Note=IFIH1 is the CADM-140 autoantigen, involved in clinically amyopathic dermatomyositis (CADM). This is a chronic inflammatory disorder that shows typical skin manifestations of dermatomyositis but has no or little evidence of clinical myositis. Anti-CADM-140 antibodies appear to be specific to dermatomyositis, especially CADM. Patients with anti-CADM-140 antibodies frequently develop life-threatening acute progressive interstitial lung disease (ILD).<ref>PMID:19565506</ref> <ref>PMID:20015976</ref>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/IFIH1_HUMAN IFIH1_HUMAN]] Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines.<ref>PMID:14645903</ref> <ref>PMID:19211564</ref> <ref>PMID:19656871</ref> <ref>PMID:21742966</ref> <ref>PMID:21217758</ref>		[[https://www.uniprot.org/uniprot/IFIH1_HUMAN IFIH1_HUMAN]] Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines.<ref>PMID:14645903</ref> <ref>PMID:19211564</ref> <ref>PMID:19656871</ref> <ref>PMID:21742966</ref> <ref>PMID:21217758</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Li, P]]		[[Category: Li, P]]
	[[Category: Alternative splicing]]		[[Category: Alternative splicing]]

OCA at 05:49, 7 December 2018

2018-12-07T05:49:51Z

← Older revision		Revision as of 05:49, 7 December 2018
Line 1:		Line 1:

	==Crystal structure of the C-terminal domain of human MDA5==		==Crystal structure of the C-terminal domain of human MDA5==
	<StructureSection load='3ga3' size='340' side='right' caption='[[3ga3]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='3ga3' size='340' side='right' caption='[[3ga3]], [[Resolution\|resolution]] 1.45Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IFIH1, IFIH1 or MDA5, MDA5, RH116 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IFIH1, IFIH1 or MDA5, MDA5, RH116 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ga3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ga3 OCA], [http://pdbe.org/3ga3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ga3 RCSB], [http://www.ebi.ac.uk/pdbsum/3ga3 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ga3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ga3 OCA], [http://pdbe.org/3ga3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ga3 RCSB], [http://www.ebi.ac.uk/pdbsum/3ga3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ga3 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ga/3ga3_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ga/3ga3_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 27:		Line 28:
	[[Category: Human]]		[[Category: Human]]
	[[Category: Li, P]]		[[Category: Li, P]]
			[[Category: Alternative splicing]]
	[[Category: Antiviral defense]]		[[Category: Antiviral defense]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
			[[Category: Cytoplasm]]
	[[Category: Diabetes mellitus]]		[[Category: Diabetes mellitus]]
	[[Category: Helicase]]		[[Category: Helicase]]
Line 39:		Line 42:
	[[Category: Nucleus]]		[[Category: Nucleus]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
			[[Category: Polymorphism]]
	[[Category: Rlr]]		[[Category: Rlr]]
	[[Category: Rna biniding]]		[[Category: Rna biniding]]
	[[Category: Rna-binding]]		[[Category: Rna-binding]]

OCA at 06:34, 9 February 2016

2016-02-09T06:34:27Z

← Older revision		Revision as of 06:34, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3ga3' size='340' side='right' caption='[[3ga3]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='3ga3' size='340' side='right' caption='[[3ga3]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ga3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GA3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GA3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ga3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GA3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GA3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IFIH1, IFIH1 or MDA5, MDA5, RH116 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IFIH1, IFIH1 or MDA5, MDA5, RH116 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ga3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ga3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ga3 RCSB], [http://www.ebi.ac.uk/pdbsum/3ga3 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ga3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ga3 OCA], [http://pdbe.org/3ga3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ga3 RCSB], [http://www.ebi.ac.uk/pdbsum/3ga3 PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ga3 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	== References ==		== References ==
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Li, P]]		[[Category: Li, P]]
	[[Category: Antiviral defense]]		[[Category: Antiviral defense]]

OCA at 14:05, 18 December 2014

2014-12-18T14:05:18Z

← Older revision		Revision as of 14:05, 18 December 2014
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	~~{{STRUCTURE_3ga3\| PDB=3ga3 \| SCENE= }}~~		==Crystal structure of the C-terminal domain of human MDA5==
	===Crystal structure of the C-terminal domain of human MDA5===		<StructureSection load='3ga3' size='340' side='right' caption='[[3ga3]], [[Resolution\|resolution]] 1.45Å' scene=''>
	~~{{ABSTRACT_PUBMED_019531363}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[3ga3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GA3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GA3 FirstGlance]. <br>
	==Disease==		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	[[http://www.uniprot.org/uniprot/IFIH1_HUMAN IFIH1_HUMAN]] Genetic variation in IFIH1 is associated with diabetes mellitus insulin-dependent type 19 (IDDM19) [MIM:[http://omim.org/entry/610155 610155]]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:16699517</ref> Note=IFIH1 is the CADM-140 autoantigen, involved in clinically amyopathic dermatomyositis (CADM). This is a chronic inflammatory disorder that shows typical skin manifestations of dermatomyositis but has no or little evidence of clinical myositis. Anti-CADM-140 antibodies appear to be specific to dermatomyositis, especially CADM. Patients with anti-CADM-140 antibodies frequently develop life-threatening acute progressive interstitial lung disease (ILD).<ref>PMID:19565506</ref><ref>PMID:20015976</ref>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IFIH1, IFIH1 or MDA5, MDA5, RH116 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ga3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ga3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ga3 RCSB], [http://www.ebi.ac.uk/pdbsum/3ga3 PDBsum]</span></td></tr>
	==Function==		</table>
	[[http://www.uniprot.org/uniprot/IFIH1_HUMAN IFIH1_HUMAN]] Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines.<ref>PMID:14645903</ref><ref>PMID:19211564</ref><ref>PMID:19656871</ref><ref>PMID:21742966</ref><ref>PMID:21217758</ref>		== Disease ==
			[[http://www.uniprot.org/uniprot/IFIH1_HUMAN IFIH1_HUMAN]] Genetic variation in IFIH1 is associated with diabetes mellitus insulin-dependent type 19 (IDDM19) [MIM:[http://omim.org/entry/610155 610155]]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:16699517</ref> Note=IFIH1 is the CADM-140 autoantigen, involved in clinically amyopathic dermatomyositis (CADM). This is a chronic inflammatory disorder that shows typical skin manifestations of dermatomyositis but has no or little evidence of clinical myositis. Anti-CADM-140 antibodies appear to be specific to dermatomyositis, especially CADM. Patients with anti-CADM-140 antibodies frequently develop life-threatening acute progressive interstitial lung disease (ILD).<ref>PMID:19565506</ref> <ref>PMID:20015976</ref>
	==~~About this Structure~~==		== Function ==
	[[~~3ga3~~]] ~~is a 1 chain~~ structure ~~with sequence from~~ [http://en.~~wikipedia~~.~~org/wiki~~/~~Homo_sapiens Homo sapiens~~]. ~~Full crystallographic information is~~ available from [http://~~oca~~.~~weizmann~~.ac.il/~~oca-bin~~/~~ocashort~~?id=~~3GA3 OCA~~].		[[http://www.uniprot.org/uniprot/IFIH1_HUMAN IFIH1_HUMAN]] Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines.<ref>PMID:14645903</ref> <ref>PMID:19211564</ref> <ref>PMID:19656871</ref> <ref>PMID:21742966</ref> <ref>PMID:21217758</ref>
			== Evolutionary Conservation ==
	==~~Reference~~==		[[Image:Consurf_key_small.gif\|200px\|right]]
	<references ~~group="xtra"~~/><~~references~~/>		Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ga/3ga3_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Li, P.]]		[[Category: Li, P]]
	[[Category: Antiviral defense]]		[[Category: Antiviral defense]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]

OCA at 03:52, 25 March 2013

2013-03-25T03:52:07Z

← Older revision		Revision as of 03:52, 25 March 2013
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	~~[[Image:3ga3.png\|left\|200px]]~~

	{{STRUCTURE_3ga3\| PDB=3ga3 \| SCENE= }}		{{STRUCTURE_3ga3\| PDB=3ga3 \| SCENE= }}
			===Crystal structure of the C-terminal domain of human MDA5===
			{{ABSTRACT_PUBMED_019531363}}

	===~~Crystal structure~~ of the C-~~terminal domain~~ of ~~human MDA5===~~		==Disease==
			[[http://www.uniprot.org/uniprot/IFIH1_HUMAN IFIH1_HUMAN]] Genetic variation in IFIH1 is associated with diabetes mellitus insulin-dependent type 19 (IDDM19) [MIM:[http://omim.org/entry/610155 610155]]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:16699517</ref> Note=IFIH1 is the CADM-140 autoantigen, involved in clinically amyopathic dermatomyositis (CADM). This is a chronic inflammatory disorder that shows typical skin manifestations of dermatomyositis but has no or little evidence of clinical myositis. Anti-CADM-140 antibodies appear to be specific to dermatomyositis, especially CADM. Patients with anti-CADM-140 antibodies frequently develop life-threatening acute progressive interstitial lung disease (ILD).<ref>PMID:19565506</ref><ref>PMID:20015976</ref>

	~~{{ABSTRACT_PUBMED_019531363}}~~		==Function==
			[[http://www.uniprot.org/uniprot/IFIH1_HUMAN IFIH1_HUMAN]] Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines.<ref>PMID:14645903</ref><ref>PMID:19211564</ref><ref>PMID:19656871</ref><ref>PMID:21742966</ref><ref>PMID:21217758</ref>

	==About this Structure==		==About this Structure==
	[[3ga3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GA3 OCA].		[[3ga3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GA3 OCA].

			==Reference==
			<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Li, P.]]		[[Category: Li, P.]]

OCA: Protected "3ga3" [edit=sysop:move=sysop]

2013-02-20T14:29:44Z

Protected "3ga3" [edit=sysop:move=sysop]

← Older revision	Revision as of 14:29, 20 February 2013
(No difference)

OCA at 14:29, 20 February 2013

2013-02-20T14:29:42Z

← Older revision		Revision as of 14:29, 20 February 2013
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	~~{{Seed}}~~
	[[Image:3ga3.png\|left\|200px]]		[[Image:3ga3.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3ga3", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
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	{{STRUCTURE_3ga3\| PDB=3ga3 \| SCENE= }}		{{STRUCTURE_3ga3\| PDB=3ga3 \| SCENE= }}

	===Crystal structure of the C-terminal domain of human MDA5===		===Crystal structure of the C-terminal domain of human MDA5===

			{{ABSTRACT_PUBMED_019531363}}

	==About this Structure==		==About this Structure==
	~~3GA3~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GA3 OCA].		[[3ga3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GA3 OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Li, P.]]		[[Category: Li, P.]]
	~~[[Category: Alternative splicing]]~~
	[[Category: Antiviral defense]]		[[Category: Antiviral defense]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	~~[[Category: Cytoplasm]]~~
	[[Category: Diabetes mellitus]]		[[Category: Diabetes mellitus]]
	[[Category: Helicase]]		[[Category: Helicase]]
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	[[Category: Nucleus]]		[[Category: Nucleus]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
	~~[[Category: Polymorphism]]~~
	[[Category: Rlr]]		[[Category: Rlr]]
	[[Category: Rna biniding]]		[[Category: Rna biniding]]
	[[Category: Rna-binding]]		[[Category: Rna-binding]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 24 08:27:04 2010''~~

OCA at 06:27, 24 March 2010

2010-03-24T06:27:04Z

← Older revision		Revision as of 06:27, 24 March 2010
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	{{Seed}}		{{Seed}}
	[[Image:3ga3.~~jpg~~\|left\|200px]]		[[Image:3ga3.png\|left\|200px]]

	<!--		<!--
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	==About this Structure==		==About this Structure==
	3GA3 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GA3 OCA].		3GA3 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GA3 OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Li, P.]]		[[Category: Li, P.]]
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	[[Category: Rna-binding]]		[[Category: Rna-binding]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Feb 25 09~~:38:~~54 2009~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 24 08:27:04 2010''

OCA: New page: {{Seed}} 200px