3hl8 - Revision history

OCA at 06:40, 26 November 2025

2025-11-26T06:40:29Z

← Older revision		Revision as of 06:40, 26 November 2025
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hl/3hl8_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hl/3hl8_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 07:23, 6 September 2023

2023-09-06T07:23:33Z

← Older revision		Revision as of 07:23, 6 September 2023
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	<StructureSection load='3hl8' size='340' side='right'caption='[[3hl8]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='3hl8' size='340' side='right'caption='[[3hl8]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3hl8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HL8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3hl8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HL8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BBP:(5R)-3-TERT-BUTYL-1-(6-CHLORO-1,3-BENZOTHIAZOL-2-YL)-4,5-DIHYDRO-1H-PYRAZOL-5-OL'>BBP</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.55Å</td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3c95\|3c95]], [[3c94\|3c94]], [[3hp9\|3hp9]]</div></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BBP:(5R)-3-TERT-BUTYL-1-(6-CHLORO-1,3-BENZOTHIAZOL-2-YL)-4,5-DIHYDRO-1H-PYRAZOL-5-OL'>BBP</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b2011, cpeA, JW1993, sbcB, xonA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Exodeoxyribonuclease_I Exodeoxyribonuclease I], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.11.1 3.1.11.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hl8 OCA], [https://pdbe.org/3hl8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hl8 RCSB], [https://www.ebi.ac.uk/pdbsum/3hl8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hl8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hl8 OCA], [https://pdbe.org/3hl8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hl8 RCSB], [https://www.ebi.ac.uk/pdbsum/3hl8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hl8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/EX1_ECOLI EX1_ECOLI]] Also functions as a DNA deoxyribophosphodiesterase that releases deoxyribose-phosphate moieties following the cleavage DNA at an apurinic/apyrimidinic (AP) site by either an AP endonuclease AP lyase.		[https://www.uniprot.org/uniprot/EX1_ECOLI EX1_ECOLI] Also functions as a DNA deoxyribophosphodiesterase that releases deoxyribose-phosphate moieties following the cleavage DNA at an apurinic/apyrimidinic (AP) site by either an AP endonuclease AP lyase.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Ecoli]]~~		[[Category: Escherichia coli K-12]]
	~~[[Category: Exodeoxyribonuclease I~~]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Satyshur~~, K A]]~~		[[Category: Satyshur KA]]
	~~[[Category: Dna damage]]~~
	~~[[Category: Dna repair]]~~
	~~[[Category: Exonuclease]]~~
	~~[[Category: Genome maintenance]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: Nuclease]]~~
	~~[[Category: Ssb~~]]

OCA at 12:51, 23 March 2022

2022-03-23T12:51:33Z

← Older revision		Revision as of 12:51, 23 March 2022
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	==Crystal structure of exonuclease I in complex with inhibitor BCBP==		==Crystal structure of exonuclease I in complex with inhibitor BCBP==
	<StructureSection load='3hl8' size='340' side='right' caption='[[3hl8]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='3hl8' size='340' side='right'caption='[[3hl8]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3hl8]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HL8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3HL8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3hl8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HL8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BBP:(5R)-3-TERT-BUTYL-1-(6-CHLORO-1,3-BENZOTHIAZOL-2-YL)-4,5-DIHYDRO-1H-PYRAZOL-5-OL'>BBP</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BBP:(5R)-3-TERT-BUTYL-1-(6-CHLORO-1,3-BENZOTHIAZOL-2-YL)-4,5-DIHYDRO-1H-PYRAZOL-5-OL'>BBP</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c95\|3c95]], [[3c94\|3c94]], [[3hp9\|3hp9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3c95\|3c95]], [[3c94\|3c94]], [[3hp9\|3hp9]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b2011, cpeA, JW1993, sbcB, xonA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b2011, cpeA, JW1993, sbcB, xonA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Exodeoxyribonuclease_I Exodeoxyribonuclease I], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.11.1 3.1.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Exodeoxyribonuclease_I Exodeoxyribonuclease I], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.11.1 3.1.11.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3hl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hl8 OCA], [~~http~~://pdbe.org/3hl8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3hl8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3hl8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3hl8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hl8 OCA], [https://pdbe.org/3hl8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hl8 RCSB], [https://www.ebi.ac.uk/pdbsum/3hl8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hl8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/EX1_ECOLI EX1_ECOLI]] Also functions as a DNA deoxyribophosphodiesterase that releases deoxyribose-phosphate moieties following the cleavage DNA at an apurinic/apyrimidinic (AP) site by either an AP endonuclease AP lyase.		[[https://www.uniprot.org/uniprot/EX1_ECOLI EX1_ECOLI]] Also functions as a DNA deoxyribophosphodiesterase that releases deoxyribose-phosphate moieties following the cleavage DNA at an apurinic/apyrimidinic (AP) site by either an AP endonuclease AP lyase.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hl/3hl8_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hl/3hl8_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 3hl8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3hl8" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Exonuclease 3D structures\|Exonuclease 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Ecoli]]		[[Category: Ecoli]]
	[[Category: Exodeoxyribonuclease I]]		[[Category: Exodeoxyribonuclease I]]
			[[Category: Large Structures]]
	[[Category: Satyshur, K A]]		[[Category: Satyshur, K A]]
	[[Category: Dna damage]]		[[Category: Dna damage]]

OCA at 07:40, 1 November 2017

2017-11-01T07:40:29Z

← Older revision		Revision as of 07:40, 1 November 2017
Line 1:		Line 1:

	==Crystal structure of exonuclease I in complex with inhibitor BCBP==		==Crystal structure of exonuclease I in complex with inhibitor BCBP==
	<StructureSection load='3hl8' size='340' side='right' caption='[[3hl8]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='3hl8' size='340' side='right' caption='[[3hl8]], [[Resolution\|resolution]] 1.55Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b2011, cpeA, JW1993, sbcB, xonA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b2011, cpeA, JW1993, sbcB, xonA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exodeoxyribonuclease_I Exodeoxyribonuclease I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.11.1 3.1.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exodeoxyribonuclease_I Exodeoxyribonuclease I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.11.1 3.1.11.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hl8 OCA], [http://pdbe.org/3hl8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hl8 RCSB], [http://www.ebi.ac.uk/pdbsum/3hl8 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hl8 OCA], [http://pdbe.org/3hl8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hl8 RCSB], [http://www.ebi.ac.uk/pdbsum/3hl8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hl8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 3hl8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3hl8" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Exonuclease\|Exonuclease]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:00, 7 February 2016

2016-02-07T12:00:34Z

← Older revision		Revision as of 12:00, 7 February 2016
Line 7:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b2011, cpeA, JW1993, sbcB, xonA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b2011, cpeA, JW1993, sbcB, xonA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exodeoxyribonuclease_I Exodeoxyribonuclease I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.11.1 3.1.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exodeoxyribonuclease_I Exodeoxyribonuclease I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.11.1 3.1.11.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hl8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hl8 RCSB], [http://www.ebi.ac.uk/pdbsum/3hl8 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hl8 OCA], [http://pdbe.org/3hl8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hl8 RCSB], [http://www.ebi.ac.uk/pdbsum/3hl8 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hl8 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3hl8" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 14:55, 24 December 2014

2014-12-24T14:55:22Z

← Older revision		Revision as of 14:55, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3hl8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HL8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HL8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3hl8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HL8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HL8 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BBP:(5R)-3-TERT-BUTYL-1-(6-CHLORO-1,3-BENZOTHIAZOL-2-YL)-4,5-DIHYDRO-1H-PYRAZOL-5-OL'>BBP</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BBP:(5R)-3-TERT-BUTYL-1-(6-CHLORO-1,3-BENZOTHIAZOL-2-YL)-4,5-DIHYDRO-1H-PYRAZOL-5-OL'>BBP</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c95\|3c95]], [[3c94\|3c94]], [[3hp9\|3hp9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c95\|3c95]], [[3c94\|3c94]], [[3hp9\|3hp9]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b2011, cpeA, JW1993, sbcB, xonA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b2011, cpeA, JW1993, sbcB, xonA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exodeoxyribonuclease_I Exodeoxyribonuclease I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.11.1 3.1.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exodeoxyribonuclease_I Exodeoxyribonuclease I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.11.1 3.1.11.1] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hl8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hl8 RCSB], [http://www.ebi.ac.uk/pdbsum/3hl8 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hl8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hl8 RCSB], [http://www.ebi.ac.uk/pdbsum/3hl8 PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/EX1_ECOLI EX1_ECOLI]] Also functions as a DNA deoxyribophosphodiesterase that releases deoxyribose-phosphate moieties following the cleavage DNA at an apurinic/apyrimidinic (AP) site by either an AP endonuclease AP lyase.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 27:
	Small-molecule tools for dissecting the roles of SSB/protein interactions in genome maintenance.,Lu D, Bernstein DA, Satyshur KA, Keck JL Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):633-8. Epub 2009 Dec 16. PMID:20018747<ref>PMID:20018747</ref>		Small-molecule tools for dissecting the roles of SSB/protein interactions in genome maintenance.,Lu D, Bernstein DA, Satyshur KA, Keck JL Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):633-8. Epub 2009 Dec 16. PMID:20018747<ref>PMID:20018747</ref>

	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>

			==See Also==
			*[[Exonuclease\|Exonuclease]]
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 38:
	[[Category: Ecoli]]		[[Category: Ecoli]]
	[[Category: Exodeoxyribonuclease I]]		[[Category: Exodeoxyribonuclease I]]
	[[Category: Satyshur, K A.]]		[[Category: Satyshur, K A]]
	[[Category: Dna damage]]		[[Category: Dna damage]]
	[[Category: Dna repair]]		[[Category: Dna repair]]

OCA at 07:14, 28 May 2014

2014-05-28T07:14:23Z

@@ Line 1: / Line 1: @@
-[[Image:3hl8.png|left|200px]]
+==Crystal structure of exonuclease I in complex with inhibitor BCBP==
-{{STRUCTURE_3hl8|  PDB=3hl8  |  SCENE=  }}
+Small-molecule tools for dissecting the roles of SSB/protein interactions in genome maintenance.,Lu D, Bernstein DA, Satyshur KA, Keck JL Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):633-8. Epub 2009 Dec 16. PMID:20018747<ref>PMID:20018747</ref>
-===Crystal structure of exonuclease I in complex with inhibitor BCBP===
+From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_20018747}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[3hl8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HL8 OCA].
+</StructureSection>
+[[Category: Ecoli]]
 [[Category: Exodeoxyribonuclease I]]
 [[Category: Satyshur, K A.]]

OCA at 06:34, 20 October 2012

2012-10-20T06:34:19Z

← Older revision		Revision as of 06:34, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[3hl8]] is a 1 chain structure ~~of [[Exonuclease]]~~ with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HL8 OCA].		[[3hl8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HL8 OCA].

	==See Also==		==See Also==

OCA: Protected "3hl8" [edit=sysop:move=sysop]

2012-07-25T13:36:55Z

Protected "3hl8" [edit=sysop:move=sysop]

← Older revision	Revision as of 13:36, 25 July 2012
(No difference)

OCA at 13:36, 25 July 2012

2012-07-25T13:36:53Z

← Older revision		Revision as of 13:36, 25 July 2012
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	~~{{Seed}}~~
	[[Image:3hl8.png\|left\|200px]]		[[Image:3hl8.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3hl8", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3hl8\| PDB=3hl8 \| SCENE= }}		{{STRUCTURE_3hl8\| PDB=3hl8 \| SCENE= }}

	===Crystal structure of exonuclease I in complex with inhibitor BCBP===		===Crystal structure of exonuclease I in complex with inhibitor BCBP===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_20018747}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 20018747 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_20018747}}		{{ABSTRACT_PUBMED_20018747}}

	==About this Structure==		==About this Structure==
	~~3HL8~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli_k-12~~ Escherichia coli ~~k-12~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HL8 OCA].		[[3hl8]] is a 1 chain structure of [[Exonuclease]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HL8 OCA].

			==See Also==
			*[[Exonuclease\|Exonuclease]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~20018747~~</ref><references group="xtra"/>		<ref group="xtra">PMID:020018747</ref><references group="xtra"/>
	[[Category: Escherichia coli ~~k-12~~]]		[[Category: Escherichia coli]]
	[[Category: Exodeoxyribonuclease I]]		[[Category: Exodeoxyribonuclease I]]
	[[Category: Satyshur, K A.]]		[[Category: Satyshur, K A.]]
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	[[Category: Nuclease]]		[[Category: Nuclease]]
	[[Category: Ssb]]		[[Category: Ssb]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 3 09:07:15 2010''~~