3hlk - Revision history

OCA at 09:58, 6 November 2024

2024-11-06T09:58:02Z

← Older revision		Revision as of 09:58, 6 November 2024
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	<StructureSection load='3hlk' size='340' side='right'caption='[[3hlk]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3hlk' size='340' side='right'caption='[[3hlk]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3hlk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HLK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HLK FirstGlance]. <br>		<table><tr><td colspan='2'>[[3hlk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HLK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HLK FirstGlance]. <br>
	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">ACOT2, PTE2, PTE2A ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5~~&~~id=9606 HUMAN])~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[https://en.wikipedia.org/wiki/Palmitoyl-CoA_hydrolase Palmitoyl-CoA hydrolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.2 3.1.2.2]~~ </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hlk OCA], [https://pdbe.org/3hlk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hlk RCSB], [https://www.ebi.ac.uk/pdbsum/3hlk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hlk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hlk OCA], [https://pdbe.org/3hlk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hlk RCSB], [https://www.ebi.ac.uk/pdbsum/3hlk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hlk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/ACOT2_HUMAN ACOT2_HUMAN]] Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs.<ref>PMID:10944470</ref>		[https://www.uniprot.org/uniprot/ACOT2_HUMAN ACOT2_HUMAN] Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs.<ref>PMID:10944470</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hl/3hlk_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hl/3hlk_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Palmitoyl-CoA hydrolase]]~~		[[Category: Mandel CR]]
	[[Category: Mandel~~, C R~~]]		[[Category: Tong L]]
	[[Category: Tong, L]]		[[Category: Tweel B]]
	[[Category: Tweel, B]]
	~~[[Category: Alpha/beta hydrolase]]~~
	~~[[Category: Alternative splicing]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: Mitochondrion]]~~
	~~[[Category: Polymorphism]]~~
	~~[[Category: Serine esterase]]~~
	~~[[Category: Transit peptide~~]]

OCA at 12:51, 23 March 2022

2022-03-23T12:51:36Z

← Older revision		Revision as of 12:51, 23 March 2022
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	==Crystal structure of human mitochondrial acyl-CoA thioesterase (ACOT2)==		==Crystal structure of human mitochondrial acyl-CoA thioesterase (ACOT2)==
	<StructureSection load='3hlk' size='340' side='right' caption='[[3hlk]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3hlk' size='340' side='right'caption='[[3hlk]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3hlk]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HLK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3HLK FirstGlance]. <br>		<table><tr><td colspan='2'>[[3hlk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HLK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HLK FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ACOT2, PTE2, PTE2A ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ACOT2, PTE2, PTE2A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Palmitoyl-CoA_hydrolase Palmitoyl-CoA hydrolase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.2 3.1.2.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Palmitoyl-CoA_hydrolase Palmitoyl-CoA hydrolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.2 3.1.2.2] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3hlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hlk OCA], [~~http~~://pdbe.org/3hlk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3hlk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3hlk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3hlk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hlk OCA], [https://pdbe.org/3hlk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hlk RCSB], [https://www.ebi.ac.uk/pdbsum/3hlk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hlk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/ACOT2_HUMAN ACOT2_HUMAN]] Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs.<ref>PMID:10944470</ref>		[[https://www.uniprot.org/uniprot/ACOT2_HUMAN ACOT2_HUMAN]] Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs.<ref>PMID:10944470</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hl/3hlk_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hl/3hlk_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 3hlk" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3hlk" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Thioesterase 3D structures\|Thioesterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Palmitoyl-CoA hydrolase]]		[[Category: Palmitoyl-CoA hydrolase]]
	[[Category: Mandel, C R]]		[[Category: Mandel, C R]]

OCA at 07:40, 1 November 2017

2017-11-01T07:40:58Z

← Older revision		Revision as of 07:40, 1 November 2017
Line 1:		Line 1:

	==Crystal structure of human mitochondrial acyl-CoA thioesterase (ACOT2)==		==Crystal structure of human mitochondrial acyl-CoA thioesterase (ACOT2)==
	<StructureSection load='3hlk' size='340' side='right' caption='[[3hlk]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3hlk' size='340' side='right' caption='[[3hlk]], [[Resolution\|resolution]] 2.10Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ACOT2, PTE2, PTE2A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ACOT2, PTE2, PTE2A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Palmitoyl-CoA_hydrolase Palmitoyl-CoA hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.2 3.1.2.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Palmitoyl-CoA_hydrolase Palmitoyl-CoA hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.2 3.1.2.2] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hlk OCA], [http://pdbe.org/3hlk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hlk RCSB], [http://www.ebi.ac.uk/pdbsum/3hlk PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hlk OCA], [http://pdbe.org/3hlk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hlk RCSB], [http://www.ebi.ac.uk/pdbsum/3hlk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hlk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 3hlk" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3hlk" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Thioesterase\|Thioesterase]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Tweel, B]]		[[Category: Tweel, B]]
	[[Category: Alpha/beta hydrolase]]		[[Category: Alpha/beta hydrolase]]
			[[Category: Alternative splicing]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Mitochondrion]]		[[Category: Mitochondrion]]
			[[Category: Polymorphism]]
	[[Category: Serine esterase]]		[[Category: Serine esterase]]
	[[Category: Transit peptide]]		[[Category: Transit peptide]]

OCA at 15:11, 7 February 2016

2016-02-07T15:11:34Z

← Older revision		Revision as of 15:11, 7 February 2016
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	<StructureSection load='3hlk' size='340' side='right' caption='[[3hlk]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3hlk' size='340' side='right' caption='[[3hlk]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3hlk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HLK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HLK FirstGlance]. <br>		<table><tr><td colspan='2'>[[3hlk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HLK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HLK FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ACOT2, PTE2, PTE2A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ACOT2, PTE2, PTE2A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Palmitoyl-CoA_hydrolase Palmitoyl-CoA hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.2 3.1.2.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Palmitoyl-CoA_hydrolase Palmitoyl-CoA hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.2 3.1.2.2] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hlk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hlk RCSB], [http://www.ebi.ac.uk/pdbsum/3hlk PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hlk OCA], [http://pdbe.org/3hlk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hlk RCSB], [http://www.ebi.ac.uk/pdbsum/3hlk PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hlk ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3hlk" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Palmitoyl-CoA hydrolase]]		[[Category: Palmitoyl-CoA hydrolase]]
	[[Category: Mandel, C R]]		[[Category: Mandel, C R]]

OCA at 16:09, 24 December 2014

2014-12-24T16:09:10Z

← Older revision		Revision as of 16:09, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3hlk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HLK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HLK FirstGlance]. <br>		<table><tr><td colspan='2'>[[3hlk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HLK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HLK FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ACOT2, PTE2, PTE2A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ACOT2, PTE2, PTE2A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Palmitoyl-CoA_hydrolase Palmitoyl-CoA hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.2 3.1.2.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Palmitoyl-CoA_hydrolase Palmitoyl-CoA hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.2 3.1.2.2] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hlk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hlk RCSB], [http://www.ebi.ac.uk/pdbsum/3hlk PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hlk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hlk RCSB], [http://www.ebi.ac.uk/pdbsum/3hlk PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/ACOT2_HUMAN ACOT2_HUMAN]] Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs.<ref>PMID:10944470</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Palmitoyl-CoA hydrolase]]		[[Category: Palmitoyl-CoA hydrolase]]
	[[Category: Mandel, C R.]]		[[Category: Mandel, C R]]
	[[Category: Tong, L.]]		[[Category: Tong, L]]
	[[Category: Tweel, B.]]		[[Category: Tweel, B]]
	[[Category: Alpha/beta hydrolase]]		[[Category: Alpha/beta hydrolase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 12:28, 29 September 2014

2014-09-29T12:28:29Z

← Older revision		Revision as of 12:28, 29 September 2014
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	[[Image:~~3hlk~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of human mitochondrial acyl-CoA thioesterase (ACOT2)==
			<StructureSection load='3hlk' size='340' side='right' caption='[[3hlk]], [[Resolution\|resolution]] 2.10Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3hlk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HLK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HLK FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ACOT2, PTE2, PTE2A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Palmitoyl-CoA_hydrolase Palmitoyl-CoA hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.2 3.1.2.2] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hlk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hlk RCSB], [http://www.ebi.ac.uk/pdbsum/3hlk PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hl/3hlk_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Acyl-CoA thioesterases (ACOTs) catalyze the hydrolysis of CoA esters to free CoA and carboxylic acids and have important functions in lipid metabolism and other cellular processes. Type I ACOTs are found only in animals and contain an alpha/beta hydrolase domain, through currently no structural information is available on any of these enzymes. We report here the crystal structure at 2.1A resolution of human mitochondrial ACOT2, a type I enzyme. The structure contains two domains, N and C domains. The C domain has the alpha/beta hydrolase fold, with the catalytic triad Ser294-His422-Asp388. The N domain contains a seven-stranded beta-sandwich, which has some distant structural homologs in other proteins. The active site is located in a large pocket at the interface between the two domains. The structural information has significant relevance for other type I ACOTs and related enzymes.

	~~{{STRUCTURE_3hlk\| PDB=3hlk \| SCENE= }}~~		Crystal structure of human mitochondrial acyl-CoA thioesterase (ACOT2).,Mandel CR, Tweel B, Tong L Biochem Biophys Res Commun. 2009 Aug 7;385(4):630-3. Epub 2009 Jun 2. PMID:19497300<ref>PMID:19497300</ref>

	~~===Crystal structure~~ of ~~human mitochondrial acyl-CoA thioesterase (ACOT2)===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_19497300}}~~

	~~==About this Structure==~~
	~~[[3hlk]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=3HLK OCA].~~

	==See Also==		==See Also==
	*[[Thioesterase\|Thioesterase]]		*[[Thioesterase\|Thioesterase]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:019497300<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Palmitoyl-CoA hydrolase]]		[[Category: Palmitoyl-CoA hydrolase]]

OCA at 07:01, 20 October 2012

2012-10-20T07:01:30Z

← Older revision		Revision as of 07:01, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[3hlk]] is a 2 chain structure ~~of [[Thioesterase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HLK OCA].		[[3hlk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HLK OCA].

	==See Also==		==See Also==

OCA: Protected "3hlk" [edit=sysop:move=sysop]

2012-07-25T15:03:28Z

Protected "3hlk" [edit=sysop:move=sysop]

← Older revision	Revision as of 15:03, 25 July 2012
(No difference)

OCA at 15:03, 25 July 2012

2012-07-25T15:03:27Z

← Older revision		Revision as of 15:03, 25 July 2012
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	~~{{Seed}}~~
	[[Image:3hlk.png\|left\|200px]]		[[Image:3hlk.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3hlk", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3hlk\| PDB=3hlk \| SCENE= }}		{{STRUCTURE_3hlk\| PDB=3hlk \| SCENE= }}

	===Crystal structure of human mitochondrial acyl-CoA thioesterase (ACOT2)===		===Crystal structure of human mitochondrial acyl-CoA thioesterase (ACOT2)===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_19497300}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 19497300 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_19497300}}		{{ABSTRACT_PUBMED_19497300}}

	==About this Structure==		==About this Structure==
	~~3HLK~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HLK OCA].		[[3hlk]] is a 2 chain structure of [[Thioesterase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HLK OCA].

			==See Also==
			*[[Thioesterase\|Thioesterase]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~19497300~~</ref><references group="xtra"/>		<ref group="xtra">PMID:019497300</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Palmitoyl-CoA hydrolase]]		[[Category: Palmitoyl-CoA hydrolase]]
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	[[Category: Tweel, B.]]		[[Category: Tweel, B.]]
	[[Category: Alpha/beta hydrolase]]		[[Category: Alpha/beta hydrolase]]
	~~[[Category: Alternative splicing]]~~
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Mitochondrion]]		[[Category: Mitochondrion]]
	~~[[Category: Polymorphism]]~~
	[[Category: Serine esterase]]		[[Category: Serine esterase]]
	[[Category: Transit peptide]]		[[Category: Transit peptide]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 5 08:58:47 2009''~~

OCA at 05:58, 5 August 2009

2009-08-05T05:58:48Z

← Older revision		Revision as of 05:58, 5 August 2009
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	{{Seed}}		{{Seed}}
	[[Image:3hlk.~~jpg~~\|left\|200px]]		[[Image:3hlk.png\|left\|200px]]

	<!--		<!--
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	[[Category: Transit peptide]]		[[Category: Transit peptide]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Jun 25 09~~:07:38 2009''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 5 08:58:47 2009''