3htt - Revision history

OCA at 15:54, 1 November 2023

2023-11-01T15:54:01Z

← Older revision		Revision as of 15:54, 1 November 2023
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	<StructureSection load='3htt' size='340' side='right'caption='[[3htt]], [[Resolution\|resolution]] 2.95Å' scene=''>		<StructureSection load='3htt' size='340' side='right'caption='[[3htt]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3htt]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Influenza_a_virus_~~(a/~~wdk~~/jx/12416/2005(~~h1n1~~)) Influenza a virus (a/~~wdk~~/jx/12416/2005(~~h1n1~~))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HTT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3HTT FirstGlance]. <br>		<table><tr><td colspan='2'>[[3htt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/WDK/JX/12416/2005(H1N1)) Influenza A virus (A/WDK/JX/12416/2005(H1N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HTT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HTT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=~~GLC~~:~~ALPHA~~-D-~~GLUCOSE~~'>~~GLC~~</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL~~-D-~~GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=~~GAL~~:~~BETA~~-D-~~GALACTOSE~~'>~~GAL~~</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene><~~/td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.95Å</td></tr>
	~~<tr id~~='~~NonStdRes'><td class~~=~~"sblockLbl"><b>[[Non~~-~~Standard_Residue\|NonStd Res:]]</b~~></~~td><td class="sblockDat"~~><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>~~</td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=PRD_900025:3-sialyl-alpha-lactose'>PRD_900025</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hto\|3hto]], [[3htp\|3htp]], [[3htq\|3htq]]~~</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3htt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3htt OCA], [https://pdbe.org/3htt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3htt RCSB], [https://www.ebi.ac.uk/pdbsum/3htt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3htt ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3htt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3htt OCA], [~~http~~://pdbe.org/3htt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3htt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3htt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3htt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/C7C6F1_9INFA C7C6F1_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013829_004_327643]		[https://www.uniprot.org/uniprot/C7C6F1_9INFA C7C6F1_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013829_004_327643]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Cai, Q]]		[[Category: Cai Q]]
	[[Category: Li, A]]		[[Category: Li A]]
	[[Category: Song, W]]		[[Category: Song W]]
	[[Category: Wang, G]]		[[Category: Wang G]]
	[[Category: Wu, C]]		[[Category: Wu C]]
	[[Category: Yuen, K Y]]		[[Category: Yuen K-Y]]
	[[Category: Zhang, Q]]		[[Category: Zhang Q]]
	[[Category: Zhang, R]]		[[Category: Zhang R]]
	~~[[Category: Receptor]]~~
	~~[[Category: Viral protein~~]]

OCA at 10:51, 16 September 2020

2020-09-16T10:51:50Z

← Older revision		Revision as of 10:51, 16 September 2020
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	==The hemagglutinin structure of an avian H1N1 influenza A virus in complex with 2,3-sialyllactose==		==The hemagglutinin structure of an avian H1N1 influenza A virus in complex with 2,3-sialyllactose==
	<StructureSection load='3htt' size='340' side='right' caption='[[3htt]], [[Resolution\|resolution]] 2.95Å' scene=''>		<StructureSection load='3htt' size='340' side='right'caption='[[3htt]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3htt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/wdk/jx/12416/2005(h1n1)) Influenza a virus (a/wdk/jx/12416/2005(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HTT OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3HTT FirstGlance]. <br>		<table><tr><td colspan='2'>[[3htt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/wdk/jx/12416/2005(h1n1)) Influenza a virus (a/wdk/jx/12416/2005(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HTT OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3HTT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~GAL~~:~~BETA~~-D-~~GALACTOSE~~'>~~GAL~~</scene>, <scene name='pdbligand=~~GLC~~:~~ALPHA~~-D-~~GLUCOSE~~'>~~GLC~~</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL~~-D-~~GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
			<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hto\|3hto]], [[3htp\|3htp]], [[3htq\|3htq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hto\|3hto]], [[3htp\|3htp]], [[3htq\|3htq]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3htt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3htt OCA], [http://pdbe.org/3htt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3htt RCSB], [http://www.ebi.ac.uk/pdbsum/3htt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3htt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3htt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3htt OCA], [http://pdbe.org/3htt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3htt RCSB], [http://www.ebi.ac.uk/pdbsum/3htt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3htt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	==See Also==		==See Also==
	*[[Hemagglutinin\|Hemagglutinin]]		*[[Hemagglutinin 3D structures\|Hemagglutinin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Cai, Q]]		[[Category: Cai, Q]]
	[[Category: Li, A]]		[[Category: Li, A]]

OCA at 08:25, 12 December 2018

2018-12-12T08:25:55Z

← Older revision		Revision as of 08:25, 12 December 2018
Line 1:		Line 1:

	==The hemagglutinin structure of an avian H1N1 influenza A virus in complex with 2,3-sialyllactose==		==The hemagglutinin structure of an avian H1N1 influenza A virus in complex with 2,3-sialyllactose==
	<StructureSection load='3htt' size='340' side='right' caption='[[3htt]], [[Resolution\|resolution]] 2.95Å' scene=''>		<StructureSection load='3htt' size='340' side='right' caption='[[3htt]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3htt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/wdk/jx/12416/2005(h1n1)) Influenza a virus (a/wdk/jx/12416/2005(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HTT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HTT FirstGlance]. <br>		<table><tr><td colspan='2'>[[3htt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/wdk/jx/12416/2005(h1n1)) Influenza a virus (a/wdk/jx/12416/2005(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HTT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HTT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~GLC~~:~~ALPHA~~-D-~~GLUCOSE~~'>~~GLC~~</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL~~-D-~~GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=~~GAL~~:~~BETA~~-D-~~GALACTOSE~~'>~~GAL~~</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hto\|3hto]], [[3htp\|3htp]], [[3htq\|3htq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hto\|3hto]], [[3htp\|3htp]], [[3htq\|3htq]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3htt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3htt OCA], [http://pdbe.org/3htt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3htt RCSB], [http://www.ebi.ac.uk/pdbsum/3htt PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3htt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3htt OCA], [http://pdbe.org/3htt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3htt RCSB], [http://www.ebi.ac.uk/pdbsum/3htt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3htt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ht/3htt_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ht/3htt_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 00:23, 9 February 2016

2016-02-09T00:23:17Z

← Older revision		Revision as of 00:23, 9 February 2016
Line 6:		Line 6:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hto\|3hto]], [[3htp\|3htp]], [[3htq\|3htq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hto\|3hto]], [[3htp\|3htp]], [[3htq\|3htq]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3htt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3htt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3htt RCSB], [http://www.ebi.ac.uk/pdbsum/3htt PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3htt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3htt OCA], [http://pdbe.org/3htt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3htt RCSB], [http://www.ebi.ac.uk/pdbsum/3htt PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3htt ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3htt" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 03:10, 25 December 2014

2014-12-25T03:10:47Z

← Older revision		Revision as of 03:10, 25 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_3htt\| PDB=3htt \| SCENE= }}~~		==The hemagglutinin structure of an avian H1N1 influenza A virus in complex with 2,3-sialyllactose==
	===The hemagglutinin structure of an avian H1N1 influenza A virus in complex with 2,3-sialyllactose===		<StructureSection load='3htt' size='340' side='right' caption='[[3htt]], [[Resolution\|resolution]] 2.95Å' scene=''>
	~~{{ABSTRACT_PUBMED_19628241}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[3htt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/wdk/jx/12416/2005(h1n1)) Influenza a virus (a/wdk/jx/12416/2005(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HTT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HTT FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
			<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hto\|3hto]], [[3htp\|3htp]], [[3htq\|3htq]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3htt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3htt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3htt RCSB], [http://www.ebi.ac.uk/pdbsum/3htt PDBsum]</span></td></tr>
			</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/C7C6F1_9INFA C7C6F1_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013829_004_327643]
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ht/3htt_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The interaction between hemagglutinin (HA) and receptors is a kernel in the study of evolution and host adaptation of H1N1 influenza A viruses. The notion that the avian HA is associated with preferential specificity for receptors with Siaalpha2,3Gal glycosidic linkage over those with Siaalpha2,6Gal linkage is not all consistent with the available data on H1N1 viruses. By x-ray crystallography, the HA structure of an avian H1N1 influenza A virus, as well as its complexes with the receptor analogs, was determined. The structures revealed no preferential binding of avian receptor analogs over that of the human analog, suggesting that the HA/receptor binding might not be as stringent as is commonly believed in determining the host receptor preference for some subtypes of influenza viruses, such as the H1N1 viruses. The structure also showed difference in glycosylation despite the preservation of related sequences, which may partly contribute to the difference between structures of human and avian origin.

	~~==Function==~~		The hemagglutinin structure of an avian H1N1 influenza A virus.,Lin T, Wang G, Li A, Zhang Q, Wu C, Zhang R, Cai Q, Song W, Yuen KY Virology. 2009 Sep 15;392(1):73-81. Epub 2009 Jul 22. PMID:19628241<ref>PMID:19628241</ref>
	~~[[http://www.uniprot.org/uniprot/C7C6F1_9INFA C7C6F1_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment~~ of ~~the~~ virus ~~particle to the cell~~. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, ~~releasing the fusion hydrophobic peptide~~. ~~Several trimers are required to form a competent fusion pore~~ (~~By similarity~~).~~[RuleBase~~:~~RU003324][SAAS~~:~~SAAS013829_004_327643]~~

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[3htt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/wdk~~/~~jx/12416/2005(h1n1)) Influenza~~ a ~~virus (a/wdk/jx/12416/2005(h1n1))]~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=3HTT OCA].~~		</div>

	==See Also==		==See Also==
	*[[Hemagglutinin\|Hemagglutinin]]		*[[Hemagglutinin\|Hemagglutinin]]
			== References ==
	==~~Reference~~==		<references/>
	~~<ref group="xtra">PMID:019628241</ref>~~<references ~~group="xtra"~~/><~~references~~/>		__TOC__
	[[Category: Cai, Q.]]		</StructureSection>
	[[Category: Li, A.]]		[[Category: Cai, Q]]
	[[Category: Song, W.]]		[[Category: Li, A]]
	[[Category: Wang, G.]]		[[Category: Song, W]]
	[[Category: Wu, C.]]		[[Category: Wang, G]]
	[[Category: Yuen, K Y.]]		[[Category: Wu, C]]
	[[Category: Zhang, Q.]]		[[Category: Yuen, K Y]]
	[[Category: Zhang, R.]]		[[Category: Zhang, Q]]
			[[Category: Zhang, R]]
	[[Category: Receptor]]		[[Category: Receptor]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 15:58, 3 March 2014

2014-03-03T15:58:27Z

← Older revision		Revision as of 15:58, 3 March 2014
Line 2:		Line 2:
	===The hemagglutinin structure of an avian H1N1 influenza A virus in complex with 2,3-sialyllactose===		===The hemagglutinin structure of an avian H1N1 influenza A virus in complex with 2,3-sialyllactose===
	{{ABSTRACT_PUBMED_19628241}}		{{ABSTRACT_PUBMED_19628241}}

			==Function==
			[[http://www.uniprot.org/uniprot/C7C6F1_9INFA C7C6F1_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013829_004_327643]

	==About this Structure==		==About this Structure==
	[[3htt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Viruses Viruses~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HTT OCA].		[[3htt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/wdk/jx/12416/2005(h1n1)) Influenza a virus (a/wdk/jx/12416/2005(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HTT OCA].

	==See Also==		==See Also==
Line 10:		Line 13:

	==Reference==		==Reference==
	<ref group="xtra">PMID:019628241</ref><references group="xtra"/>		<ref group="xtra">PMID:019628241</ref><references group="xtra"/><references/>
	~~[[Category: Viruses]]~~
	[[Category: Cai, Q.]]		[[Category: Cai, Q.]]
	[[Category: Li, A.]]		[[Category: Li, A.]]

OCA at 09:38, 11 March 2013

2013-03-11T09:38:33Z

← Older revision		Revision as of 09:38, 11 March 2013
Line 1:		Line 1:
	~~[[Image:3htt.png\|left\|200px]]~~

	{{STRUCTURE_3htt\| PDB=3htt \| SCENE= }}		{{STRUCTURE_3htt\| PDB=3htt \| SCENE= }}

	===The hemagglutinin structure of an avian H1N1 influenza A virus in complex with 2,3-sialyllactose===		===The hemagglutinin structure of an avian H1N1 influenza A virus in complex with 2,3-sialyllactose===

	{{ABSTRACT_PUBMED_19628241}}		{{ABSTRACT_PUBMED_19628241}}

OCA at 11:59, 20 October 2012

2012-10-20T11:59:18Z

← Older revision		Revision as of 11:59, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[3htt]] is a 2 chain structure ~~of [[Hemagglutinin]]~~ with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HTT OCA].		[[3htt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HTT OCA].

	==See Also==		==See Also==

OCA: Protected "3htt" [edit=sysop:move=sysop]

2012-07-26T07:15:23Z

Protected "3htt" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:15, 26 July 2012
(No difference)

OCA at 07:15, 26 July 2012

2012-07-26T07:15:22Z

← Older revision		Revision as of 07:15, 26 July 2012
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	~~{{Seed}}~~
	[[Image:3htt.png\|left\|200px]]		[[Image:3htt.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3htt", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3htt\| PDB=3htt \| SCENE= }}		{{STRUCTURE_3htt\| PDB=3htt \| SCENE= }}

	===The hemagglutinin structure of an avian H1N1 influenza A virus in complex with 2,3-sialyllactose===		===The hemagglutinin structure of an avian H1N1 influenza A virus in complex with 2,3-sialyllactose===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_19628241}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 19628241 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_19628241}}		{{ABSTRACT_PUBMED_19628241}}

	==About this Structure==		==About this Structure==
	~~3HTT~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HTT OCA].		[[3htt]] is a 2 chain structure of [[Hemagglutinin]] with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HTT OCA].

			==See Also==
			*[[Hemagglutinin\|Hemagglutinin]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~19628241~~</ref><references group="xtra"/>		<ref group="xtra">PMID:019628241</ref><references group="xtra"/>
	[[Category: Viruses]]		[[Category: Viruses]]
	[[Category: Cai, Q.]]		[[Category: Cai, Q.]]
Line 35:		Line 26:
	[[Category: Receptor]]		[[Category: Receptor]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 21 09:53:18 2009''~~