3inx - Revision history

OCA at 07:54, 6 September 2023

2023-09-06T07:54:20Z

← Older revision		Revision as of 07:54, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3inx' size='340' side='right'caption='[[3inx]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='3inx' size='340' side='right'caption='[[3inx]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3inx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3INX FirstGlance]. <br>		<table><tr><td colspan='2'>[[3inx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3INX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=JZC:(5E,9E,11E)-14,16-DIHYDROXY-3,4,7,8-TETRAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,11(12H)-DIONE+11-[O-(2-OXO-2-PIPERIDIN-1-YLETHYL)OXIME]'>JZC</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.75Å</td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3inw\|3inw]]</div></td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=JZC:(5E,9E,11E)-14,16-DIHYDROXY-3,4,7,8-TETRAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,11(12H)-DIONE+11-[O-(2-OXO-2-PIPERIDIN-1-YLETHYL)OXIME]'>JZC</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSP90AA1, HSP90A, HSPC1, HSPCA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-chaperonin_molecular_chaperone_ATPase Non-chaperonin molecular chaperone ATPase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.10 3.6.4.10] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3inx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3inx OCA], [https://pdbe.org/3inx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3inx RCSB], [https://www.ebi.ac.uk/pdbsum/3inx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3inx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3inx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3inx OCA], [https://pdbe.org/3inx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3inx RCSB], [https://www.ebi.ac.uk/pdbsum/3inx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3inx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>		[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Non-chaperonin molecular chaperone ATPase]]~~		[[Category: Korndoerfer IP]]
	[[Category: Korndoerfer~~, I P]]~~
	~~[[Category: 2-layer sandwich]]~~
	~~[[Category: Alpha beta]]~~
	~~[[Category: Atp-binding]]~~
	~~[[Category: Chaperone]]~~
	~~[[Category: Nucleotide-binding]]~~
	~~[[Category: Phosphoprotein]]~~
	~~[[Category: Pochonin]]~~
	~~[[Category: Pochoxime]]~~
	~~[[Category: Radicicol]]~~
	~~[[Category: Ral]]~~
	~~[[Category: Sp]]~~
	~~[[Category: Stress response~~]]

OCA at 03:37, 21 April 2022

2022-04-21T03:37:26Z

← Older revision		Revision as of 03:37, 21 April 2022
Line 1:		Line 1:

	==HSP90 N-TERMINAL DOMAIN with pochoxime B==		==HSP90 N-TERMINAL DOMAIN with pochoxime B==
	<StructureSection load='3inx' size='340' side='right' caption='[[3inx]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='3inx' size='340' side='right'caption='[[3inx]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3inx]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3INX FirstGlance]. <br>		<table><tr><td colspan='2'>[[3inx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3INX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=JZC:(5E,9E,11E)-14,16-DIHYDROXY-3,4,7,8-TETRAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,11(12H)-DIONE+11-[O-(2-OXO-2-PIPERIDIN-1-YLETHYL)OXIME]'>JZC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=JZC:(5E,9E,11E)-14,16-DIHYDROXY-3,4,7,8-TETRAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,11(12H)-DIONE+11-[O-(2-OXO-2-PIPERIDIN-1-YLETHYL)OXIME]'>JZC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3inw\|3inw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3inw\|3inw]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSP90AA1, HSP90A, HSPC1, HSPCA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSP90AA1, HSP90A, HSPC1, HSPCA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Non-chaperonin_molecular_chaperone_ATPase Non-chaperonin molecular chaperone ATPase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.10 3.6.4.10] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-chaperonin_molecular_chaperone_ATPase Non-chaperonin molecular chaperone ATPase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.10 3.6.4.10] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3inx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3inx OCA], [~~http~~://pdbe.org/3inx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3inx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3inx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3inx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3inx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3inx OCA], [https://pdbe.org/3inx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3inx RCSB], [https://www.ebi.ac.uk/pdbsum/3inx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3inx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>		[[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:

	==See Also==		==See Also==
	*[[Heat Shock ~~Proteins~~\|Heat Shock ~~Proteins~~]]		*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 39:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Non-chaperonin molecular chaperone ATPase]]		[[Category: Non-chaperonin molecular chaperone ATPase]]
	[[Category: Korndoerfer, I P]]		[[Category: Korndoerfer, I P]]

OCA at 09:24, 19 December 2018

2018-12-19T09:24:47Z

← Older revision		Revision as of 09:24, 19 December 2018
Line 16:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/in/3inx_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/in/3inx_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 09:24, 5 August 2016

2016-08-05T09:24:18Z

← Older revision		Revision as of 09:24, 5 August 2016
Line 1:		Line 1:

	==HSP90 N-TERMINAL DOMAIN with pochoxime B==		==HSP90 N-TERMINAL DOMAIN with pochoxime B==
	<StructureSection load='3inx' size='340' side='right' caption='[[3inx]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='3inx' size='340' side='right' caption='[[3inx]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3inx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3INX FirstGlance]. <br>		<table><tr><td colspan='2'>[[3inx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3INX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=JZC:(5E,9E,11E)-14,16-DIHYDROXY-3,4,7,8-TETRAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,11(12H)-DIONE+11-[O-(2-OXO-2-PIPERIDIN-1-YLETHYL)OXIME]'>JZC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=JZC:(5E,9E,11E)-14,16-DIHYDROXY-3,4,7,8-TETRAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,11(12H)-DIONE+11-[O-(2-OXO-2-PIPERIDIN-1-YLETHYL)OXIME]'>JZC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3inw\|3inw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3inw\|3inw]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSP90AA1, HSP90A, HSPC1, HSPCA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSP90AA1, HSP90A, HSPC1, HSPCA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-chaperonin_molecular_chaperone_ATPase Non-chaperonin molecular chaperone ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.10 3.6.4.10] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-chaperonin_molecular_chaperone_ATPase Non-chaperonin molecular chaperone ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.10 3.6.4.10] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3inx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3inx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3inx RCSB], [http://www.ebi.ac.uk/pdbsum/3inx PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3inx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3inx OCA], [http://pdbe.org/3inx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3inx RCSB], [http://www.ebi.ac.uk/pdbsum/3inx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3inx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3inx ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 30:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3inx" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Non-chaperonin molecular chaperone ATPase]]		[[Category: Non-chaperonin molecular chaperone ATPase]]
	[[Category: Korndoerfer, I P]]		[[Category: Korndoerfer, I P]]

OCA at 01:09, 25 December 2014

2014-12-25T01:09:49Z

← Older revision		Revision as of 01:09, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3inx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3inx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3inx RCSB], [http://www.ebi.ac.uk/pdbsum/3inx PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3inx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3inx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3inx RCSB], [http://www.ebi.ac.uk/pdbsum/3inx PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:50, 8 December 2014

2014-12-08T08:50:49Z

← Older revision		Revision as of 08:50, 8 December 2014
Line 1:		Line 1:
	[[Image:~~3inx~~.~~png~~\|~~left~~\|~~200px~~]]		==HSP90 N-TERMINAL DOMAIN with pochoxime B==
			<StructureSection load='3inx' size='340' side='right' caption='[[3inx]], [[Resolution\|resolution]] 1.75Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3inx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3INX FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=JZC:(5E,9E,11E)-14,16-DIHYDROXY-3,4,7,8-TETRAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,11(12H)-DIONE+11-[O-(2-OXO-2-PIPERIDIN-1-YLETHYL)OXIME]'>JZC</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3inw\|3inw]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSP90AA1, HSP90A, HSPC1, HSPCA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-chaperonin_molecular_chaperone_ATPase Non-chaperonin molecular chaperone ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.10 3.6.4.10] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3inx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3inx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3inx RCSB], [http://www.ebi.ac.uk/pdbsum/3inx PDBsum]</span></td></tr>
			</table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/in/3inx_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The pochoximes, based on the radicicol pharmacophore, are potent inhibitors of heat shock protein 90 (HSP90) that retain their activity in vivo. Herein we report an extended library that broadly explores the structure-activity relationship (SAR) of the pochoximes with four points of diversity. Several modifications were identified that afford improved cellular efficacy, new opportunities for conjugation, and further diversifications. Cocrystal structures of pochoximes A and B with HSP90 show that pochoximes bind to a different conformation of HSP90 than radicicol and provide a rationale for the enhanced affinity of the pochoximes relative to radicicol and the pochonins.

	~~{{STRUCTURE_3inx\| PDB=3inx \| SCENE= }}~~		Inhibition of HSP90 with pochoximes: SAR and structure-based insights.,Barluenga S, Fontaine JG, Wang C, Aouadi K, Chen R, Beebe K, Neckers L, Winssinger N Chembiochem. 2009 Nov 23;10(17):2753-9. PMID:19856365<ref>PMID:19856365</ref>

	~~===HSP90 N-TERMINAL DOMAIN with pochoxime B===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_19856365}}~~

	~~==About this Structure==~~
	~~[[3inx]] is~~ a ~~1 chain structure with sequence from [http://en.wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann.ac.il/oca-bin~~/~~ocashort?id=3INX OCA].~~

	==See Also==		==See Also==
	*[[Heat Shock Proteins\|Heat Shock Proteins]]		*[[Heat Shock Proteins\|Heat Shock Proteins]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:019856365<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Non-chaperonin molecular chaperone ATPase]]		[[Category: Non-chaperonin molecular chaperone ATPase]]
	[[Category: Korndoerfer, I P.]]		[[Category: Korndoerfer, I P]]
	[[Category: 2-layer sandwich]]		[[Category: 2-layer sandwich]]
	[[Category: Alpha beta]]		[[Category: Alpha beta]]

OCA at 10:59, 20 October 2012

2012-10-20T10:59:23Z

← Older revision		Revision as of 10:59, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[3inx]] is a 1 chain structure ~~of [[Heat Shock Proteins]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INX OCA].		[[3inx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INX OCA].

	==See Also==		==See Also==

OCA at 03:54, 26 July 2012

2012-07-26T03:54:06Z

← Older revision		Revision as of 03:54, 26 July 2012
Line 1:		Line 1:
	[[Image:3inx.png\|left\|200px]]		[[Image:3inx.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3inx", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3inx\| PDB=3inx \| SCENE= }}		{{STRUCTURE_3inx\| PDB=3inx \| SCENE= }}

	===HSP90 N-TERMINAL DOMAIN with pochoxime B===		===HSP90 N-TERMINAL DOMAIN with pochoxime B===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_19856365}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 19856365 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_19856365}}		{{ABSTRACT_PUBMED_19856365}}

Line 22:		Line 11:

	==See Also==		==See Also==
	*[[Heat Shock Proteins]]		*[[Heat Shock Proteins\|Heat Shock Proteins]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~19856365~~</ref><references group="xtra"/>		<ref group="xtra">PMID:019856365</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Non-chaperonin molecular chaperone ATPase]]		[[Category: Non-chaperonin molecular chaperone ATPase]]

OCA: Protected "3inx" [edit=sysop:move=sysop]

2010-12-27T01:04:20Z

Protected "3inx" [edit=sysop:move=sysop]

← Older revision	Revision as of 01:04, 27 December 2010
(No difference)

OCA at 01:04, 27 December 2010

2010-12-27T01:04:19Z

← Older revision		Revision as of 01:04, 27 December 2010
Line 1:		Line 1:
	~~{{Seed}}~~
	[[Image:3inx.png\|left\|200px]]		[[Image:3inx.png\|left\|200px]]

Line 20:		Line 19:

	==About this Structure==		==About this Structure==
	~~3INX~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INX OCA].		[[3inx]] is a 1 chain structure of [[Heat Shock Proteins]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INX OCA].

			==See Also==
			*[[Heat Shock Proteins]]

	==Reference==		==Reference==
Line 39:		Line 41:
	[[Category: Sp]]		[[Category: Sp]]
	[[Category: Stress response]]		[[Category: Stress response]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 25 08:24:54 2010''~~