3isp - Revision history

OCA at 08:28, 20 March 2024

2024-03-20T08:28:07Z

← Older revision		Revision as of 08:28, 20 March 2024
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	<StructureSection load='3isp' size='340' side='right'caption='[[3isp]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='3isp' size='340' side='right'caption='[[3isp]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3isp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Myctu Myctu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ISP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ISP FirstGlance]. <br>		<table><tr><td colspan='2'>[[3isp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ISP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ISP FirstGlance]. <br>
	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~Rv1985c (~~[~~https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5~~&~~id=83332 MYCTU])~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3isp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3isp OCA], [https://pdbe.org/3isp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3isp RCSB], [https://www.ebi.ac.uk/pdbsum/3isp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3isp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3isp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3isp OCA], [https://pdbe.org/3isp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3isp RCSB], [https://www.ebi.ac.uk/pdbsum/3isp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3isp ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/LYSG_MYCTU LYSG_MYCTU] Positively regulates the expression of the exporter LysE and represses its own expression. Activity requires the presence of a coinducer, lysine or histidine. Acts by binding to lysG-lysE promoter region. Also up-regulates the expression of ppsB, ppsC and ppsD, by binding to the upstream region of ppsB.<ref>PMID:29049397</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3isp ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3isp ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Mycobacterium tuberculosis presents a challenging medical problem partly due to its persistent nonreplicative state. The inhibitor of chromosomal replication (iciA) protein encoded by M. tuberculosis has been suggested to inhibit chromosome replication initiation in vitro. However, iciA has also been identified as arginine permease (ArgP), a regulatory transcription factor for arginine outward transport. In order to understand the function of ArgP, we have determined its crystal structure by X-ray crystallography to a resolution of 2.7 A. ArgP is a member of the LysR-type transcriptional regulators (LTTRs) and forms a homodimer with each subunit containing two domains: a DNA binding domain (DBD) and a regulatory domain (RD). Two conformationally distinct subunits were identified: closed subunit and open subunit. This phenomenon was first observed in LTTR CbnR, but not in LTTR CrgA, and might be common in LTTRs. We identified two forms of dimers: DBD-type dimers and RD-type dimers. The former is confirmed in solution, and the latter is considered to form oligomers during function. We provide the first structural insights into the interaction of the extreme C-terminal residues with the DBD, which is confirmed by mutagenesis and analytical ultracentrifugation to be important for stability of the functional dimer. The structure serves as a model to suggest how three critical aspects, namely, DNA binding, homo-oligomerization, and interaction with RNAP, are mediated during regulation processing. A model is proposed for the LysR family of dimeric regulators.

	Crystal structure of ArgP from Mycobacterium tuberculosis confirms two distinct conformations of full-length LysR transcriptional regulators and reveals its function in DNA binding and transcriptional regulation.,Zhou X, Lou Z, Fu S, Yang A, Shen H, Li Z, Feng Y, Bartlam M, Wang H, Rao Z J Mol Biol. 2010 Mar 5;396(4):1012-24. Epub 2009 Dec 28. PMID:20036253<ref>PMID:20036253</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 3isp" style="background-color:#fffaf0;"></div>~~
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Myctu~~]]		[[Category: Mycobacterium tuberculosis H37Rv]]
	[[Category: Bartlam, M]]		[[Category: Bartlam M]]
	[[Category: Lou, Z]]		[[Category: Lou Z]]
	[[Category: Rao, Z]]		[[Category: Rao Z]]
	[[Category: Sheng, F]]		[[Category: Sheng F]]
	[[Category: Wang, H]]		[[Category: Wang H]]
	[[Category: Zhou, X]]		[[Category: Zhou X]]
	~~[[Category: Dna binding domain]]~~
	~~[[Category: Dna-binding]]~~
	~~[[Category: Regulatory domain]]~~
	~~[[Category: Rod shaped structure]]~~
	~~[[Category: Transcription]]~~
	~~[[Category: Transcription regulation~~]]

OCA at 03:40, 21 April 2022

2022-04-21T03:40:50Z

← Older revision		Revision as of 03:40, 21 April 2022
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	==Crystal structure of ArgP from Mycobacterium tuberculosis==		==Crystal structure of ArgP from Mycobacterium tuberculosis==
	<StructureSection load='3isp' size='340' side='right' caption='[[3isp]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='3isp' size='340' side='right'caption='[[3isp]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3isp]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ISP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ISP FirstGlance]. <br>		<table><tr><td colspan='2'>[[3isp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ISP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ISP FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rv1985c ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rv1985c ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3isp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3isp OCA], [~~http~~://pdbe.org/3isp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3isp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3isp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3isp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3isp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3isp OCA], [https://pdbe.org/3isp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3isp RCSB], [https://www.ebi.ac.uk/pdbsum/3isp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3isp ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Myctu]]		[[Category: Myctu]]
	[[Category: Bartlam, M]]		[[Category: Bartlam, M]]

OCA at 09:18, 19 December 2018

2018-12-19T09:18:40Z

← Older revision		Revision as of 09:18, 19 December 2018
Line 1:		Line 1:

	==Crystal structure of ArgP from Mycobacterium tuberculosis==		==Crystal structure of ArgP from Mycobacterium tuberculosis==
	<StructureSection load='3isp' size='340' side='right' caption='[[3isp]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='3isp' size='340' side='right' caption='[[3isp]], [[Resolution\|resolution]] 2.70Å' scene=''>
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	<table><tr><td colspan='2'>[[3isp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ISP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ISP FirstGlance]. <br>		<table><tr><td colspan='2'>[[3isp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ISP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ISP FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rv1985c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rv1985c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3isp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3isp OCA], [http://pdbe.org/3isp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3isp RCSB], [http://www.ebi.ac.uk/pdbsum/3isp PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3isp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3isp OCA], [http://pdbe.org/3isp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3isp RCSB], [http://www.ebi.ac.uk/pdbsum/3isp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3isp ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/is/3isp_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/is/3isp_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 12:32, 9 February 2016

2016-02-09T12:32:40Z

← Older revision		Revision as of 12:32, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3isp' size='340' side='right' caption='[[3isp]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='3isp' size='340' side='right' caption='[[3isp]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3isp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis Mycobacterium tuberculosis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ISP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ISP FirstGlance]. <br>		<table><tr><td colspan='2'>[[3isp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ISP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ISP FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rv1985c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~1773 Mycobacterium tuberculosis~~])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rv1985c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3isp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3isp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3isp RCSB], [http://www.ebi.ac.uk/pdbsum/3isp PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3isp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3isp OCA], [http://pdbe.org/3isp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3isp RCSB], [http://www.ebi.ac.uk/pdbsum/3isp PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3isp ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3isp" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Mycobacterium tuberculosis~~]]		[[Category: Myctu]]
	[[Category: Bartlam, M]]		[[Category: Bartlam, M]]
	[[Category: Lou, Z]]		[[Category: Lou, Z]]

OCA at 14:46, 18 December 2014

2014-12-18T14:46:14Z

← Older revision		Revision as of 14:46, 18 December 2014
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	~~{{STRUCTURE_3isp~~\| ~~PDB~~=3isp \| ~~SCENE~~= }}		==Crystal structure of ArgP from Mycobacterium tuberculosis==
	===~~Crystal~~ structure of ~~ArgP~~ from ~~Mycobacterium tuberculosis~~===		<StructureSection load='3isp' size='340' side='right' caption='[[3isp]], [[Resolution\|resolution]] 2.70Å' scene=''>
	~~{{ABSTRACT_PUBMED_20036253}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[3isp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ISP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ISP FirstGlance]. <br>
			</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rv1985c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3isp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3isp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3isp RCSB], [http://www.ebi.ac.uk/pdbsum/3isp PDBsum]</span></td></tr>
			</table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/is/3isp_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Mycobacterium tuberculosis presents a challenging medical problem partly due to its persistent nonreplicative state. The inhibitor of chromosomal replication (iciA) protein encoded by M. tuberculosis has been suggested to inhibit chromosome replication initiation in vitro. However, iciA has also been identified as arginine permease (ArgP), a regulatory transcription factor for arginine outward transport. In order to understand the function of ArgP, we have determined its crystal structure by X-ray crystallography to a resolution of 2.7 A. ArgP is a member of the LysR-type transcriptional regulators (LTTRs) and forms a homodimer with each subunit containing two domains: a DNA binding domain (DBD) and a regulatory domain (RD). Two conformationally distinct subunits were identified: closed subunit and open subunit. This phenomenon was first observed in LTTR CbnR, but not in LTTR CrgA, and might be common in LTTRs. We identified two forms of dimers: DBD-type dimers and RD-type dimers. The former is confirmed in solution, and the latter is considered to form oligomers during function. We provide the first structural insights into the interaction of the extreme C-terminal residues with the DBD, which is confirmed by mutagenesis and analytical ultracentrifugation to be important for stability of the functional dimer. The structure serves as a model to suggest how three critical aspects, namely, DNA binding, homo-oligomerization, and interaction with RNAP, are mediated during regulation processing. A model is proposed for the LysR family of dimeric regulators.

	~~==About this Structure==~~		Crystal structure of ArgP from Mycobacterium tuberculosis confirms two distinct conformations of full-length LysR transcriptional regulators and reveals its function in DNA binding and transcriptional regulation.,Zhou X, Lou Z, Fu S, Yang A, Shen H, Li Z, Feng Y, Bartlam M, Wang H, Rao Z J Mol Biol. 2010 Mar 5;396(4):1012-24. Epub 2009 Dec 28. PMID:20036253<ref>PMID:20036253</ref>
	~~[[3isp]] is a 2 chain~~ structure ~~with sequence~~ from ~~[http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis~~ Mycobacterium tuberculosis]. ~~Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il/oca-bin~~/~~ocashort?id=3ISP OCA].~~

	==~~Reference~~==		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~<ref group="xtra">PMID:020036253</ref>~~<references ~~group="xtra"~~/><~~references~~/>		</div>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Bartlam, M.]]		[[Category: Bartlam, M]]
	[[Category: Lou, Z.]]		[[Category: Lou, Z]]
	[[Category: Rao, Z.]]		[[Category: Rao, Z]]
	[[Category: Sheng, F.]]		[[Category: Sheng, F]]
	[[Category: Wang, H.]]		[[Category: Wang, H]]
	[[Category: Zhou, X.]]		[[Category: Zhou, X]]
	[[Category: Dna binding domain]]		[[Category: Dna binding domain]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]

OCA: Protected "3isp" [edit=sysop:move=sysop]

2013-03-27T09:13:35Z

Protected "3isp" [edit=sysop:move=sysop]

← Older revision	Revision as of 09:13, 27 March 2013
(No difference)

OCA at 09:13, 27 March 2013

2013-03-27T09:13:32Z

← Older revision		Revision as of 09:13, 27 March 2013
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	~~{{Seed}}~~
	~~[[Image:3isp.jpg\|left\|200px]]~~

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3isp", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3isp\| PDB=3isp \| SCENE= }}		{{STRUCTURE_3isp\| PDB=3isp \| SCENE= }}

	===Crystal structure of ArgP from Mycobacterium tuberculosis===		===Crystal structure of ArgP from Mycobacterium tuberculosis===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_20036253}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 20036253 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_20036253}}		{{ABSTRACT_PUBMED_20036253}}

	==About this Structure==		==About this Structure==
	~~3ISP~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ISP OCA].		[[3isp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ISP OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~20036253~~</ref><references group="xtra"/>		<ref group="xtra">PMID:020036253</ref><references group="xtra"/><references/>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Bartlam, M.]]		[[Category: Bartlam, M.]]
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	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 17 10:24:45 2010''~~

OCA at 08:24, 17 February 2010

2010-02-17T08:24:46Z

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-'''Unreleased structure'''
+{{Seed}}
-The entry 3isp is ON HOLD  until Paper Publication
+<!--
-Authors: Zhou, X., Lou, Z., Sheng, F., Bartlam, M., Wang, H., Rao, Z.
+===Crystal structure of ArgP from Mycobacterium tuberculosis===
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 16 08:44:10 2009''
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OCA at 05:44, 16 September 2009

2009-09-16T05:44:11Z

← Older revision		Revision as of 05:44, 16 September 2009
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 3isp is ON HOLD		The entry 3isp is ON HOLD until Paper Publication

	Authors: Zhou, X., Lou, Z., Sheng, F., Bartlam, M., Wang, H., Rao, Z.		Authors: Zhou, X., Lou, Z., Sheng, F., Bartlam, M., Wang, H., Rao, Z.
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	Description: Crystal structure of ArgP from Mycobacterium tuberculosis		Description: Crystal structure of ArgP from Mycobacterium tuberculosis

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep ~~9 09~~:07:27 2009''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 16 08:44:10 2009''

OCA at 06:07, 9 September 2009

2009-09-09T06:07:27Z

← Older revision		Revision as of 06:07, 9 September 2009
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	The entry 3isp is ON HOLD		The entry 3isp is ON HOLD

	Authors: Zhou, X., Lou, Z., Sheng, F~~., Shen, H., Li, Z., Feng, Y~~., Bartlam, M., Wang, H., Rao, Z.		Authors: Zhou, X., Lou, Z., Sheng, F., Bartlam, M., Wang, H., Rao, Z.

	Description: Crystal structure of ArgP from Mycobacterium tuberculosis		Description: Crystal structure of ArgP from Mycobacterium tuberculosis

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu~~ Sep ~~3 15~~:23:35 2009''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 9 09:07:27 2009''