3jsb - Revision history

OCA at 08:29, 20 March 2024

2024-03-20T08:29:04Z

← Older revision		Revision as of 08:29, 20 March 2024
Line 1:		Line 1:

	==Crystal structure of the N-terminal domain of the Lymphocytic Choriomeningitis Virus L protein==		==Crystal structure of the N-terminal domain of the Lymphocytic Choriomeningitis Virus L protein==
	<StructureSection load='3jsb' size='340' side='right' caption='[[3jsb]], [[Resolution\|resolution]] 2.13Å' scene=''>		<StructureSection load='3jsb' size='340' side='right'caption='[[3jsb]], [[Resolution\|resolution]] 2.13Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3jsb]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lcmv Lcmv~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3JSB FirstGlance]. <br>		<table><tr><td colspan='2'>[[3jsb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lymphocytic_choriomeningitis_virus_(strain_Armstrong) Lymphocytic choriomeningitis virus (strain Armstrong)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JSB FirstGlance]. <br>
	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=11624 LCMV])</td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.13Å</td></tr>
	~~<tr id='activity'><td class~~="~~sblockLbl~~">~~<b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA~~-~~directed RNA polymerase]~~, ~~with EC number~~ [~~http://www.brenda-enzymes.info/php/result_flat.php4?ecno=~~2.~~7.7.48 2.7.7.48] </span>~~</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsb OCA], [https://pdbe.org/3jsb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jsb RCSB], [https://www.ebi.ac.uk/pdbsum/3jsb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jsb ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3jsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsb OCA], [~~http~~://pdbe.org/3jsb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3jsb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3jsb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3jsb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/L_LYCVA L_LYCVA]] RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome. During transcription, synthesizes 4 subgenomic RNAs, and assures their capping by a cap-snatching mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. The 3'-end of subgenomic mRNAs molecules are heterogeneous and not polyadenylated. The replicase function is to direct synthesis of antigenomic and genomic RNA which are encapsidated and non capped. As a consequence of the use of the same enzyme for both transcription and replication, these mechanisms need to be well coordinated. These processes may be regulated by proteins N and Z in a dose-dependent manner.<ref>PMID:7682625</ref>		[https://www.uniprot.org/uniprot/L_LYCVA L_LYCVA] RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome. During transcription, synthesizes 4 subgenomic RNAs, and assures their capping by a cap-snatching mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. The 3'-end of subgenomic mRNAs molecules are heterogeneous and not polyadenylated. The replicase function is to direct synthesis of antigenomic and genomic RNA which are encapsidated and non capped. As a consequence of the use of the same enzyme for both transcription and replication, these mechanisms need to be well coordinated. These processes may be regulated by proteins N and Z in a dose-dependent manner.<ref>PMID:7682625</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jsb ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jsb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Arenaviridae synthesize viral mRNAs using short capped primers presumably acquired from cellular transcripts by a 'cap-snatching' mechanism. Here, we report the crystal structure and functional characterization of the N-terminal 196 residues (NL1) of the L protein from the prototypic arenavirus: lymphocytic choriomeningitis virus. The NL1 domain is able to bind and cleave RNA. The 2.13 A resolution crystal structure of NL1 reveals a type II endonuclease alpha/beta architecture similar to the N-terminal end of the influenza virus PA protein. Superimposition of both structures, mutagenesis and reverse genetics studies reveal a unique spatial arrangement of key active site residues related to the PD...(D/E)XK type II endonuclease signature sequence. We show that this endonuclease domain is conserved and active across the virus families Arenaviridae, Bunyaviridae and Orthomyxoviridae and propose that the arenavirus NL1 domain is the Arenaviridae cap-snatching endonuclease.

	The N-terminal domain of the arenavirus L protein is an RNA endonuclease essential in mRNA transcription.,Morin B, Coutard B, Lelke M, Ferron F, Kerber R, Jamal S, Frangeul A, Baronti C, Charrel R, de Lamballerie X, Vonrhein C, Lescar J, Bricogne G, Gunther S, Canard B PLoS Pathog. 2010 Sep 16;6(9). pii: e1001038. PMID:20862324<ref>PMID:20862324</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 3jsb" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==
	*[[RNA polymerase\|RNA polymerase]]		*[[RNA polymerase 3D structures\|RNA polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Lcmv]]~~		[[Category: Large Structures]]
	~~[[Category: RNA-directed RNA polymerase~~]]		[[Category: Bricogne G]]
	[[Category: Bricogne, G]]		[[Category: Canard B]]
	[[Category: Canard, B]]		[[Category: Coutard B]]
	[[Category: Coutard, B]]		[[Category: Ferron FP]]
	[[Category: Ferron~~, F P~~]]		[[Category: Jamal S]]
	[[Category: Jamal, S]]		[[Category: Morin B]]
	~~[[Category: Structural genomic~~]]		[[Category: Vonrhein C]]
	[[Category: Morin, B]]
	[[Category: Vonrhein, C]]
	~~[[Category: Msgp]]~~
	~~[[Category: Nucleotide-binding]]~~
	~~[[Category: Nucleotidyltransferase]]~~
	~~[[Category: Rna binding protein]]~~
	~~[[Category: Rna replication]]~~
	~~[[Category: Rna-directed rna polymerase]]~~
	~~[[Category: Transferase]]~~
	~~[[Category: Viral protein]]~~
	~~[[Category: Virion]]~~
	~~[[Category: Vizier~~]]

OCA at 09:48, 26 December 2018

2018-12-26T09:48:44Z

← Older revision		Revision as of 09:48, 26 December 2018
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/3jsb_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/3jsb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 12:02, 4 August 2016

2016-08-04T12:02:31Z

← Older revision		Revision as of 12:02, 4 August 2016
Line 1:		Line 1:

	==Crystal structure of the N-terminal domain of the Lymphocytic Choriomeningitis Virus L protein==		==Crystal structure of the N-terminal domain of the Lymphocytic Choriomeningitis Virus L protein==
	<StructureSection load='3jsb' size='340' side='right' caption='[[3jsb]], [[Resolution\|resolution]] 2.13Å' scene=''>		<StructureSection load='3jsb' size='340' side='right' caption='[[3jsb]], [[Resolution\|resolution]] 2.13Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3jsb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Lymphocytic_choriomeningitis_virus Lymphocytic choriomeningitis virus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JSB FirstGlance]. <br>		<table><tr><td colspan='2'>[[3jsb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lcmv Lcmv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JSB FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~11623 Lymphocytic choriomeningitis virus~~])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11624 LCMV])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jsb RCSB], [http://www.ebi.ac.uk/pdbsum/3jsb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsb OCA], [http://pdbe.org/3jsb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jsb RCSB], [http://www.ebi.ac.uk/pdbsum/3jsb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3jsb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jsb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3jsb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Lymphocytic choriomeningitis virus~~]]		[[Category: Lcmv]]
	[[Category: RNA-directed RNA polymerase]]		[[Category: RNA-directed RNA polymerase]]
	[[Category: Bricogne, G]]		[[Category: Bricogne, G]]

OCA at 14:15, 24 December 2014

2014-12-24T14:15:57Z

← Older revision		Revision as of 14:15, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jsb RCSB], [http://www.ebi.ac.uk/pdbsum/3jsb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jsb RCSB], [http://www.ebi.ac.uk/pdbsum/3jsb PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/L_LYCVA L_LYCVA]] RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome. During transcription, synthesizes 4 subgenomic RNAs, and assures their capping by a cap-snatching mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. The 3'-end of subgenomic mRNAs molecules are heterogeneous and not polyadenylated. The replicase function is to direct synthesis of antigenomic and genomic RNA which are encapsidated and non capped. As a consequence of the use of the same enzyme for both transcription and replication, these mechanisms need to be well coordinated. These processes may be regulated by proteins N and Z in a dose-dependent manner.<ref>PMID:7682625</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:42, 8 December 2014

2014-12-08T09:42:55Z

← Older revision		Revision as of 09:42, 8 December 2014
Line 1:		Line 1:
	[[Image:~~3jsb~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of the N-terminal domain of the Lymphocytic Choriomeningitis Virus L protein==
			<StructureSection load='3jsb' size='340' side='right' caption='[[3jsb]], [[Resolution\|resolution]] 2.13Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3jsb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lymphocytic_choriomeningitis_virus Lymphocytic choriomeningitis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JSB FirstGlance]. <br>
			</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11623 Lymphocytic choriomeningitis virus])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jsb RCSB], [http://www.ebi.ac.uk/pdbsum/3jsb PDBsum]</span></td></tr>
			</table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/3jsb_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Arenaviridae synthesize viral mRNAs using short capped primers presumably acquired from cellular transcripts by a 'cap-snatching' mechanism. Here, we report the crystal structure and functional characterization of the N-terminal 196 residues (NL1) of the L protein from the prototypic arenavirus: lymphocytic choriomeningitis virus. The NL1 domain is able to bind and cleave RNA. The 2.13 A resolution crystal structure of NL1 reveals a type II endonuclease alpha/beta architecture similar to the N-terminal end of the influenza virus PA protein. Superimposition of both structures, mutagenesis and reverse genetics studies reveal a unique spatial arrangement of key active site residues related to the PD...(D/E)XK type II endonuclease signature sequence. We show that this endonuclease domain is conserved and active across the virus families Arenaviridae, Bunyaviridae and Orthomyxoviridae and propose that the arenavirus NL1 domain is the Arenaviridae cap-snatching endonuclease.

	~~{{STRUCTURE_3jsb\| PDB=3jsb \| SCENE= }}~~		The N-terminal domain of the arenavirus L protein is an RNA endonuclease essential in mRNA transcription.,Morin B, Coutard B, Lelke M, Ferron F, Kerber R, Jamal S, Frangeul A, Baronti C, Charrel R, de Lamballerie X, Vonrhein C, Lescar J, Bricogne G, Gunther S, Canard B PLoS Pathog. 2010 Sep 16;6(9). pii: e1001038. PMID:20862324<ref>PMID:20862324</ref>

	~~===Crystal structure of the N-terminal domain~~ of the ~~Lymphocytic Choriomeningitis Virus L protein===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_20862324}}~~

	~~==About this Structure==~~
	~~[[3jsb]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Lymphocytic_choriomeningitis_virus Lymphocytic choriomeningitis virus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3JSB OCA].~~

	==See Also==		==See Also==
	*[[RNA polymerase\|RNA polymerase]]		*[[RNA polymerase\|RNA polymerase]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:020862324<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Lymphocytic choriomeningitis virus]]		[[Category: Lymphocytic choriomeningitis virus]]
	[[Category: RNA-directed RNA polymerase]]		[[Category: RNA-directed RNA polymerase]]
	[[Category: Bricogne, G.]]		[[Category: Bricogne, G]]
	[[Category: Canard, B.]]		[[Category: Canard, B]]
	[[Category: Coutard, B.]]		[[Category: Coutard, B]]
	[[Category: Ferron, F P.]]		[[Category: Ferron, F P]]
	[[Category: Jamal, S.]]		[[Category: Jamal, S]]
	[[Category: ~~MSGP, Marseilles~~ Structural ~~Genomics Program.@.AFMB.~~]]		[[Category: Structural genomic]]
	[[Category: Morin, B.]]		[[Category: Morin, B]]
	[[Category: Vonrhein, C~~.]]~~		[[Category: Vonrhein, C]]
	~~[[Category: Marseilles structural genomics program @ afmb~~]]
	[[Category: Msgp]]		[[Category: Msgp]]
	[[Category: Nucleotide-binding]]		[[Category: Nucleotide-binding]]
Line 32:		Line 48:
	[[Category: Rna replication]]		[[Category: Rna replication]]
	[[Category: Rna-directed rna polymerase]]		[[Category: Rna-directed rna polymerase]]
	~~[[Category: Structural genomic]]~~
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Viral protein]]		[[Category: Viral protein]]
	[[Category: Virion]]		[[Category: Virion]]
	[[Category: Vizier]]		[[Category: Vizier]]

OCA at 06:18, 20 October 2012

2012-10-20T06:18:48Z

← Older revision		Revision as of 06:18, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[3jsb]] is a 2 chain structure ~~of [[RNA polymerase]]~~ with sequence from [http://en.wikipedia.org/wiki/Lymphocytic_choriomeningitis_virus Lymphocytic choriomeningitis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSB OCA].		[[3jsb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lymphocytic_choriomeningitis_virus Lymphocytic choriomeningitis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSB OCA].

	==See Also==		==See Also==

OCA at 12:46, 25 July 2012

2012-07-25T12:46:54Z

← Older revision		Revision as of 12:46, 25 July 2012
Line 1:		Line 1:
	[[Image:3jsb.png\|left\|200px]]		[[Image:3jsb.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3jsb", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3jsb\| PDB=3jsb \| SCENE= }}		{{STRUCTURE_3jsb\| PDB=3jsb \| SCENE= }}

	===Crystal structure of the N-terminal domain of the Lymphocytic Choriomeningitis Virus L protein===		===Crystal structure of the N-terminal domain of the Lymphocytic Choriomeningitis Virus L protein===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_20862324}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 20862324 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_20862324}}		{{ABSTRACT_PUBMED_20862324}}

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	==See Also==		==See Also==
	*[[RNA polymerase]]		*[[RNA polymerase\|RNA polymerase]]

	==Reference==		==Reference==

OCA: Protected "3jsb" [edit=sysop:move=sysop]

2012-02-15T06:02:50Z

Protected "3jsb" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:02, 15 February 2012
(No difference)

OCA at 06:02, 15 February 2012

2012-02-15T06:02:48Z

← Older revision		Revision as of 06:02, 15 February 2012
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	~~{{Seed}}~~
	[[Image:3jsb.png\|left\|200px]]		[[Image:3jsb.png\|left\|200px]]

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	==About this Structure==		==About this Structure==
	~~3JSB~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Lymphocytic_choriomeningitis_virus Lymphocytic choriomeningitis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSB OCA].		[[3jsb]] is a 2 chain structure of [[RNA polymerase]] with sequence from [http://en.wikipedia.org/wiki/Lymphocytic_choriomeningitis_virus Lymphocytic choriomeningitis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSB OCA].

			==See Also==
			*[[RNA polymerase]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~20862324~~</ref><references group="xtra"/>		<ref group="xtra">PMID:020862324</ref><references group="xtra"/>
	[[Category: Lymphocytic choriomeningitis virus]]		[[Category: Lymphocytic choriomeningitis virus]]
	[[Category: RNA-directed RNA polymerase]]		[[Category: RNA-directed RNA polymerase]]
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	[[Category: Virion]]		[[Category: Virion]]
	[[Category: Vizier]]		[[Category: Vizier]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 6 05:39:26 2010''~~

OCA at 02:29, 6 October 2010

2010-10-06T02:29:55Z

← Older revision		Revision as of 02:29, 6 October 2010
Line 12:		Line 12:
	===Crystal structure of the N-terminal domain of the Lymphocytic Choriomeningitis Virus L protein===		===Crystal structure of the N-terminal domain of the Lymphocytic Choriomeningitis Virus L protein===


			<!--
			The line below this paragraph, {{ABSTRACT_PUBMED_20862324}}, adds the Publication Abstract to the page
			(as it appears on PubMed at http://www.pubmed.gov), where 20862324 is the PubMed ID number.
			-->
			{{ABSTRACT_PUBMED_20862324}}

	==About this Structure==		==About this Structure==
	3JSB is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Lymphocytic_choriomeningitis_virus Lymphocytic choriomeningitis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSB OCA].		3JSB is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Lymphocytic_choriomeningitis_virus Lymphocytic choriomeningitis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSB OCA].

			==Reference==
			<ref group="xtra">PMID:20862324</ref><references group="xtra"/>
	[[Category: Lymphocytic choriomeningitis virus]]		[[Category: Lymphocytic choriomeningitis virus]]
	[[Category: RNA-directed RNA polymerase]]		[[Category: RNA-directed RNA polymerase]]
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	[[Category: Vizier]]		[[Category: Vizier]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Sep 29 07~~:47:38 2010''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 6 05:39:26 2010''