3jsf - Revision history

OCA at 06:22, 27 November 2024

2024-11-27T06:22:27Z

← Older revision		Revision as of 06:22, 27 November 2024
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/3jsf_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/3jsf_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 08:02, 6 September 2023

2023-09-06T08:02:56Z

← Older revision		Revision as of 08:02, 6 September 2023
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	==Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 638 at 1.93a resolution==		==Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 638 at 1.93a resolution==
	<StructureSection load='3jsf' size='340' side='right' caption='[[3jsf]], [[Resolution\|resolution]] 1.93Å' scene=''>		<StructureSection load='3jsf' size='340' side='right'caption='[[3jsf]], [[Resolution\|resolution]] 1.93Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3jsf]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3JSF FirstGlance]. <br>		<table><tr><td colspan='2'>[[3jsf]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JSF FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=SO4:SULFATE+ION'>SO4</scene~~>, ~~<scene name='pdbligand=XV1:7-(2-FLUOROBENZYL)QUINOLIN-8-OL'>XV1</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.93Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[3jsg\|3jsg]], [[3jtu\|3jtu]]~~<~~/td~~></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XV1:7-(2-FLUOROBENZYL)QUINOLIN-8-OL'>XV1</scene></td></tr>
	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">GLIF, MIF, MMIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsf OCA], [https://pdbe.org/3jsf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jsf RCSB], [https://www.ebi.ac.uk/pdbsum/3jsf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jsf ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3jsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsf OCA], [~~http~~://pdbe.org/3jsf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3jsf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3jsf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3jsf ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[~~[http~~://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[~~http~~://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.		[https://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[https://omim.org/entry/604302 604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>		[https://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/3jsf_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/3jsf_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 3jsf" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3jsf" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Macrophage inhibitory factor 3D structures\|Macrophage inhibitory factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: ~~Mclean, L~~]]		[[Category: Large Structures]]
	[[Category: ~~Zhang, Y~~]]		[[Category: Mclean L]]
	[[Category: ~~Cytokine]]~~		[[Category: Zhang Y]]
	~~[[Category: Cytoplasm]]~~
	~~[[Category: Immune response]]~~
	~~[[Category: Inflammatory response]]~~
	~~[[Category: Innate immunity]]~~
	~~[[Category: Isomerase]]~~
	~~[[Category: Phosphoprotein]]~~
	~~[[Category: Protein-ligand complex]]~~
	~~[[Category: Secreted~~]]

OCA at 08:18, 1 November 2017

2017-11-01T08:18:07Z

← Older revision		Revision as of 08:18, 1 November 2017
Line 32:		Line 32:
	</div>		</div>
	<div class="pdbe-citations 3jsf" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3jsf" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Macrophage inhibitory factor\|Macrophage inhibitory factor]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Zhang, Y]]		[[Category: Zhang, Y]]
	[[Category: Cytokine]]		[[Category: Cytokine]]
			[[Category: Cytoplasm]]
	[[Category: Immune response]]		[[Category: Immune response]]
	[[Category: Inflammatory response]]		[[Category: Inflammatory response]]

OCA at 07:43, 5 August 2016

2016-08-05T07:43:32Z

← Older revision		Revision as of 07:43, 5 August 2016
Line 1:		Line 1:

	==Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 638 at 1.93a resolution==		==Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 638 at 1.93a resolution==
	<StructureSection load='3jsf' size='340' side='right' caption='[[3jsf]], [[Resolution\|resolution]] 1.93Å' scene=''>		<StructureSection load='3jsf' size='340' side='right' caption='[[3jsf]], [[Resolution\|resolution]] 1.93Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3jsf]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JSF FirstGlance]. <br>		<table><tr><td colspan='2'>[[3jsf]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JSF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XV1:7-(2-FLUOROBENZYL)QUINOLIN-8-OL'>XV1</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XV1:7-(2-FLUOROBENZYL)QUINOLIN-8-OL'>XV1</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jsg\|3jsg]], [[3jtu\|3jtu]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jsg\|3jsg]], [[3jtu\|3jtu]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GLIF, MIF, MMIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GLIF, MIF, MMIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jsf RCSB], [http://www.ebi.ac.uk/pdbsum/3jsf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsf OCA], [http://pdbe.org/3jsf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jsf RCSB], [http://www.ebi.ac.uk/pdbsum/3jsf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3jsf ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jsf ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3jsf" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Mclean, L]]		[[Category: Mclean, L]]
	[[Category: Zhang, Y]]		[[Category: Zhang, Y]]

OCA at 17:57, 18 December 2014

2014-12-18T17:57:37Z

← Older revision		Revision as of 17:57, 18 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_3jsf\| PDB=3jsf \| SCENE= }}~~		==Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 638 at 1.93a resolution==
	===Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 638 at 1.93a resolution===		<StructureSection load='3jsf' size='340' side='right' caption='[[3jsf]], [[Resolution\|resolution]] 1.93Å' scene=''>
	~~{{ABSTRACT_PUBMED_19836948}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[3jsf]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JSF FirstGlance]. <br>
	==Disease==		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XV1:7-(2-FLUOROBENZYL)QUINOLIN-8-OL'>XV1</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jsg\|3jsg]], [[3jtu\|3jtu]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GLIF, MIF, MMIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jsf RCSB], [http://www.ebi.ac.uk/pdbsum/3jsf PDBsum]</span></td></tr>
			</table>
			== Disease ==
	[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.		[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
			== Function ==
			[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/3jsf_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Biochemical and X-ray crystallographic studies confirmed that hydroxyquinoline derivatives identified by virtual screening were actually covalent inhibitors of the MIF tautomerase. Adducts were formed by N-alkylation of the Pro-1 at the catalytic site with a loss of an amino group of the inhibitor.

	~~==Function==~~		Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening.,McLean LR, Zhang Y, Li H, Li Z, Lukasczyk U, Choi YM, Han Z, Prisco J, Fordham J, Tsay JT, Reiling S, Vaz RJ, Li Y Bioorg Med Chem Lett. 2009 Dec 1;19(23):6717-20. Epub 2009 Oct 1. PMID:19836948<ref>PMID:19836948</ref>
	~~[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression~~ of MIF ~~at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense~~. ~~Counteracts the anti-inflammatory activity of glucocorticoids~~. ~~Has phenylpyruvate tautomerase and dopachrome tautomerase activity~~ (~~in vitro~~)~~, but the physiological substrate is not known~~. ~~It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity~~.~~<ref>~~PMID:~~15908412</ref>~~<ref>PMID:~~17443469~~</ref>

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[3jsf]] is~~ a ~~3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:/~~/~~oca.weizmann.ac.il/oca-bin/ocashort?id=3JSF OCA].~~		</div>

	==~~Reference~~==		==See Also==
	~~<ref group~~=~~"xtra">PMID:019836948</ref>~~<references ~~group="xtra"~~/><~~references~~/>		*[[Macrophage inhibitory factor\|Macrophage inhibitory factor]]
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mclean, L.]]		[[Category: Mclean, L]]
	[[Category: Zhang, Y.]]		[[Category: Zhang, Y]]
	[[Category: Cytokine]]		[[Category: Cytokine]]
	[[Category: Immune response]]		[[Category: Immune response]]

OCA: Protected "3jsf" [edit=sysop:move=sysop]

2013-03-24T17:56:24Z

Protected "3jsf" [edit=sysop:move=sysop]

← Older revision	Revision as of 17:56, 24 March 2013
(No difference)

OCA at 17:56, 24 March 2013

2013-03-24T17:56:22Z

← Older revision		Revision as of 17:56, 24 March 2013
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	~~{{Seed}}~~
	~~[[Image:3jsf.png\|left\|200px]]~~

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3jsf", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3jsf\| PDB=3jsf \| SCENE= }}		{{STRUCTURE_3jsf\| PDB=3jsf \| SCENE= }}

	===Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 638 at 1.93a resolution===		===Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 638 at 1.93a resolution===
			{{ABSTRACT_PUBMED_19836948}}

			==Disease==
			[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.

	~~<!--~~		==Function==
	~~The line below this paragraph, {{ABSTRACT_PUBMED_19836948}}, adds the Publication Abstract to the page~~		[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref><ref>PMID:17443469</ref>
	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~), ~~where 19836948~~ is the ~~PubMed ID number~~.
	-->
	~~{{ABSTRACT_PUBMED_19836948}}~~

	==About this Structure==		==About this Structure==
	~~3JSF~~ is a 3 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSF OCA].		[[3jsf]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSF OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~19836948~~</ref><references group="xtra"/>		<ref group="xtra">PMID:019836948</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mclean, L.]]		[[Category: Mclean, L.]]
	[[Category: Zhang, Y.]]		[[Category: Zhang, Y.]]
	[[Category: Cytokine]]		[[Category: Cytokine]]
	~~[[Category: Cytoplasm]]~~
	[[Category: Immune response]]		[[Category: Immune response]]
	[[Category: Inflammatory response]]		[[Category: Inflammatory response]]
Line 36:		Line 25:
	[[Category: Protein-ligand complex]]		[[Category: Protein-ligand complex]]
	[[Category: Secreted]]		[[Category: Secreted]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 25 11:18:13 2009''~~

OCA at 09:18, 25 November 2009

2009-11-25T09:18:14Z

← Older revision		Revision as of 09:18, 25 November 2009
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	{{Seed}}		{{Seed}}
	[[Image:3jsf.~~jpg~~\|left\|200px]]		[[Image:3jsf.png\|left\|200px]]

	<!--		<!--
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	[[Category: Secreted]]		[[Category: Secreted]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 11 22:33:28 2009''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 25 11:18:13 2009''

OCA at 20:33, 11 November 2009

2009-11-11T20:33:30Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{Seed}}
-The entry 3jsf is ON HOLD  until Paper Publication
+<!--
-Authors: Mclean, L., Zhang, Y.
+===Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 638 at 1.93a resolution===
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 23 08:30:26 2009''
+<!--

OCA at 05:30, 23 September 2009

2009-09-23T05:30:26Z

← Older revision		Revision as of 05:30, 23 September 2009
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 3jsf is ON HOLD		The entry 3jsf is ON HOLD until Paper Publication

	Authors: L.~~MCLEAN, Y.ZHANG, H.LI, Z.LI, U.LUKASCZYK~~, ~~Y.M.CHOI, Z.HAN, J.PRISCO, J.FORDHAM, J.T.TSAY, S.REILING, R.J.VAZ~~, Y.LI		Authors: Mclean, L., Zhang, Y.

	Description: ~~CRYSTAL STRUCTURE OF MACROPHAGE MIGRATION INHIBITORY FACTOR~~ (~~MIF~~) ~~WITH HYDROXYQUINOLINE INHIBITOR~~ 638 AT 1.~~93A RESOLUTION~~		Description: Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 638 at 1.93a resolution

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 16 08:46:06 2009''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 23 08:30:26 2009''