3jwr - Revision history

OCA at 10:03, 6 November 2024

2024-11-06T10:03:30Z

← Older revision		Revision as of 10:03, 6 November 2024
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jw/3jwr_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jw/3jwr_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 08:05, 6 September 2023

2023-09-06T08:05:28Z

← Older revision		Revision as of 08:05, 6 September 2023
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	<StructureSection load='3jwr' size='340' side='right'caption='[[3jwr]], [[Resolution\|resolution]] 2.99Å' scene=''>		<StructureSection load='3jwr' size='340' side='right'caption='[[3jwr]], [[Resolution\|resolution]] 2.99Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3jwr]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JWR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3JWR FirstGlance]. <br>		<table><tr><td colspan='2'>[[3jwr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JWR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JWR FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=IBM:3-ISOBUTYL-1~~-~~METHYLXANTHINE'>IBM</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.994Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[3jwq\|3jwq]]~~<~~/td~~></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IBM:3-ISOBUTYL-1-METHYLXANTHINE'>IBM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<~~tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[http://en.wikipedia.org/wiki/3',5'-cyclic-GMP_phosphodiesterase 3',5'-cyclic-GMP phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.35 3.1.4.35]~~ </~~span~~></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jwr OCA], [https://pdbe.org/3jwr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jwr RCSB], [https://www.ebi.ac.uk/pdbsum/3jwr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jwr ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3jwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jwr OCA], [~~http~~://pdbe.org/3jwr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3jwr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3jwr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3jwr ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[~~[http~~://www.uniprot.org/uniprot/~~CNRG_HUMAN CNRG_HUMAN~~]~~] Defects in PDE6G are the cause of retinitis pigmentosa type 57 (RP57) [MIM:[http://omim.org/entry/613582 613582]]. RP57 is a retinal~~ dystrophy ~~belonging to the group of pigmentary retinopathies~~. ~~Retinitis pigmentosa~~ is ~~characterized~~ by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.~~<ref>PMID:20655036</ref>~~		[https://www.uniprot.org/uniprot/PDE6C_HUMAN PDE6C_HUMAN] Progressive cone dystrophy;Achromatopsia. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. [~~[http~~://www.uniprot.org/uniprot/~~CNRG_HUMAN CNRG_HUMAN~~]~~] Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.~~		[https://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.[https://www.uniprot.org/uniprot/PDE6C_HUMAN PDE6C_HUMAN]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[Phosphodiesterase\|Phosphodiesterase]]		*[[Phosphodiesterase 3D structures\|Phosphodiesterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~3',5'-cyclic-GMP phosphodiesterase]]~~		[[Category: Homo sapiens]]
	~~[[Category: Human~~]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Artemyev~~, N O~~]]		[[Category: Artemyev NO]]
	[[Category: Barren, B]]		[[Category: Barren B]]
	[[Category: Boyd~~, K K~~]]		[[Category: Boyd KK]]
	[[Category: Gakhar, L]]		[[Category: Gakhar L]]
	[[Category: Muradov, H]]		[[Category: Muradov H]]
	[[Category: Ramaswamy, S]]		[[Category: Ramaswamy S]]
	~~[[Category: Cgmp]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: Mostly alpha]]~~
	~~[[Category: Polymorphism]]~~
	~~[[Category: Sensory transduction]]~~
	~~[[Category: Vision~~]]

OCA at 16:15, 28 August 2019

2019-08-28T16:15:24Z

← Older revision		Revision as of 16:15, 28 August 2019
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	==Crystal structure of chimeric PDE5/PDE6 catalytic domain complexed with 3-isobutyl-1-methylxanthine (IBMX) and PDE6 gamma-subunit inhibitory peptide 70-87.==		==Crystal structure of chimeric PDE5/PDE6 catalytic domain complexed with 3-isobutyl-1-methylxanthine (IBMX) and PDE6 gamma-subunit inhibitory peptide 70-87.==
	<StructureSection load='3jwr' size='340' side='right' caption='[[3jwr]], [[Resolution\|resolution]] 2.99Å' scene=''>		<StructureSection load='3jwr' size='340' side='right'caption='[[3jwr]], [[Resolution\|resolution]] 2.99Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3jwr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JWR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JWR FirstGlance]. <br>		<table><tr><td colspan='2'>[[3jwr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JWR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JWR FirstGlance]. <br>
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jw/3jwr_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jw/3jwr_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 3jwr" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3jwr" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Phosphodiesterase\|Phosphodiesterase]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: 3',5'-cyclic-GMP phosphodiesterase]]		[[Category: 3',5'-cyclic-GMP phosphodiesterase]]
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Artemyev, N O]]		[[Category: Artemyev, N O]]
	[[Category: Barren, B]]		[[Category: Barren, B]]

OCA at 08:20, 1 November 2017

2017-11-01T08:20:47Z

← Older revision		Revision as of 08:20, 1 November 2017
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	</div>		</div>
	<div class="pdbe-citations 3jwr" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3jwr" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Phosphodiesterase\|Phosphodiesterase]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Mostly alpha]]		[[Category: Mostly alpha]]
			[[Category: Polymorphism]]
	[[Category: Sensory transduction]]		[[Category: Sensory transduction]]
	[[Category: Vision]]		[[Category: Vision]]

OCA at 07:55, 5 August 2016

2016-08-05T07:55:24Z

← Older revision		Revision as of 07:55, 5 August 2016
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	==Crystal structure of chimeric PDE5/PDE6 catalytic domain complexed with 3-isobutyl-1-methylxanthine (IBMX) and PDE6 gamma-subunit inhibitory peptide 70-87.==		==Crystal structure of chimeric PDE5/PDE6 catalytic domain complexed with 3-isobutyl-1-methylxanthine (IBMX) and PDE6 gamma-subunit inhibitory peptide 70-87.==
	<StructureSection load='3jwr' size='340' side='right' caption='[[3jwr]], [[Resolution\|resolution]] 2.99Å' scene=''>		<StructureSection load='3jwr' size='340' side='right' caption='[[3jwr]], [[Resolution\|resolution]] 2.99Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3jwr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JWR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JWR FirstGlance]. <br>		<table><tr><td colspan='2'>[[3jwr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JWR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JWR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IBM:3-ISOBUTYL-1-METHYLXANTHINE'>IBM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IBM:3-ISOBUTYL-1-METHYLXANTHINE'>IBM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jwq\|3jwq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jwq\|3jwq]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-GMP_phosphodiesterase 3',5'-cyclic-GMP phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.35 3.1.4.35] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-GMP_phosphodiesterase 3',5'-cyclic-GMP phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.35 3.1.4.35] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jwr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jwr RCSB], [http://www.ebi.ac.uk/pdbsum/3jwr PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jwr OCA], [http://pdbe.org/3jwr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jwr RCSB], [http://www.ebi.ac.uk/pdbsum/3jwr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3jwr ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jwr ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3jwr" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	</StructureSection>		</StructureSection>
	[[Category: 3',5'-cyclic-GMP phosphodiesterase]]		[[Category: 3',5'-cyclic-GMP phosphodiesterase]]
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Artemyev, N O]]		[[Category: Artemyev, N O]]
	[[Category: Barren, B]]		[[Category: Barren, B]]

OCA at 14:43, 18 December 2014

2014-12-18T14:43:59Z

← Older revision		Revision as of 14:43, 18 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_3jwr\| PDB=3jwr \| SCENE= }}~~		==Crystal structure of chimeric PDE5/PDE6 catalytic domain complexed with 3-isobutyl-1-methylxanthine (IBMX) and PDE6 gamma-subunit inhibitory peptide 70-87.==
	===Crystal structure of chimeric PDE5/PDE6 catalytic domain complexed with 3-isobutyl-1-methylxanthine (IBMX) and PDE6 gamma-subunit inhibitory peptide 70-87.===		<StructureSection load='3jwr' size='340' side='right' caption='[[3jwr]], [[Resolution\|resolution]] 2.99Å' scene=''>
	~~{{ABSTRACT_PUBMED_19798052}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[3jwr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JWR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JWR FirstGlance]. <br>
	==Disease==		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IBM:3-ISOBUTYL-1-METHYLXANTHINE'>IBM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	[[http://www.uniprot.org/uniprot/CNRG_HUMAN CNRG_HUMAN]] Defects in PDE6G are the cause of retinitis pigmentosa type 57 (RP57) [MIM:[http://omim.org/entry/613582 613582]]. RP57 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.<ref>PMID:20655036</ref>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jwq\|3jwq]]</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-GMP_phosphodiesterase 3',5'-cyclic-GMP phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.35 3.1.4.35] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jwr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jwr RCSB], [http://www.ebi.ac.uk/pdbsum/3jwr PDBsum]</span></td></tr>
			</table>
			== Disease ==
			[[http://www.uniprot.org/uniprot/CNRG_HUMAN CNRG_HUMAN]] Defects in PDE6G are the cause of retinitis pigmentosa type 57 (RP57) [MIM:[http://omim.org/entry/613582 613582]]. RP57 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.<ref>PMID:20655036</ref>
			== Function ==
			[[http://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. [[http://www.uniprot.org/uniprot/CNRG_HUMAN CNRG_HUMAN]] Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jw/3jwr_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The inhibitory interaction of phosphodiesterase-6 (PDE6) with its gamma-subunit (Pgamma) is pivotal in vertebrate phototransduction. Here, crystal structures of a chimaeric PDE5/PDE6 catalytic domain (PDE5/6cd) complexed with sildenafil or 3-isobutyl-1-methylxanthine and the Pgamma-inhibitory peptide Pgamma(70-87) have been determined at 2.9 and 3.0 A, respectively. These structures show the determinants and the mechanism of the PDE6 inhibition by Pgamma and suggest the conformational change of Pgamma on transducin activation. Two variable H- and M-loops of PDE5/6cd form a distinct interface that contributes to the Pgamma-binding site. This allows the Pgamma C-terminus to fit into the opening of the catalytic pocket, blocking cGMP access to the active site. Our analysis suggests that disruption of the H-M loop interface and Pgamma-binding site is a molecular cause of retinal degeneration in atrd3 mice. Comparison of the two PDE5/6cd structures shows an overlap between the sildenafil and Pgamma(70-87)-binding sites, thereby providing critical insights into the side effects of PDE5 inhibitors on vision.

	~~==Function==~~		Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the gamma-subunit.,Barren B, Gakhar L, Muradov H, Boyd KK, Ramaswamy S, Artemyev NO EMBO J. 2009 Nov 18;28(22):3613-22. Epub 2009 Oct 1. PMID:19798052<ref>PMID:19798052</ref>
	~~[[http://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN]] Plays a role in signal transduction~~ by ~~regulating~~ the ~~intracellular concentration~~ of ~~cyclic nucleotides. This phosphodiesterase catalyzes~~ the ~~specific hydrolysis of cGMP to 5'~~-~~GMP~~. ~~[[http~~:~~//www~~.~~uniprot~~.~~org~~/uniprot/CNRG_HUMAN CNRG_HUMAN]] Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[3jwr]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:/~~/~~oca.weizmann.ac.il/oca-bin/ocashort?id=3JWR OCA].~~		</div>

	==See Also==		==See Also==
	*[[Phosphodiesterase\|Phosphodiesterase]]		*[[Phosphodiesterase\|Phosphodiesterase]]
			== References ==
	==~~Reference~~==		<references/>
	~~<ref group="xtra">PMID:019798052</ref>~~<references ~~group="xtra"~~/><~~references~~/>		__TOC__
			</StructureSection>
	[[Category: 3',5'-cyclic-GMP phosphodiesterase]]		[[Category: 3',5'-cyclic-GMP phosphodiesterase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Artemyev, N O.]]		[[Category: Artemyev, N O]]
	[[Category: Barren, B.]]		[[Category: Barren, B]]
	[[Category: Boyd, K K.]]		[[Category: Boyd, K K]]
	[[Category: Gakhar, L.]]		[[Category: Gakhar, L]]
	[[Category: Muradov, H.]]		[[Category: Muradov, H]]
	[[Category: Ramaswamy, S.]]		[[Category: Ramaswamy, S]]
	[[Category: Cgmp]]		[[Category: Cgmp]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 18:06, 24 March 2013

2013-03-24T18:06:45Z

← Older revision		Revision as of 18:06, 24 March 2013
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	~~[[Image:3jwr.png\|left\|200px]]~~

	{{STRUCTURE_3jwr\| PDB=3jwr \| SCENE= }}		{{STRUCTURE_3jwr\| PDB=3jwr \| SCENE= }}
			===Crystal structure of chimeric PDE5/PDE6 catalytic domain complexed with 3-isobutyl-1-methylxanthine (IBMX) and PDE6 gamma-subunit inhibitory peptide 70-87.===
			{{ABSTRACT_PUBMED_19798052}}

	===~~Crystal structure~~ of ~~chimeric PDE5/PDE6 catalytic domain complexed with 3-isobutyl-1-methylxanthine~~ (~~IBMX~~) and ~~PDE6 gamma-subunit inhibitory peptide 70-87~~.~~===~~		==Disease==
			[[http://www.uniprot.org/uniprot/CNRG_HUMAN CNRG_HUMAN]] Defects in PDE6G are the cause of retinitis pigmentosa type 57 (RP57) [MIM:[http://omim.org/entry/613582 613582]]. RP57 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.<ref>PMID:20655036</ref>

	~~{{ABSTRACT_PUBMED_19798052}}~~		==Function==
			[[http://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. [[http://www.uniprot.org/uniprot/CNRG_HUMAN CNRG_HUMAN]] Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

	==About this Structure==		==About this Structure==
Line 14:		Line 16:

	==Reference==		==Reference==
	<ref group="xtra">PMID:019798052</ref><references group="xtra"/>		<ref group="xtra">PMID:019798052</ref><references group="xtra"/><references/>
	[[Category: 3',5'-cyclic-GMP phosphodiesterase]]		[[Category: 3',5'-cyclic-GMP phosphodiesterase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 19:14, 20 October 2012

2012-10-20T19:14:17Z

← Older revision		Revision as of 19:14, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[3jwr]] is a 4 chain structure ~~of [[Phosphodiesterase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JWR OCA].		[[3jwr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JWR OCA].

	==See Also==		==See Also==

OCA: Protected "3jwr" [edit=sysop:move=sysop]

2012-07-27T06:42:44Z

Protected "3jwr" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:42, 27 July 2012
(No difference)

OCA at 06:42, 27 July 2012

2012-07-27T06:42:42Z

← Older revision		Revision as of 06:42, 27 July 2012
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	~~{{Seed}}~~
	[[Image:3jwr.png\|left\|200px]]		[[Image:3jwr.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3jwr", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3jwr\| PDB=3jwr \| SCENE= }}		{{STRUCTURE_3jwr\| PDB=3jwr \| SCENE= }}

	===Crystal structure of chimeric PDE5/PDE6 catalytic domain complexed with 3-isobutyl-1-methylxanthine (IBMX) and PDE6 gamma-subunit inhibitory peptide 70-87.===		===Crystal structure of chimeric PDE5/PDE6 catalytic domain complexed with 3-isobutyl-1-methylxanthine (IBMX) and PDE6 gamma-subunit inhibitory peptide 70-87.===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_19798052}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 19798052 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_19798052}}		{{ABSTRACT_PUBMED_19798052}}

	==About this Structure==		==About this Structure==
	~~3JWR~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JWR OCA].		[[3jwr]] is a 4 chain structure of [[Phosphodiesterase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JWR OCA].

			==See Also==
			*[[Phosphodiesterase\|Phosphodiesterase]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~19798052~~</ref><references group="xtra"/>		<ref group="xtra">PMID:019798052</ref><references group="xtra"/>
	[[Category: 3',5'-cyclic-GMP phosphodiesterase]]		[[Category: 3',5'-cyclic-GMP phosphodiesterase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
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	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Mostly alpha]]		[[Category: Mostly alpha]]
	~~[[Category: Polymorphism]]~~
	[[Category: Sensory transduction]]		[[Category: Sensory transduction]]
	[[Category: Vision]]		[[Category: Vision]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jan 28 14:24:50 2010''~~