3kl1 - Revision history

OCA at 08:45, 7 February 2024

2024-02-07T08:45:19Z

← Older revision		Revision as of 08:45, 7 February 2024
Line 3:		Line 3:
	<StructureSection load='3kl1' size='340' side='right'caption='[[3kl1]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='3kl1' size='340' side='right'caption='[[3kl1]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3kl1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Arath Arath~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KL1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KL1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3kl1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KL1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KL1 FirstGlance]. <br>
	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3klx\|3klx]]</div></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.55Å</td></tr>
	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">At2g26040, PYL2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax~~.~~cgi?mode=Info~~&~~srchmode=5&id=3702 ARATH])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kl1 OCA], [https://pdbe.org/3kl1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kl1 RCSB], [https://www.ebi.ac.uk/pdbsum/3kl1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kl1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kl1 OCA], [https://pdbe.org/3kl1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kl1 RCSB], [https://www.ebi.ac.uk/pdbsum/3kl1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kl1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/PYL2_ARATH PYL2_ARATH]] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.<ref>PMID:19898420</ref> <ref>PMID:19893533</ref>		[https://www.uniprot.org/uniprot/PYL2_ARATH PYL2_ARATH] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.<ref>PMID:19898420</ref> <ref>PMID:19893533</ref>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Abscisic acid (ABA) controls many physiological processes and mediates adaptive responses to abiotic stresses. The ABA signaling mechanisms for abscisic acid receptors PYR/PYL/RCAR (PYLs) were reported. However, it remains unclear whether the molecular mechanisms are suitable for other PYLs. Here, complex structures of PYL3 with (+)-ABA, pyrabactin and HAB1 are reported. An unexpected trans-homodimer intermediate observed in the crystal is confirmed in solution. ABA-bound PYL3 greatly promotes the generation of monomeric PYL3, which can excessively increase the efficiency of inhibiting PP2Cs. Structure-guided biochemical experiments show that Ser195 accounts for the key intermediate. Interestingly, pyrabactin binds to PYL3 in a distinct nonproductive mode with gate closure, which sheds light on the design of agonists and antagonists for abscisic acid receptors. According to different conformations of ligand-bound PYLs, the PYLs family can be divided into three subclasses, among which the trans-dimeric subclass, represented by PYL3, reveals a distinct regulatory mechanism.

	Complex Structures of the Abscisic Acid Receptor PYL3/RCAR13 Reveal a Unique Regulatory Mechanism.,Zhang X, Zhang Q, Xin Q, Yu L, Wang Z, Wu W, Jiang L, Wang G, Tian W, Deng Z, Wang Y, Liu Z, Long J, Gong Z, Chen Z Structure. 2012 May 9;20(5):780-90. PMID:22579247<ref>PMID:22579247</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 3kl1" style="background-color:#fffaf0;"></div~~>

	==See Also==		==See Also==
Line 26:		Line 16:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Arath~~]]		[[Category: Arabidopsis thaliana]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Chen, Z]]		[[Category: Chen Z]]
	[[Category: Wang, G]]		[[Category: Wang G]]
	[[Category: Zhang, X]]		[[Category: Zhang X]]
	~~[[Category: Abscisic acid receptor]]~~
	~~[[Category: Crystal]]~~
	~~[[Category: High resolution]]~~
	~~[[Category: Hormone receptor]]~~
	~~[[Category: Pp2c~~]]

OCA at 13:35, 4 May 2022

2022-05-04T13:35:36Z

← Older revision		Revision as of 13:35, 4 May 2022
Line 1:		Line 1:

	==Crystal structure of abscisic acid receptor PYL2 at 1.55 A==		==Crystal structure of abscisic acid receptor PYL2 at 1.55 A==
	<StructureSection load='3kl1' size='340' side='right' caption='[[3kl1]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='3kl1' size='340' side='right'caption='[[3kl1]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3kl1]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KL1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3KL1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3kl1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KL1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KL1 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3klx\|3klx]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3klx\|3klx]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At2g26040, PYL2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At2g26040, PYL2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3kl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kl1 OCA], [~~http~~://pdbe.org/3kl1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3kl1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3kl1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3kl1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kl1 OCA], [https://pdbe.org/3kl1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kl1 RCSB], [https://www.ebi.ac.uk/pdbsum/3kl1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kl1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/PYL2_ARATH PYL2_ARATH]] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.<ref>PMID:19898420</ref> <ref>PMID:19893533</ref>		[[https://www.uniprot.org/uniprot/PYL2_ARATH PYL2_ARATH]] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.<ref>PMID:19898420</ref> <ref>PMID:19893533</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:

	==See Also==		==See Also==
	*[[Abscisic acid receptor\|Abscisic acid receptor]]		*[[Abscisic acid receptor 3D structures\|Abscisic acid receptor 3D structures]]
	*[[PYR/PYL/RCAR family of ABA receptors\|PYR/PYL/RCAR family of ABA receptors]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Arath]]		[[Category: Arath]]
			[[Category: Large Structures]]
	[[Category: Chen, Z]]		[[Category: Chen, Z]]
	[[Category: Wang, G]]		[[Category: Wang, G]]

OCA at 09:20, 26 December 2018

2018-12-26T09:20:02Z

← Older revision		Revision as of 09:20, 26 December 2018
Line 21:		Line 21:

	==See Also==		==See Also==
			*[[Abscisic acid receptor\|Abscisic acid receptor]]
	*[[PYR/PYL/RCAR family of ABA receptors\|PYR/PYL/RCAR family of ABA receptors]]		*[[PYR/PYL/RCAR family of ABA receptors\|PYR/PYL/RCAR family of ABA receptors]]
	== References ==		== References ==

OCA at 01:51, 5 August 2016

2016-08-05T01:51:47Z

← Older revision		Revision as of 01:51, 5 August 2016
Line 1:		Line 1:

	==Crystal structure of abscisic acid receptor PYL2 at 1.55 A==		==Crystal structure of abscisic acid receptor PYL2 at 1.55 A==
	<StructureSection load='3kl1' size='340' side='right' caption='[[3kl1]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='3kl1' size='340' side='right' caption='[[3kl1]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3kl1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Arabidopsis_thaliana Arabidopsis thaliana~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KL1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KL1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3kl1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KL1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KL1 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3klx\|3klx]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3klx\|3klx]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At2g26040, PYL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ~~Arabidopsis thaliana~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At2g26040, PYL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kl1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kl1 RCSB], [http://www.ebi.ac.uk/pdbsum/3kl1 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kl1 OCA], [http://pdbe.org/3kl1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kl1 RCSB], [http://www.ebi.ac.uk/pdbsum/3kl1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kl1 ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/PYL2_ARATH PYL2_ARATH]] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.<ref>PMID:19898420</ref> <ref>PMID:19893533</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 15:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3kl1" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 22:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Arabidopsis thaliana~~]]		[[Category: Arath]]
	[[Category: Chen, Z]]		[[Category: Chen, Z]]
	[[Category: Wang, G]]		[[Category: Wang, G]]

OCA at 22:58, 3 January 2015

2015-01-03T22:58:48Z

← Older revision		Revision as of 22:58, 3 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3kl1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KL1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KL1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3kl1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KL1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KL1 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3klx\|3klx]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3klx\|3klx]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At2g26040, PYL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At2g26040, PYL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kl1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kl1 RCSB], [http://www.ebi.ac.uk/pdbsum/3kl1 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kl1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kl1 RCSB], [http://www.ebi.ac.uk/pdbsum/3kl1 PDBsum]</span></td></tr>
	<table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 13:		Line 13:
	Complex Structures of the Abscisic Acid Receptor PYL3/RCAR13 Reveal a Unique Regulatory Mechanism.,Zhang X, Zhang Q, Xin Q, Yu L, Wang Z, Wu W, Jiang L, Wang G, Tian W, Deng Z, Wang Y, Liu Z, Long J, Gong Z, Chen Z Structure. 2012 May 9;20(5):780-90. PMID:22579247<ref>PMID:22579247</ref>		Complex Structures of the Abscisic Acid Receptor PYL3/RCAR13 Reveal a Unique Regulatory Mechanism.,Zhang X, Zhang Q, Xin Q, Yu L, Wang Z, Wu W, Jiang L, Wang G, Tian W, Deng Z, Wang Y, Liu Z, Long J, Gong Z, Chen Z Structure. 2012 May 9;20(5):780-90. PMID:22579247<ref>PMID:22579247</ref>

	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>

			==See Also==
			*[[PYR/PYL/RCAR family of ABA receptors\|PYR/PYL/RCAR family of ABA receptors]]
	== References ==		== References ==
	<references/>		<references/>
Line 20:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
	[[Category: Chen, Z.]]		[[Category: Chen, Z]]
	[[Category: Wang, G.]]		[[Category: Wang, G]]
	[[Category: Zhang, X.]]		[[Category: Zhang, X]]
	[[Category: Abscisic acid receptor]]		[[Category: Abscisic acid receptor]]
	[[Category: Crystal]]		[[Category: Crystal]]

OCA at 09:52, 21 May 2014

2014-05-21T09:52:38Z

← Older revision		Revision as of 09:52, 21 May 2014
Line 1:		Line 1:
	[[~~Image~~:~~3kl1~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of abscisic acid receptor PYL2 at 1.55 A==
			<StructureSection load='3kl1' size='340' side='right' caption='[[3kl1]], [[Resolution\|resolution]] 1.55Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3kl1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KL1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KL1 FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3klx\|3klx]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At2g26040, PYL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kl1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kl1 RCSB], [http://www.ebi.ac.uk/pdbsum/3kl1 PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Abscisic acid (ABA) controls many physiological processes and mediates adaptive responses to abiotic stresses. The ABA signaling mechanisms for abscisic acid receptors PYR/PYL/RCAR (PYLs) were reported. However, it remains unclear whether the molecular mechanisms are suitable for other PYLs. Here, complex structures of PYL3 with (+)-ABA, pyrabactin and HAB1 are reported. An unexpected trans-homodimer intermediate observed in the crystal is confirmed in solution. ABA-bound PYL3 greatly promotes the generation of monomeric PYL3, which can excessively increase the efficiency of inhibiting PP2Cs. Structure-guided biochemical experiments show that Ser195 accounts for the key intermediate. Interestingly, pyrabactin binds to PYL3 in a distinct nonproductive mode with gate closure, which sheds light on the design of agonists and antagonists for abscisic acid receptors. According to different conformations of ligand-bound PYLs, the PYLs family can be divided into three subclasses, among which the trans-dimeric subclass, represented by PYL3, reveals a distinct regulatory mechanism.

	~~<!--~~		Complex Structures of the Abscisic Acid Receptor PYL3/RCAR13 Reveal a Unique Regulatory Mechanism.,Zhang X, Zhang Q, Xin Q, Yu L, Wang Z, Wu W, Jiang L, Wang G, Tian W, Deng Z, Wang Y, Liu Z, Long J, Gong Z, Chen Z Structure. 2012 May 9;20(5):780-90. PMID:22579247<ref>PMID:22579247</ref>
	~~The line below this paragraph~~, ~~containing "STRUCTURE_3kl1"~~, ~~creates the "~~Structure ~~Box" on the page~~.
	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display~~.
	-->
	~~{{STRUCTURE_3kl1\| PDB=3kl1 \| SCENE= }}~~

	~~===Crystal structure~~ of ~~abscisic acid receptor PYL2 at 1.55 A===~~		From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
			</div>
			== References ==
	~~<!--~~		<references/>
	~~The line below this paragraph, {{ABSTRACT_PUBMED_22579247}}, adds the Publication Abstract to~~ the ~~page~~		__TOC__
	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22579247 is the PubMed ID number~~.		</StructureSection>
	-->
	~~{{ABSTRACT_PUBMED_22579247}}~~

	~~==About this Structure==~~
	~~[[3kl1]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KL1 OCA].~~

	==~~Reference~~==
	<~~ref group="xtra">PMID:022579247<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
	[[Category: Chen, Z.]]		[[Category: Chen, Z.]]

OCA: Protected "3kl1" [edit=sysop:move=sysop]

2012-06-06T07:00:58Z

Protected "3kl1" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:00, 6 June 2012
(No difference)

OCA at 07:00, 6 June 2012

2012-06-06T07:00:56Z

← Older revision		Revision as of 07:00, 6 June 2012
Line 1:		Line 1:
	~~{{Seed}}~~		[[Image:3kl1.png\|left\|200px]]
	[[Image:3kl1.~~jpg~~\|left\|200px]]

	<!--		<!--
Line 12:		Line 11:
	===Crystal structure of abscisic acid receptor PYL2 at 1.55 A===		===Crystal structure of abscisic acid receptor PYL2 at 1.55 A===


			<!--
			The line below this paragraph, {{ABSTRACT_PUBMED_22579247}}, adds the Publication Abstract to the page
			(as it appears on PubMed at http://www.pubmed.gov), where 22579247 is the PubMed ID number.
			-->
			{{ABSTRACT_PUBMED_22579247}}

	==About this Structure==		==About this Structure==
	~~3KL1~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KL1 OCA].		[[3kl1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KL1 OCA].

			==Reference==
			<ref group="xtra">PMID:022579247</ref><references group="xtra"/>
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
	[[Category: Chen, Z.]]		[[Category: Chen, Z.]]
Line 24:		Line 32:
	[[Category: Hormone receptor]]		[[Category: Hormone receptor]]
	[[Category: Pp2c]]		[[Category: Pp2c]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 10 06:47:39 2010''~~

OCA at 03:36, 10 November 2010

2010-11-10T03:36:44Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{Seed}}
-The entry 3kl1 is ON HOLD  until Paper Publication
+<!--
-Authors: Zhang, X., Wang, G., Chen, Z.
+===Crystal structure of abscisic acid receptor PYL2 at 1.55 A===
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 18 18:58:14 2009''
+==About this Structure==

OCA: New page: '''Unreleased structure''' The entry 3kl1 is ON HOLD until Paper Publication Authors: Zhang, X., Wang, G., Chen, Z. Description: Crystal structure of abscisic acid receptor PYL2 at 1.5...

2009-11-18T16:58:15Z

New page: '''Unreleased structure''' The entry 3kl1 is ON HOLD until Paper Publication Authors: Zhang, X., Wang, G., Chen, Z. Description: Crystal structure of abscisic acid receptor PYL2 at 1.5...

New page

'''Unreleased structure'''

The entry 3kl1 is ON HOLD until Paper Publication

Authors: Zhang, X., Wang, G., Chen, Z.

Description: Crystal structure of abscisic acid receptor PYL2 at 1.55 A

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 18 18:58:14 2009''