3kl9 - Revision history

OCA at 16:13, 1 November 2023

2023-11-01T16:13:47Z

← Older revision		Revision as of 16:13, 1 November 2023
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	==Crystal structure of PepA from Streptococcus pneumoniae==		==Crystal structure of PepA from Streptococcus pneumoniae==
	<StructureSection load='3kl9' size='340' side='right' caption='[[3kl9]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='3kl9' size='340' side='right'caption='[[3kl9]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3kl9]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Strr6 Strr6~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KL9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3KL9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3kl9]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_R6 Streptococcus pneumoniae R6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KL9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KL9 FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">pepA ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5~~&~~id=171101 STRR6])~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[http://en.wikipedia.org/wiki/Glutamyl_aminopeptidase Glutamyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.7 3.4.11.7]~~ </~~span~~></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kl9 OCA], [https://pdbe.org/3kl9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kl9 RCSB], [https://www.ebi.ac.uk/pdbsum/3kl9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kl9 ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3kl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kl9 OCA], [~~http~~://pdbe.org/3kl9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3kl9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3kl9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3kl9 ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/Q8DNJ7_STRR6 Q8DNJ7_STRR6]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kl/3kl9_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kl/3kl9_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 3kl9" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3kl9" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Aminopeptidase 3D structures\|Aminopeptidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Glutamyl aminopeptidase~~]]		[[Category: Large Structures]]
	[[Category: ~~Strr6~~]]		[[Category: Streptococcus pneumoniae R6]]
	[[Category: Kim, D]]		[[Category: Kim D]]
	[[Category: Kim~~, K K~~]]		[[Category: Kim KK]]
	[[Category: Lee, S]]		[[Category: Lee S]]
	~~[[Category: Aminopeptidase]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: Metallopeptidase m42]]~~
	~~[[Category: Pepa]]~~
	~~[[Category: Substrate specificity]]~~
	~~[[Category: Tetrahedral aminopeptidase~~]]

OCA at 08:35, 1 November 2017

2017-11-01T08:35:49Z

← Older revision		Revision as of 08:35, 1 November 2017
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	==Crystal structure of PepA from Streptococcus pneumoniae==		==Crystal structure of PepA from Streptococcus pneumoniae==
	<StructureSection load='3kl9' size='340' side='right' caption='[[3kl9]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='3kl9' size='340' side='right' caption='[[3kl9]], [[Resolution\|resolution]] 2.70Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pepA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=171101 STRR6])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pepA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=171101 STRR6])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamyl_aminopeptidase Glutamyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.7 3.4.11.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamyl_aminopeptidase Glutamyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.7 3.4.11.7] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kl9 OCA], [http://pdbe.org/3kl9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kl9 RCSB], [http://www.ebi.ac.uk/pdbsum/3kl9 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kl9 OCA], [http://pdbe.org/3kl9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kl9 RCSB], [http://www.ebi.ac.uk/pdbsum/3kl9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kl9 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	</div>		</div>
	<div class="pdbe-citations 3kl9" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3kl9" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Aminopeptidase\|Aminopeptidase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 23:55, 9 February 2016

2016-02-09T23:55:08Z

← Older revision		Revision as of 23:55, 9 February 2016
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	<StructureSection load='3kl9' size='340' side='right' caption='[[3kl9]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='3kl9' size='340' side='right' caption='[[3kl9]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3kl9]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Streptococcus_pneumoniae Streptococcus pneumoniae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KL9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KL9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3kl9]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Strr6 Strr6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KL9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KL9 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pepA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~1313 Streptococcus pneumoniae~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pepA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=171101 STRR6])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamyl_aminopeptidase Glutamyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.7 3.4.11.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamyl_aminopeptidase Glutamyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.7 3.4.11.7] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kl9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kl9 RCSB], [http://www.ebi.ac.uk/pdbsum/3kl9 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kl9 OCA], [http://pdbe.org/3kl9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kl9 RCSB], [http://www.ebi.ac.uk/pdbsum/3kl9 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kl9 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3kl9" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	</StructureSection>		</StructureSection>
	[[Category: Glutamyl aminopeptidase]]		[[Category: Glutamyl aminopeptidase]]
	[[Category: ~~Streptococcus pneumoniae~~]]		[[Category: Strr6]]
	[[Category: Kim, D]]		[[Category: Kim, D]]
	[[Category: Kim, K K]]		[[Category: Kim, K K]]

OCA at 10:28, 20 January 2015

2015-01-20T10:28:28Z

← Older revision		Revision as of 10:28, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3kl9]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KL9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KL9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3kl9]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KL9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KL9 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pepA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 Streptococcus pneumoniae])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pepA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 Streptococcus pneumoniae])</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamyl_aminopeptidase Glutamyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.7 3.4.11.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamyl_aminopeptidase Glutamyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.7 3.4.11.7] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kl9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kl9 RCSB], [http://www.ebi.ac.uk/pdbsum/3kl9 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kl9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kl9 RCSB], [http://www.ebi.ac.uk/pdbsum/3kl9 PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Glutamyl aminopeptidase]]		[[Category: Glutamyl aminopeptidase]]
	[[Category: Streptococcus pneumoniae]]		[[Category: Streptococcus pneumoniae]]
	[[Category: Kim, D.]]		[[Category: Kim, D]]
	[[Category: Kim, K K.]]		[[Category: Kim, K K]]
	[[Category: Lee, S.]]		[[Category: Lee, S]]
	[[Category: Aminopeptidase]]		[[Category: Aminopeptidase]]
	~~[[Category: Glutamyl aminopeptidase]]~~
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Metallopeptidase m42]]		[[Category: Metallopeptidase m42]]

OCA at 12:27, 29 September 2014

2014-09-29T12:27:28Z

← Older revision		Revision as of 12:27, 29 September 2014
Line 1:		Line 1:
	[[Image:~~3kl9~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of PepA from Streptococcus pneumoniae==
			<StructureSection load='3kl9' size='340' side='right' caption='[[3kl9]], [[Resolution\|resolution]] 2.70Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3kl9]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KL9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KL9 FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pepA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 Streptococcus pneumoniae])</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamyl_aminopeptidase Glutamyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.7 3.4.11.7] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kl9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kl9 RCSB], [http://www.ebi.ac.uk/pdbsum/3kl9 PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kl/3kl9_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Regulated cytosolic proteolysis is one of the key cellular processes ensuring proper functioning of a cell. M42 family proteases show a broad spectrum of substrate specificities, but the structural basis for such diversity of the substrate specificities is lagging behind biochemical data. Here we report the crystal structure of PepA from Streptococcus pneumoniae, a glutamyl aminopeptidase belonging to M42 family (SpPepA). We found that Arg-257 in the substrate binding pocket is strategically positioned so that Arg-257 can make electrostatic interactions with the acidic residue of a substrate at its N-terminus. Structural comparison of the substrate binding pocket of the M42 family proteases, along with the structure-based multiple sequence alignment, argues that the appropriate electrostatic interactions contribute to the selective substrate specificity of SpPepA.

	~~{{STRUCTURE_3kl9\| PDB=3kl9 \| SCENE= }}~~		Structural basis for the substrate specificity of PepA from Streptococcus pneumoniae, a dodecameric tetrahedral protease.,Kim D, San BH, Moh SH, Park H, Kim DY, Lee S, Kim KK Biochem Biophys Res Commun. 2010 Jan 1;391(1):431-6. Epub 2009 Nov 13. PMID:19914209<ref>PMID:19914209</ref>

	~~===Crystal structure~~ of ~~PepA from Streptococcus pneumoniae===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_19914209}}~~

	~~==About this Structure==~~
	~~[[3kl9]] is a 12 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]~~. ~~Full crystallographic information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=3KL9 OCA].~~

	==See Also==		==See Also==
	*[[Aminopeptidase\|Aminopeptidase]]		*[[Aminopeptidase\|Aminopeptidase]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:019914209<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Glutamyl aminopeptidase]]		[[Category: Glutamyl aminopeptidase]]
	[[Category: Streptococcus pneumoniae]]		[[Category: Streptococcus pneumoniae]]

OCA at 15:35, 20 October 2012

2012-10-20T15:35:21Z

← Older revision		Revision as of 15:35, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[3kl9]] is a 12 chain structure ~~of [[Aminopeptidase]]~~ with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KL9 OCA].		[[3kl9]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KL9 OCA].

	==See Also==		==See Also==

OCA: Protected "3kl9" [edit=sysop:move=sysop]

2012-07-26T18:51:38Z

Protected "3kl9" [edit=sysop:move=sysop]

← Older revision	Revision as of 18:51, 26 July 2012
(No difference)

OCA at 18:51, 26 July 2012

2012-07-26T18:51:36Z

← Older revision		Revision as of 18:51, 26 July 2012
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	~~{{Seed}}~~		[[Image:3kl9.png\|left\|200px]]
	[[Image:3kl9.~~jpg~~\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3kl9", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
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	{{STRUCTURE_3kl9\| PDB=3kl9 \| SCENE= }}		{{STRUCTURE_3kl9\| PDB=3kl9 \| SCENE= }}

	===Crystal structure of PepA from Streptococcus pneumoniae===		===Crystal structure of PepA from Streptococcus pneumoniae===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_19914209}}, adds the Publication Abstract to the page~~
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	{{ABSTRACT_PUBMED_19914209}}		{{ABSTRACT_PUBMED_19914209}}

	==About this Structure==		==About this Structure==
	~~3KL9~~ is a 12 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/~~Streptococcus_pneumoniae_r6~~ Streptococcus pneumoniae r6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KL9 OCA].		[[3kl9]] is a 12 chain structure of [[Aminopeptidase]] with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KL9 OCA].

			==See Also==
			*[[Aminopeptidase\|Aminopeptidase]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~19914209~~</ref><references group="xtra"/>		<ref group="xtra">PMID:019914209</ref><references group="xtra"/>
	[[Category: Glutamyl aminopeptidase]]		[[Category: Glutamyl aminopeptidase]]
	[[Category: Streptococcus pneumoniae r6]]		[[Category: Streptococcus pneumoniae]]
	[[Category: Kim, D.]]		[[Category: Kim, D.]]
	[[Category: Kim, K K.]]		[[Category: Kim, K K.]]
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	[[Category: Substrate specificity]]		[[Category: Substrate specificity]]
	[[Category: Tetrahedral aminopeptidase]]		[[Category: Tetrahedral aminopeptidase]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 3 09:31:16 2010''~~

OCA at 07:31, 3 February 2010

2010-02-03T07:31:17Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{Seed}}
-The entry 3kl9 is ON HOLD  until sometime in the future
+<!--
-Authors: Kim, K.K., Lee, S., Kim, D.
+===Crystal structure of PepA from Streptococcus pneumoniae===
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan  6 09:12:38 2010''
+<!--

OCA at 07:12, 6 January 2010

2010-01-06T07:12:39Z

← Older revision		Revision as of 07:12, 6 January 2010
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 3kl9 is ON HOLD		The entry 3kl9 is ON HOLD until sometime in the future

	Authors: Kim, K.K., Lee, S., Kim, D.		Authors: Kim, K.K., Lee, S., Kim, D.
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	Description: Crystal structure of PepA from Streptococcus pneumoniae		Description: Crystal structure of PepA from Streptococcus pneumoniae

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Nov 18 18~~:58:~~24 2009~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 6 09:12:38 2010''