3klx - Revision history

OCA at 08:45, 7 February 2024

2024-02-07T08:45:22Z

← Older revision		Revision as of 08:45, 7 February 2024
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	<StructureSection load='3klx' size='340' side='right'caption='[[3klx]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3klx' size='340' side='right'caption='[[3klx]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3klx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Arath Arath~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KLX FirstGlance]. <br>		<table><tr><td colspan='2'>[[3klx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KLX FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[3kl1\|3kl1]]~~<~~/div></td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">At1g73000, F3N23.20, pyl3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3klx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3klx OCA], [https://pdbe.org/3klx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3klx RCSB], [https://www.ebi.ac.uk/pdbsum/3klx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3klx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3klx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3klx OCA], [https://pdbe.org/3klx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3klx RCSB], [https://www.ebi.ac.uk/pdbsum/3klx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3klx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/PYL3_ARATH PYL3_ARATH]] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA (By similarity).		[https://www.uniprot.org/uniprot/PYL3_ARATH PYL3_ARATH] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA (By similarity).
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Abscisic acid (ABA) controls many physiological processes and mediates adaptive responses to abiotic stresses. The ABA signaling mechanisms for abscisic acid receptors PYR/PYL/RCAR (PYLs) were reported. However, it remains unclear whether the molecular mechanisms are suitable for other PYLs. Here, complex structures of PYL3 with (+)-ABA, pyrabactin and HAB1 are reported. An unexpected trans-homodimer intermediate observed in the crystal is confirmed in solution. ABA-bound PYL3 greatly promotes the generation of monomeric PYL3, which can excessively increase the efficiency of inhibiting PP2Cs. Structure-guided biochemical experiments show that Ser195 accounts for the key intermediate. Interestingly, pyrabactin binds to PYL3 in a distinct nonproductive mode with gate closure, which sheds light on the design of agonists and antagonists for abscisic acid receptors. According to different conformations of ligand-bound PYLs, the PYLs family can be divided into three subclasses, among which the trans-dimeric subclass, represented by PYL3, reveals a distinct regulatory mechanism.

	Complex Structures of the Abscisic Acid Receptor PYL3/RCAR13 Reveal a Unique Regulatory Mechanism.,Zhang X, Zhang Q, Xin Q, Yu L, Wang Z, Wu W, Jiang L, Wang G, Tian W, Deng Z, Wang Y, Liu Z, Long J, Gong Z, Chen Z Structure. 2012 May 9;20(5):780-90. PMID:22579247<ref>PMID:22579247</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 3klx" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==
	*[[Abscisic acid receptor 3D structures\|Abscisic acid receptor 3D structures]]		*[[Abscisic acid receptor 3D structures\|Abscisic acid receptor 3D structures]]
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Arath~~]]		[[Category: Arabidopsis thaliana]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Chen, Z]]		[[Category: Chen Z]]
	[[Category: Wang, G]]		[[Category: Wang G]]
	[[Category: Zhang, X]]		[[Category: Zhang X]]
	~~[[Category: Abscisic acid receptor]]~~
	~~[[Category: Crystal]]~~
	~~[[Category: Hormone receptor]]~~
	~~[[Category: Pp2c~~]]

OCA at 13:35, 4 May 2022

2022-05-04T13:35:49Z

← Older revision		Revision as of 13:35, 4 May 2022
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	==Crystal structure of native abscisic acid receptor PYL3==		==Crystal structure of native abscisic acid receptor PYL3==
	<StructureSection load='3klx' size='340' side='right' caption='[[3klx]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3klx' size='340' side='right'caption='[[3klx]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3klx]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3KLX FirstGlance]. <br>		<table><tr><td colspan='2'>[[3klx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KLX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3kl1\|3kl1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3kl1\|3kl1]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At1g73000, F3N23.20, pyl3 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At1g73000, F3N23.20, pyl3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3klx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3klx OCA], [~~http~~://pdbe.org/3klx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3klx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3klx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3klx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3klx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3klx OCA], [https://pdbe.org/3klx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3klx RCSB], [https://www.ebi.ac.uk/pdbsum/3klx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3klx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/PYL3_ARATH PYL3_ARATH]] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA (By similarity).		[[https://www.uniprot.org/uniprot/PYL3_ARATH PYL3_ARATH]] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
	*[[Abscisic acid receptor\|Abscisic acid receptor]]		*[[Abscisic acid receptor 3D structures\|Abscisic acid receptor 3D structures]]
	*[[PYR/PYL/RCAR family of ABA receptors\|PYR/PYL/RCAR family of ABA receptors]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Arath]]		[[Category: Arath]]
			[[Category: Large Structures]]
	[[Category: Chen, Z]]		[[Category: Chen, Z]]
	[[Category: Wang, G]]		[[Category: Wang, G]]

OCA at 08:58, 26 December 2018

2018-12-26T08:58:27Z

← Older revision		Revision as of 08:58, 26 December 2018
Line 22:		Line 22:

	==See Also==		==See Also==
			*[[Abscisic acid receptor\|Abscisic acid receptor]]
	*[[PYR/PYL/RCAR family of ABA receptors\|PYR/PYL/RCAR family of ABA receptors]]		*[[PYR/PYL/RCAR family of ABA receptors\|PYR/PYL/RCAR family of ABA receptors]]
	== References ==		== References ==

OCA at 15:42, 4 August 2016

2016-08-04T15:42:24Z

← Older revision		Revision as of 15:42, 4 August 2016
Line 1:		Line 1:

	==Crystal structure of native abscisic acid receptor PYL3==		==Crystal structure of native abscisic acid receptor PYL3==
	<StructureSection load='3klx' size='340' side='right' caption='[[3klx]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3klx' size='340' side='right' caption='[[3klx]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3klx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Arabidopsis_thaliana Arabidopsis thaliana~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KLX FirstGlance]. <br>		<table><tr><td colspan='2'>[[3klx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KLX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3kl1\|3kl1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3kl1\|3kl1]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At1g73000, F3N23.20, pyl3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ~~Arabidopsis thaliana~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At1g73000, F3N23.20, pyl3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3klx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3klx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3klx RCSB], [http://www.ebi.ac.uk/pdbsum/3klx PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3klx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3klx OCA], [http://pdbe.org/3klx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3klx RCSB], [http://www.ebi.ac.uk/pdbsum/3klx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3klx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3klx" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Arabidopsis thaliana~~]]		[[Category: Arath]]
	[[Category: Chen, Z]]		[[Category: Chen, Z]]
	[[Category: Wang, G]]		[[Category: Wang, G]]

OCA at 10:39, 25 December 2014

2014-12-25T10:39:37Z

← Older revision		Revision as of 10:39, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3klx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KLX FirstGlance]. <br>		<table><tr><td colspan='2'>[[3klx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KLX FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3kl1\|3kl1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3kl1\|3kl1]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At1g73000, F3N23.20, pyl3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At1g73000, F3N23.20, pyl3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3klx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3klx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3klx RCSB], [http://www.ebi.ac.uk/pdbsum/3klx PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3klx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3klx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3klx RCSB], [http://www.ebi.ac.uk/pdbsum/3klx PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/PYL3_ARATH PYL3_ARATH]] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 16:
	Complex Structures of the Abscisic Acid Receptor PYL3/RCAR13 Reveal a Unique Regulatory Mechanism.,Zhang X, Zhang Q, Xin Q, Yu L, Wang Z, Wu W, Jiang L, Wang G, Tian W, Deng Z, Wang Y, Liu Z, Long J, Gong Z, Chen Z Structure. 2012 May 9;20(5):780-90. PMID:22579247<ref>PMID:22579247</ref>		Complex Structures of the Abscisic Acid Receptor PYL3/RCAR13 Reveal a Unique Regulatory Mechanism.,Zhang X, Zhang Q, Xin Q, Yu L, Wang Z, Wu W, Jiang L, Wang G, Tian W, Deng Z, Wang Y, Liu Z, Long J, Gong Z, Chen Z Structure. 2012 May 9;20(5):780-90. PMID:22579247<ref>PMID:22579247</ref>

	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>

			==See Also==
			*[[PYR/PYL/RCAR family of ABA receptors\|PYR/PYL/RCAR family of ABA receptors]]
	== References ==		== References ==
	<references/>		<references/>
Line 21:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
	[[Category: Chen, Z.]]		[[Category: Chen, Z]]
	[[Category: Wang, G.]]		[[Category: Wang, G]]
	[[Category: Zhang, X.]]		[[Category: Zhang, X]]
	[[Category: Abscisic acid receptor]]		[[Category: Abscisic acid receptor]]
	[[Category: Crystal]]		[[Category: Crystal]]
	[[Category: Hormone receptor]]		[[Category: Hormone receptor]]
	[[Category: Pp2c]]		[[Category: Pp2c]]

OCA at 09:40, 21 May 2014

2014-05-21T09:40:35Z

← Older revision		Revision as of 09:40, 21 May 2014
Line 1:		Line 1:
	[[~~Image~~:~~3klx~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of native abscisic acid receptor PYL3==
			<StructureSection load='3klx' size='340' side='right' caption='[[3klx]], [[Resolution\|resolution]] 2.50Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[3klx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KLX FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3kl1\|3kl1]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At1g73000, F3N23.20, pyl3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3klx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3klx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3klx RCSB], [http://www.ebi.ac.uk/pdbsum/3klx PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Abscisic acid (ABA) controls many physiological processes and mediates adaptive responses to abiotic stresses. The ABA signaling mechanisms for abscisic acid receptors PYR/PYL/RCAR (PYLs) were reported. However, it remains unclear whether the molecular mechanisms are suitable for other PYLs. Here, complex structures of PYL3 with (+)-ABA, pyrabactin and HAB1 are reported. An unexpected trans-homodimer intermediate observed in the crystal is confirmed in solution. ABA-bound PYL3 greatly promotes the generation of monomeric PYL3, which can excessively increase the efficiency of inhibiting PP2Cs. Structure-guided biochemical experiments show that Ser195 accounts for the key intermediate. Interestingly, pyrabactin binds to PYL3 in a distinct nonproductive mode with gate closure, which sheds light on the design of agonists and antagonists for abscisic acid receptors. According to different conformations of ligand-bound PYLs, the PYLs family can be divided into three subclasses, among which the trans-dimeric subclass, represented by PYL3, reveals a distinct regulatory mechanism.

	~~<!--~~		Complex Structures of the Abscisic Acid Receptor PYL3/RCAR13 Reveal a Unique Regulatory Mechanism.,Zhang X, Zhang Q, Xin Q, Yu L, Wang Z, Wu W, Jiang L, Wang G, Tian W, Deng Z, Wang Y, Liu Z, Long J, Gong Z, Chen Z Structure. 2012 May 9;20(5):780-90. PMID:22579247<ref>PMID:22579247</ref>
	~~The line below this paragraph~~, ~~containing "STRUCTURE_3klx"~~, ~~creates the "~~Structure ~~Box" on the page~~.
	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display~~.
	-->
	~~{{STRUCTURE_3klx\| PDB=3klx \| SCENE= }}~~

	~~===Crystal structure~~ of ~~native abscisic acid receptor PYL3===~~		From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
			</div>
			== References ==
	~~<!--~~		<references/>
	~~The line below this paragraph, {{ABSTRACT_PUBMED_22579247}}, adds the Publication Abstract to~~ the ~~page~~		__TOC__
	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22579247 is the PubMed ID number~~.		</StructureSection>
	-->
	~~{{ABSTRACT_PUBMED_22579247}}~~

	~~==About this Structure==~~
	~~[[3klx]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLX OCA].~~

	==~~Reference~~==
	<~~ref group="xtra">PMID:022579247<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
	[[Category: Chen, Z.]]		[[Category: Chen, Z.]]

OCA: Protected "3klx" [edit=sysop:move=sysop]

2012-06-06T06:44:38Z

Protected "3klx" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:44, 6 June 2012
(No difference)

OCA at 06:44, 6 June 2012

2012-06-06T06:44:36Z

← Older revision		Revision as of 06:44, 6 June 2012
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	~~{{Seed}}~~		[[Image:3klx.png\|left\|200px]]
	[[Image:3klx.~~jpg~~\|left\|200px]]

	<!--		<!--
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	===Crystal structure of native abscisic acid receptor PYL3===		===Crystal structure of native abscisic acid receptor PYL3===


			<!--
			The line below this paragraph, {{ABSTRACT_PUBMED_22579247}}, adds the Publication Abstract to the page
			(as it appears on PubMed at http://www.pubmed.gov), where 22579247 is the PubMed ID number.
			-->
			{{ABSTRACT_PUBMED_22579247}}

	==About this Structure==		==About this Structure==
	~~3KLX~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLX OCA].		[[3klx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLX OCA].

			==Reference==
			<ref group="xtra">PMID:022579247</ref><references group="xtra"/>
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
	[[Category: Chen, Z.]]		[[Category: Chen, Z.]]
Line 23:		Line 31:
	[[Category: Hormone receptor]]		[[Category: Hormone receptor]]
	[[Category: Pp2c]]		[[Category: Pp2c]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 10 06:47:39 2010''~~

OCA at 03:36, 10 November 2010

2010-11-10T03:36:44Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{Seed}}
-The entry 3klx is ON HOLD  until Paper Publication
+<!--
-Authors: Zhang, X., Wang, G., Chen, Z.
+===Crystal structure of native abscisic acid receptor PYL3===
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 25 09:13:18 2009''
+==About this Structure==

OCA at 07:13, 25 November 2009

2009-11-25T07:13:19Z

← Older revision		Revision as of 07:13, 25 November 2009
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 3klx is ON HOLD		The entry 3klx is ON HOLD until Paper Publication

	Authors: Zhang, X., Wang, G., Chen, Z.		Authors: Zhang, X., Wang, G., Chen, Z.
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	Description: Crystal structure of native abscisic acid receptor PYL3		Description: Crystal structure of native abscisic acid receptor PYL3

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov ~~18 18~~:58:52 2009''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 25 09:13:18 2009''