3kos - Revision history

OCA at 06:24, 27 November 2024

2024-11-27T06:24:46Z

← Older revision		Revision as of 06:24, 27 November 2024
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	==Structure of the AmpR effector binding domain from Citrobacter freundii==		==Structure of the AmpR effector binding domain from Citrobacter freundii==
	<StructureSection load='3kos' size='340' side='right' caption='[[3kos]], [[Resolution\|resolution]] 1.83Å' scene=''>		<StructureSection load='3kos' size='340' side='right'caption='[[3kos]], [[Resolution\|resolution]] 1.83Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3kos]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacterium_freundii"_braak_1928 "bacterium~~ freundii~~" braak 1928~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KOS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3KOS FirstGlance]. <br>		<table><tr><td colspan='2'>[[3kos]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Citrobacter_freundii Citrobacter freundii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KOS FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=GOL:GLYCEROL'>GOL</scene~~>, ~~<scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.83Å</td></tr>
	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~MSE~~:~~SELENOMETHIONINE~~'>~~MSE~~</scene><~~/td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td><~~td class="sblockDat">[[3kot\|3kot]]</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kos OCA], [https://pdbe.org/3kos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kos RCSB], [https://www.ebi.ac.uk/pdbsum/3kos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kos ProSAT]</span></td></tr>
	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></~~td><td class="sblockDat"~~>~~ampR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=546 "Bacterium freundii" Braak 1928])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3kos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kos OCA], [~~http~~://pdbe.org/3kos PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3kos RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3kos PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3kos ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/AMPR_CITFR AMPR_CITFR]] Regulates the expression of the beta-lactamase gene. Represses cephalosporinase (AmpC) in the presence of beta-lactams and induces it in the absence of them.		[https://www.uniprot.org/uniprot/AMPR_CITFR AMPR_CITFR] Regulates the expression of the beta-lactamase gene. Represses cephalosporinase (AmpC) in the presence of beta-lactams and induces it in the absence of them.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ko/3kos_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ko/3kos_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
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	</div>		</div>
	<div class="pdbe-citations 3kos" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3kos" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Transcriptional activator 3D structures\|Transcriptional activator 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Bacterium~~ freundii ~~braak 1928~~]]		[[Category: Citrobacter freundii]]
	[[Category: ~~Balcewich, M D~~]]		[[Category: Large Structures]]
	[[Category: ~~Mark, B L~~]]		[[Category: Balcewich MD]]
	[[Category: ~~Activator]]~~		[[Category: Mark BL]]
	~~[[Category: Alpha-beta sandwich]]~~
	~~[[Category: Dna-binding]]~~
	~~[[Category: Transcription]]~~
	~~[[Category: Transcription regulation~~]]

OCA at 19:23, 24 January 2018

2018-01-24T19:23:37Z

← Older revision		Revision as of 19:23, 24 January 2018
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ko/3kos_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ko/3kos_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 3kos" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3kos" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Transcriptional activator\|Transcriptional activator]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:04, 4 August 2016

2016-08-04T13:04:36Z

← Older revision		Revision as of 13:04, 4 August 2016
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	==Structure of the AmpR effector binding domain from Citrobacter freundii==		==Structure of the AmpR effector binding domain from Citrobacter freundii==
	<StructureSection load='3kos' size='340' side='right' caption='[[3kos]], [[Resolution\|resolution]] 1.83Å' scene=''>		<StructureSection load='3kos' size='340' side='right' caption='[[3kos]], [[Resolution\|resolution]] 1.83Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3kos]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Citrobacter_freundii Citrobacter~~ freundii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KOS FirstGlance]. <br>		<table><tr><td colspan='2'>[[3kos]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_freundii"_braak_1928 "bacterium freundii" braak 1928]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KOS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3kot\|3kot]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3kot\|3kot]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ampR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=546 ~~Citrobacter~~ freundii])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ampR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=546 "Bacterium freundii" Braak 1928])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kos RCSB], [http://www.ebi.ac.uk/pdbsum/3kos PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kos OCA], [http://pdbe.org/3kos PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kos RCSB], [http://www.ebi.ac.uk/pdbsum/3kos PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kos ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kos ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 3kos" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Citrobacter~~ freundii]]		[[Category: Bacterium freundii braak 1928]]
	[[Category: Balcewich, M D]]		[[Category: Balcewich, M D]]
	[[Category: Mark, B L]]		[[Category: Mark, B L]]

OCA at 09:34, 25 December 2014

2014-12-25T09:34:00Z

← Older revision		Revision as of 09:34, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kos RCSB], [http://www.ebi.ac.uk/pdbsum/3kos PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kos RCSB], [http://www.ebi.ac.uk/pdbsum/3kos PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/AMPR_CITFR AMPR_CITFR]] Regulates the expression of the beta-lactamase gene. Represses cephalosporinase (AmpC) in the presence of beta-lactams and induces it in the absence of them.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 15:33, 18 December 2014

2014-12-18T15:33:48Z

← Older revision		Revision as of 15:33, 18 December 2014
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	~~{{STRUCTURE_3kos~~\| ~~PDB~~=3kos \| ~~SCENE~~= }}		==Structure of the AmpR effector binding domain from Citrobacter freundii==
	===~~Structure~~ of the AmpR effector binding domain from Citrobacter freundii~~===~~		<StructureSection load='3kos' size='340' side='right' caption='[[3kos]], [[Resolution\|resolution]] 1.83Å' scene=''>
	~~{{ABSTRACT_PUBMED_20594961}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[3kos]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Citrobacter_freundii Citrobacter freundii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KOS FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
			<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3kot\|3kot]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ampR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=546 Citrobacter freundii])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kos RCSB], [http://www.ebi.ac.uk/pdbsum/3kos PDBsum]</span></td></tr>
			</table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ko/3kos_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Hyperproduction of AmpC beta-lactamase (AmpC) is a formidable mechanism of resistance to penicillins and cephalosporins in Gram-negative bacteria such as Pseudomonas aeruginosa and Enterobacteriaceae. AmpC expression is regulated by the LysR-type transcriptional regulator AmpR. ampR and ampC genes form a divergent operon with overlapping promoters to which AmpR binds and regulates the transcription of both genes. AmpR induces ampC by binding to one member of the family of 1,6-anhydro-N-acetylmuramyl peptides, which are cytosolic catabolites of peptidoglycan that accumulate during beta-lactam challenge. To gain structural insights into AmpR regulation, we determined the crystal structure of the effector binding domain (EBD) of AmpR from Citrobacter freundii up to 1.83 A resolution. The AmpR EBD is dimeric and each monomer comprises two subdomains that adopt alpha/beta Rossmann-like folds. Located between the monomer subdomains is a pocket that was found to bind the crystallization buffer molecule 2-(N-morpholino)ethanesulfonic acid. The pocket, together with a groove along the surface of subdomain I, forms a putative effector binding site into which a molecule of 1,6-anhydro-N-acetylmuramyl pentapeptide could be modeled. Amino acid substitutions at the base of the interdomain pocket either were found to render AmpR incapable of inducing ampC (Thr103Val, Ser221Ala and Tyr264Phe) or resulted in constitutive ampC expression (Gly102Glu). While the substitutions that prevented ampC induction did not alter the overall AmpR EBD structure, circular dichroism spectroscopy revealed that the nonconservative Gly102Glu mutation affected EBD secondary structure, confirming previous work suggesting that Gly102Glu induces a conformational change to result in constitutive AmpC production.

	~~==Function==~~		Crystal structure of the AmpR effector binding domain provides insight into the molecular regulation of inducible ampc beta-lactamase.,Balcewich MD, Reeve TM, Orlikow EA, Donald LJ, Vocadlo DJ, Mark BL J Mol Biol. 2010 Jul 30;400(5):998-1010. Epub 2010 May 31. PMID:20594961<ref>PMID:20594961</ref>
	~~[[http://www.uniprot.org/uniprot/AMPR_CITFR AMPR_CITFR]] Regulates~~ the ~~expression~~ of ~~the~~ beta-lactamase ~~gene~~. ~~Represses cephalosporinase~~ (~~AmpC~~) ~~in the presence of beta~~-~~lactams and induces it in the absence of them~~.

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[3kos]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Citrobacter_freundii Citrobacter freundii]~~. ~~Full crystallographic information is available from [http:/~~/~~oca.weizmann.ac.il/oca-bin/ocashort?id=3KOS OCA].~~		</div>

	==~~Reference~~==		==See Also==
	~~<ref group~~=~~"xtra">PMID:020594961</ref>~~<references ~~group="xtra"~~/><~~references~~/>		*[[Transcriptional activator\|Transcriptional activator]]
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Citrobacter freundii]]		[[Category: Citrobacter freundii]]
	[[Category: Balcewich, M D]]		[[Category: Balcewich, M D]]
	[[Category: Mark, B L.]]		[[Category: Mark, B L]]
	[[Category: Activator]]		[[Category: Activator]]
	[[Category: Alpha-beta sandwich]]		[[Category: Alpha-beta sandwich]]

OCA: Protected "3kos" [edit=sysop:move=sysop]

2013-04-04T02:32:32Z

Protected "3kos" [edit=sysop:move=sysop]

← Older revision	Revision as of 02:32, 4 April 2013
(No difference)

OCA at 02:32, 4 April 2013

2013-04-04T02:32:28Z

← Older revision		Revision as of 02:32, 4 April 2013
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	~~{{Seed}}~~
	~~[[Image:3kos.png\|left\|200px]]~~

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3kos", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_3kos\| PDB=3kos \| SCENE= }}		{{STRUCTURE_3kos\| PDB=3kos \| SCENE= }}

	===Structure of the AmpR effector binding domain from Citrobacter freundii===		===Structure of the AmpR effector binding domain from Citrobacter freundii===
			{{ABSTRACT_PUBMED_20594961}}

			==Function==
	~~<!--~~		[[http://www.uniprot.org/uniprot/AMPR_CITFR AMPR_CITFR]] Regulates the expression of the beta-lactamase gene. Represses cephalosporinase (AmpC) in the presence of beta-lactams and induces it in the absence of them.
	~~The line below this paragraph, {{ABSTRACT_PUBMED_20594961}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~)~~, where 20594961 is~~ the ~~PubMed ID number~~.
	~~-->~~
	~~{{ABSTRACT_PUBMED_20594961}}~~

	==About this Structure==		==About this Structure==
	~~3KOS~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Citrobacter_freundii Citrobacter freundii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KOS OCA].		[[3kos]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Citrobacter_freundii Citrobacter freundii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KOS OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~20594961~~</ref><references group="xtra"/>		<ref group="xtra">PMID:020594961</ref><references group="xtra"/><references/>
	[[Category: Citrobacter freundii]]		[[Category: Citrobacter freundii]]
	[[Category: Balcewich, M D]]		[[Category: Balcewich, M D]]
Line 32:		Line 19:
	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 28 12:05:19 2010''~~

OCA at 07:58, 28 July 2010

2010-07-28T07:58:37Z

← Older revision		Revision as of 07:58, 28 July 2010
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	{{Seed}}		{{Seed}}
	[[Image:3kos.~~jpg~~\|left\|200px]]		[[Image:3kos.png\|left\|200px]]

	<!--		<!--
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	===Structure of the AmpR effector binding domain from Citrobacter freundii===		===Structure of the AmpR effector binding domain from Citrobacter freundii===


			<!--
			The line below this paragraph, {{ABSTRACT_PUBMED_20594961}}, adds the Publication Abstract to the page
			(as it appears on PubMed at http://www.pubmed.gov), where 20594961 is the PubMed ID number.
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			{{ABSTRACT_PUBMED_20594961}}

	==About this Structure==		==About this Structure==
	3KOS is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Citrobacter_freundii Citrobacter freundii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KOS OCA].		3KOS is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Citrobacter_freundii Citrobacter freundii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KOS OCA].

			==Reference==
			<ref group="xtra">PMID:20594961</ref><references group="xtra"/>
	[[Category: Citrobacter freundii]]		[[Category: Citrobacter freundii]]
	[[Category: Balcewich, M D]]		[[Category: Balcewich, M D]]
Line 20:		Line 29:
	[[Category: Activator]]		[[Category: Activator]]
	[[Category: Alpha-beta sandwich]]		[[Category: Alpha-beta sandwich]]
	~~[[Category: Cytoplasm]]~~
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~May 26 08~~:32:05 2010''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 28 12:05:19 2010''

OCA at 04:27, 26 May 2010

2010-05-26T04:27:56Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{Seed}}
-The entry 3kos is ON HOLD  until Paper Publication
+<!--
-Authors: Mark, B.L., Balcewich, M.D
+===Structure of the AmpR effector binding domain from Citrobacter freundii===
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb  3 09:17:05 2010''
+==About this Structure==

OCA at 07:17, 3 February 2010

2010-02-03T07:17:06Z

← Older revision		Revision as of 07:17, 3 February 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 3kos is ON HOLD		The entry 3kos is ON HOLD until Paper Publication

	Authors: Mark, B.L., Balcewich, M.D		Authors: Mark, B.L., Balcewich, M.D
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	Description: Structure of the AmpR effector binding domain from Citrobacter freundii		Description: Structure of the AmpR effector binding domain from Citrobacter freundii

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Nov 25~~ 09:14:~~02 2009~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 3 09:17:05 2010''