3m8a - Revision history

OCA at 08:49, 6 September 2023

2023-09-06T08:49:39Z

← Older revision		Revision as of 08:49, 6 September 2023
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	<StructureSection load='3m8a' size='340' side='right'caption='[[3m8a]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3m8a' size='340' side='right'caption='[[3m8a]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3m8a]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Influenza_a_virus_~~(a/~~california~~/07/2009(~~h1n1~~)) Influenza a virus (a/~~california~~/07/2009(~~h1n1~~))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M8A FirstGlance]. <br>		<table><tr><td colspan='2'>[[3m8a]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/California/07/2009(H1N1)) Influenza A virus (A/California/07/2009(H1N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M8A FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3m5r\|3m5r]]</div~~></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m8a OCA], [https://pdbe.org/3m8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m8a RCSB], [https://www.ebi.ac.uk/pdbsum/3m8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m8a ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m8a OCA], [https://pdbe.org/3m8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m8a RCSB], [https://www.ebi.ac.uk/pdbsum/3m8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m8a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/C3W611_9INFA C3W611_9INFA]] Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor (CPSF4) and the poly(A)-binding protein 2 (PABPN1). This results in the accumulation of unprocessed 3' end pre-mRNAs which can't be exported from the nucleus. Cellular protein synthesis is thereby shut off very early after virus infection. Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.[SAAS:SAAS00141143] Prevents the establishment of the cellular antiviral state by inhibiting TRIM25-mediated DDX58 ubiquitination, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by transcription factors like IRF3 and IRF7. Prevents human EIF2AK2/PKR activation, either by binding double-strand RNA, or by interacting directly with EIF2AK2/PKR. This function may be important at the very beginning of the infection, when NS1 is mainly present in the cytoplasm. Also binds poly(A) and U6 snRNA. Suppresses the RNA silencing-based antiviral response in Drosophila cells.[SAAS:SAAS00141179]		[https://www.uniprot.org/uniprot/C3W611_9INFA C3W611_9INFA] Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor (CPSF4) and the poly(A)-binding protein 2 (PABPN1). This results in the accumulation of unprocessed 3' end pre-mRNAs which can't be exported from the nucleus. Cellular protein synthesis is thereby shut off very early after virus infection. Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.[SAAS:SAAS00141143] Prevents the establishment of the cellular antiviral state by inhibiting TRIM25-mediated DDX58 ubiquitination, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by transcription factors like IRF3 and IRF7. Prevents human EIF2AK2/PKR activation, either by binding double-strand RNA, or by interacting directly with EIF2AK2/PKR. This function may be important at the very beginning of the infection, when NS1 is mainly present in the cytoplasm. Also binds poly(A) and U6 snRNA. Suppresses the RNA silencing-based antiviral response in Drosophila cells.[SAAS:SAAS00141179]

	==See Also==		==See Also==
Line 16:		Line 16:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Anderson~~, W F~~]]		[[Category: Anderson WF]]
	[[Category: Brunzelle~~, J S]]~~		[[Category: Brunzelle JS]]
	~~[[Category: Structural genomic~~]]		[[Category: Savchenko A]]
	[[Category: Savchenko, A]]		[[Category: Skarina T]]
	[[Category: Skarina, T]]		[[Category: Wawrzak Z]]
	[[Category: Wawrzak, Z]]
	~~[[Category: Csgid]]~~
	~~[[Category: H1n1]]~~
	~~[[Category: Host cytoplasm]]~~
	~~[[Category: Host nucleus]]~~
	~~[[Category: Host-virus interaction]]~~
	~~[[Category: Influenza a virus]]~~
	~~[[Category: Interferon antiviral system evasion]]~~
	~~[[Category: N-terminal rna binding domain]]~~
	~~[[Category: Ns1]]~~
	~~[[Category: Rna-binding]]~~
	~~[[Category: Viral protein~~]]

OCA at 07:33, 20 July 2022

2022-07-20T07:33:14Z

← Older revision		Revision as of 07:33, 20 July 2022
Line 3:		Line 3:
	<StructureSection load='3m8a' size='340' side='right'caption='[[3m8a]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3m8a' size='340' side='right'caption='[[3m8a]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3m8a]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Influenza_a_virus_(a/california/07/2009(h1n1)) Influenza a virus (a/california/07/2009(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M8A OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3M8A FirstGlance]. <br>		<table><tr><td colspan='2'>[[3m8a]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_a_virus_(a/california/07/2009(h1n1)) Influenza a virus (a/california/07/2009(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M8A FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3m5r\|3m5r]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3m5r\|3m5r]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3m8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m8a OCA], [~~http~~://pdbe.org/3m8a PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3m8a RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3m8a PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3m8a ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m8a OCA], [https://pdbe.org/3m8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m8a RCSB], [https://www.ebi.ac.uk/pdbsum/3m8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m8a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/C3W611_9INFA C3W611_9INFA]] Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor (CPSF4) and the poly(A)-binding protein 2 (PABPN1). This results in the accumulation of unprocessed 3' end pre-mRNAs which can't be exported from the nucleus. Cellular protein synthesis is thereby shut off very early after virus infection. Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.[SAAS:SAAS00141143] Prevents the establishment of the cellular antiviral state by inhibiting TRIM25-mediated DDX58 ubiquitination, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by transcription factors like IRF3 and IRF7. Prevents human EIF2AK2/PKR activation, either by binding double-strand RNA, or by interacting directly with EIF2AK2/PKR. This function may be important at the very beginning of the infection, when NS1 is mainly present in the cytoplasm. Also binds poly(A) and U6 snRNA. Suppresses the RNA silencing-based antiviral response in Drosophila cells.[SAAS:SAAS00141179]		[[https://www.uniprot.org/uniprot/C3W611_9INFA C3W611_9INFA]] Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor (CPSF4) and the poly(A)-binding protein 2 (PABPN1). This results in the accumulation of unprocessed 3' end pre-mRNAs which can't be exported from the nucleus. Cellular protein synthesis is thereby shut off very early after virus infection. Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.[SAAS:SAAS00141143] Prevents the establishment of the cellular antiviral state by inhibiting TRIM25-mediated DDX58 ubiquitination, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by transcription factors like IRF3 and IRF7. Prevents human EIF2AK2/PKR activation, either by binding double-strand RNA, or by interacting directly with EIF2AK2/PKR. This function may be important at the very beginning of the infection, when NS1 is mainly present in the cytoplasm. Also binds poly(A) and U6 snRNA. Suppresses the RNA silencing-based antiviral response in Drosophila cells.[SAAS:SAAS00141179]

	==See Also==		==See Also==

OCA at 06:40, 14 October 2020

2020-10-14T06:40:08Z

← Older revision		Revision as of 06:40, 14 October 2020
Line 1:		Line 1:

	==Crystal Structure of Swine Flu Virus NS1 N-Terminal RNA Binding Domain from H1N1 Influenza A/California/07/2009==		==Crystal Structure of Swine Flu Virus NS1 N-Terminal RNA Binding Domain from H1N1 Influenza A/California/07/2009==
	<StructureSection load='3m8a' size='340' side='right' caption='[[3m8a]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3m8a' size='340' side='right'caption='[[3m8a]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3m8a]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/california/07/2009(h1n1)) Influenza a virus (a/california/07/2009(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M8A OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3M8A FirstGlance]. <br>		<table><tr><td colspan='2'>[[3m8a]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/california/07/2009(h1n1)) Influenza a virus (a/california/07/2009(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M8A OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3M8A FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3m5r\|3m5r]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3m5r\|3m5r]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3m8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m8a OCA], [http://pdbe.org/3m8a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3m8a RCSB], [http://www.ebi.ac.uk/pdbsum/3m8a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3m8a ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3m8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m8a OCA], [http://pdbe.org/3m8a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3m8a RCSB], [http://www.ebi.ac.uk/pdbsum/3m8a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3m8a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 12:

	==See Also==		==See Also==
	*[[Nonstructural protein\|Nonstructural protein]]		*[[Nonstructural protein 3D structures\|Nonstructural protein 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Anderson, W F]]		[[Category: Anderson, W F]]
	[[Category: Brunzelle, J S]]		[[Category: Brunzelle, J S]]

OCA at 16:24, 5 August 2016

2016-08-05T16:24:50Z

← Older revision		Revision as of 16:24, 5 August 2016
Line 1:		Line 1:

	==Crystal Structure of Swine Flu Virus NS1 N-Terminal RNA Binding Domain from H1N1 Influenza A/California/07/2009==		==Crystal Structure of Swine Flu Virus NS1 N-Terminal RNA Binding Domain from H1N1 Influenza A/California/07/2009==
	<StructureSection load='3m8a' size='340' side='right' caption='[[3m8a]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3m8a' size='340' side='right' caption='[[3m8a]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3m8a]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Influenza_a_virus~~ Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M8A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M8A FirstGlance]. <br>		<table><tr><td colspan='2'>[[3m8a]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/california/07/2009(h1n1)) Influenza a virus (a/california/07/2009(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M8A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M8A FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3m5r\|3m5r]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3m5r\|3m5r]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m8a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3m8a RCSB], [http://www.ebi.ac.uk/pdbsum/3m8a PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m8a OCA], [http://pdbe.org/3m8a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3m8a RCSB], [http://www.ebi.ac.uk/pdbsum/3m8a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3m8a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Influenza a virus]]~~
	[[Category: Anderson, W F]]		[[Category: Anderson, W F]]
	[[Category: Brunzelle, J S]]		[[Category: Brunzelle, J S]]
Line 26:		Line 26:
	[[Category: Host nucleus]]		[[Category: Host nucleus]]
	[[Category: Host-virus interaction]]		[[Category: Host-virus interaction]]
			[[Category: Influenza a virus]]
	[[Category: Interferon antiviral system evasion]]		[[Category: Interferon antiviral system evasion]]
	[[Category: N-terminal rna binding domain]]		[[Category: N-terminal rna binding domain]]

OCA at 20:14, 25 December 2014

2014-12-25T20:14:39Z

← Older revision		Revision as of 20:14, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m8a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3m8a RCSB], [http://www.ebi.ac.uk/pdbsum/3m8a PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m8a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3m8a RCSB], [http://www.ebi.ac.uk/pdbsum/3m8a PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/C3W611_9INFA C3W611_9INFA]] Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor (CPSF4) and the poly(A)-binding protein 2 (PABPN1). This results in the accumulation of unprocessed 3' end pre-mRNAs which can't be exported from the nucleus. Cellular protein synthesis is thereby shut off very early after virus infection. Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.[SAAS:SAAS00141143] Prevents the establishment of the cellular antiviral state by inhibiting TRIM25-mediated DDX58 ubiquitination, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by transcription factors like IRF3 and IRF7. Prevents human EIF2AK2/PKR activation, either by binding double-strand RNA, or by interacting directly with EIF2AK2/PKR. This function may be important at the very beginning of the infection, when NS1 is mainly present in the cytoplasm. Also binds poly(A) and U6 snRNA. Suppresses the RNA silencing-based antiviral response in Drosophila cells.[SAAS:SAAS00141179]

	==See Also==		==See Also==

OCA at 09:32, 9 December 2014

2014-12-09T09:32:17Z

← Older revision		Revision as of 09:32, 9 December 2014
Line 1:		Line 1:
	~~[[Image:3m8a.png\|left\|200px]]~~		==Crystal Structure of Swine Flu Virus NS1 N-Terminal RNA Binding Domain from H1N1 Influenza A/California/07/2009==
			<StructureSection load='3m8a' size='340' side='right' caption='[[3m8a]], [[Resolution\|resolution]] 2.10Å' scene=''>
	~~{{STRUCTURE_3m8a\| PDB=3m8a \| SCENE= }}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[3m8a]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M8A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M8A FirstGlance]. <br>
	===Crystal Structure of Swine Flu Virus NS1 N-Terminal RNA Binding Domain from H1N1 Influenza A/California/07/2009===		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3m5r\|3m5r]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m8a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3m8a RCSB], [http://www.ebi.ac.uk/pdbsum/3m8a PDBsum]</span></td></tr>
	==~~About this Structure~~==		</table>
	[[3m8a]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M8A OCA].

	==See Also==		==See Also==
	*[[Nonstructural protein\|Nonstructural protein]]		*[[Nonstructural protein\|Nonstructural protein]]
			__TOC__
			</StructureSection>
	[[Category: Influenza a virus]]		[[Category: Influenza a virus]]
	[[Category: Anderson, W F.]]		[[Category: Anderson, W F]]
	[[Category: Brunzelle, J S.]]		[[Category: Brunzelle, J S]]
	[[Category: ~~CSGID, Center for~~ Structural ~~Genomics of Infectious Diseases.~~]]		[[Category: Structural genomic]]
	[[Category: Savchenko, A.]]		[[Category: Savchenko, A]]
	[[Category: Skarina, T.]]		[[Category: Skarina, T]]
	[[Category: Wawrzak, Z~~.]]~~		[[Category: Wawrzak, Z]]
	~~[[Category: Center for structural genomics of infectious disease~~]]
	[[Category: Csgid]]		[[Category: Csgid]]
	[[Category: H1n1]]		[[Category: H1n1]]
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	[[Category: Host nucleus]]		[[Category: Host nucleus]]
	[[Category: Host-virus interaction]]		[[Category: Host-virus interaction]]
	~~[[Category: Influenza a virus]]~~
	[[Category: Interferon antiviral system evasion]]		[[Category: Interferon antiviral system evasion]]
	[[Category: N-terminal rna binding domain]]		[[Category: N-terminal rna binding domain]]

OCA at 20:59, 20 October 2012

2012-10-20T20:59:40Z

← Older revision		Revision as of 20:59, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[3m8a]] is a 12 chain structure ~~of [[Nonstructural protein]]~~ with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M8A OCA].		[[3m8a]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M8A OCA].

	==See Also==		==See Also==

OCA at 12:15, 27 July 2012

2012-07-27T12:15:31Z

← Older revision		Revision as of 12:15, 27 July 2012
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	[[Image:3m8a.png\|left\|200px]]		[[Image:3m8a.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_3m8a", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
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	{{STRUCTURE_3m8a\| PDB=3m8a \| SCENE= }}		{{STRUCTURE_3m8a\| PDB=3m8a \| SCENE= }}

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	==See Also==		==See Also==
	*[[Nonstructural protein]]		*[[Nonstructural protein\|Nonstructural protein]]
	[[Category: Influenza a virus]]		[[Category: Influenza a virus]]
	[[Category: Anderson, W F.]]		[[Category: Anderson, W F.]]

OCA: Protected "3m8a" [edit=sysop:move=sysop]

2011-12-14T10:43:50Z

Protected "3m8a" [edit=sysop:move=sysop]

← Older revision	Revision as of 10:43, 14 December 2011
(No difference)

OCA at 10:43, 14 December 2011

2011-12-14T10:43:48Z

← Older revision		Revision as of 10:43, 14 December 2011
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	~~{{Seed}}~~		[[Image:3m8a.png\|left\|200px]]
	[[Image:3m8a.~~jpg~~\|left\|200px]]

	<!--		<!--
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	==About this Structure==		==About this Structure==
	~~3M8A~~ is a 12 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M8A OCA].		[[3m8a]] is a 12 chain structure of [[Nonstructural protein]] with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M8A OCA].

			==See Also==
			*[[Nonstructural protein]]
	[[Category: Influenza a virus]]		[[Category: Influenza a virus]]
	[[Category: Anderson, W F.]]		[[Category: Anderson, W F.]]
	[[Category: Brunzelle, J S.]]		[[Category: Brunzelle, J S.]]
	[[Category: CSGID, Center for Structural Genomics of ~~Infections~~ Diseases.]]		[[Category: CSGID, Center for Structural Genomics of Infectious Diseases.]]
	[[Category: Savchenko, A.]]		[[Category: Savchenko, A.]]
	[[Category: Skarina, T.]]		[[Category: Skarina, T.]]
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	[[Category: Rna-binding]]		[[Category: Rna-binding]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 28 11:09:36 2010''~~